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References from Recurrent VTE in patients with thrombophilia after stopping anticoagulation: a systematic review and meta-analysis. Local targets link to admitted publications; unresolved targets remain external evidence.
Epidemiology of venous thromboembolism
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Who should get long-term anticoagulant therapy for venous thromboembolism and with what?
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Categorization of patients as having provoked or unprovoked venous thromboembolism: guidance from the SSC of ISTH
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American Society of Hematology 2020 guidelines for management of venous thromboembolism: treatment of deep vein thrombosis and pulmonary embolism
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Thrombophilia testing and venous thrombosis
10.1056/nejmra1700365 · 2017 · External reference
Thrombophilia testing in venous thromboembolism
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Adherence to thrombophilia testing guidelines and its influence on anticoagulation therapy: a single-center cross-sectional study
10.1016/j.thromres.2022.12.001 · 2023 · External reference
Thrombophilia impact on treatment decisions, subsequent venous or arterial thrombosis and pregnancy-related morbidity: a retrospective single-center cohort study
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Optimal utilization of thrombophilia testing
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Clinical utility and costs of inpatient hereditary thrombophilia testing following acute VTE: a 5-year retrospective study
10.1007/s11239-025-03183-2 · 2026 · External reference
Thrombophilia testing for prevention of recurrent venous thromboembolism
2012 · External reference
Risk of recurrent venous thromboembolism in patients with common thrombophilia: a systematic review
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The risk of recurrent venous thromboembolism among heterozygous carriers of factor V Leiden or prothrombin G20210A mutation. A systematic review of prospective studies
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Current knowledge on factor V Leiden mutation as a risk factor for recurrent venous thromboembolism: a systematic review and meta-analysis
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Predictive value of factor V Leiden and prothrombin G20210A in adults with venous thromboembolism and in family members of those with a mutation: a systematic review
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Risk of venous thrombosis in antithrombin deficiency: a systematic review and Bayesian meta-analysis
10.1055/s-0038-1625983 · 2018 · External reference
Venous thromboembolism risk in adults with hereditary thrombophilia: a systematic review and meta-analysis
10.1007/s00277-024-05926-2 · 2024 · External reference
Natural anticoagulants deficiency and the risk of venous thromboembolism: a meta-analysis of observational studies
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Recommendations for clinical laboratory testing for protein S deficiency: communication from the SSC committee plasma coagulation inhibitors of the ISTH
10.1111/jth.15109 · 2021 · External reference
Diagnosis and management of severe congenital protein C deficiency (SCPCD): communication from the SSC of the ISTH
10.1111/jth.15732 · 2022 · External reference
Recommendations for clinical laboratory testing for antithrombin deficiency; communication from the SSC of the ISTH
10.1111/jth.14648 · 2020 · External reference
An update on laboratory detection and interpretation of antiphospholipid antibodies for diagnosis of antiphospholipid syndrome: guidance from the ISTH-SSC Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibodies
10.1016/j.jtha.2024.10.022 · 2025 · External reference
Assessing bias in studies of prognostic factors
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10.1002/jrsm.1411 · 2021 · External reference
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Unresolved reference
2013 · External reference
Methods to estimate the between-study variance and its uncertainty in meta-analysis
10.1002/jrsm.1164 · 2016 · External reference
Meta-analysis in clinical trials
10.1016/0197-2456(86)90046-2 · 1986 · External reference
Factor V Leiden and risks of recurrent idiopathic venous thromboembolism
10.1161/01.cir.92.10.2800 · 1995 · External reference
Thrombophilia and risk of VTE recurrence according to the age at the time of first VTE manifestation
10.1024/0301-1526/a000447 · 2015 · External reference
Risk factors for venous thromboembolism (VTE) recurrences in Thai patients without cancer
10.1080/10245332.2018.1535535 · 2019 · External reference
Utility of hereditary thrombophilia testing among patients with lower extremity deep vein thrombosis
10.1016/j.jvsv.2022.02.019 · 2022 · External reference
Risk factors for recurrence of venous thromboembolism associated with the use of oral contraceptives
10.1016/j.contraception.2011.06.008 · 2011 · External reference
Risk of recurrent venous thrombosis in homozygous carriers and double heterozygous carriers of factor V Leiden and prothrombin G20210A
10.1161/circulationaha.109.906347 · 2010 · External reference
Clinical relevance of decreased free protein S levels: results from a retrospective family cohort study involving 1143 relatives
10.1182/blood-2008-08-174128 · 2009 · External reference
High long-term absolute risk of recurrent venous thromboembolism in patients with hereditary deficiencies of protein S, protein C or antithrombin
10.1160/th08-06-0364 · 2009 · External reference
FV Leiden mutation and risk of recurrent venous thromboembolism in Serbian population
10.1007/s11239-007-0059-z · 2008 · External reference
Risk of recurrence after a first venous thromboembolic event in young women
10.3324/haematol.10967 · 2007 · External reference
Probability of recurrence of thrombosis in patients with and without factor V Leiden
10.1055/s-0038-1650249 · 1996 · External reference
The risk of recurrent venous thromboembolism in patients with inherited deficiency of natural anticoagulants antithrombin, protein C and protein S
2006 · External reference
The risk of recurrent deep venous thrombosis among heterozygous carriers of both factor V Leiden and the G20210A prothrombin mutation
10.1056/nejm199909093411104 · 1999 · External reference
Risk of recurrent venous thromboembolism or bleeding in relation to thrombophilic risk factors in patients receiving ximelagatran or placebo for long-term secondary prevention of venous thromboembolism
10.1111/j.1365-2141.2006.05960.x · 2006 · External reference
Thrombophilic abnormalities and recurrence of venous thromboembolism in patients treated with standardized anticoagulant treatment
10.1016/j.thromres.2004.12.012 · 2005 · External reference
Increased risk of recurrent venous thromboembolism during hormone replacement therapy--results of the randomized, double-blind, placebo-controlled estrogen in venous thromboembolism trial (EVTET)
2000 · External reference
Comparison of 1 month with 3 months of anticoagulation for a first episode of venous thromboembolism associated with a transient risk factor
10.1046/j.1538-7836.2004.00698.x · 2004 · External reference
The risk of recurrent venous thromboembolism in carriers and non-carriers of the G1691A allele in the coagulation factor V gene and the G20210A allele in the prothrombin gene. DURAC Trial Study Group. Duration of Anticoagulation
10.1055/s-0037-1614554 · 1999 · External reference
A comparison of three months of anticoagulation with extended anticoagulation for a first episode of idiopathic venous thromboembolism
10.1056/nejm199903253401201 · 1999 · External reference
Anticardiolipin antibodies predict early recurrence of thromboembolism and death among patients with venous thromboembolism following anticoagulant therapy. Duration of Anticoagulation Study Group
10.1016/s0002-9343(98)00060-6 · 1998 · External reference
The risk of recurrent venous thromboembolism in patients with and without factor V Leiden
10.1055/s-0038-1656023 · 1997 · External reference
The risk of recurrent venous thromboembolism in patients with an Arg506→Gln mutation in the gene for factor V (factor V Leiden)
10.1056/nejm199702063360602 · 1997 · External reference
G20210A mutation in the prothrombin gene and the risk of recurrent venous thromboembolism
10.1016/s0735-1097(00)01080-9 · 2001 · External reference
Is recurrent venous thromboembolism more frequent in homozygous patients for the factor V Leiden mutation than in heterozygous patients?
10.1097/00001721-200309000-00002 · 2003 · External reference
Incidence of recurrent venous thromboembolism in relation to clinical and thrombophilic risk factors: prospective cohort study
10.1016/s0140-6736(03)14111-6 · 2003 · External reference
Predictive value of D-dimer test for recurrent venous thromboembolism after anticoagulation withdrawal in subjects with a previous idiopathic event and in carriers of congenital thrombophilia
10.1161/01.cir.0000079162.69615.0f · 2003 · External reference
Risk factors and recurrence rate of primary deep vein thrombosis of the upper extremities
10.1161/01.cir.0000137123.55051.9b · 2004 · External reference
Genetic polymorphisms and risk of recurrent deep venous thrombosis in young people: prospective cohort study
10.1016/j.ejvs.2005.05.038 · 2005 · External reference
Recurrence rate after a first venous thrombosis in patients with familial thrombophilia
10.1161/01.atv.0000174806.76629.7b · 2005 · External reference
Risk of recurrent venous thrombosis in patients with G20210A mutation in the prothrombin gene or factor V Leiden mutation
10.1097/01.mbc.0000201488.33143.09 · 2006 · External reference
Venous thromboembolism in carriers of the Factor V Leiden mutation and in patients without known thrombophilic risk factor; prediction of recurrence and APC-PCI complex concentration and/or soluble thrombomodulin antigen and activity
10.1016/j.thromres.2007.03.020 · 2007 · External reference
The risk of recurrent venous thromboembolism after discontinuing anticoagulation in patients with acute proximal deep vein thrombosis or pulmonary embolism. A prospective cohort study in 1,626 patients
10.3324/haematol.10516 · 2007 · External reference
Identifying unprovoked thromboembolism patients at low risk for recurrence who can discontinue anticoagulant therapy
10.1503/cmaj.080493 · 2008 · External reference
Incidence of recurrent venous thromboembolism and of chronic thromboembolic pulmonary hypertension in patients after a first episode of pulmonary embolism
10.1007/s11239-010-0452-x · 2010 · External reference
Long-term prospective study of recurrent venous thromboembolism in a Hispanic population
10.1097/mbc.0b013e32833ceaef · 2010 · External reference
Long-term evaluation of the risk of recurrence after cerebral sinus-venous thrombosis
10.1161/circulationaha.109.927046 · 2010 · External reference
Sex-specific risk factors for recurrent venous thromboembolism
10.1016/j.thromres.2011.10.026 · 2012 · External reference
Mild antithrombin deficiency and risk of recurrent venous thromboembolism: a prospective cohort study
10.1161/circulationaha.113.003756 · 2014 · External reference
Plasminogen activator inhibitor-1 4G/5G polymorphism, factor V Leiden, prothrombin mutations and the risk of VTE recurrence
10.1160/th15-01-0031 · 2015 · External reference
F11 is associated with recurrent VTE in women. A prospective cohort study
10.1160/th15-06-0459 · 2016 · External reference
A risk score for prediction of recurrence in patients with unprovoked venous thromboembolism (DAMOVES)
10.1016/j.ejim.2015.12.010 · 2016 · External reference
Antiphospholipid antibodies and recurrent thrombosis after a first unprovoked venous thromboembolism
10.1182/blood-2017-09-805689 · 2018 · External reference
Mild antithrombin deficiency and risk of recurrent venous thromboembolism: results from the MEGA follow-up study
10.1111/jth.13960 · 2018 · External reference
Circumstances of provoked recurrent venous thromboembolism: the Austrian study on recurrent venous thromboembolism
10.1007/s11239-019-01965-z · 2020 · External reference
Risk and risk factors associated with recurrent venous thromboembolism following surgery in patients with history of venous thromboembolism
10.1001/jamanetworkopen.2019.3690 · 2019 · External reference
Genetic risk profiling associated with recurrent unprovoked venous thromboembolism
10.3390/genes12060874 · 2021 · External reference
Thrombophilia and outcomes of venous thromboembolism in older patients
10.1016/j.rpth.2022.100015 · 2023 · External reference
Venous thromboembolism characteristics and outcomes among RIETE patients tested and untested for inherited thrombophilia
10.1182/bloodadvances.2024012611 · 2024 · External reference
Risk factors associated with recurrent venous thromboembolism after a first cerebral venous thrombosis event: a cohort study
10.1016/j.thromres.2019.04.008 · 2019 · External reference
AS-MO-004, risk of recurrence among heterozygous carriers of factor II (FII) and a first unprovoked venous thromboembolism (VTE)
2009 · External reference
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10.1016/j.rpth.2023.101780 · 2023 · External reference
Recurrent venous thromboembolism and bleeding with extended anticoagulation: the VTE-PREDICT risk score
10.1093/eurheartj/ehac776 · 2023 · External reference
Indefinite anticoagulant therapy for first unprovoked venous thromboembolism : a cost-effectiveness study
10.7326/m22-3559 · 2023 · External reference
Risk of recurrent venous thromboembolism: a Danish nationwide cohort study
10.1016/j.amjmed.2018.04.042 · 2018 · External reference
Risk of recurrent venous thromboembolism according to baseline risk factor profiles
10.1182/bloodadvances.2018017160 · 2018 · External reference
External validation of the VTE-PREDICT score for predicting recurrence and bleeding in venous thromboembolism: results from the Registro Informatizado Enfermedad TromboEmbὀlica Registry
10.1016/j.jtha.2025.08.007 · 2025 · External reference
Usefulness of repeated D-dimer testing after stopping anticoagulation for a first episode of unprovoked venous thromboembolism: the PROLONG II prospective study
10.1182/blood-2009-08-237354 · 2010 · External reference
Role of factor VIII, IX, and XI in venous thrombosis recurrence risk in adults and children: a systematic review
10.1016/j.rpth.2023.100064 · 2023 · External reference
Is thrombin generation at the time of an acute thromboembolic episode a predictor of recurrence? The LInköping Study on Thrombosis (LIST)--a 7-year follow-up
10.1016/j.thromres.2012.11.015 · 2013 · External reference
Plasma proteomics does not identify biomarkers of venous thromboembolism recurrence during and after anticoagulation: results from the VISTA study
10.1016/j.jtha.2025.11.019 · 2026 · External reference
D-dimer to guide the duration of anticoagulation in patients with venous thromboembolism: a management study
10.1182/blood-2014-01-548065 · 2014 · External reference
Validating the HERDOO2 rule to guide treatment duration for women with unprovoked venous thrombosis: multinational prospective cohort management study
10.1136/bmj.j1065 · 2017 · External reference
Risk assessment of recurrence in patients with unprovoked deep vein thrombosis or pulmonary embolism: the Vienna prediction model
10.1161/circulationaha.109.925214 · 2010 · External reference
American Society of Hematology 2023 guidelines for management of venous thromboembolism: thrombophilia testing
10.1182/bloodadvances.2023010177 · 2023 · External reference
Antithrombotic therapy for VTE disease: second update of the CHEST guideline and expert panel report
10.1016/j.chest.2021.07.055 · 2021 · External reference
Thrombophilia testing: a British Society for Haematology guideline
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Clinical utilization and cost of thrombophilia testing in patients with venous thromboembolism
10.1055/s-0040-1714334 · 2020 · External reference
Prevalence and factors associated with high-risk thrombophilia: a single-center cross-sectional study of 3550 patients at a tertiary Thrombosis Centre in Switzerland
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