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References from Baseline plasma metabolites associated with subsequent response to lifestyle intervention in people with prediabetes. Local targets link to admitted publications; unresolved targets remain external evidence.
A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance
10.1016/j.cmet.2009.02.002 · 2009 · External reference
Metabolite profiles and the risk of developing diabetes
10.1038/nm.2307 · 2011 · External reference
Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans
10.1172/jci44442 · 2011 · External reference
Role of ceramides in the pathogenesis of diabetes mellitus and its complications
10.1016/j.jdiacomp.2020.107734 · 2021 · External reference
Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance
10.2337/db08-1228 · 2009 · External reference
Amino acid signature predictive of incident prediabetes: a case–control study nested within the longitudinal pathobiology of prediabetes in a biracial cohort
10.1016/j.metabol.2019.06.011 · 2019 · External reference
Association of plasma acylcarnitines with insulin sensitivity, insulin secretion, and prediabetes in a biracial cohort
10.1177/15353702211009493 · 2021 · External reference
Plasma ceramides and other sphingolipids in relation to incident prediabetes in a longitudinal biracial cohort
10.1210/clinem/dgae179 · 2024 · External reference
Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach
10.2337/db12-0495 · 2013 · External reference
Circulating ceramides predict cardiovascular outcomes in the population-based FINRISK 2002 cohort
10.1161/atvbaha.116.307497 · 2016 · External reference
Metabolomic profile associated with insulin resistance and conversion to diabetes in the insulin resistance atherosclerosis study
10.1210/jc.2014-2357 · 2015 · External reference
Increased levels of plasma acylcarnitines in obesity and type 2 diabetes and identification of a marker of glucolipotoxicity
10.1038/oby.2009.510 · 2010 · External reference
Acylcarnitines: nomenclature, biomarkers, therapeutic potential, drug targets, and clinical trials
10.1124/pharmrev.121.000408 · 2022 · External reference
Inflammation, metaflammation and immunometabolic disorders
10.1038/nature21363 · 2017 · External reference
Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity
10.1038/msb.2008.50 · 2008 · External reference
Improved insulin sensitivity after exercise training is linked to reduced plasma C14:0 ceramide in obesity and type 2 diabetes
10.1002/oby.21117 · 2015 · External reference
Changes in serum sphingomyelin after roux-en-Y gastric bypass surgery are related to diabetes status
10.3389/fendo.2018.00172 · 2018 · External reference
Differential metabolic impact of gastric bypass surgery versus dietary intervention in obese diabetic subjects despite identical weight loss
10.1126/scitranslmed.3002043 · 2011 · External reference
Regression from prediabetes to normal glucose regulation: state of the science
10.1177/1535370220915644 · 2020 · External reference
Pathobiology and reversibility of prediabetes in a biracial cohort (PROP-ABC) study: design of lifestyle intervention
10.1136/bmjdrc-2019-000899 · 2020 · External reference
Outcome of lifestyle intervention in relation to duration of pre-diabetes: the Pathobiology and Reversibility of Prediabetes in a Biracial Cohort (PROP-ABC) study
10.1136/bmjdrc-2021-002748 · 2022 · External reference
Pathobiology of prediabetes in a biracial cohort (POP-ABC) study: baseline characteristics of enrolled subjects
10.1210/jc.2012-2902 · 2013 · External reference
Plasma lipid levels predict dysglycemia in a biracial cohort of nondiabetic subjects: potential mechanisms
10.1177/1535370216659946 · 2016 · External reference
Lack of racial disparity in incident prediabetes and glycemic progression among black and white offspring of parents with type 2 diabetes: the pathobiology of prediabetes in a biracial cohort (POP-ABC) study
10.1210/jc.2014-1077 · 2014 · External reference
The Look AHEAD study: a description of the lifestyle intervention and the evidence supporting it
10.1038/oby.2006.84 · 2006 · External reference
Physical activity and weight loss: does prescribing higher physical activity goals improve outcome?
10.1093/ajcn/78.4.684 · 2003 · External reference
2. Diagnosis and Classification of Diabetes: standards of care in diabetes—2026
10.2337/dc26-s002 · 2026 · External reference
Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp
10.2337/diacare.22.9.1462 · 1999 · External reference
Role of insulin secretion and sensitivity in the evolution of type 2 diabetes in the diabetes prevention program: effects of lifestyle intervention and metformin
10.2337/diabetes.54.8.2404 · 2005 · External reference
Quantification of the relationship between insulin sensitivity and β-cell function in human subjects. Evidence for a hyperbolic function
10.2337/diab.42.11.1663 · 1993 · External reference
Quantitative analysis of sphingolipids for lipidomics using triple quadrupole and quadrupole linear ion trap mass spectrometers
10.1194/jlr.d800051-jlr200 · 2009 · External reference
Plasma dihydroceramides are diabetes susceptibility biomarker candidates in mice and humans
10.1016/j.celrep.2017.02.019 · 2017 · External reference
Ceramide stearic to palmitic acid ratio predicts incident diabetes
10.1007/s00125-018-4590-6 · 2018 · External reference
Associations among circulating sphingolipids, β-cell function, and risk of developing type 2 diabetes: a population-based cohort study in China
10.1371/journal.pmed.1003451 · 2020 · External reference
Selective association of plasma sphingolipid species with insulin sensitivity and secretion in normoglycemic Black and White American adults
10.3389/ebm.2025.10538 · 2025 · External reference
Plasma sphingolipids in relation to glycemia and glucose tolerance in people without diabetes
10.1210/clinem/dgaf378 · 2026 · External reference
Skeletal muscle and plasma lipidomic signatures of insulin resistance and overweight/obesity in humans
10.1002/oby.21448 · 2016 · External reference
Exercise increases adiponectin levels and insulin sensitivity in humans
10.2337/diacare.27.2.629 · 2004 · External reference
Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin
10.1210/jcem.86.8.7741 · 2001 · External reference
Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin
10.1038/nm.2277 · 2011 · External reference
Serum levels of acylcarnitines are altered in prediabetic conditions
10.1371/journal.pone.0082459 · 2013 · External reference
Unresolved reference
2000 · External reference
Recent advances in the pathophysiology of fatty acid oxidation defects: secondary alterations of bioenergetics and mitochondrial calcium homeostasis caused by the accumulating fatty acids
10.3389/fgene.2020.598976 · 2020 · External reference
Clinical and biochemical outcomes of patients with medium-chain acyl-CoA dehydrogenase deficiency
10.1016/j.ymgme.2019.11.006 · 2020 · External reference
Human protein metabolism: its measurement and regulation
10.1152/ajpendo.00337.2002 · 2002 · External reference
Insulin resistance and the metabolism of branched-chain amino acids
10.1007/s11684-013-0255-5 · 2013 · External reference
Metabolites associated with abnormal glucose metabolism responding to primary care lifestyle intervention
10.1038/s41598-025-25749-z · 2025 · External reference