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References from In Vitro Inhibition of STAT5 Signaling Limits CD8+ T-cell Exhaustion and Improves Outcomes in Adoptive T-cell Therapy. Local targets link to admitted publications; unresolved targets remain external evidence.
Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy
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CAR-T cell therapy: current limitations and potential strategies
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Mechanisms of resistance to CAR T cell therapy
10.1038/s41571-019-0184-6 · 2019 · External reference
Clinical implications of T cell exhaustion for cancer immunotherapy
10.1038/s41571-022-00689-z · 2022 · External reference
Molecular mechanisms governing CD8 T cell differentiation and checkpoint inhibitor response in cancer
10.1146/annurev-immunol-082223-044122 · 2025 · External reference
Intratumoral Tcf1+PD-1+CD8+ T cells with stem-like properties promote tumor control in response to vaccination and checkpoint blockade immunotherapy
10.1016/j.immuni.2018.12.021 · 2019 · External reference
Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer
10.1126/science.abb9847 · 2020 · External reference
Cellular networks controlling T cell persistence in adoptive cell therapy
10.1038/s41577-021-00539-6 · 2021 · External reference
Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells
10.1172/jci24480 · 2005 · External reference
T-cell dysfunction as a limitation of adoptive immunotherapy: current concepts and mitigation strategies
10.3390/cancers13040598 · 2021 · External reference
Next generation immunotherapy: enhancing stemness of polyclonal T cells to improve anti-tumor activity
10.1016/j.coi.2021.10.001 · 2022 · External reference
Cytokines and persistent viral infections
10.1016/j.cyto.2016.02.006 · 2016 · External reference
Common gamma chain cytokines and CD8 T cells in cancer
10.1016/j.smim.2019.101307 · 2019 · External reference
The γc family of cytokines: basic biology to therapeutic ramifications
10.1016/j.immuni.2019.03.028 · 2019 · External reference
IL-2 and IL-15 regulate CD8+ memory T-cell differentiation but are dispensable for protective recall responses
10.1002/eji.201546000 · 2015 · External reference
Distinct roles for IL-2 and IL-15 in the differentiation and survival of CD8+ effector and memory T cells
10.4049/jimmunol.0904089 · 2010 · External reference
The shared and contrasting roles of IL2 and IL15 in the life and death of normal and neoplastic lymphocytes: implications for cancer therapy
10.1158/2326-6066.cir-15-0009 · 2015 · External reference
The role of interleukin-2 during homeostasis and activation of the immune system
10.1038/nri3156 · 2012 · External reference
Prolonged interleukin-2Ralpha expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo
10.1016/j.immuni.2009.11.010 · 2010 · External reference
IL-7 and IL-21 are superior to IL-2 and IL-15 in promoting human T cell-mediated rejection of systemic lymphoma in immunodeficient mice
10.1182/blood-2009-09-241398 · 2010 · External reference
An engineered IL-2 partial agonist promotes CD8+ T cell stemness
10.1038/s41586-021-03861-0 · 2021 · External reference
IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor
10.1038/s41590-020-00850-9 · 2021 · External reference
IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors
10.1182/blood-2012-05-431718 · 2013 · External reference
IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells
10.1073/pnas.0307298101 · 2004 · External reference
Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function
10.1084/jem.20041057 · 2005 · External reference
IL2Rβ-dependent signals drive terminal exhaustion and suppress memory development during chronic viral infection
10.1073/pnas.1604256113 · 2016 · External reference
Discovery of chromone-based inhibitors of the transcription factor STAT5
10.1002/cbic.200700701 · 2008 · External reference
RNA extraction from adult Aiptasia
10.17504/protocols.io.sp5edq6 · 2018 · External reference
STAR: ultrafast universal RNA-seq aligner
10.1093/bioinformatics/bts635 · 2013 · External reference
Cutadapt removes adapter sequences from high-throughput sequencing reads
10.14806/ej.17.1.200 · 2011 · External reference
HTSeq–a Python framework to work with high-throughput sequencing data
10.1093/bioinformatics/btu638 · 2015 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
Developmental relationships of four exhausted CD8+ T cell subsets reveals underlying transcriptional and epigenetic landscape control mechanisms
10.1016/j.immuni.2020.04.014 · 2020 · External reference
CD8 T cell exhaustion during chronic viral infection and cancer
10.1146/annurev-immunol-041015-055318 · 2019 · External reference
T cell factor 1-expressing memory-like CD8+ T cells sustain the immune response to chronic viral infections
10.1016/j.immuni.2016.07.021 · 2016 · External reference
Efficient and robust NK-cell transduction with baboon envelope pseudotyped lentivector
10.3389/fimmu.2019.02873 · 2019 · External reference
Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade
10.1038/s41590-019-0312-6 · 2019 · External reference
A new specific promoter allow hematopoietic stem cell immunotherapy approach against acute lymphoblastic leukemia using chimeric antigen receptor
10.1016/j.bbmt.2018.12.464 · 2019 · External reference
Epigenomic-guided mass cytometry profiling reveals disease-specific features of exhausted CD8 T cells
10.1016/j.immuni.2018.04.026 · 2018 · External reference
Network analysis reveals centrally connected genes and pathways involved in CD8+ T cell exhaustion versus memory
10.1016/j.immuni.2012.08.021 · 2012 · External reference
Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade
10.1126/science.aaf2807 · 2016 · External reference
The epigenetic landscape of T cell exhaustion
10.1126/science.aae0491 · 2016 · External reference
Tyrosine phosphorylation of both STAT5A and STAT5B is necessary for maximal IL-2 signaling and T cell proliferation
10.1038/s41467-024-50925-6 · 2024 · External reference
10.1007/978-3-319-24277-4
10.1007/978-3-319-24277-4 · 2016 · External reference
Inter-generational nuclear crosstalk links the control of gene expression to programmed genome rearrangement during the Paramecium sexual cycle
10.1093/nar/gkad1006 · 2023 · External reference
Anti-CD22-chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia
10.1182/blood-2012-06-438002 · 2013 · External reference
Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15
10.1038/ni.2449 · 2012 · External reference
Proliferating transitory T cells with an effector-like transcriptional signature emerge from PD-1+ stem-like CD8+ T cells during chronic infection
10.1016/j.immuni.2019.11.002 · 2019 · External reference
CD4+ T cell help is required for the formation of a cytolytic CD8+ T cell subset that protects against chronic infection and cancer
10.1016/j.immuni.2019.10.009 · 2019 · External reference
The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design
10.1038/nri1901 · 2006 · External reference
The transcription factor FoxO1 sustains expression of the inhibitory receptor PD-1 and survival of antiviral CD8+ T cells during chronic infection
10.1016/j.immuni.2014.10.013 · 2014 · External reference
Stat5 opposes the transcription factor Tox and rewires exhausted CD8+ T cells toward durable effector-like states during chronic antigen exposure
10.1016/j.immuni.2023.11.005 · 2023 · External reference
T memory stem cells in health and disease
10.1038/nm.4241 · 2017 · External reference
Molecular and cellular insights into T cell exhaustion
10.1038/nri3862 · 2015 · External reference
Rapid in vitro generation of bona fide exhausted CD8+ T cells is accompanied by Tcf7 promotor methylation
10.1371/journal.ppat.1008555 · 2020 · External reference
In vitro modeling of CD8+ T cell exhaustion enables CRISPR screening to reveal a role for BHLHE40
10.1126/sciimmunol.ade3369 · 2023 · External reference
Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling
10.1126/science.aba1786 · 2021 · External reference
PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program
10.1038/s41586-022-05257-0 · 2022 · External reference
An engineered viral protein activates STAT5 to prevent T cell suppression
10.1126/sciimmunol.adn9633 · 2025 · External reference
The ubiquitin ligase MDM2 sustains STAT5 stability to control T cell-mediated antitumor immunity
10.1038/s41590-021-00888-3 · 2021 · External reference
A novel chimeric antigen receptor containing a JAK-STAT signaling domain mediates superior antitumor effects
10.1038/nm.4478 · 2018 · External reference
Inhibition of AKT signaling uncouples T cell differentiation from expansion for receptor-engineered adoptive immunotherapy
10.1172/jci.insight.95103 · 2017 · External reference
Uncoupling T-cell expansion from effector differentiation in cell-based immunotherapy
10.1111/imr.12135 · 2014 · External reference
Combined JAK inhibition and PD-1 immunotherapy for non-small cell lung cancer patients
10.1126/science.adf1329 · 2024 · External reference
A human memory T cell subset with stem cell-like properties
10.1038/nm.2446 · 2011 · External reference
“Stem-like” precursors are the fount to sustain persistent CD8+ T cell responses
10.1038/s41590-022-01219-w · 2022 · External reference
Defining T cell states associated with response to checkpoint immunotherapy in melanoma
10.1016/j.cell.2018.10.038 · 2018 · External reference
