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References from Periductal Fibroblast Density Defines Lymphocyte Exclusion via a CD44-Dependent Stromal Checkpoint in Pancreatic Cancer. Local targets link to admitted publications; unresolved targets remain external evidence.
Cancer statistics, 2024
10.3322/caac.21820 · 2024 · External reference
Phase 2 trial of single agent Ipilimumab (anti-CTLA-4) for locally advanced or metastatic pancreatic adenocarcinoma
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Safety and activity of anti–PD-L1 antibody in patients with advanced cancer
10.1056/nejmoa1200694 · 2012 · External reference
Durvalumab with or without tremelimumab for patients with metastatic pancreatic ductal adenocarcinoma: a phase 2 randomized clinical trial
10.1001/jamaoncol.2019.1588 · 2019 · External reference
Tumour microenvironment of pancreatic cancer: immune landscape is dictated by molecular and histopathological features
10.1038/s41416-019-0479-5 · 2019 · External reference
The immune landscape of human pancreatic ductal carcinoma: key players, clinical implications, and challenges
10.3390/cancers14040995 · 2022 · External reference
Biology of pancreatic stellate cells—more than just pancreatic cancer
10.1007/s00424-017-1968-0 · 2017 · External reference
Spatial transcriptomic analysis of primary and metastatic pancreatic cancers highlights tumor microenvironmental heterogeneity
10.1038/s41588-024-01914-4 · 2024 · External reference
Cross-species single-cell analysis of pancreatic ductal adenocarcinoma reveals antigen-presenting cancer-associated fibroblasts
10.1158/2159-8290.cd-19-0094 · 2019 · External reference
Multimodal single cell-resolved spatial proteomics reveal pancreatic tumor heterogeneity
10.1038/s41467-024-54438-0 · 2024 · External reference
Multiplexed imaging mass cytometry analysis characterizes the vascular niche in pancreatic cancer
10.1158/0008-5472.can-23-2352 · 2024 · External reference
Spatially resolved multi-omics single-cell analyses inform mechanisms of immune dysfunction in pancreatic cancer
10.1053/j.gastro.2023.05.036 · 2023 · External reference
Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer
10.1038/s41588-022-01157-1 · 2022 · External reference
Integrative analysis of spatial and single-cell transcriptome data from human pancreatic cancer reveals an intermediate cancer cell population associated with poor prognosis
10.1186/s13073-024-01287-7 · 2024 · External reference
Leukocyte heterogeneity in pancreatic ductal adenocarcinoma: phenotypic and spatial features associated with clinical outcome
10.1158/2159-8290.cd-20-0841 · 2021 · External reference
Activated pancreatic stellate cells sequester CD8+ T cells to reduce their infiltration of the juxtatumoral compartment of pancreatic ductal adenocarcinoma
10.1053/j.gastro.2013.07.025 · 2013 · External reference
Spatial profiling of human pancreatic ductal adenocarcinoma reveals molecular alterations associated with venous invasion
10.1126/scitranslmed.ady7524 · 2025 · External reference
PanIN and CAF transitions in pancreatic carcinogenesis revealed with spatial data integration
10.1016/j.cels.2024.07.001 · 2024 · External reference
IL1-induced JAK/STAT signaling is antagonized by TGFβ to shape CAF heterogeneity in pancreatic ductal adenocarcinoma
10.1158/2159-8290.cd-18-0710 · 2019 · External reference
Coordinated single-cell tumor microenvironment dynamics reinforce pancreatic cancer subtype
10.1038/s41467-023-40895-6 · 2023 · External reference
Tumor cell-intrinsic epigenetic dysregulation shapes cancer-associated fibroblasts heterogeneity to metabolically support pancreatic cancer
10.1016/j.ccell.2024.03.005 · 2024 · External reference
Stromal microenvironment shapes the intratumoral architecture of pancreatic cancer
10.1016/j.cell.2019.05.012 · 2019 · External reference
Multimodal mapping of the tumor and peripheral blood immune landscape in human pancreatic cancer
10.1038/s43018-020-00121-4 · 2020 · External reference
Mass cytometry tags: where chemistry meets single-cell analysis
10.1021/acs.analchem.0c03560 · 2021 · External reference
An end-to-end workflow for multiplexed image processing and analysis
10.1038/s41596-023-00881-0 · 2023 · External reference
histoCAT: analysis of cell phenotypes and interactions in multiplex image cytometry data
10.1038/nmeth.4391 · 2017 · External reference
Integrated analysis of multimodal single-cell data
10.1016/j.cell.2021.04.048 · 2021 · External reference
Neoadjuvant cabozantinib and nivolumab convert locally advanced HCC into resectable disease with enhanced antitumor immunity
10.1038/s43018-021-00234-4 · 2021 · External reference
Multiplex immunofluorescence staining and image analysis assay for diffuse large B cell lymphoma
10.1016/j.jim.2019.112714 · 2020 · External reference
QuPath: open source software for digital pathology image analysis
10.1038/s41598-017-17204-5 · 2017 · External reference
Unresolved reference
2018 · External reference
Single-cell transcriptional diversity is a hallmark of developmental potential
10.1126/science.aax0249 · 2020 · External reference
mclust 5: clustering, classification and density estimation using Gaussian finite mixture models
10.32614/rj-2016-021 · 2016 · External reference
Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma
10.1038/s41419-022-05351-1 · 2022 · External reference
Inference and analysis of cell-cell communication using CellChat
10.1038/s41467-021-21246-9 · 2021 · External reference
Antibody dependent cell-mediated cytotoxicity selection pressure induces diverse mechanisms of resistance
10.1080/15384047.2023.2269637 · 2023 · External reference
Antitumor T-cell immunity contributes to pancreatic cancer immune resistance
10.1158/2326-6066.cir-20-0272 · 2021 · External reference
Human natural killer cell expansion in vitro using mitomycin-C treatment as an alternative to irradiation of modified K562 feeder cells
10.4049/jimmunol.198.supp.82.16 · 2017 · External reference
Fibroblast activation protein promotes natural killer cell invasion and tumor infiltration
10.1093/jimmun/vkaf279 · 2026 · External reference
Fiji: an open-source platform for biological-image analysis
10.1038/nmeth.2019 · 2012 · External reference
Imaging mass cytometry
10.1002/cyto.a.23053 · 2017 · External reference
Integrating single-cell transcriptomic data across different conditions, technologies, and species
10.1038/nbt.4096 · 2018 · External reference
Comprehensive integration of single-cell data
10.1016/j.cell.2019.05.031 · 2019 · External reference
Spatial reconstruction of single-cell gene expression data
10.1038/nbt.3192 · 2015 · External reference
Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression
10.1186/s13059-019-1874-1 · 2019 · External reference
Coordinated cellular neighborhoods orchestrate antitumoral immunity at the colorectal cancer invasive front
10.1016/j.cell.2020.07.005 · 2020 · External reference
Interferon-γ: teammate or opponent in the tumour microenvironment?
10.1038/s41577-021-00566-3 · 2022 · External reference
Intratumoral CD16+ macrophages are associated with clinical outcomes of patients with metastatic melanoma treated with combination anti-PD-1 and anti-CTLA-4 therapy
10.1158/1078-0432.ccr-22-2657 · 2023 · External reference
Regulation of human NK-cell cytokine and chemokine production by target cell recognition
10.1182/blood-2009-08-238469 · 2010 · External reference
Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer
10.1084/jem.20162024 · 2017 · External reference
Type I collagen deletion in αSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer
10.1016/j.ccell.2021.02.007 · 2021 · External reference
NKG2D receptor and its ligands in host defense
10.1158/2326-6066.cir-15-0098 · 2015 · External reference
Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer
10.1038/ncomms15095 · 2017 · External reference
Differentiation therapy and the mechanisms that terminate cancer cell proliferation without harming normal cells
10.1038/s41419-018-0919-9 · 2018 · External reference
Single-cell analysis of pancreatic ductal adenocarcinoma identifies a novel fibroblast subtype associated with poor prognosis but better immunotherapy response
10.1038/s41421-021-00271-4 · 2021 · External reference
CD44 and hyaluronan-dependent rolling interactions of lymphocytes on tonsillar stroma
10.1083/jcb.134.4.1075 · 1996 · External reference
Matrigel: a complex protein mixture required for optimal growth of cell culture
10.1002/pmic.200900758 · 2010 · External reference
The biology and role of CD44 in cancer progression: therapeutic implications
10.1186/s13045-018-0605-5 · 2018 · External reference
Extracellular matrix enzymes and immune cell biology
10.3389/fmolb.2021.703868 · 2021 · External reference
Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti–PD-L1 immunotherapy in pancreatic cancer
10.1073/pnas.1320318110 · 2013 · External reference
The fibronectin–ILT3 interaction functions as a stromal checkpoint that suppresses myeloid cells
10.1158/2326-6066.cir-21-0240 · 2021 · External reference
Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival
10.1016/j.ccr.2014.04.005 · 2014 · External reference
Randomized phase III trial of pegvorhyaluronidase alfa with nab-paclitaxel plus gemcitabine for patients with hyaluronan-high metastatic pancreatic adenocarcinoma
10.1200/jco.20.00590 · 2020 · External reference
