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References from Comutation of asxl1 and IDH2 R172K enhances leukemogenesis and correlates with epigenetic activation of MAPK and AP-1 in zebrafish. Local targets link to admitted publications; unresolved targets remain external evidence.
Application of next generation sequencing in laboratory medicine
10.3343/alm.2021.41.1.25 · 2021 · External reference
Clinical utility of next-generation sequencing in acute myeloid leukemia
10.1007/s40291-019-00443-9 · 2020 · External reference
Impact of next-generation sequencing in diagnosis, prognosis and therapeutic management of acute myeloid leukemia/myelodysplastic neoplasms
10.3390/cancers15133280 · 2023 · External reference
Next-generation sequencing-based posttransplant monitoring of acute myeloid leukemia identifies patients at high risk of relapse
10.1182/blood-2018-04-848028 · 2018 · External reference
Prognostic risk signature in patients with acute myeloid leukemia treated with hypomethylating agents and venetoclax
10.1182/bloodadvances.2023011757 · 2024 · External reference
Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability
10.1073/pnas.1117773108 · 2011 · External reference
Wild-type IDH2 is a therapeutic target for triple-negative breast cancer
10.1038/s41467-024-47536-6 · 2024 · External reference
Transgenic IDH2R172K and IDH2R140Q zebrafish models recapitulated features of human acute myeloid leukemia
10.1038/s41388-023-02611-y · 2023 · External reference
Redefining prognostication of de novo cytogenetically normal acute myeloid leukemia in young adults
10.1038/s41408-020-00373-4 · 2020 · External reference
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
10.1038/nature08617 · 2009 · External reference
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
10.1016/j.ccr.2010.01.020 · 2010 · External reference
The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases
10.1038/embor.2011.43 · 2011 · External reference
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases
10.1016/j.ccr.2010.12.014 · 2011 · External reference
IDH1R132, IDH2R140 and IDH2R172 in AML: different genetic landscapes correlate with outcome and may influence targeted treatment strategies
10.1038/s41375-018-0026-z · 2018 · External reference
Acute myeloid leukemia (AML) with IDH1 and IDH2 mutations can be effectively risk stratified based on the presence adverse risk genomic features [abstract]
10.1097/01.hs9.0000968724.09323.c5 · 2023 · External reference
Differential impact of IDH1/2 mutational subclasses on outcome in adult AML: results from a large multicenter study
10.1182/bloodadvances.2021004934 · 2022 · External reference
ASXL1/2 mutations and myeloid malignancies
10.1186/s13045-022-01336-x · 2022 · External reference
Functional and cancer genomics of ASXL family members
10.1038/bjc.2013.281 · 2013 · External reference
Mutual exclusion of ASXL1 and NPM1 mutations in a series of acute myeloid leukemias
10.1038/leu.2009.218 · 2010 · External reference
Mutations of polycomb-associated gene ASXL1 in myelodysplastic syndromes and chronic myelomonocytic leukaemia
10.1111/j.1365-2141.2009.07697.x · 2009 · External reference
Frequent mutation of the polycomb-associated gene ASXL1 in the myelodysplastic syndromes and in acute myeloid leukemia
10.1038/leu.2010.20 · 2010 · External reference
Mutations of ASXL1 gene in myeloproliferative neoplasms
10.1038/leu.2009.141 · 2009 · External reference
High-density single nucleotide polymorphism array analysis and ASXL1 gene mutation screening in chronic myeloid leukemia during disease progression
10.1038/leu.2010.65 · 2010 · External reference
Spectrum of molecular defects in juvenile myelomonocytic leukaemia includes ASXL1 mutations
10.1111/j.1365-2141.2010.08196.x · 2010 · External reference
CBL, CBLC, TET2, ASXL1, and IDH1/2 mutations and additional chromosomal aberrations constitute molecular events in chronic myelogenous leukemia
10.1182/blood-2010-06-292433 · 2011 · External reference
ASXL1 exon 12 mutations are frequent in AML with intermediate risk karyotype and are independently associated with an adverse outcome
10.1038/leu.2012.262 · 2013 · External reference
A practical approach to curate clonal hematopoiesis of indeterminate potential in human genetic data sets
2023 · External reference
The PHD finger: a versatile epigenome reader
2011 · External reference
ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression
10.1016/j.ccr.2012.06.032 · 2012 · External reference
Polycomb repressor complex 2 regulates HOXA9 and HOXA10, activating ID2 in NK/T-cell lines
10.1186/1476-4598-9-151 · 2010 · External reference
Nucleosome-binding activities within JARID2 and EZH1 regulate the function of PRC2 on chromatin
10.1101/gad.225888.113 · 2013 · External reference
Ezh1 and Ezh2 differentially regulate PSD-95 gene transcription in developing hippocampal neurons
10.1016/j.mcn.2013.07.012 · 2013 · External reference
Ezh2 loss in hematopoietic stem cells predisposes mice to develop heterogeneous malignancies in an Ezh1-dependent manner
10.1182/blood-2015-03-634428 · 2015 · External reference
Asxl1 C-terminal mutation perturbs neutrophil differentiation in zebrafish
10.1038/s41375-021-01121-8 · 2021 · External reference
Optimized intravenous injection in adult zebrafish
2024 · External reference
Integrating single-cell transcriptomic data across different conditions, technologies, and species
10.1038/nbt.4096 · 2018 · External reference
Single-cell transcriptomic analysis identifies the conversion of zebrafish Etv2-deficient vascular progenitors into skeletal muscle
10.1038/s41467-020-16515-y · 2020 · External reference
Essential role for Gata2 in modulating lineage output from hematopoietic stem cells in zebrafish
10.1182/bloodadvances.2020002993 · 2021 · External reference
An improved zebrafish transcriptome annotation for sensitive and comprehensive detection of cell type-specific genes
10.7554/elife.55792 · 2020 · External reference
Single-cell transcriptional analysis of normal, aberrant, and malignant hematopoiesis in zebrafish
10.1084/jem.20152013 · 2016 · External reference
Single-cell analysis of mixed-lineage states leading to a binary cell fate choice
10.1038/nature19348 · 2016 · External reference
A single-cell resolution developmental atlas of hematopoietic stem and progenitor cell expansion in zebrafish
10.1073/pnas.2015748118 · 2021 · External reference
CXCL12 and MYC control energy metabolism to support adaptive responses after kidney injury
10.1038/s41467-018-06094-4 · 2018 · External reference
Reversed graph embedding resolves complex single-cell trajectories
10.1038/nmeth.4402 · 2017 · External reference
The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells
10.1038/nbt.2859 · 2014 · External reference
GFNB: Gini index-based Fuzzy Naive Bayes and blast cell segmentation for leukemia detection using multi-cell blood smear images
10.1007/s11517-020-02249-y · 2020 · External reference
The IDH2 R172K mutation associated with angioimmunoblastic T-cell lymphoma produces 2HG in T cells and impacts lymphoid development
10.1073/pnas.1617929114 · 2016 · External reference
Optimized cell transplantation using adult rag2 mutant zebrafish
10.1038/nmeth.3031 · 2014 · External reference
TET2 mutations are associated with hypermethylation at key regulatory enhancers in normal and malignant hematopoiesis
10.1038/s41467-021-26093-2 · 2021 · External reference
Effects of TET2 mutations on DNA methylation in chronic myelomonocytic leukemia
10.4161/epi.7.2.19015 · 2012 · External reference
TET2 coactivates gene expression through demethylation of enhancers
10.1126/sciadv.aau6986 · 2018 · External reference
Targeting ROS production through inhibition of NADPH oxidases
10.1038/s41589-023-01457-5 · 2023 · External reference
Overproduction of NOX-derived ROS in AML promotes proliferation and is associated with defective oxidative stress signaling
10.1182/blood-2013-04-491944 · 2013 · External reference
Integrative analysis of drug response and clinical outcome in acute myeloid leukemia
10.1016/j.ccell.2022.07.002 · 2022 · External reference
Pseudo-Pelger-Huët anomaly and granulocytic dysplasia associated with human granulocytic anaplasmosis
10.1007/s12185-015-1769-1 · 2015 · External reference
Hemophagocytic syndrome in patients with acute myeloid leukemia undergoing intensive chemotherapy
10.3324/haematol.2013.097394 · 2014 · External reference
The significance of splenomegaly in 101 adults with acute lymphoblastic leukemia (ALL) at presentation and during remission
10.1182/blood.v57.4.798.798 · 1981 · External reference
Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo
10.1084/jem.20131141 · 2013 · External reference
Distinct and opposite effects of leukemogenic Idh and Tet2 mutations in hematopoietic stem and progenitor cells
10.1073/pnas.2208176120 · 2023 · External reference
asxl1 C-terminal truncation and SRSF2 mutation drive leukemogenesis via immune reprogramming
10.1038/s41375-025-02790-5 · 2025 · External reference
IDH1 and IDH2 mutations in gliomas
10.1056/nejmoa0808710 · 2009 · External reference
ASXL1 mutations are associated with distinct epigenomic alterations that lead to sensitivity to venetoclax and azacytidine
10.1038/s41408-021-00541-0 · 2021 · External reference
Asxl1 loss cooperates with oncogenic Nras in mice to reprogram the immune microenvironment and drive leukemic transformation
10.1182/blood.2021012519 · 2022 · External reference
AP-1-dependent transcriptional regulation of NADPH oxidase in human aortic smooth muscle cells: role of p22phox subunit
10.1161/atvbaha.108.163592 · 2008 · External reference
Reactive oxygen species signaling and oxidative stress: transcriptional regulation and evolution
10.3390/antiox13030312 · 2024 · External reference
PLCG1 is required for AML1-ETO leukemia stem cell self-renewal
10.1182/blood.2021012778 · 2022 · External reference
AP-1 expression and its clinical relevance in immune disorders and cancer
10.1016/j.amjms.2017.01.019 · 2017 · External reference
Advances in the relationship between AP-1 and tumorigenesis, development and therapy resistance
10.1007/s12672-025-01783-1 · 2025 · External reference
Chronic FLT3-ITD signaling in acute myeloid leukemia is connected to a specific chromatin signature
10.1016/j.celrep.2015.06.069 · 2015 · External reference
The oncogenic transcription factor RUNX1/ETO corrupts cell cycle regulation to drive leukemic transformation
10.1016/j.ccell.2018.08.015 · 2018 · External reference
Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells
10.1038/nm1388 · 2006 · External reference
Reactive oxygen species and metabolism in leukemia: a dangerous liaison
10.3389/fimmu.2022.889875 · 2022 · External reference
Efficacy and safety of enasidenib and azacitidine combination in patients with IDH2 mutated acute myeloid leukemia and not eligible for intensive chemotherapy
10.1038/s41408-021-00604-2 · 2022 · External reference
