Research graph
References from JARID2 inhibition reprograms human hematopoietic progenitor cells to enhance bone marrow transplantation. Local targets link to admitted publications; unresolved targets remain external evidence.
Indications for autologous and allogeneic hematopoietic cell transplantation: guidelines from the American Society for Blood and Marrow Transplantation
10.1016/j.bbmt.2015.07.032 · 2015 · External reference
Overview of hematopoietic cell transplantation for the treatment of hematologic malignancies
10.1016/j.ccm.2017.07.001 · 2017 · External reference
Graft-versus-leukemia effect and its clinical implications
10.3109/10428199609054857 · 1996 · External reference
Selection of unrelated donors and cord blood units for hematopoietic cell transplantation: guidelines from the NMDP/CIBMTR
10.1182/blood.2019001212 · 2019 · External reference
HLA match likelihoods for hematopoietic stem-cell grafts in the US Registry
10.1056/nejmsa1311707 · 2014 · External reference
Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: a comparison study
10.1016/s0140-6736(07)60915-5 · 2007 · External reference
Graft-versus-host disease in children who have received a cord-blood or bone marrow transplant from an HLA-identical sibling. Eurocord and International Bone Marrow Transplant Registry Working Committee on Alternative Donor and Stem Cell Sources
10.1056/nejm200006223422501 · 2000 · External reference
Umbilical cord blood transplantation: current practice and future innovations
10.1016/s1040-8428(03)00092-1 · 2003 · External reference
Availability of cord blood extends allogeneic hematopoietic stem cell transplant access to racial and ethnic minorities
10.1016/j.bbmt.2010.08.011 · 2010 · External reference
Comparison of hematopoietic activities of human bone marrow and umbilical cord blood CD34 positive and negative cells
10.1002/stem.170286 · 1999 · External reference
Graft-versus-leukemia effect of allogeneic stem-cell transplantation and minimal residual disease in patients with acute myeloid leukemia in first complete remission
10.1200/po.17.00078 · 2017 · External reference
Single-unit versus double-unit umbilical cord blood transplantation in children and young adults with residual leukemic disease
10.1016/j.bbmt.2018.10.016 · 2019 · External reference
Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells
10.1126/science.1191536 · 2010 · External reference
Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal
10.1126/science.1256337 · 2014 · External reference
Antagonism of PPAR-gamma signaling expands human hematopoietic stem and progenitor cells by enhancing glycolysis
10.1038/nm.4477 · 2018 · External reference
Prostaglandin E-2 enhances hematopoietic stem cell homing, survival, and proliferation
10.1182/blood-2009-01-201335 · 2009 · External reference
A high-throughput chemical genetic screen in zebrafish establishes that prostaglandin E2 is a potent regulator of hematopoietic stem cell formation
10.1016/j.bcmd.2006.10.159 · 2007 · External reference
Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis
10.1038/nature05883 · 2007 · External reference
Phase I/II trial of StemRegenin-1 expanded umbilical cord blood hematopoietic stem cells supports testing as a stand-alone graft
10.1016/j.stem.2015.10.004 · 2016 · External reference
Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation
10.1182/blood-2013-05-503177 · 2013 · External reference
Epigenetic regulation in hematopoiesis and its implications in the targeted therapy of hematologic malignancies
10.1038/s41392-023-01342-6 · 2023 · External reference
JARID2 functions as a tumor suppressor in myeloid neoplasms by repressing self-renewal in hematopoietic progenitor cells
10.1016/j.ccell.2018.10.008 · 2018 · External reference
Jarid2 regulates hematopoietic stem cell function by acting with polycomb repressive complex 2
10.1182/blood-2014-10-603969 · 2015 · External reference
An optimized microRNA backbone for effective single-copy RNAi
10.1016/j.celrep.2013.11.020 · 2013 · External reference
Enhancing lentiviral and alpharetroviral transduction of human hematopoietic stem cells for clinical application
10.1016/j.omtm.2019.05.015 · 2019 · External reference
Frequent deletions of JARID2 in leukemic transformation of chronic myeloid malignancies
10.1002/ajh.22257 · 2012 · External reference
Clinical significance of genetic aberrations in secondary acute myeloid leukemia
10.1002/ajh.23309 · 2012 · External reference
Genomic and functional analysis of leukemic transformation of myeloproliferative neoplasms
10.1073/pnas.1407792111 · 2014 · External reference
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia
10.1056/nejmoa1301689 · 2013 · External reference
UM171 preserves epigenetic marks that are reduced in ex vivo culture of human HSCs via potentiation of the CLR3-KBTBD4 complex
10.1016/j.stem.2020.12.002 · 2021 · External reference
Improved outcomes of UM171-expanded cord blood transplantation compared with other graft sources: real-world evidence
10.1182/bloodadvances.2023010599 · 2023 · External reference
Human bone marrow assessment by single-cell RNA sequencing, mass cytometry, and flow cytometry
10.1172/jci.insight.124928 · 2018 · External reference
Single-cell multiomic analysis identifies regulatory programs in mixed-phenotype acute leukemia
10.1038/s41587-019-0332-7 · 2019 · External reference
Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA polymerase II to developmental regulators
10.1038/ncb2065 · 2010 · External reference
JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells
10.1038/nature08788 · 2010 · External reference
Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment
10.1126/science.1201219 · 2011 · External reference
Human hematopoietic stem cells from mobilized peripheral blood can be purified based on CD49f integrin expression
10.1182/blood-2015-07-660670 · 2015 · External reference
Hematopoietic stem cells in human fetal liver selectively express CD49f
10.1016/j.exphem.2025.104788 · 2025 · External reference
Characterization and phenotypic analysis of differentiating CD34+ human bone marrow cells in liquid culture
10.1111/j.1600-0609.1997.tb01693.x · 1997 · External reference
Comparison with Ezh2 reveals the PRC2-dependent functions of Jarid2 in hematopoietic stem Cell lineage commitment
10.1016/j.stemcr.2026.102793 · 2026 · External reference
MYCT1 controls environmental sensing in human haematopoietic stem cells
10.1038/s41586-024-07478-x · 2024 · External reference
MLLT3 governs human haematopoietic stem-cell self-renewal and engraftment
10.1038/s41586-019-1790-2 · 2019 · External reference
Antigen presentation safeguards the integrity of the hematopoietic stem cell pool
10.1016/j.stem.2022.04.007 · 2022 · External reference
STAT1 is essential for HSC function and maintains MHCIIhi stem cells that resist myeloablation and neoplastic expansion
10.1182/blood.2021014009 · 2022 · External reference
