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References from Sex-dependent mild cardiac dysfunction and neurometabolic abnormalities in a model of Huntington's disease. Local targets link to admitted publications; unresolved targets remain external evidence.
DIAMetAlyzer allows automated false-discovery rate-controlled analysis for data-independent acquisition in metabolomics
10.1038/s41467-022-29006-z · 2022 · External reference
Characteristics; Pathophysiology and clinical management of weight loss in Huntington's disease
10.2217/nmt.13.22 · 2013 · External reference
Controlling the false discovery rate: a practical and powerful approach to multiple testing
10.1111/j.2517-6161.1995.tb02031.x · 1995 · External reference
Sex-dependent behavioral impairments in the HdhQ350/+ mouse line
10.1016/j.bbr.2017.09.026 · 2018 · External reference
Neuro-cardio mechanisms in Huntington's disease and other neurodegenerative disorders
10.3389/fphys.2018.00559 · 2018 · External reference
Functional anatomy of movement disorders
10.1046/j.1469-7580.2000.19640519.x · 2000 · External reference
Practical solutions for including sex as a biological variable (SABV) in preclinical neuropsychopharmacological research
10.1016/j.jneumeth.2023.110003 · 2024 · External reference
Heart and brain: complex relationships for left ventricular dysfunction
10.1007/s11886-020-01318-w · 2020 · External reference
The expanded CAG repeat in the huntingtin gene as target for therapeutic RNA modulation throughout the HD mouse brain
10.1371/journal.pone.0171127 · 2017 · External reference
A metabolome atlas of the aging mouse brain
10.1038/s41467-021-26310-y · 2021 · External reference
Sex differences in behavior and striatal ascorbate release in the 140 CAG knock-in mouse model of Huntington's disease
10.1016/j.bbr.2006.12.004 · 2007 · External reference
Proton NMR chemical shifts and coupling constants for brain metabolites
10.1002/1099-1492(200005)13:3<129::aid-nbm619>3.0.co;2-v · 2000 · External reference
Magnetic resonance imaging to detect structural brain changes in Huntington's disease: a review of data from mouse models
10.3233/jhd-240045 · 2024 · External reference
Multiplatform metabolomic analysis of the R6/2 mouse model of Huntington's disease
10.1002/2211-5463.13285 · 2021 · External reference
Characterization of neurophysiological and behavioral changes, MRI brain volumetry and 1H MRS in zQ175 knock-in mouse model of Huntington's disease
10.1371/journal.pone.0050717 · 2012 · External reference
Quantitative proton-decoupled 31P MRS and 1H MRS in the evaluation of Huntington's and Parkinson's diseases
10.1212/wnl.50.4.1033 · 1998 · External reference
Evidence for impairment of energy metabolism in vivo in Huntington's disease using localized 1H NMR spectroscopy
10.1212/wnl.43.12.2689 · 1993 · External reference
1H NMR spectroscopy studies of Huntington's disease: correlations with CAG repeat numbers
10.1212/wnl.50.5.1357 · 1998 · External reference
Effects of CAG repeat length, HTT protein length and protein context on cerebral metabolism measured using magnetic resonance spectroscopy in transgenic mouse models of Huntington's disease
10.1111/j.1471-4159.2005.03411.x · 2005 · External reference
Early white matter abnormalities, progressive brain pathology and motor deficits in a novel knock-in mouse model of Huntington's disease
10.1093/hmg/ddv016 · 2015 · External reference
Neurochemical changes in the progression of Huntington's disease: a meta-analysis of in vivo 1H-MRS studies
10.1016/j.nbd.2024.106574 · 2024 · External reference
Neurocardiac dysregulation and neurogenic arrhythmias in a transgenic mouse model of Huntington's disease
10.1113/jphysiol.2012.238113 · 2012 · External reference
Lower left ventricular ejection fraction relates to cerebrospinal fluid biomarker evidence of neurodegeneration in older adults
10.3233/jad-190813 · 2020 · External reference
Cerebral glucose consumption measured by PET in patients with and without psychiatric symptoms of Huntington's disease
10.1016/0165-1781(89)90090-5 · 1989 · External reference
Huntington's disease mortality in the United States
10.1212/wnl.38.5.769 · 1988 · External reference
Comparison of Huntington's disease phenotype progression in male and female heterozygous FDNQ175 mice
10.1186/s13041-023-01054-6 · 2023 · External reference
Guidelines for measuring cardiac physiology in mice
10.1152/ajpheart.00339.2017 · 2018 · External reference
Biological Aging and the Cellular Pathogenesis of Huntington's Disease
10.3233/jhd-200395 · 2020 · External reference
An exploratory metabolomic comparison of participants with fast or absent functional progression from 2CARE, a randomized, double-blind clinical trial in Huntington's disease
10.1038/s41598-023-50553-y · 2024 · External reference
Protocol to monitor cardiac function and hemodynamics in septic rodents
10.1016/j.xpro.2024.102942 · 2024 · External reference
Huntington's disease is a multi-system disorder
10.1080/21675511.2015.1058464 · 2015 · External reference
Dysfunction of the CNS-heart axis in mouse models of Huntington's disease
10.1371/journal.pgen.1004550 · 2014 · External reference
Cardiac dysfunction in the R6/2 mouse model of Huntington's disease
10.1016/j.nbd.2006.09.016 · 2007 · External reference
Metabolomics using high-resolution magic angle spinning nuclear magnetic resonance: neurotoxicological applications
10.1016/j.vascn.2025.108382 · 2025 · External reference
Age- and sex-related changes in cortical and striatal nitric oxide synthase in the Q175 mouse model of Huntington's disease
10.1016/j.niox.2018.12.002 · 2019 · External reference
MetaboAnalyst 6.0: towards a unified platform for metabolomics data processing, analysis and interpretation
10.1093/nar/gkae253 · 2024 · External reference
Huntington disease
10.1016/b978-0-323-85654-6.00042-3 · 2023 · External reference
Metabolite mapping reveals severe widespread perturbation of multiple metabolic processes in Huntington's disease human brain
10.1016/j.bbadis.2016.06.002 · 2016 · External reference
Characterization of behavioral, neuropathological, brain metabolic and key molecular changes in zQ175 knock-in mouse model of Huntington's disease
10.1371/journal.pone.0148839 · 2016 · External reference
In vivo imaging of brain glutamate defects in a knock-in mouse model of Huntington's disease
10.1016/j.neuroimage.2016.06.023 · 2016 · External reference
Hypothalamic and limbic system changes in Huntington's disease
10.3233/jhd-2012-120006 · 2012 · External reference
A whole brain longitudinal study in the YAC128 mouse model of Huntington's disease shows distinct trajectories of neurochemical, structural connectivity and volumetric changes
10.1093/hmg/ddy119 · 2018 · External reference
Striatal cholesterol precursors are altered with age in female Huntington's disease model mice
10.3233/jhd-180321 · 2019 · External reference
Integrated multi-omics analysis of Huntington disease identifies pathways that modulate protein aggregation
10.1242/dmm.049492 · 2022 · External reference
Sex differences in Huntington's disease from a neuroinflammation perspective
10.3389/fneur.2024.1384480 · 2024 · External reference
Huntington disease: natural history, biomarkers and prospects for therapeutics
10.1038/nrneurol.2014.24 · 2014 · External reference
Clinical correlation of striatal 1H MRS changes in Huntington's disease
10.1212/wnl.53.4.806 · 1999 · External reference
Baroreceptor reflex dysfunction in the BACHD mouse model of Huntington's disease
10.1371/currents.rrn1266 · 2011 · External reference
Cardiac dysfunction in the BACHD mouse model of Huntington's disease
10.1371/journal.pone.0147269 · 2016 · External reference
Empirical null and false discovery rate analysis in neuroimaging
10.1016/j.neuroimage.2008.04.182 · 2009 · External reference
A critical evaluation of wet biomarkers for Huntington's disease: current status and ways forward
10.3233/jhd-170273 · 2018 · External reference
Unresolved reference
2011 · External reference
A fully humanized transgenic mouse model of Huntington disease
10.1093/hmg/dds397 · 2013 · External reference
A novel humanized mouse model of Huntington disease for preclinical development of therapeutics targeting mutant huntingtin alleles
10.1093/hmg/ddx021 · 2017 · External reference
Huntingtin suppression restores cognitive function in a mouse model of Huntington's disease
10.1126/scitranslmed.aar3959 · 2018 · External reference
Electrocardiogram abnormalities suggest aberrant cardiac conduction in Huntington's disease
10.1002/mdc3.12596 · 2018 · External reference
Widespread expression of the human and rat Huntington's disease gene in brain and nonneural tissues
10.1038/ng1193-259 · 1993 · External reference
Magnetic resonance spectroscopy biomarkers in premanifest and early Huntington disease
10.1212/wnl.0b013e3181fc27e4 · 2010 · External reference
Neurochemical changes in Huntington R6/2 mouse striatum detected by in vivo 1H NMR spectroscopy
10.1111/j.1471-4159.2006.04323.x · 2007 · External reference
Homeostatic adaptations in brain energy metabolism in mouse models of Huntington disease
10.1038/jcbfm.2012.104 · 2012 · External reference
Metabolic characterization of the R6/2 transgenic mouse model of Huntington's disease by high-resolution MAS 1H NMR spectroscopy
10.1021/pr050244o · 2006 · External reference
Molecular characterization of human gastric mucosa by HR-MAS magnetic resonance spectroscopy
10.3892/ijmm.14.6.1065 · 2004 · External reference
Regional aerobic glycolysis in the human brain
10.1073/pnas.1010459107 · 2010 · External reference
Longitudinal metabolite changes in Huntington's disease during disease onset
10.3233/jhd-140117 · 2014 · External reference
Mass spectrometry analysis of wild-type and knock-in Q140/Q140 Huntington's disease mouse brains reveals changes in glycerophospholipids including alterations in phosphatidic acid and lyso-phosphatidic acid
10.3233/jhd-150149 · 2015 · External reference
Hippocampal morphology in Huntington's disease, implications for plasticity and pathogenesis: the IMAGE-HD study
10.1016/j.pscychresns.2023.111694 · 2023 · External reference
Direct evidence of progressive cardiac dysfunction in a transgenic mouse model of Huntington's disease
10.3233/jhd-2012-120004 · 2012 · External reference
Interrelationship between Alzheimer's disease and cardiac dysfunction: the brain-heart continuum?
10.1093/abbs/gmz115 · 2020 · External reference
Towards standardization of echocardiography for the evaluation of left ventricular function in adult rodents: a position paper of the ESC Working Group on Myocardial Function
10.1093/cvr/cvaa110 · 2021 · External reference
Cortical metabolites as biomarkers in the R6/2 model of Huntington's disease
10.1038/jcbfm.2011.157 · 2012 · External reference
Neurochemical correlates of synapse density in a Huntington's disease mouse model
10.1111/jnc.15714 · 2023 · External reference
Progressive cardiac arrhythmias and ECG abnormalities in the Huntington's disease BACHD mouse model
10.1093/hmg/ddz295 · 2020 · External reference
Cardiac dysfunction in Huntington's disease
2025 · External reference
