Research graph
References from Burkitt lymphoma: current understanding, unmet needs, and research directions. Local targets link to admitted publications; unresolved targets remain external evidence.
A sarcoma involving the jaws in African children
10.1002/bjs.18004619704 · 1958 · External reference
The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms
10.1038/s41375-022-01620-2 · 2022 · External reference
DNA methylation epitypes of Burkitt lymphoma with distinct molecular and clinical features
10.1158/2643-3230.bcd-24-0240 · 2025 · External reference
Subtyping Burkitt Lymphoma by DNA Methylation
10.1002/gcc.70042 · 2025 · External reference
Burkitt lymphoma
10.1038/s41572-022-00404-3 · 2022 · External reference
Burkitt's Lymphoma
10.1056/nejmra2025746 · 2022 · External reference
Evaluating the baseline survival outcomes of the “six Global Initiative for Childhood Cancer index cancers” in Africa
10.1080/08880018.2022.2140860 · 2023 · External reference
Five decades of low intensity and low survival: adapting intensified regimens to cure pediatric Burkitt lymphoma in Africa
10.1182/bloodadvances.2020002178 · 2020 · External reference
Significant impact of treatment abandonment on survival of children with “common and curable” GICC index cancers in sub-Saharan Africa: a multicenter prospective CANCaRe Africa Study
10.1002/pbc.31997 · 2025 · External reference
Burkitt Lymphoma Incidence in Five Continents
10.3390/hemato3030030 · 2022 · External reference
Incidence and geographic distribution of endemic Burkitt lymphoma in northern Uganda revisited
10.1002/ijc.23800 · 2008 · External reference
Characteristic features of the SERA multigene family in the malaria parasite
10.1186/s13071-020-04044-y · 2020 · External reference
Epstein-Barr virus in Burkitt lymphoma in Africa reveals a limited set of whole genome and LMP-1 sequence patterns: analysis of archival datasets and field samples from Uganda, Tanzania, and Kenya
10.3389/fonc.2022.812224 · 2022 · External reference
Genetic signatures of gene flow and malaria-driven natural selection in sub-Saharan populations of the “endemic Burkitt Lymphoma belt”
10.1371/journal.pgen.1008027 · 2019 · External reference
Incidence of Burkitt lymphoma in the United States during 2000 to 2019
10.1002/ijc.34618 · 2023 · External reference
Trimodal age-specific incidence patterns for Burkitt lymphoma in the United States, 1973-2005
10.1002/ijc.24934 · 2010 · External reference
Age-related changes of human bone marrow: a histometric estimation of proliferative cells, apoptotic cells, T cells, B cells and macrophages
10.1016/s0047-6374(00)00137-8 · 2000 · External reference
AIDS-related Burkitt lymphoma in the United States: what do age and CD4 lymphocyte patterns tell us about etiology and/or biology?
10.1182/blood-2010-03-275917 · 2010 · External reference
Epstein-Barr virus patterns in US Burkitt lymphoma tumors from the SEER residual tissue repository during 1979-2009
10.1111/apm.12078 · 2013 · External reference
Spectrum of cancers among HIV-infected persons in Africa: the Uganda AIDS-Cancer Registry Match Study
10.1002/ijc.21443 · 2006 · External reference
Associations between Burkitt lymphoma among children in Malawi and infection with HIV, EBV and malaria: results from a case-control study
10.1371/journal.pone.0002505 · 2008 · External reference
HIV and cancer registry linkage identifies a substantial burden of cancers in persons with HIV in India
10.1097/md.0000000000004850 · 2016 · External reference
Tumor-suppressor genes that escape from X-inactivation contribute to cancer sex bias
10.1038/ng.3726 · 2017 · External reference
Expression of SH2D1A in five classical Hodgkin's disease-derived cell lines
10.1002/ijc.10986 · 2003 · External reference
Virus particles in cultured lymphoblasts from Burkitt’s lymphoma
10.1016/s0140-6736(64)91524-7 · 1964 · External reference
Epidemiological evidence for causal relationship between Epstein-Barr virus and Burkitt's lymphoma from Ugandan prospective study
10.1038/274756a0 · 1978 · External reference
Presence of EB virus nucleic acid homology in a "virus-free" line of Burkitt tumour cells
10.1038/227245a0 · 1970 · External reference
The structure of the termini of the Epstein-Barr virus as a marker of clonal cellular proliferation
10.1016/0092-8674(86)90803-2 · 1986 · External reference
Association of Burkitt’s lymphoma with the Epstein-Barr virus in two developing countries
10.3109/10428190009065832 · 2000 · External reference
The investigation of Epstein-Barr viral sequences in 41 cases of Burkitt's lymphoma from Egypt: epidemiologic correlations
10.1002/1097-0142(19951001)76:7<1245::aid-cncr2820760723>3.0.co;2-d · 1995 · External reference
Genome-wide discovery of somatic coding and noncoding mutations in pediatric endemic and sporadic Burkitt lymphoma
10.1182/blood-2018-09-871418 · 2019 · External reference
A study of the association of Epstein-Barr virus with Burkitt's lymphoma occurring in a Chinese population
10.1111/j.1365-2559.1995.tb01437.x · 1995 · External reference
Prevalence of Epstein-Barr viral sequences and EBV LMP1 oncogene deletions in Burkitt's lymphoma from Pakistan: epidemiological correlations
10.1016/s0046-8177(97)90125-8 · 1997 · External reference
Frequent Association of Epstein-Barr Virus in Japanese Patients with Burkitt's Lymphoma
1992 · External reference
Japanese Burkitt's lymphoma: clinicopathological review of 14 cases
1983 · External reference
A multifactorial role for P. falciparum malaria in endemic Burkitt's lymphoma pathogenesis
10.1371/journal.ppat.1004170 · 2014 · External reference
Plasmodium infection promotes genomic instability and AID-dependent B cell lymphoma
10.1016/j.cell.2015.07.019 · 2015 · External reference
Endemic Burkitt lymphoma is associated with strength and diversity of Plasmodium falciparum malaria stage-specific antigen antibody response
10.1182/blood-2012-12-475665 · 2013 · External reference
Associations between IgG reactivity to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) antigens and Burkitt lymphoma in Ghana and Uganda case-control studies
10.1016/j.ebiom.2018.12.020 · 2019 · External reference
A malaria-resistant phenotype with immunological correlates in a Tanzanian birth cohort exposed to intense malaria transmission
10.4269/ajtmh.16-0554 · 2017 · External reference
Burkitt lymphoma risk shows geographic and temporal associations with Plasmodium falciparum infections in Uganda, Tanzania, and Kenya
10.1073/pnas.2211055120 · 2023 · External reference
Endemic Burkitt lymphoma: a complication of asymptomatic malaria in sub-Saharan Africa based on published literature and primary data from Uganda, Tanzania, and Kenya
10.1186/s12936-020-03312-7 · 2020 · External reference
Molecular basis of Epstein-Barr virus latency establishment and lytic reactivation
10.3390/v13122344 · 2021 · External reference
A molecular link between malaria and Epstein-Barr virus reactivation
10.1371/journal.ppat.0030080 · 2007 · External reference
Antibodies against malaria and Epstein-Barr virus in childhood Burkitt lymphoma: a case-control study in Uganda
10.1002/ijc.23254 · 2008 · External reference
Does Epstein-Barr virus infection confer selective advantage to malaria-infected children?
10.1016/0140-6736(93)90364-m · 1993 · External reference
IL-10: the master regulator of immunity to infection
10.4049/jimmunol.180.9.5771 · 2008 · External reference
Expression of Interleukin-10 Activity by Epstein-Barr Virus Protein BCRF1
10.1126/science.2173142 · 1990 · External reference
Viral interleukin 10 is critical for the induction of B cell growth transformation by Epstein-Barr virus
10.1084/jem.178.2.439 · 1993 · External reference
Circulating Epstein-Barr virus-carrying B cells in acute malaria
10.1016/0140-6736(91)90203-2 · 1991 · External reference
The effects of acute malaria on Epstein-Barr virus (EBV) load and EBV-specific T cell immunity in Gambian children
10.1086/594373 · 2009 · External reference
Relation between falciparum malaria and bacteraemia in Kenyan children: a population-based, case-control study and a longitudinal study
10.1016/s0140-6736(11)60888-x · 2011 · External reference
Therapeutic vaccines for Epstein–Barr virus: a way forward
10.1016/s0140-6736(24)01082-1 · 2024 · External reference
XMEN disease: a new primary immunodeficiency affecting Mg2+ regulation of immunity against Epstein-Barr virus
10.1182/blood-2013-11-538686 · 2014 · External reference
Endemic Burkitt Lymphoma in second-degree relatives in Northern Uganda: in-depth genome-wide analysis suggests clues about genetic susceptibility
10.1038/s41375-020-01052-w · 2021 · External reference
Sickle cell allele HBB-rs334(T) is associated with decreased risk of childhood Burkitt lymphoma in East Africa
10.1002/ajh.27149 · 2024 · External reference
Human leukocyte antigen-DQA1∗04:01 and rs2040406 variants are associated with elevated risk of childhood Burkitt lymphoma
10.1038/s42003-023-05701-5 · 2024 · External reference
A genome-wide association study identifies an African-specific locus on chromosome 21q22.12 associated with Burkitt lymphoma risk and survival
10.1038/s41375-025-02690-8 · 2025 · External reference
Mosaic chromosomal alterations in peripheral blood leukocytes of children in sub-Saharan Africa
10.1038/s41467-023-43881-0 · 2023 · External reference
Is endemic Burkitt's lymphoma an alliance between three infections and a tumour promoter?
10.1016/s1470-2045(04)01650-x · 2004 · External reference
Plasma magnesium is inversely associated with Epstein-Barr virus load in peripheral blood and Burkitt lymphoma in Uganda
10.1016/j.canep.2017.12.004 · 2018 · External reference
Microgeographic variations in Burkitt's lymphoma incidence correlate with differences in malnutrition, malaria and Epstein-Barr virus
10.1038/sj.bjc.6605947 · 2010 · External reference
Persistence of immunoglobulin heavy chain/c-myc recombination-positive lymphocyte clones in the blood of human immunodeficiency virus-infected homosexual men
10.1073/pnas.92.14.6577 · 1995 · External reference
Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics
10.1038/nature11378 · 2012 · External reference
Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing
10.1038/ng.2469 · 2012 · External reference
DNA methylome analysis in Burkitt and follicular lymphomas identifies differentially methylated regions linked to somatic mutation and transcriptional control
10.1038/ng.3413 · 2015 · External reference
Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age
10.1038/s41467-022-31355-8 · 2022 · External reference
Unresolved reference
2024 · External reference
A refined approach to the diagnosis of Burkitt lymphoma in a resource-poor setting
10.1111/his.14594 · 2022 · External reference
The impact of MYC and BCL2 structural variants in tumors of DLBCL morphology and mechanisms of false-negative MYC IHC
2021 · External reference
Treatment delays in children and young adults with lymphoma: report from an East Africa Lymphoma Cohort Study
10.1182/bloodadvances.2022009398 · 2023 · External reference
Diagnosis of Burkitt lymphoma using an algorithmic approach--applicable in both resource-poor and resource-rich countries
10.1111/j.1365-2141.2011.08771.x · 2011 · External reference
Clinical application of circulating cell-free lymphoma DNA for fast and precise diagnosis of Burkitt lymphoma: Precision medicine for sub-Saharan Africa
10.1017/pcm.2023.1 · 2023 · External reference
Circulating plasma EBV DNA: a potential tool to facilitate diagnosis of pediatric Burkitt lymphoma in sub-Saharan Africa
10.1016/j.bglo.2025.100025 · 2025 · External reference
Plasma EBV DNA: a promising diagnostic marker for endemic Burkitt lymphoma
10.3389/fonc.2021.804083 · 2021 · External reference
Targeted next-generation sequencing of cell-free DNA to detect MYC-immunoglobulin translocation and Epstein-Barr virus DNA in plasma of Burkitt lymphoma patients in East Africa
10.1200/go.24.00210 · 2025 · External reference
Liquid biopsy for the diagnosis of EBV-positive Burkitt’s lymphoma in endemic areas
10.1038/s41591-026-04291-z · 2026 · External reference
The Societe Francaise d'Oncologie Pediatrique LMB89 protocol: highly effective multiagent chemotherapy tailored to the tumor burden and initial response in 561 unselected children with B-cell lymphomas and L3 leukemia
10.1182/blood.v97.11.3370 · 2001 · External reference
Adults and children with small non-cleaved-cell lymphoma have a similar excellent outcome when treated with the same chemotherapy regimen
10.1200/jco.1996.14.3.925 · 1996 · External reference
Burkitt's lymphoma: single-centre experience with modified BFM protocol
10.1046/j.1365-2257.2002.00429.x · 2002 · External reference
Rituximab for High-Risk, Mature B-Cell Non-Hodgkin's Lymphoma in Children
10.1056/nejmoa1915315 · 2020 · External reference
A prospective clinicopathologic study of dose-modified CODOX-M/IVAC in patients with sporadic Burkitt lymphoma defined using cytogenetic and immunophenotypic criteria (MRC/NCRI LY10 trial)
10.1182/blood-2008-03-145128 · 2008 · External reference
Burkitt Lymphoma International Prognostic Index
10.1200/jco.20.03288 · 2021 · External reference
Multicenter Study of Risk-Adapted Therapy With Dose-Adjusted EPOCH-R in Adults With Untreated Burkitt Lymphoma
10.1200/jco.20.00303 · 2020 · External reference
Patients with Burkitt’s lymphoma have a better survival probability if treated in an academic cancer program
10.1182/blood-2025-6311 · 2025 · External reference
Treatment results of 54 American patients with Burkitt's lymphoma are similar to the African experience
10.1056/nejm197707142970202 · 1977 · External reference
Cure of Burkitt's lymphoma. Ten-year follow-up of 157 Ugandan patients
10.1016/s0140-6736(79)92627-8 · 1979 · External reference
Burkitt's lymphoma. A clinical study of 110 patients
10.1002/1097-0142(197602)37:2<671::aid-cncr2820370210>3.0.co;2-d · 1976 · External reference
Practical recommendations for the management of children with endemic Burkitt lymphoma (BL) in a resource limited setting
10.1002/pbc.24407 · 2013 · External reference
Treatment of Burkitt lymphoma in equatorial Africa using a simple three-drug combination followed by a salvage regimen for patients with persistent or recurrent disease
10.1111/j.1365-2141.2012.09236.x · 2012 · External reference
The 2000 Burkitt lymphoma trial in Malawi
10.1002/pbc.20254 · 2005 · External reference
Outcomes for paediatric Burkitt lymphoma treated with anthracycline-based therapy in Malawi
10.1111/bjh.13986 · 2016 · External reference
Rituximab for children with EBV-positive Burkitt lymphoma in East Africa
10.1182/bloodadvances.2024015234 · 2025 · External reference
Improved survival rate in children with stage III and IV B cell non-Hodgkin's lymphoma and leukemia using multi-agent chemotherapy: results of a study of 114 children from the French Pediatric Oncology Society
10.1200/jco.1986.4.8.1219 · 1986 · External reference
Burkitt lymphoma: bridging the gap between advances in molecular biology and therapy
10.1080/10428194.2020.1747068 · 2020 · External reference
Burkitt lymphoma in the modern era: real-world outcomes and prognostication across 30 US cancer centers
10.1182/blood.2020006926 · 2021 · External reference
Reconstructing clonal evolution in relapsed and non-relapsed Burkitt lymphoma
10.1038/s41375-020-0862-5 · 2021 · External reference
The genomic landscape of two Burkitt lymphoma cases and derived cell lines: comparison between primary and relapse samples
10.1080/10428194.2017.1413186 · 2018 · External reference
Outcomes among adult recipients of CAR T-cell therapy for Burkitt lymphoma
10.1182/blood.2024026831 · 2025 · External reference
Is liquid biopsy a cost-effective method to diagnose Burkitt Lymphoma in children and young adults? A health economic evaluation in Tanzania
10.1186/s12916-026-04694-2 · 2026 · External reference
African Burkitt's lymphoma: could collaboration with HIV-1 and malaria programmes reduce the high mortality rate?
10.1016/s0140-6736(10)60134-1 · 2010 · External reference
Global burden of cancer in children and adolescents aged 0-19 years, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023
10.1016/s0140-6736(26)00200-x · 2026 · External reference
Progress towards the WHO Global Initiative for Childhood Cancer target of 60% 5-year survival for all childhood cancers combined, 1990-2019 (CONCORD-4): a Cancer Survival Index derived for 68 countries by analysis of individual records for 613 021 children from 307 population-based cancer registries
10.1016/s0140-6736(26)00189-3 · 2026 · External reference
Humanized Mouse Models of Clinical Disease
10.1146/annurev-pathol-052016-100332 · 2017 · External reference
Paediatric Burkitt lymphoma patient-derived xenografts capture disease characteristics over time and are a model for therapy
10.1111/bjh.17043 · 2021 · External reference
Patient-derived xenograft models of ALK+ ALCL reveal preclinical promise for therapy with brigatinib
10.1111/bjh.18953 · 2023 · External reference
Endemic Burkitt lymphoma avatar mouse models for exploring inter-patient tumor variation and testing targeted therapies
10.26508/lsa.202101355 · 2023 · External reference
B-Cell Lymphoma Patient-Derived Xenograft Models Enable Drug Discovery and Are a Platform for Personalized Therapy
10.1158/1078-0432.ccr-16-2703 · 2017 · External reference
Complex genetic and histopathological study of 15 patient-derived xenografts of aggressive lymphomas
10.1038/s41374-022-00784-w · 2022 · External reference
Priming of protective T cell responses against virus-induced tumors in mice with human immune system components
10.1084/jem.20081720 · 2009 · External reference
Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r gamma(null) humanized mice
10.1073/pnas.1000475107 · 2010 · External reference
Modeling EBV infection and pathogenesis in new-generation humanized mice
10.1038/emm.2014.88 · 2015 · External reference
Modification of EBV Associated Lymphomagenesis and Its Immune Control by Co-Infections and Genetics in Humanized Mice
10.3389/fimmu.2021.640918 · 2021 · External reference
Humanized hemato-lymphoid system mice
10.3324/haematol.2014.115212 · 2016 · External reference
Generation of Human Immunosuppressive Myeloid Cell Populations in Human Interleukin-6 Transgenic NOG Mice
10.3389/fimmu.2018.00152 · 2018 · External reference
The Use of the Humanized Mouse Model in Gene Therapy and Immunotherapy for HIV and Cancer
10.3389/fimmu.2018.00746 · 2018 · External reference
EBNA2-deleted Epstein-Barr virus (EBV) isolate, P3HR1, causes Hodgkin-like lymphomas and diffuse large B cell lymphomas with type II and Wp-restricted latency types in humanized mice
10.1371/journal.ppat.1008590 · 2020 · External reference
Development of a human adaptive immune system in cord blood cell-transplanted mice
10.1126/science.1093933 · 2004 · External reference
Development and function of human innate immune cells in a humanized mouse model
10.1038/nbt.2858 · 2014 · External reference
Co-transplantation of human hematopoietic stem cells and human breast cancer cells in NSG mice: a novel approach to generate tumor cell specific human antibodies
10.4161/mabs.29111 · 2014 · External reference
Development of patient-derived lymphomoids with preserved tumor architecture for lymphoma therapy screening
10.1038/s41467-024-55098-w · 2024 · External reference
A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity
10.1016/j.cell.2017.11.010 · 2018 · External reference
Organoid Modeling of the Tumor Immune Microenvironment
10.1016/j.cell.2018.11.021 · 2018 · External reference
A human lymphoma organoid model for evaluating and targeting the follicular lymphoma tumor immune microenvironment
10.1016/j.stem.2024.01.012 · 2024 · External reference
Immune disparities in the TME of EBV+ and EBV- BL: role of ROS generation pathways and platelet activation
10.1182/bloodadvances.2025018518 · 2026 · External reference
Tumor microenvironment of Burkitt lymphoma: different immune signatures with different clinical behavior
10.1182/bloodadvances.2023011506 · 2024 · External reference
Burkitt lymphoma with a granulomatous reaction: an M1/Th1-polarised microenvironment is associated with controlled growth and spontaneous regression
10.1111/his.14391 · 2022 · External reference
Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids
10.1016/j.cell.2018.07.009 · 2018 · External reference
Data augmentation and multimodal learning for predicting drug response in patient-derived xenografts from gene expressions and histology images
10.3389/fmed.2023.1058919 · 2023 · External reference
Pan-Cancer Pharmacogenomic Analysis of Patient-Derived Tumor Cells Using Clinically Relevant Drug Exposures
10.1158/1535-7163.mct-22-0486 · 2023 · External reference
A human breast cancer-derived xenograft and organoid platform for drug discovery and precision oncology
10.1038/s43018-022-00337-6 · 2022 · External reference
PDXGEM: patient-derived tumor xenograft-based gene expression model for predicting clinical response to anticancer therapy in cancer patients
10.1186/s12859-020-03633-z · 2020 · External reference
Relevance of ID3-TCF3-CCND3 pathway mutations in pediatric aggressive B-cell lymphoma treated according to the non-Hodgkin Lymphoma Berlin-Frankfurt-Münster protocols
10.3324/haematol.2016.156885 · 2017 · External reference
Genetic modification of primary human B cells to model high-grade lymphoma
10.1038/s41467-019-12494-x · 2019 · External reference
Circulating Tumor DNA Measurements As Early Outcome Predictors in Diffuse Large B-Cell Lymphoma
10.1200/jco.2018.78.5246 · 2018 · External reference
Circulating tumour DNA and CT monitoring in patients with untreated diffuse large B-cell lymphoma: a correlative biomarker study
10.1016/s1470-2045(15)70106-3 · 2015 · External reference
Haematological malignancies in sub-Saharan Africa: east Africa as an example for improving care
10.1016/s2352-3026(21)00198-8 · 2021 · External reference
Diagnosing Burkitt Lymphoma in Sub-Saharan Africa by Sequencing of Circulating Tumor DNA: A Comparative Microcosting Study
10.1016/j.vhri.2025.101113 · 2025 · External reference
Viral driven epigenetic events alter the expression of cancer-related genes in Epstein-Barr-virus naturally infected Burkitt lymphoma cell lines
10.1038/s41598-017-05713-2 · 2017 · External reference
