Research graph
References from A Patient-Derived Screen Identifies HDAC Inhibitors as Enhancers of Phagocytosis and Potent Immunotherapy Partners. Local targets link to admitted publications; unresolved targets remain external evidence.
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
10.1056/nejmoa043330 · 2005 · External reference
Microenvironmental regulation of tumor progression and metastasis
10.1038/nm.3394 · 2013 · External reference
The role of microglia and macrophages in glioma maintenance and progression
10.1038/nn.4185 · 2016 · External reference
Interrogation of the microenvironmental landscape in brain tumors reveals disease-specific alterations of immune cells
10.1016/j.cell.2020.05.007 · 2020 · External reference
Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization
10.1038/s41593-020-00789-y · 2021 · External reference
Characterization of a pathogenic subpopulation of human glioma associated macrophages linked to glioma progression
10.1016/j.ccell.2025.12.010 · 2026 · External reference
Origin and differentiation of microglia
10.3389/fncel.2013.00045 · 2013 · External reference
Microglia are effector cells of CD47-SIRPα antiphagocytic axis disruption against glioblastoma
10.1073/pnas.1721434116 · 2019 · External reference
CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy
10.1038/s41586-019-1456-0 · 2019 · External reference
Engagement of MHC class I by the inhibitory receptor LILRB1 suppresses macrophages and is a target of cancer immunotherapy
10.1038/s41590-017-0004-z · 2018 · External reference
CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells
10.1016/j.cell.2009.05.045 · 2009 · External reference
The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors
10.1073/pnas.1121623109 · 2012 · External reference
Therapeutic antibody targeting of CD47 eliminates human acute lymphoblastic leukemia
10.1158/0008-5472.can-10-2238 · 2011 · External reference
PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity
10.1038/nature22396 · 2017 · External reference
Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens
10.1038/s41588-018-0254-1 · 2018 · External reference
Genome-wide CRISPR/Cas9-knockout in human induced Pluripotent Stem Cell (iPSC)-derived macrophages
10.1038/s41598-021-82137-z · 2021 · External reference
Inter-cellular CRISPR screens reveal regulators of cancer cell phagocytosis
10.1038/s41586-021-03879-4 · 2021 · External reference
Histone deacetylases 1 and 2 regulate microglia function during development, homeostasis, and neurodegeneration in a context-dependent manner
10.1016/j.immuni.2018.02.016 · 2018 · External reference
Histone deacetylase inhibitors impair antibacterial defenses of macrophages
10.1093/infdis/jir553 · 2011 · External reference
The HDAC2-SP1 axis orchestrates protumor macrophage polarization
10.1158/0008-5472 · 2023 · External reference
Histone deacetylase 3 regulates microglial function through histone deacetylation
10.1080/15592294.2023.2241008 · 2023 · External reference
Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages
10.1038/nature21409 · 2017 · External reference
Anti-CD47 treatment stimulates phagocytosis of glioblastoma by M1 and M2 polarized macrophages and promotes M1 polarized macrophages in vivo
10.1371/journal.pone.0153550 · 2016 · External reference
Disrupting the CD47-SIRPα anti-phagocytic axis by a humanized anti-CD47 antibody is an efficacious treatment for malignant pediatric brain tumors
10.1126/scitranslmed.aaf2968 · 2017 · External reference
Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines
10.1016/j.ccr.2006.03.030 · 2006 · External reference
Relating protein pharmacology by ligand chemistry
10.1038/nbt1284 · 2007 · External reference
CUT&Tag for efficient epigenomic profiling of small samples and single cells
10.1038/s41467-019-09982-5 · 2019 · External reference
Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence
10.1016/j.ccell.2022.06.001 · 2022 · External reference
The somatic genomic landscape of glioblastoma
10.1016/j.cell.2013.09.034 · 2013 · External reference
Modulation of macrophage metabolism as an emerging immunotherapy strategy for cancer
10.1172/jci175445 · 2024 · External reference
Macrophages as tools and targets in cancer therapy
10.1038/s41573-022-00520-5 · 2022 · External reference
Interferon-gamma at the crossroads of tumor immune surveillance or evasion
10.3389/fimmu.2018.00847 · 2018 · External reference
Macrophages and metabolism in the tumor microenvironment
10.1016/j.cmet.2019.06.001 · 2019 · External reference
S100A4 enhances protumor macrophage polarization by control of PPAR-γ-dependent induction of fatty acid oxidation
10.1136/jitc-2021-002548 · 2021 · External reference
Programmed cell removal by calreticulin in tissue homeostasis and cancer
10.1038/s41467-018-05211-7 · 2018 · External reference
Duration of nuclear NF-kappaB action regulated by reversible acetylation
10.1126/science.1062374 · 2001 · External reference
Targeting HDAC6 improves anti-CD47 immunotherapy
10.1186/s13046-024-02982-4 · 2024 · External reference
