Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Privacy-aware community infrastructureResearch graph
References from One-stage assay factor VIII activity reflects AAV-derived factor VIII–enhanced thrombin activation and predicts phenotype. Local targets link to admitted publications; unresolved targets remain external evidence.
Novel forms of B-domain-deleted recombinant factor VIII molecules. Construction and biochemical characterization
10.1111/j.1432-1033.1995.tb20776.x · 1995 · External reference
Coagulation factor VIII: biological basis of emerging hemophilia A therapies
10.1182/blood.2023023275 · 2024 · External reference
A conditional knockout mouse model reveals endothelial cells as the principal and possibly exclusive source of plasma factor VIII
10.1182/blood-2014-02-555151 · 2014 · External reference
Murine coagulation factor VIII is synthesized in endothelial cells
10.1182/blood-2014-02-554501 · 2014 · External reference
Activity of transgene-produced B-domain-deleted factor VIII in human plasma following AAV5 gene therapy
10.1182/blood.2020005683 · 2020 · External reference
Multiyear factor VIII expression after AAV gene transfer for hemophilia A
10.1056/nejmoa2104205 · 2021 · External reference
Giroctocogene fitelparvovec gene therapy for severe hemophilia A: 104-week analysis of the phase 1/2 Alta study
10.1182/blood.2022018971 · External reference
Two-year outcomes of valoctocogene roxaparvovec therapy for hemophilia A
10.1056/nejmoa2211075 · 2023 · External reference
Measurement of factor VIII activity of B-domain deleted recombinant factor VIII
10.1016/s0037-1963(01)90104-0 · 2001 · External reference
A critical appraisal of one-stage and chromogenic assays of factor VIII activity
10.1111/jth.13215 · 2016 · External reference
Association of the factor VIII light chain with von Willebrand factor
10.1016/s0021-9258(19)81537-5 · 1988 · External reference
Differential proteolytic activation of factor VIII-von Willebrand factor complex by thrombin
10.1073/pnas.86.17.6508 · 1989 · External reference
Unresolved reference
External reference
Activated protein C has a regulatory role in factor VIII function
10.1182/blood.2020007562 · 2021 · External reference
Pre-clinical evaluation of an enhanced-function factor VIII variant for durable hemophilia A gene therapy in male mice
10.1038/s41467-024-51296-8 · 2024 · External reference
Factor IXa and factor X influence factor VIIIa stability and inactivation mechanisms in vitro and in vivo
10.1182/blood.2024027705 · External reference
The role of phospholipid and factor VIIIa in the activation of bovine factor X
10.1016/s0021-9258(19)69627-4 · 1981 · External reference
Binding of factor VIIIa and factor VIII to factor IXa on phospholipid vesicles
10.1016/s0021-9258(18)41885-6 · 1992 · External reference
Combining mutations of charged residues at the A2 domain interface enhances factor VIII stability over single point mutations
10.1111/j.1538-7836.2008.03256.x · 2009 · External reference
Thrombin functions during tissue factor-induced blood coagulation
10.1182/blood.v100.1.148 · 2002 · External reference
The kinetics of inhibition of thrombin by antithrombin in the presence of components of the hemostatic system
10.1182/blood.v66.5.1189.1189 · 1985 · External reference
Clinical severity of haemophilia A: does the classification of the 1950s still stand?
10.1111/j.1365-2516.2011.02539.x · 2011 · External reference
Minimum factor VIII levels to prevent joint bleeding in mild hemophilia A
10.1182/bloodadvances.2023011366 · 2023 · External reference
