Research graph
References from C. elegans dauer morphogenesis requires inhibition of DBL-1/BMP signaling by ztf-30. Local targets link to admitted publications; unresolved targets remain external evidence.
DAF-16/FoxO and DAF-12/VDR control cellular plasticity both cell-autonomously and via interorgan signaling
10.1371/journal.pbio.3001204 · 2021 · External reference
Mutants of Caenorhabditis elegans that form dauer-like larvae
10.1016/0012-1606(88)90138-8 · 1988 · External reference
Basic local alignment search tool
10.1016/s0022-2836(05)80360-2 · 1990 · External reference
Phenotypic plasticity and remodeling in the stress-induced Caenorhabditis elegans dauer
10.1002/wdev.278 · 2017 · External reference
daf-12 regulates developmental age and the dauer alternative in Caenorhabditis elegans
10.1242/dev.125.7.1191 · 1998 · External reference
Integrating bulk and single cell RNA-seq refines transcriptomic profiles of individual C. elegans neurons
10.7554/elife.106183.1 · 2025 · External reference
ilastik: interactive machine learning for (bio)image analysis
10.1038/s41592-019-0582-9 · 2019 · External reference
Nuclear hormone receptor regulation of microRNAs controls developmental progression
10.1126/science.1164899 · 2009 · External reference
The dauerlarva, a post-embryonic developmental variant of the nematode Caenorhabditis elegans
10.1016/0012-1606(75)90109-8 · 1975 · External reference
BMP pathway regulation of insulin signaling components promotes lipid storage in Caenorhabditis elegans
10.1371/journal.pgen.1009836 · 2021 · External reference
Developmental and cell cycle quiescence is mediated by the nuclear hormone receptor coregulator DIN-1S in the Caenorhabditis elegans dauer larva
10.1534/genetics.116.191858 · 2016 · External reference
Specific insulin-like peptides encode sensory information to regulate distinct developmental processes
10.1242/dev.060905 · 2011 · External reference
The cuticle of Caenorhabditis elegans. II. Stage-specific changes in ultrastructure and protein composition during postembryonic development
10.1016/0012-1606(81)90204-9 · 1981 · External reference
DAF-5 is a SKi oncoprotein homolog that functions in a neuronal TGFβ pathway to regulate C. elegans dauer development
10.1242/dev.00922 · 2004 · External reference
Twelve years of SAMtools and BCFtools
10.1093/gigascience/giab008 · 2021 · External reference
Falco: High-speed FastQC emulation for quality control of sequencing data
10.12688/f1000research.21142.2 · 2021 · External reference
STAR: ultrafast universal RNA-seq aligner
10.1093/bioinformatics/bts635 · 2013 · External reference
C. elegans dauer formation and the molecular basis of plasticity
10.1101/gad.1701508 · 2008 · External reference
crm-1 facilitates BMP signaling to control body size in Caenorhabditis elegans
10.1016/j.ydbio.2007.08.016 · 2007 · External reference
Hormonal signals produced by DAF-9/cytochrome P450 regulate C. elegans dauer diapause in response to environmental cues
10.1242/dev.01068 · 2004 · External reference
Transcriptional and spatiotemporal regulation of the dauer program
10.1080/21541264.2023.2190295 · 2023 · External reference
The Caenorhabditis elegans dauer larva: Developmental effects of pheromone, food, and temperature
10.1016/0012-1606(84)90201-x · 1984 · External reference
A feedback circuit involving let-7-family miRNAs and DAF-12 integrates environmental signals and developmental timing in Caenorhabditis elegans
10.1073/pnas.0908131106 · 2009 · External reference
Liquid-culture protocols for synchronous starvation, growth, dauer formation, and dietary restriction of Caenorhabditis elegans
10.1016/j.xpro.2020.100276 · 2021 · External reference
DAF-12 regulates a connected network of genes to ensure robust developmental decisions
10.1371/journal.pgen.1002179 · 2011 · External reference
Ageing is reversed, and metabolism is reset to young levels in recovering dauer larvae of C. elegans
10.1016/s0531-5565(02)00063-3 · 2002 · External reference
A Caenorhabditis elegans developmental decision requires insulin signaling-mediated neuron-intestine communication
10.1242/dev.103846 · 2014 · External reference
Targets of TGF-β signaling in Caenorhabditis elegans dauer formation
10.1006/dbio.1999.9545 · 2000 · External reference
Use of an activated beta-catenin to identify Wnt pathway target genes in Caenorhabditis elegans, including a subset of collagen genes expressed in late larval development
10.1534/g3.113.009522 · 2014 · External reference
The CHARGE syndrome ortholog CHD-7 regulates TGF-β pathways in Caenorhabditis elegans
10.1073/pnas.2109508119 · 2022 · External reference
The extracellular matrix: structure, composition, biological functions, diseases, and therapeutic targets
10.1186/s43556-026-00436-1 · 2026 · External reference
Genome-wide RNAi screening in Caenorhabditis elegans
10.1016/s1046-2023(03)00050-1 · 2003 · External reference
daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
10.1126/science.277.5328.942 · 1997 · External reference
Specificity of TGFβ signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans
10.1242/dev.126.2.251 · 1999 · External reference
modEnrichr: a suite of gene set enrichment analysis tools for model organisms
10.1093/nar/gkz347 · 2019 · External reference
Caenorhabditis elegans is a model host for Salmonella typhimurium
10.1016/s0960-9822(00)00833-2 · 2000 · External reference
Genetic interactions between the DBL-1/BMP-like pathway and dpy body size-associated genes in Caenorhabditis elegans
10.1091/mbc.e19-09-0500 · 2019 · External reference
Fast gapped-read alignment with Bowtie 2
10.1038/nmeth.1923 · 2012 · External reference
Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway
10.1016/s0960-9822(01)00595-4 · 2001 · External reference
FMRFamide-like peptides expand the behavioral repertoire of a densely connected nervous system
10.1073/pnas.1710374114 · 2017 · External reference
Transcriptional repressor and activator activities of SMA-9 contribute differentially to BMP-related signaling outputs
10.1016/j.ydbio.2007.02.038 · 2007 · External reference
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
10.1093/bioinformatics/btt656 · 2014 · External reference
daf-42 is an evolutionarily young gene essential for dauer development in Caenorhabditis elegans
10.1093/genetics/iyad097 · 2023 · External reference
Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling
10.1038/88850 · 2001 · External reference
Regulation of signaling genes by TGFβ during entry into dauer diapause in C. elegans
10.1186/1471-213x-4-11 · 2004 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
A novel nuclear receptor/coregulator complex controls C. elegans lipid metabolism, larval development, and aging
10.1101/gad.312604 · 2004 · External reference
BMP signaling determines body size via transcriptional regulation of collagen genes in Caenorhabditis elegans
10.1534/genetics.118.301631 · 2018 · External reference
Feedback regulation of BMP signaling by Caenorhabditis elegans cuticle collagens
10.1091/mbc.e19-07-0390 · 2020 · External reference
The DBL-1/TGF-β signaling pathway tailors behavioral and molecular host responses to a variety of bacteria in Caenorhabditis elegans
10.7554/elife.75831 · 2023 · External reference
C. elegans serine-threonine kinase KIN-29 modulates TGFβ signaling and regulates body size formation
10.1186/1471-213x-5-8 · 2005 · External reference
Intercellular signaling of reproductive development by the C. elegans DAF-9 cytochrome P450
10.1242/dev.01069 · 2004 · External reference
Cutadapt removes adapter sequences from high-throughput sequencing reads
10.14806/ej.17.1.200 · 2011 · External reference
Autophagy genes are essential for dauer development and life-span extension in C. elegans
10.1126/science.1087782 · 2003 · External reference
Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-β family
10.1242/dev.126.6.1337 · 1999 · External reference
Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans
10.1016/j.cell.2006.01.037 · 2006 · External reference
Inhibition of germline proliferation during C. elegans dauer development requires PTEN, LKB1 and AMPK signalling
10.1242/dev.02232 · 2006 · External reference
Fluorescent beads are a Versatile tool for staging Caenorhabditis elegans in different life histories
10.1534/g3.116.030163 · 2016 · External reference
The fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
10.1038/40194 · 1997 · External reference
Qualimap 2: advanced multi-sample quality control for high-throughput sequencing data
10.1093/bioinformatics/btv566 · 2016 · External reference
Dauer formation in C. elegans is modulated through AWC and ASI-dependent chemosensation
10.1523/eneuro.0473-20.2021 · 2021 · External reference
Antagonistic Smad transcription factors control the dauer/non-dauer switch in C. elegans
10.1242/dev.043752 · 2010 · External reference
The DAF-3 Smad protein antagonizes TGF-β-related receptor signaling in the Caenorhabditis elegans dauer pathway
10.1101/gad.11.20.2679 · 1997 · External reference
A metabolic switch regulates the transition between growth and diapause in C. elegans
10.1186/s12915-020-0760-3 · 2020 · External reference
Insulin signaling activity in the somatic gonad controls dauer entry via the germ line in C. elegans
10.1016/j.cub.2025.05.028 · 2025 · External reference
CEH-28 activates dbl-1 expression and TGF-β signaling in the C. elegans M4 neuron
10.1016/j.ydbio.2014.03.015 · 2014 · External reference
Control of C. elegans larval development by neuronal expression of a TGF-β homolog
10.1126/science.274.5291.1389 · 1996 · External reference
Regulation of genes affecting body size and innate immunity by the DBL-1/BMP-like pathway in Caenorhabditis elegans
10.1186/1471-213x-10-61 · 2010 · External reference
Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of Transforming Growth Factor β pathway components
10.1073/pnas.93.2.790 · 1996 · External reference
The TGF-β family in Caenorhabditis elegans
10.1101/cshperspect.a022178 · 2017 · External reference
Non-stringent tissue-source requirements for BMP ligand expression in regulation of body size in Caenorhabditis elegans
10.1017/s0016672311000310 · 2011 · External reference
Hormonal signal amplification mediates environmental conditions during development and controls an irreversible commitment to adulthood
10.1371/journal.pbio.1001306 · 2012 · External reference
Fiji: An open-source platform for biological-image analysis
10.1038/nmeth.2019 · 2012 · External reference
In vivo imaging of Dauer-specific neuronal remodeling in C. elegans
10.3791/51834-v · 2014 · External reference
Dauer-specific dendrite arborization in C. elegans is regulated by KPC-1/furin
10.1016/j.cub.2013.06.058 · 2013 · External reference
Regulation of extracellular matrix organization by BMP signaling in Caenorhabditis elegans
10.1371/journal.pone.0101929 · 2014 · External reference
Genetic markers enable the verification and manipulation of the dauer entry decision
10.1016/j.ydbio.2019.06.009 · 2019 · External reference
The Caenorhabditis elegans cuticle and precuticle: a model for studying dynamic apical extracellular matrices in vivo
10.1093/genetics/iyae072 · 2024 · External reference
A BMP homolog acts as a dose-dependent regulator of body size and male tail patterning in Caenorhabditis elegans
10.1242/dev.126.2.241 · 1999 · External reference
Competition between type I activin and BMP receptors for binding to ACVR2A regulates signaling to distinct Smad pathways
10.1186/s12915-022-01252-z · 2022 · External reference
Cell non-autonomous function of daf-18/PTEN in the somatic gonad coordinates somatic gonad and germline development in C. elegans dauer larvae
10.1016/j.cub.2019.01.076 · 2019 · External reference
On the role of dauer in the adaptation of nematodes to a parasitic lifestyle
10.1186/s13071-021-04953-6 · 2021 · External reference
Genome-wide analysis of Smad and Schnurri transcription factors in C. elegans demonstrates widespread interaction and a function in collagen secretion
10.7554/elife.99394.3 · 2025 · External reference
Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans
10.1093/genetics/130.1.105 · 1992 · External reference
The expression of TGFβ signal transducers in the hypodermis regulates body size in C. elegans
10.1242/dev.129.21.4989 · 2002 · External reference
The biotin-ligating protein BPL-1 is critical for lipid biosynthesis and polarization of the Caenorhabditis elegans embryo
10.1074/jbc.m117.798553 · 2018 · External reference
Daf-16/FOXO blocks adult cell fate in Caenorhabditis elegans dauer larvae via lin-41/TRIM71
10.1371/journal.pgen.1009881 · 2021 · External reference
The Dauer Cuticle
10.3908/wormatlas.3.1 · 2011 · External reference
Hypodermal Expression of Caenorhabditis elegans TGF-β Type I Receptor SMA-6 Is Essential for the Growth and Maintenance of Body Length
10.1006/dbio.2001.0443 · 2001 · External reference
DBL-1, a TGF-β, is essential for Caenorhabditis elegans aversive olfactory learning
10.1073/pnas.1205982109 · 2012 · External reference
Neuroimmune regulation of antimicrobial peptide expression by a noncanonical TGF-β signaling pathway in Caenorhabditis elegans epidermis
10.1038/ni.1700 · 2009 · External reference
