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References from Characterization of a mouse model to study mechanisms of hemophilia A pain. Local targets link to admitted publications; unresolved targets remain external evidence.
Pain and pain management in haemophilia
10.1097/mbc.0000000000000571 · 2016 · External reference
Understanding the pain management landscape within the US bleeding disorder community: a multi-center survey
10.1093/pm/pnab196 · 2022 · External reference
The past and future of haemophilia: diagnosis, treatments, and its complications
10.1016/s0140-6736(15)01123-x · 2016 · External reference
Pain and functional limitations in patients with severe haemophilia
10.1111/j.1365-2516.2006.01203.x · 2006 · External reference
Prevalence and interference of chronic pain among people with hemophilia: a systematic review and meta-analysis
10.1016/j.jpain.2021.03.157 · 2021 · External reference
Impact of haemophilia on patients with mild-to-moderate disease: results from the P-FiQ and B-HERO-S studies
10.1111/hae.14251 · 2021 · External reference
Pain management in hemophilia: expert recommendations
10.1007/s00508-020-01798-4 · 2021 · External reference
Pain assessment and management in Italian haemophilia centres
2021 · External reference
Pain prevalence, characteristics, and impact among people with hemophilia: findings from the first Portuguese survey and implications for pain management
10.1093/pm/pny309 · 2020 · External reference
Pain management in patients with haemophilia: a European survey
10.1111/j.1365-2516.2012.02808.x · 2012 · External reference
Joint disease in haemophilia: pathophysiology, pain and imaging
10.1111/hae.13449 · 2018 · External reference
Human synovial mast cell involvement in rheumatoid arthritis and osteoarthritis. Relationship to disease type, clinical activity, and antirheumatic therapy
10.1002/art.1780340907 · 1991 · External reference
Hemophilic arthropathy
10.5435/00124635-200407000-00004 · 2004 · External reference
A longitudinal study of orthopaedic outcomes for severe factor-VIII-deficient haemophiliacs. The Orthopaedic Outcome Study Group
10.1111/j.1365-2796.1994.tb00815.x · 1994 · External reference
The role of total ankle replacement in patients with haemophilia and end-stage ankle arthropathy: a review
10.1111/hae.14196 · 2021 · External reference
Different faces of the heme-heme oxygenase system in inflammation
10.1124/pr.55.3.5 · 2003 · External reference
High heme and low heme oxygenase-1 are associated with mast cell activation/degranulation in HIV-induced chronic widespread pain
10.3390/antiox12061213 · 2023 · External reference
Mast cell-neural interactions contribute to pain and itch
10.1111/imr.12622 · 2018 · External reference
Neutrophil activation by heme: implications for inflammatory processes
10.1182/blood.v99.11.4160 · 2002 · External reference
Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease
10.1182/blood-2013-10-529982 · 2014 · External reference
Mast cell activation contributes to sickle cell pathobiology and pain in mice
10.1182/blood-2013-04-498105 · 2013 · External reference
Protease activated receptor 2 (PAR2) activation causes migraine-like pain behaviors in mice
10.1177/0333102418779548 · 2019 · External reference
Proteinase-activated receptor-2 and hyperalgesia: a novel pain pathway
10.1038/89945 · 2001 · External reference
Neutrophil elastase induces inflammation and pain in mouse knee joints via activation of proteinase-activated receptor-2
10.1111/bph.13237 · 2016 · External reference
A role for thrombin in the initiation of the immune response to therapeutic factor VIII
10.1182/blood-2008-10-186452 · 2009 · External reference
Assessment of acute and persistent pain management in patients with haemophilia
10.1111/j.1365-2516.2010.02479.x · 2011 · External reference
Regional brain volumes and their relationship to neurocognitive outcomes in children with severe hemophilia A
10.1016/j.bvth.2024.100021 · 2024 · External reference
The eTHINK study: cognitive and behavioral outcomes in children with hemophilia
10.1016/j.jpeds.2024.114089 · 2024 · External reference
Shortened lifespan and lethal hemorrhage in a hemophilia a mouse model
10.1371/journal.pone.0154857 · 2016 · External reference
Blood-induced bone loss in murine hemophilic arthropathy is prevented by blocking the iRhom2/ADAM17/TNF-α pathway
10.1182/blood-2017-12-820571 · 2018 · External reference
EPCR deficiency or function-blocking antibody protects against joint bleeding-induced pathology in hemophilia mice
10.1182/blood.2019003824 · 2020 · External reference
Defective TAFI activation in hemophilia A mice is a major contributor to joint bleeding
10.1182/blood-2018-01-828434 · 2018 · External reference
Defective lymphangiogenesis and iron removal after hemarthrosis in factor VIII-deficient mice are rectified with therapeutic factor VIII administration-implications for joint health
10.1016/j.jtha.2025.08.016 · 2026 · External reference
Maladaptive lymphangiogenesis is associated with synovial iron accumulation and delayed clearance in factor VIII-deficient mice after induced hemarthrosis
10.1016/j.jtha.2023.04.022 · 2023 · External reference
Targeted disruption of the mouse factor VIII gene produces a model of haemophilia A
10.1038/ng0595-119 · 1995 · External reference
Pre-clinical evaluation of an enhanced-function factor VIII variant for durable hemophilia A gene therapy in male mice
10.1038/s41467-024-51296-8 · 2024 · External reference
Vascular permeability and remodelling coincide with inflammatory and reparative processes after joint bleeding in factor VIII-deficient mice
10.1055/s-0038-1641755 · 2018 · External reference
Experimental haemophilic arthropathy in a mouse model of a massive haemarthrosis: gross, radiological and histological changes
10.1111/j.1365-2516.2008.01689.x · 2008 · External reference
Intraarticular factor IX protein or gene replacement protects against development of hemophilic synovitis in the absence of circulating factor IX
10.1182/blood-2008-01-131417 · 2008 · External reference
Mechanisms of vascular permeability and remodeling associated with hemarthrosis in factor VIII-deficient mice
10.1111/jth.14567 · 2019 · External reference
Assessment of gait in mice using simplified analysis tools
10.21203/rs.3.pex-2191/v1 · External reference
Neural ensembles that encode nocifensive mechanical and heat pain in mouse spinal cord
10.1038/s41593-025-01921-6 · 2025 · External reference
Impact of pain and functional impairment in US adults with haemophilia: patient-reported outcomes and musculoskeletal evaluation in the pain, functional impairment and quality of life (P-FiQ) study
10.1111/hae.13377 · 2018 · External reference
Vascular remodeling underlies rebleeding in hemophilic arthropathy
10.1002/ajh.24133 · 2015 · External reference
Spatiotemporal alterations in gait in humanized transgenic sickle mice
10.3389/fimmu.2020.561947 · 2020 · External reference
Quantification of gait parameters in freely walking rodents
10.1186/s12915-015-0154-0 · 2015 · External reference
Cannabidiol attenuates hyperalgesia in a mouse model of sickle cell disease
10.1182/blood.2022016382 · 2023 · External reference
Mouse models for studying pain in sickle cell disease: effects of strain, age, and acuteness
10.1111/j.1365-2141.2011.08977.x · 2012 · External reference
Morphine effects within the rodent anterior cingulate cortex and rostral ventromedial medulla reveal separable modulation of affective and sensory qualities of acute or chronic pain
10.1097/j.pain.0000000000001355 · 2018 · External reference
Normative spatiotemporal gait parameters in older adults
10.1016/j.gaitpost.2011.03.024 · 2011 · External reference
Neuroprotective, anti-inflammatory, and analgesic activity of palmitoylethanolamide in sickle cell mice
10.1182/bloodadvances.2024015439 · 2025 · External reference
Histological changes in murine haemophilic synovitis: a quantitative grading system to assess blood-induced synovitis
10.1111/j.1365-2516.2006.01348.x · 2006 · External reference
Tanshinone IIA ameliorates chronic arthritis in mice by modulating neutrophil activities
10.1111/cei.12993 · 2017 · External reference
Mouse models of pain in sickle cell disease
10.1002/cpns.54 · 2018 · External reference
Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain
10.1016/j.pain.2005.01.002 · 2005 · External reference
Pain in hemophilia: unexplored role of oxidative stress
10.3390/antiox11061113 · 2022 · External reference
Collagen-induced arthritis as a model of hyperalgesia: functional and cellular analysis of the analgesic actions of tumor necrosis factor blockade
10.1002/art.23063 · 2007 · External reference
A review of pain assessment methods in laboratory rodents
10.30802/aalas-cm-19-000042 · 2019 · External reference
Impairment in locomotor activity as an objective measure of pain and analgesia in a rat model of osteoarthritis
10.3892/etm.2020.9294 · 2020 · External reference
The impact of joint bleeding and synovitis on physical ability and joint function in a murine model of haemophilic synovitis
10.1111/j.1365-2516.2007.01527.x · 2008 · External reference
Gait characteristics associated with the foot and ankle in inflammatory arthritis: a systematic review and meta-analysis
10.1186/s12891-015-0596-0 · 2015 · External reference
Gait alteration due to haemophilic arthropathies in patients with moderate haemophilia
10.3390/ijerph19127527 · 2022 · External reference
Molecular mechanisms of neurogenic inflammation of the skin
10.3390/ijms24055001 · 2023 · External reference
Methods used to evaluate pain behaviors in rodents
10.3389/fnmol.2017.00284 · 2017 · External reference
Chronic pain impact on rodents’ behavioral repertoire
10.1016/j.neubiorev.2020.09.022 · 2020 · External reference
Weight bearing as an objective measure of arthritic pain in the rat
10.1016/1056-8719(94)90046-9 · 1994 · External reference
Weight bearing as a measure of disease progression and efficacy of anti-inflammatory compounds in a model of monosodium iodoacetate-induced osteoarthritis
10.1016/s1063-4584(03)00163-8 · 2003 · External reference
A rat model of bone cancer pain
10.1016/s0304-3959(01)00437-7 · 2002 · External reference
Novel use of perineural pregabalin infusion for analgesia in a rat neuropathic pain model
10.1213/ane.0000000000000291 · 2014 · External reference
Peak pressure during gait in patients with severe haemophilia: a controlled cross-sectional study
10.1016/j.gaitpost.2022.01.008 · 2022 · External reference
Hemophilic arthropathy of the knee and its association with reduced muscle strength and activation and the pressure pain threshold: a case-control study
10.3390/jcm12093275 · 2023 · External reference
Changes in pain profile of patients with haemophilia during 1-year follow-up
10.1111/hae.14380 · 2021 · External reference
Can early subclinical gait changes in children with haemophilia be identified using the GAITRite walkway
10.1111/j.1365-2516.2007.01429.x · 2007 · External reference
Prophylaxis versus episodic treatment to prevent joint disease in boys with severe hemophilia
10.1056/nejmoa067659 · 2007 · External reference
Prophylactic inhibition of neutrophil elastase prevents the development of chronic neuropathic pain in osteoarthritic mice
10.1186/s12974-017-0944-0 · 2017 · External reference
Neutrophil elastase and its inhibitors-overlooked players in osteoarthritis
10.1111/febs.16194 · 2022 · External reference
Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism
10.1038/72247 · 2000 · External reference
Shared fate of meningeal mast cells and sensory neurons in migraine
10.3389/fncel.2019.00136 · 2019 · External reference
Neurotransmitter and neuropeptide regulation of mast cell function: a systematic review
10.1186/s12974-020-02029-3 · 2020 · External reference
Roles of mast cells in rheumatoid arthritis
10.3904/kjim.2019.271 · 2020 · External reference
A novel mice model of acute flares in osteoarthritis elicited by intra-articular injection of cultured mast cells
10.1186/s40634-021-00391-6 · 2021 · External reference
Involvement of calcitonin gene-related peptide and CCL2 production in CD40-mediated behavioral hypersensitivity in a model of neuropathic pain
10.1017/s1740925x12000026 · 2011 · External reference
Determination of specific neuropeptides modulation time course in a rat model of osteoarthritis pain by liquid chromatography ion trap mass spectrometry
10.1016/j.npep.2011.07.007 · 2011 · External reference
A mast-cell-specific receptor mediates neurogenic inflammation and pain
10.1016/j.neuron.2019.01.012 · 2019 · External reference
Alpha-1-antitrypsin reduces inflammation and exerts chondroprotection in arthritis
10.1096/fj.202001801r · 2021 · External reference
IL-1β, in contrast to TNFα, is pivotal in blood-induced cartilage damage and is a potential target for therapy
10.1182/blood-2015-03-635524 · 2015 · External reference
A translational study of TNF-Alpha antagonists as an adjunctive therapy for preventing hemophilic arthropathy
10.3390/jcm9010075 · 2019 · External reference
Factor VIIa-released extracellular vesicles attenuate joint bleed-induced hemophilic arthropathy
10.1182/blood.2024027143 · 2026 · External reference
Unmet needs in hemophilic arthropathy
10.1016/j.blre.2025.101304 · 2025 · External reference
Targeting synovitis by immunomodulation as a novel strategy to prevent hemophilic arthropathy
10.1016/j.jtha.2026.04.033 · 2026 · External reference
Pathogenesis of osteoarthritis, rheumatoid arthritis, and hemophilic arthropathy: the role of angiogenesis
10.1111/hae.15097 · 2024 · External reference
Inflammatory diseases causing joint and bone destruction: rheumatoid arthritis and hemophilic arthropathy
10.1007/s00774-024-01520-8 · 2024 · External reference
Hemochromatosis osteoarthritis
10.3389/fendo.2026.1735750 · 2026 · External reference
Haemophilia and joint disease: pathophysiology, evaluation, and management
10.15256/joc.2011.1.2 · 2011 · External reference
Iron overload causes macrophages to produce a pro-inflammatory phenotype in the synovium of hemophiliac arthritis via the acetyl-p53 pathway
10.1111/hae.14905 · 2024 · External reference
Neutrophil elastase induces chondrocyte apoptosis and facilitates the occurrence of osteoarthritis via caspase signaling pathway
10.3389/fphar.2021.666162 · 2021 · External reference
Mast cell: a multi-functional master cell
2015 · External reference
The role of mast cells in allergic inflammation
10.1016/j.rmed.2011.09.007 · 2012 · External reference
Mast cells increase vascular permeability by heparin-initiated bradykinin formation in vivo
10.1016/j.immuni.2011.02.008 · 2011 · External reference
Mast cell and basophil granule proteases - in vivo targets and function
10.3389/fimmu.2022.918305 · 2022 · External reference
Pain status of patients with severe haemophilic arthropathy
10.1046/j.1365-2516.2001.00540.x · 2001 · External reference
Targeting sickle cell pathobiology and pain with novel transdermal curcumin
10.1093/pnasnexus/pgaf053 · 2025 · External reference
A randomized controlled trial assessing the safety and efficacy of palmitoylethanolamide for treating diabetic-related peripheral neuropathic pain
10.1007/s10787-022-01033-8 · 2022 · External reference
Palmitoylethanolamide for the treatment of pain: pharmacokinetics, safety and efficacy
10.1111/bcp.13020 · 2016 · External reference
A scoping review of clinical trials on the efficacy of curcumin and its formulations for wound healing
10.1111/jocd.70615 · 2025 · External reference
Regulatory effects of curcumin on platelets: an update and future directions
10.3390/biomedicines10123180 · 2022 · External reference