Research graph
References from A single-cell atlas identifies oncogenic transcriptional programs and immune escape mechanisms in CTCL. Local targets link to admitted publications; unresolved targets remain external evidence.
Mycosis fungoides, Sezary syndrome, and cutaneous B-cell lymphomas: 2025 update on diagnosis, risk-stratification, and management
10.1002/ajh.27735 · 2025 · External reference
Transformation of cutaneous T cell lymphoma to large cell lymphoma. A clinicopathologic and immunologic study
1988 · External reference
Clinicopathologic and immunologic features associated with transformation of mycosis fungoides to large-cell lymphoma
10.1097/00000478-199206000-00002 · 1992 · External reference
Prognostic factors in transformed mycosis fungoides: a retrospective analysis of 100 cases
10.1182/blood-2011-08-376319 · 2012 · External reference
Survival outcomes and prognostic factors in mycosis fungoides/Sezary syndrome: validation of the revised International Society for Cutaneous Lymphomas/European Organisation for Research and Treatment of Cancer staging proposal
10.1200/jco.2009.27.7665 · 2010 · External reference
Characteristics associated with significantly worse quality of life in mycosis fungoides/Sezary syndrome from the Prospective Cutaneous Lymphoma International Prognostic Index (PROCLIPI) study
10.1111/bjd.18089 · 2019 · External reference
Lack of durable disease control with chemotherapy for mycosis fungoides and Sezary syndrome: a comparative study of systemic therapy
10.1182/blood-2014-07-588236 · 2015 · External reference
A retrospective comparative outcome analysis following systemic therapy in mycosis fungoides and Sezary syndrome
10.1002/ajh.24564 · 2016 · External reference
NCCN guidelines insights: primary cutaneous lymphomas, version 2.2020
10.6004/jnccn.2020.0022 · 2020 · External reference
Targeted deep sequencing of mycosis fungoides reveals intracellular signaling pathways associated with aggressiveness and large cell transformation
10.3390/cancers13215512 · 2021 · External reference
Naturally occurring T cell mutations enhance engineered T cell therapies
10.1038/s41586-024-07018-7 · 2024 · External reference
Genomic landscape of cutaneous T cell lymphoma
10.1038/ng.3356 · 2015 · External reference
PLCG1 mutations in cutaneous T-cell lymphomas
10.1182/blood-2013-05-504308 · 2014 · External reference
Genomic analyses reveal recurrent mutations in epigenetic modifiers and the JAK-STAT pathway in Sezary syndrome
10.1038/ncomms9470 · 2015 · External reference
The mutational landscape of cutaneous T cell lymphoma and Sezary syndrome
10.1038/ng.3442 · 2015 · External reference
Genomic analysis of mycosis fungoides and Sezary syndrome identifies recurrent alterations in TNFR2
10.1038/ng.3370 · 2015 · External reference
Genomic analysis of 220 CTCLs identifies a novel recurrent gain-of-function alteration in RLTPR (p.Q575E)
10.1182/blood-2017-02-768234 · 2017 · External reference
Genomic and single-cell landscape reveals novel drivers and therapeutic vulnerabilities of transformed cutaneous T-cell lymphoma
10.1158/2159-8290.cd-21-1207 · 2022 · External reference
The skin microbiome stratifies patients with cutaneous T cell lymphoma and determines event-free survival
10.1038/s41522-024-00542-4 · 2024 · External reference
T-cell receptor signaling activates an ITK/NF-kappaB/GATA-3 axis in T-cell lymphomas facilitating resistance to chemotherapy
10.1158/1078-0432.ccr-16-1996 · 2017 · External reference
GATA-3 is a proto-oncogene in T-cell lymphoproliferative neoplasms
10.1038/s41408-022-00745-y · 2022 · External reference
GATA-3-dependent gene transcription is impaired upon HDAC inhibition
10.1158/1078-0432.ccr-23-1699 · 2024 · External reference
The GATA-3-dependent transcriptome and tumor microenvironment are regulated by eIF4E and XPO1 in T-cell lymphomas
10.1182/blood.2024025484 · 2025 · External reference
CDK9 is a dependency in GATA-3 driven and MCL-1 independent T-cell Lymphomas
10.1038/s41408-025-01427-1 · 2025 · External reference
Targeting lymphoma-associated macrophage expansion via CSF1R/JAK inhibition is a therapeutic vulnerability in peripheral T-cell lymphomas
10.1158/2767-9764.crc-22-0336 · 2022 · External reference
B7-H1 (PD-L1, CD274) suppresses host immunity in T-cell lymphoproliferative disorders
10.1182/blood-2009-04-216671 · 2009 · External reference
Monocytes promote tumor cell survival in T-cell lymphoproliferative disorders and are impaired in their ability to differentiate into mature dendritic cells
10.1182/blood-2009-05-220111 · 2009 · External reference
FOXP3+ regulatory T cells in cutaneous T-cell lymphomas: association with disease stage and survival
10.1038/sj.leu.2404913 · 2007 · External reference
Primary T cells from cutaneous T-cell lymphoma skin explants display an exhausted immune checkpoint profile
10.1158/2326-6066.cir-17-0270 · 2018 · External reference
The mycosis fungoides cutaneous microenvironment shapes dysfunctional cell trafficking, antitumor immunity, matrix interactions, and angiogenesis
10.1172/jci.insight.170015 · 2023 · External reference
Cutaneous T cell lymphoma atlas reveals malignant T(H)2 cells supported by a B cell-rich tumor microenvironment
10.1038/s41590-024-02018-1 · 2024 · External reference
Multimodal single-cell analysis of cutaneous T-cell lymphoma reveals distinct subclonal tissue-dependent signatures
10.1182/blood.2020009346 · 2021 · External reference
Single-cell RNA sequencing reveals tissue compartment-specific plasticity of mycosis fungoides tumor cells
10.3389/fimmu.2021.666935 · 2021 · External reference
Single-cell RNA sequencing reveals markers of disease progression in primary cutaneous T-cell lymphoma
10.1186/s12943-021-01419-2 · 2021 · External reference
Single-cell RNA sequencing unveils the clonal and transcriptional landscape of cutaneous T-cell lymphomas
10.1158/1078-0432.ccr-21-4437 · 2022 · External reference
Single-cell analysis of Sezary syndrome reveals novel markers and shifting gene profiles associated with treatment
10.1182/bloodadvances.2021005991 · 2023 · External reference
Sezary syndrome originates from heavily mutated hematopoietic progenitors
10.1182/bloodadvances.2022008562 · 2023 · External reference
Integrated transcriptome and trajectory analysis of cutaneous T-cell lymphoma identifies putative precancer populations
10.1182/bloodadvances.2022008168 · 2023 · External reference
Single-cell transcriptomics links malignant T cells to the tumor immune landscape in cutaneous T cell lymphoma
10.1038/s41467-022-28799-3 · 2022 · External reference
Genetic alteration of class I HLA in cutaneous T-cell lymphoma
10.1182/blood.2024024817 · 2025 · External reference
SCANPY: large-scale single-cell gene expression data analysis
10.1186/s13059-017-1382-0 · 2018 · External reference
The scverse project provides a computational ecosystem for single-cell omics data analysis
10.1038/s41587-023-01733-8 · 2023 · External reference
Automatic cell-type harmonization and integration across Human Cell Atlas datasets
10.1016/j.cell.2023.11.026 · 2023 · External reference
The IL6/JAK/STAT3 signaling axis is a therapeutic vulnerability in SMARCB1-deficient bladder cancer
10.1038/s41467-024-45132-2 · 2024 · External reference
Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells
10.1038/ni1513 · 2007 · External reference
Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands
10.1172/jci89535 · 2017 · External reference
Follicular lymphoma triggers phenotypic and functional remodeling of the human lymphoid stromal cell landscape
10.1016/j.immuni.2021.05.019 · 2021 · External reference
GATA-3 expression identifies a high-risk subset of PTCL, NOS with distinct molecular and clinical features
10.1182/blood-2013-12-544809 · 2014 · External reference
Targeting cereblon in hematologic malignancies
10.1016/j.blre.2022.100994 · 2023 · External reference
Leveraging efficiency metrics for the optimization of CELMoDs as cereblon-based molecular glue degraders
10.1039/d4md00870g · External reference
Novel cereblon-binding immunomodulators have increased potency against gammaherpesvirus- associated lymphomas in vitro
10.1002/jmv.70537 · 2025 · External reference
Global patterns of care in advanced stage mycosis fungoides/Sezary syndrome: a multicenter retrospective follow-up study from the Cutaneous Lymphoma International Consortium
10.1093/annonc/mdx352 · 2017 · External reference
Cancer immunoediting: from immunosurveillance to tumor escape
10.1038/ni1102-991 · 2002 · External reference
Primary cutaneous posttransplant lymphoproliferative disorders in solid organ transplant recipients: a multicenter European case series
10.1111/ajt.12281 · 2013 · External reference
Approaches to treat immune hot, altered and cold tumours with combination immunotherapies
10.1038/s41573-018-0007-y · 2019 · External reference
CD8+ T cells in cutaneous T-cell lymphoma: expression of cytotoxic proteins, Fas ligand, and killing inhibitory receptors and their relationship with clinical behavior
10.1200/jco.2001.19.23.4322 · 2001 · External reference
A rare subset of skin-tropic regulatory T cells expressing Il10/Gzmb inhibits the cutaneous immune response
10.1038/srep35002 · 2016 · External reference
Terminal differentiation and persistence of effector regulatory T cells essential for preventing intestinal inflammation
10.1038/s41590-024-02075-6 · 2025 · External reference
PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance
10.1084/jem.20182232 · 2021 · External reference
PD-1 receptor deficiency enhances CD30(+) T(reg) cell function in melanoma
10.1038/s41590-025-02172-0 · 2025 · External reference
PD-1(+) regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer
10.1073/pnas.1822001116 · 2019 · External reference
Reduction of regulatory T cells by mogamulizumab, a defucosylated anti-CC chemokine receptor 4 antibody, in patients with aggressive/refractory mycosis fungoides and Sezary syndrome
10.1158/1078-0432.ccr-14-0830 · 2015 · External reference
Ferritin light chain promotes the reprogramming of glioma immune microenvironment and facilitates glioma progression
10.7150/thno.82975 · 2023 · External reference
Stabilin-1 in tumor-associated macrophages: a potential therapeutic target in cancer immunotherapy
2025 · External reference
Expression of C1q by macrophages and fibroblasts in tumor microenvironment is associated with progression and metastasis of cutaneous squamous cell carcinoma
10.1016/j.jid.2025.04.007 · 2025 · External reference
Antigen presentation by tumor-associated macrophages drives T cells from a progenitor exhaustion state to terminal exhaustion
10.1016/j.immuni.2024.11.026 · 2025 · External reference
STAT5 and STAT3 balance shapes dendritic cell function and tumour immunity
10.1038/s41586-025-09000-3 · 2025 · External reference
GATA-3 directly remodels the IL-10 locus independently of IL-4 in CD4+ T cells
10.4049/jimmunol.176.6.3470 · 2006 · External reference
Ikaros is a regulator of Il10 expression in CD4+ T cells
10.4049/jimmunol.0901284 · 2009 · External reference
Degradation of IKZF1 prevents epigenetic progression of T cell exhaustion in an antigen-specific assay
10.1016/j.xcrm.2024.101804 · 2024 · External reference
Phase 1 trial of durvalumab (anti-PD-L1) combined with lenalidomide in relapsed/refractory cutaneous T-cell lymphoma
10.1182/bloodadvances.2024014655 · 2025 · External reference
