Research graph
References from Apolipoprotein E2/2 ( <i>APOE2/2</i> ) Genotype Is Associated With Reduced Choroidal Thickness. Local targets link to admitted publications; unresolved targets remain external evidence.
Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis
10.1016/s2214-109x(13)70145-1 · 2014 · External reference
Causes of vision loss worldwide, 1990-2010: a systematic analysis
10.1016/s2214-109x(13)70113-x · 2013 · External reference
Drusen in AMD from the perspective of cholesterol metabolism and hypoxic response
10.3390/jcm13092608 · 2024 · External reference
The role of inflammation in age-related macular degeneration-therapeutic landscapes in geographic atrophy
10.3390/cells12162092 · 2023 · External reference
The complement system in age-related macular degeneration
10.1007/s00018-021-03796-9 · 2021 · External reference
The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD
10.1016/j.preteyeres.2017.03.002 · 2017 · External reference
Complement factor I and age-related macular degeneration
2014 · External reference
Increased circulating levels of Factor H-Related Protein 4 are strongly associated with age-related macular degeneration
10.1038/s41467-020-14499-3 · 2020 · External reference
C-reactive protein and CFH, ARMS2/HTRA1 gene variants are independently associated with risk of macular degeneration
10.1016/j.ophtha.2009.11.020 · 2010 · External reference
Apolipoprotein E: cholesterol transport protein with expanding role in cell biology
10.1126/science.3283935 · 1988 · External reference
Apoprotein E as a lipid transport and signaling protein in the blood, liver, and artery wall
10.1194/jlr.r800058-jlr200 · 2009 · External reference
A new perspective on lipid research in age-related macular degeneration
10.1016/j.preteyeres.2018.04.006 · 2018 · External reference
Interactions between Apolipoprotein E Metabolism and Retinal Inflammation in Age-Related Macular Degeneration
10.3390/life11070635 · 2021 · External reference
Apolipoprotein E variation at the sequence haplotype level: implications for the origin and maintenance of a major human polymorphism
10.1086/303070 · 2000 · External reference
Associations of Alzheimer disease–protective APOE variants with age-related macular degeneration
10.1001/jamaophthalmol.2022.4602 · 2023 · External reference
Worldwide allele frequencies of the human apolipoprotein E gene: climate, local adaptations, and evolutionary history
10.1002/ajpa.21298 · 2010 · External reference
APOE and Alzheimer's disease: from lipid transport to physiopathology and therapeutics
10.3389/fnins.2021.630502 · 2021 · External reference
Genetic association of apolipoprotein E with age-related macular degeneration
10.1086/301901 · 1998 · External reference
APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches
10.1016/s1474-4422(20)30412-9 · 2021 · External reference
Evidence of association of APOE with age-related macular degeneration: a pooled analysis of 15 studies
10.1002/humu.21577 · 2011 · External reference
Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study
10.1038/s41467-019-14279-8 · 2020 · External reference
Cohort profile: The Oxford Biobank
10.1093/ije/dyx132 · 2018 · External reference
Nutritional methods in the European Prospective Investigation of Cancer in Norfolk
10.1079/phn2000102 · 2001 · External reference
Early Treatment Diabetic Retinopathy Study design and baseline patient characteristics. ETDRS report number 7
1991 · External reference
Microperimetry reliability assessed from fixation performance
10.1167/tvst.12.5.21 · 2023 · External reference
Comparison of DNA quantification methodology used in the DNA extraction protocol for the UK Biobank cohort
10.1186/s12864-016-3391-x · 2017 · External reference
Fitting linear mixed-effects models using lme4
10.18637/jss.v067.i01 · 2015 · External reference
A Kenward-Roger approximation and parametric bootstrap methods for tests in linear mixed models – the R Package pbkrtest
10.18637/jss.v059.i09 · 2014 · External reference
Increased cholesterol uptake is associated with the altered gene expression in white adipose tissue of ApoE-/- mice fed a high-fat high-cholesterol diet
2023 · External reference
Association of choroidal thickness with intermediate age-related macular degeneration in a Japanese population
10.1016/j.oret.2020.09.001 · 2021 · External reference
Choroidal vasculature changes in age-related macular degeneration: from a molecular to a clinical perspective
10.3390/ijms231912010 · 2022 · External reference
Reticular pseudodrusen in early age-related macular degeneration are associated with choroidal thinning
10.1167/iovs.13-12474 · 2013 · External reference
Choroidal thickness associated with spherical equivalent in healthy young adults: The Raine Eye Health Study
2012 · External reference
Rare complement factor I variants associated with reduced macular thickness and age-related macular degeneration in the UK Biobank
10.1093/hmg/ddac060 · 2022 · External reference
Phenotypic expression of CFH rare variants in age-related macular degeneration patients in the Coimbra Eye Study
10.1167/iovs.63.9.5 · 2022 · External reference
Genome-wide association analyses identify 139 loci associated with macular thickness in the UK Biobank cohort
10.1093/hmg/ddy422 · 2019 · External reference
Genetic variation affects morphological retinal phenotypes extracted from UK Biobank optical coherence tomography images
10.1371/journal.pgen.1009497 · 2021 · External reference
Dark adaptation and its role in age-related macular degeneration
10.3390/jcm11051358 · 2022 · External reference
Associations of Alzheimer disease–protective APOE variants with age-related macular degeneration
10.1001/jamaophthalmol.2022.4602 · ExternalCitation · doi-reference
Worldwide allele frequencies of the human apolipoprotein E gene: climate, local adaptations, and evolutionary history
10.1002/ajpa.21298 · ExternalCitation · doi-reference
Evidence of association of APOE with age-related macular degeneration: a pooled analysis of 15 studies
10.1002/humu.21577 · ExternalCitation · doi-reference
The complement system in age-related macular degeneration
10.1007/s00018-021-03796-9 · ExternalCitation · doi-reference
C-reactive protein and CFH, ARMS2/HTRA1 gene variants are independently associated with risk of macular degeneration
10.1016/j.ophtha.2009.11.020 · ExternalCitation · doi-reference
Association of choroidal thickness with intermediate age-related macular degeneration in a Japanese population
10.1016/j.oret.2020.09.001 · ExternalCitation · doi-reference
The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD
10.1016/j.preteyeres.2017.03.002 · ExternalCitation · doi-reference
A new perspective on lipid research in age-related macular degeneration
10.1016/j.preteyeres.2018.04.006 · ExternalCitation · doi-reference
APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches
10.1016/s1474-4422(20)30412-9 · ExternalCitation · doi-reference
Causes of vision loss worldwide, 1990-2010: a systematic analysis
10.1016/s2214-109x(13)70113-x · ExternalCitation · doi-reference
Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis
10.1016/s2214-109x(13)70145-1 · ExternalCitation · doi-reference
Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study
10.1038/s41467-019-14279-8 · ExternalCitation · doi-reference
Increased circulating levels of Factor H-Related Protein 4 are strongly associated with age-related macular degeneration
10.1038/s41467-020-14499-3 · ExternalCitation · doi-reference
Nutritional methods in the European Prospective Investigation of Cancer in Norfolk
10.1079/phn2000102 · ExternalCitation · doi-reference
Genetic association of apolipoprotein E with age-related macular degeneration
10.1086/301901 · ExternalCitation · doi-reference
Apolipoprotein E variation at the sequence haplotype level: implications for the origin and maintenance of a major human polymorphism
10.1086/303070 · ExternalCitation · doi-reference
Rare complement factor I variants associated with reduced macular thickness and age-related macular degeneration in the UK Biobank
10.1093/hmg/ddac060 · ExternalCitation · doi-reference
Genome-wide association analyses identify 139 loci associated with macular thickness in the UK Biobank cohort
10.1093/hmg/ddy422 · ExternalCitation · doi-reference
Cohort profile: The Oxford Biobank
10.1093/ije/dyx132 · ExternalCitation · doi-reference
Apolipoprotein E: cholesterol transport protein with expanding role in cell biology
10.1126/science.3283935 · ExternalCitation · doi-reference
Reticular pseudodrusen in early age-related macular degeneration are associated with choroidal thinning
10.1167/iovs.13-12474 · ExternalCitation · doi-reference
Phenotypic expression of CFH rare variants in age-related macular degeneration patients in the Coimbra Eye Study
10.1167/iovs.63.9.5 · ExternalCitation · doi-reference
Microperimetry reliability assessed from fixation performance
10.1167/tvst.12.5.21 · ExternalCitation · doi-reference
Comparison of DNA quantification methodology used in the DNA extraction protocol for the UK Biobank cohort
10.1186/s12864-016-3391-x · ExternalCitation · doi-reference
Apoprotein E as a lipid transport and signaling protein in the blood, liver, and artery wall
10.1194/jlr.r800058-jlr200 · ExternalCitation · doi-reference
Genetic variation affects morphological retinal phenotypes extracted from UK Biobank optical coherence tomography images
10.1371/journal.pgen.1009497 · ExternalCitation · doi-reference
A Kenward-Roger approximation and parametric bootstrap methods for tests in linear mixed models – the R Package pbkrtest
10.18637/jss.v059.i09 · ExternalCitation · doi-reference
Fitting linear mixed-effects models using lme4
10.18637/jss.v067.i01 · ExternalCitation · doi-reference
APOE and Alzheimer's disease: from lipid transport to physiopathology and therapeutics
10.3389/fnins.2021.630502 · ExternalCitation · doi-reference
The role of inflammation in age-related macular degeneration-therapeutic landscapes in geographic atrophy
10.3390/cells12162092 · ExternalCitation · doi-reference
Choroidal vasculature changes in age-related macular degeneration: from a molecular to a clinical perspective
10.3390/ijms231912010 · ExternalCitation · doi-reference
Dark adaptation and its role in age-related macular degeneration
10.3390/jcm11051358 · ExternalCitation · doi-reference
Drusen in AMD from the perspective of cholesterol metabolism and hypoxic response
10.3390/jcm13092608 · ExternalCitation · doi-reference
Interactions between Apolipoprotein E Metabolism and Retinal Inflammation in Age-Related Macular Degeneration
10.3390/life11070635 · ExternalCitation · doi-reference
