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References from Tim-3 Sustains Tumor Treg Stability and Function, Limiting Checkpoint Blockade Therapy Efficacy. Local targets link to admitted publications; unresolved targets remain external evidence.
The immunobiology of cancer immunosurveillance and immunoediting
10.1016/j.immuni.2004.07.017 · 2004 · External reference
Cancer immunoediting: integrating immunity’s roles in cancer suppression and promotion
10.1126/science.1203486 · 2011 · External reference
Mechanisms of immune evasion by tumors
10.1016/s0065-2776(06)90002-9 · 2006 · External reference
Checkpoint therapy in cancer treatment: progress, challenges, and future directions
10.1172/jci184846 · 2024 · External reference
Regulatory T cells in cancer immunosuppression - implications for anticancer therapy
10.1038/s41571-019-0175-7 · 2019 · External reference
Regulatory T cells in cancer immunotherapy
10.1038/cr.2016.151 · 2017 · External reference
Regulatory T cells: differentiation and function
10.1158/2326-6066.cir-16-0193 · 2016 · External reference
Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunity
10.4049/jimmunol.163.10.5211 · 1999 · External reference
Regulatory cells and the effect of cancer immunotherapy
10.1186/s12943-023-01714-0 · 2023 · External reference
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma
10.1084/jem.20130579 · 2013 · External reference
Conditional regulatory T-cell depletion releases adaptive immunity preventing carcinogenesis and suppressing established tumor growth
10.1158/0008-5472.can-10-1681 · 2010 · External reference
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
10.1038/nm1093 · 2004 · External reference
Understanding and targeting human cancer regulatory T cells to improve therapy
10.1007/978-981-15-6407-9_12 · 2021 · External reference
Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody
1999 · External reference
Interferon-γ drives Treg fragility to promote anti-tumor immunity
10.1016/j.cell.2017.05.005 · 2017 · External reference
Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease
10.1038/415536a · 2002 · External reference
Lag-3, Tim-3, and TIGIT: co-inhibitory receptors with specialized functions in immune regulation
10.1016/j.immuni.2016.05.001 · 2016 · External reference
Immune regulation by Tim-3
10.12688/f1000research.13446.1 · 2018 · External reference
Beyond T cell exhaustion: TIM-3 regulation of myeloid cells
10.1126/sciimmunol.adf2223 · 2024 · External reference
Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells
10.1128/jvi.00639-09 · 2009 · External reference
Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients
10.1084/jem.20100637 · 2010 · External reference
Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection
10.1073/pnas.1009731107 · 2010 · External reference
HCV-specific T cells in HCV/HIV co-infection show elevated frequencies of dual Tim-3/PD-1 expression that correlate with liver disease progression
10.1002/eji.201040340 · 2010 · External reference
Tim-3, a negative regulator of anti-tumor immunity
10.1016/j.coi.2011.12.005 · 2012 · External reference
Novel effector phenotype of Tim-3+ regulatory T cells leads to enhanced suppressive function in head and neck cancer patients
10.1158/1078-0432.ccr-17-1350 · 2018 · External reference
Intratumoral regulatory T cells upregulate immunosuppressive molecules in head and neck cancer patients
10.1038/bjc.2013.645 · 2013 · External reference
TIM-3 expression characterizes regulatory T cells in tumor tissues and is associated with lung cancer progression
10.1371/journal.pone.0030676 · 2012 · External reference
Tumor-infiltrating regulatory T cells delineated by upregulation of PD-1 and inhibitory receptors
10.1016/j.cellimm.2012.07.001 · 2012 · External reference
Tim-3 expression defines regulatory T cells in human tumors
10.1371/journal.pone.0058006 · 2013 · External reference
TIM3+FOXP3+ regulatory T cells are tissue-specific promoters of T-cell dysfunction in cancer
10.4161/onci.23849 · 2013 · External reference
Transcriptional landscape of human tissue lymphocytes unveils uniqueness of tumor-infiltrating T regulatory cells
10.1016/j.immuni.2016.10.021 · 2016 · External reference
Expression of Tim-3 drives phenotypic and functional changes in Treg cells in secondary lymphoid organs and the tumor microenvironment
10.1016/j.celrep.2021.109699 · 2021 · External reference
TIM-3 signaling contributes to the suppressive capacity of Tregs from people with HIV on antiretroviral therapy
10.1093/jleuko/qiad068 · 2023 · External reference
Tim-3 is required for regulatory T cell-mediated promotion of T cell exhaustion and viral persistence during chronic lymphocytic choriomeningitis virus infection
10.4049/jimmunol.2400119 · 2024 · External reference
Enhanced suppressor function of TIM-3+ FoxP3+ regulatory T cells
10.1002/eji.201344392 · 2014 · External reference
Blockade of TIM3 relieves immunosuppression through reducing regulatory T cells in head and neck cancer
10.1186/s13046-018-0713-7 · 2018 · External reference
Stability of the regulatory T cell lineage in vivo
10.1126/science.1191996 · 2010 · External reference
Distinct CD8+ T cell dynamics associate with response to neoadjuvant cancer immunotherapies
10.1016/j.ccell.2025.02.026 · 2025 · External reference
Identification of a neo-epitope dominating endogenous CD8 T cell responses to MC-38 colorectal cancer
10.1080/2162402x.2019.1673125 · 2019 · External reference
Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy
10.1038/nature19330 · 2016 · External reference
Developmental relationships of four exhausted CD8+ T cell subsets reveals underlying transcriptional and epigenetic landscape control mechanisms
10.1016/j.immuni.2020.04.014 · 2020 · External reference
Anti-TIM3 antibody promotes T cell IFN-γ-mediated antitumor immunity and suppresses established tumors
10.1158/0008-5472.can-11-0096 · 2011 · External reference
Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity
10.1084/jem.20100643 · 2010 · External reference
Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion
10.1038/s41590-020-00834-9 · 2021 · External reference
Graded Foxo1 activity in Treg cells differentiates tumour immunity from spontaneous autoimmunity
10.1038/nature16486 · 2016 · External reference
B-cell-specific conditional expression of Myd88p.L252P leads to the development of diffuse large B-cell lymphoma in mice
10.1182/blood-2015-11-684183 · 2016 · External reference
Regulatory T cells: barriers of immune infiltration into the tumor microenvironment
10.3389/fimmu.2021.702726 · 2021 · External reference
The tumor-draining lymph node as a reservoir for systemic immune surveillance
10.1016/j.trecan.2023.09.006 · 2024 · External reference
Macrophage Tim-3 maintains intestinal homeostasis in DSS-induced colitis by suppressing neutrophil necroptosis
10.1016/j.redox.2024.103072 · 2024 · External reference
Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells
10.1038/ni.1884 · 2010 · External reference
Novel Foxo1-dependent transcriptional programs control T(reg) cell function
10.1038/nature11581 · 2012 · External reference
Tim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustion
10.1073/pnas.1712107115 · 2018 · External reference
The costimulatory activity of Tim-3 requires Akt and MAPK signaling and its recruitment to the immune synapse
10.1126/scisignal.aba0717 · 2021 · External reference
Phosphotyrosine-dependent coupling of Tim-3 to T-cell receptor signaling pathways
10.1128/mcb.05297-11 · 2011 · External reference
The plasticity and stability of regulatory T cells
10.1038/nri3464 · 2013 · External reference
Treg fragility: a prerequisite for effective antitumor immunity?
10.1158/2326-6066.cir-18-0066 · 2018 · External reference
IFNγ-induction of TH1-like regulatory T cells controls antiviral responses
10.1038/s41590-023-01453-w · 2023 · External reference
Too much of a good thing? Tim-3 and TCR signaling in T cell exhaustion
10.4049/jimmunol.1400557 · 2014 · External reference
Deletion of PD-1 destabilizes the lineage identity and metabolic fitness of tumor-infiltrating regulatory T cells
10.1038/s41590-022-01373-1 · 2023 · External reference
Interruption of the intratumor CD8+ T cell:Treg crosstalk improves the efficacy of PD-1 immunotherapy
10.1016/j.ccell.2024.05.013 · 2024 · External reference
LAG-3, TIM-3, and TIGIT: distinct functions in immune regulation
10.1016/j.immuni.2024.01.010 · 2024 · External reference
Blocking TIM-3 in treatment-refractory advanced solid tumors: a phase Ia/b study of LY3321367 with or without an anti-PD-L1 antibody
10.1158/1078-0432.ccr-20-4405 · 2021 · External reference
Cancer cell intrinsic TIM-3 induces glioblastoma progression
10.1016/j.isci.2022.105329 · 2022 · External reference
TIM3 expression on tumor cells predicts response to anti-PD-1 therapy for renal cancer
10.1016/j.tranon.2020.100918 · 2021 · External reference
CEACAM1 regulates TIM-3-mediated tolerance and exhaustion
10.1038/nature13848 · 2015 · External reference
The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity
10.1038/ni1271 · 2005 · External reference
Galectin-9 regulates T helper cell function independently of Tim-3
10.1093/glycob/cwq214 · 2011 · External reference
Tim-3 mediates T cell trogocytosis to limit antitumor immunity
10.1172/jci152864 · 2022 · External reference
Phosphatidylserine binding directly regulates TIM-3 function
10.1042/bcj20210425 · 2021 · External reference
Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1
10.1038/ni.2376 · 2012 · External reference
