Research graph
References from Fuelling repair: metabolic regulation of alveolar type 2 cell fate in lung regeneration and disease. Local targets link to admitted publications; unresolved targets remain external evidence.
Pulmonary cellular toxicity in alpha-1 antitrypsin deficiency
10.1016/j.chest.2024.02.013 · 2024 · External reference
Short-term cigarette smoke exposure leads to metabolic alterations in lung alveolar cells
10.1165/rcmb.2013-0523oc · 2014 · External reference
Decreased surfactant lipids correlate with lung function in chronic obstructive pulmonary disease (COPD)
10.1371/journal.pone.0228279 · 2020 · External reference
Global initiative for chronic obstructive lung disease 2023 report: GOLD executive summary
10.1183/13993003.00239-2023 · 2023 · External reference
Interstitial lung disease: a review of classification, etiology, epidemiology, clinical diagnosis, pharmacological and non-pharmacological treatment
10.3389/fmed.2024.1296890 · 2024 · External reference
Old mitochondria regulate niche renewal via α-ketoglutarate metabolism in stem cells
10.1038/s42255-025-01325-7 · 2025 · External reference
Regulation of lung progenitor plasticity and repair by fatty acid oxidation
10.1172/jci.insight.165837 · 2025 · External reference
Glutaminolysis and fumarate accumulation integrate immunometabolic and epigenetic programs in trained immunity
10.1016/j.cmet.2016.10.008 · 2016 · External reference
mTOR dysregulation induces IL-6 and paracrine AT2 cell senescence impeding lung repair in lymphangioleiomyomatosis
10.1038/s41467-025-64036-3 · 2025 · External reference
Vitamin C attenuates low-level PM2.5 exposure-induced lung inflammation and mitochondrial loss
10.1016/j.envint.2025.109929 · 2025 · External reference
Type 2 alveolar cells are stem cells in adult lung
10.1172/jci68782 · 2013 · External reference
Lung repair and regeneration: Advanced models and insights into human disease
10.1016/j.stem.2024.02.009 · 2024 · External reference
Deletion of Scap in alveolar type II cells influences lung lipid homeostasis and identifies a compensatory role for pulmonary lipofibroblasts
10.1074/jbc.m805388200 · 2009 · External reference
Systemic autoimmune rheumatic diseases-associated interstitial lung disease: a pulmonologist's perspective
10.1183/20734735.0171-2024 · 2025 · External reference
Ascorbate deficiency and oxidative stress in the alveolar type II cell
10.1152/ajplung.1997.273.4.l782 · 1997 · External reference
PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis
10.1172/jci74942 · 2015 · External reference
Marked alveolar apoptosis/proliferation imbalance in end-stage emphysema
10.1186/1465-9921-6-14 · 2005 · External reference
Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells
10.1038/nature13981 · 2015 · External reference
Understanding interstitial lung diseases associated with connective tissue disease (CTD-ILD): genetics, cellular pathophysiology, and biologic drivers
10.3390/ijms24032405 · 2023 · External reference
Metabolic adaptations direct cell fate during tissue regeneration
10.1038/s41586-025-09097-6 · 2025 · External reference
TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species
10.1084/jem.20081297 · 2008 · External reference
Iron deposition-induced ferroptosis in alveolar type II cells promotes the development of pulmonary fibrosis
10.1016/j.bbadis.2021.166204 · 2021 · External reference
Dynamic changes in mitochondrial biogenesis and antioxidant enzymes during the spontaneous differentiation of human embryonic stem cells
10.1016/j.bbrc.2006.08.020 · 2006 · External reference
Inflammatory signals induce AT2 cell-derived damage-associated transient progenitors that mediate alveolar regeneration
10.1016/j.stem.2020.06.020 · 2020 · External reference
Regenerative capacity of alveolar type 2 cells is proportionally reduced following disease progression in idiopathic pulmonary fibrosis-derived organoid cultures
10.4046/trd.2024.0094 · 2025 · External reference
Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis
10.1038/s41467-019-11327-1 · 2019 · External reference
Alveolar epithelial cells mitigate neutrophilic inflammation in lung injury through regulating mitochondrial fatty acid oxidation
10.1038/s41467-024-51683-1 · 2024 · External reference
Regeneration or repair? The role of alveolar epithelial cells in the pathogenesis of idiopathic pulmonary fibrosis (IPF)
10.3390/cells11132095 · 2022 · External reference
NAD+ metabolism and its roles in cellular processes during ageing
10.1038/s41580-020-00313-x · 2021 · External reference
Repair of airway epithelia requires metabolic rewiring towards fatty acid oxidation
10.1038/s41467-023-36352-z · 2023 · External reference
Oxidative stress contributes to the induction and persistence of TGF-β1 induced pulmonary fibrosis
10.1016/j.biocel.2011.04.005 · 2011 · External reference
Impairment of fatty acid oxidation in alveolar epithelial cells mediates acute lung injury
10.1165/rcmb.2018-0152oc · 2019 · External reference
Fatty acid synthesis in fetal lung
10.1016/0006-291x(80)90783-4 · 1980 · External reference
Single-cell atlas of human lung aging identifies cell type dyssynchrony and increased transcriptional entropy
10.1038/s41467-026-68810-9 · 2026 · External reference
Alveolar progenitor and stem cells in lung development, renewal and cancer
10.1038/nature12930 · 2014 · External reference
Epithelial Yap/Taz are required for functional alveolar regeneration following acute lung injury
10.1172/jci.insight.173374 · 2023 · External reference
Alveolar type II epithelial cell FASN maintains lipid homeostasis in experimental COPD
10.1172/jci.insight.163403 · 2023 · External reference
Nicotinamide mononucleotide ameliorates senescence in alveolar epithelial cells
10.1002/mco2.62 · 2021 · External reference
Alpha-1 antitrypsin promotes re-epithelialization by regulating inflammation and migration
10.3389/fimmu.2025.1586039 · 2025 · External reference
Extracellular vesicle cargo from lipofibroblasts mitigates chronic obstructive pulmonary disease by alveolar type 2 cell restoration
10.1093/ajrccm/aamag025 · 2026 · External reference
Retinoic acid promotes primary fetal alveolar epithelial type II cell proliferation and differentiation to alveolar epithelial type I cells
10.1007/s11626-014-9850-2 · 2015 · External reference
Interstitial lung disease and pulmonary fibrosis in Hermansky-Pudlak syndrome type 2, an adaptor protein-3 complex disease
10.2119/molmed.2011.00198 · 2012 · External reference
Pretreatment of aged mice with retinoic acid supports alveolar regeneration via upregulation of reciprocal PDGFA signalling
10.1136/thoraxjnl-2020-214986 · 2021 · External reference
mTOR overactivation and compromised autophagy in the pathogenesis of pulmonary fibrosis
10.1371/journal.pone.0138625 · 2015 · External reference
Interleukin-6 promotes ferroptosis in bronchial epithelial cells by inducing reactive oxygen species-dependent lipid peroxidation and disrupting iron homeostasis
10.1080/21655979.2021.1964158 · 2021 · External reference
Mitochondrial integrated stress response controls lung epithelial cell fate
10.1038/s41586-023-06423-8 · 2023 · External reference
Mitochondrial fragmentation in cigarette smoke-induced bronchial epithelial cell senescence
10.1152/ajplung.00146.2013 · 2013 · External reference
AMPK: a nutrient and energy sensor that maintains energy homeostasis
10.1038/nrm3311 · 2012 · External reference
NOX4 mediates epithelial cell death in hyperoxic acute lung injury through mitochondrial reactive oxygen species
10.3389/fphar.2022.880878 · 2022 · External reference
Mitochondrial pyruvate metabolism controls alveolar stem cell fate and inflammatory balance
10.1007/s10753-026-02470-1 · 2026 · External reference
Phospholipid molecular species of bronchoalveolar lavage fluid after local allergen challenge in asthma
10.1152/ajplung.2000.278.2.l305 · 2000 · External reference
Autophagy maintains the metabolism and function of young and old stem cells
10.1038/nature21388 · 2017 · External reference
Prolonged cigarette smoke exposure alters mitochondrial structure and function in airway epithelial cells
10.1186/1465-9921-14-97 · 2013 · External reference
Airway-derived emphysema-specific alveolar type II cells exhibit impaired regenerative potential in COPD
10.1183/13993003.02071-2023 · 2024 · External reference
Short-term intermittent cigarette smoke exposure enhances alveolar type 2 cell stemness via fatty acid oxidation
10.1186/s12931-022-01948-4 · 2022 · External reference
Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
10.1038/nature02989 · 2004 · External reference
A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche
10.1182/blood-2007-05-087759 · 2007 · External reference
Pulmonary fibrosis: from mechanisms to therapies
10.1186/s12967-025-06514-2 · 2025 · External reference
Senolytics in idiopathic pulmonary fibrosis: results from a first-in-human, open-label, pilot study
10.1016/j.ebiom.2018.12.052 · 2019 · External reference
Contributions of alveolar epithelial cell quality control to pulmonary fibrosis
10.1172/jci139519 · 2020 · External reference
Demographics and survival of patients with idiopathic pulmonary fibrosis in the FinnishIPF registry
10.1183/23120541.00170-2018 · 2019 · External reference
Mitochondrial dynamics impacts stem cell identity and fate decisions by regulating a nuclear transcriptional program
10.1016/j.stem.2016.04.015 · 2016 · External reference
The mechanism of mitochondrial injury in Alpha-1 antitrypsin deficiency mediated liver disease
10.3390/ijms222413255 · 2021 · External reference
Persistence of a regeneration-associated, transitional alveolar epithelial cell state in pulmonary fibrosis
10.1038/s41556-020-0542-8 · 2020 · External reference
Impaired lysosomal integral membrane protein 2-dependent peroxiredoxin 6 delivery to lamellar bodies accounts for altered alveolar phospholipid content in adaptor protein-3-deficient pearl mice
10.1074/jbc.m116.720201 · 2016 · External reference
Mitochondrial dysfunction in human primary alveolar type II cells in emphysema
10.1016/j.ebiom.2019.07.063 · 2019 · External reference
Txnip regulates the Oct4-mediated pluripotency circuitry via metabolic changes upon differentiation
10.1007/s00018-024-05161-y · 2024 · External reference
Metabolic features and regulation in cell senescence
10.5483/bmbrep.2019.52.1.291 · 2019 · External reference
Differentiation, ageing and leukaemia alter the metabolic profile of human bone marrow haematopoietic stem and progenitor cells
10.1038/s41556-025-01709-7 · 2025 · External reference
The WntNAD+ axis in cancer, aging, and tissue regeneration
10.1016/j.tcb.2025.07.006 · 2026 · External reference
mTOR signaling at a glance
10.1242/jcs.051011 · 2009 · External reference
Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo
10.1183/13993003.02367-2016 · 2017 · External reference
Clinical course and prediction of survival in idiopathic pulmonary fibrosis
10.1164/rccm.201006-0894ci · 2011 · External reference
CFTR is required for maximal transepithelial liquid transport in pig alveolar epithelia
10.1152/ajplung.00116.2012 · 2012 · External reference
Autophagy reprograms alveolar progenitor cell metabolism in response to lung injury
10.1016/j.stemcr.2020.01.008 · 2020 · External reference
DOT1L regulates lung developmental epithelial cell fate and adult alveolar stem cell differentiation after acute injury
10.1016/j.stemcr.2023.07.006 · 2023 · External reference
ITGA3 promotes pancreatic cancer progression through HIF1α- and c-Myc-driven glycolysis in a collagen I-dependent autocrine manner
10.1038/s41417-024-00864-7 · 2025 · External reference
The ZIP8/SIRT1 axis regulates alveolar progenitor cell renewal in aging and idiopathic pulmonary fibrosis
10.1172/jci157338 · 2022 · External reference
Lipid deficiency contributes to impaired alveolar progenitor cell function in aging and idiopathic pulmonary fibrosis
10.1165/rcmb.2023-0290oc · 2024 · External reference
Impaired alveolar re-epithelialization in pulmonary emphysema
10.3390/cells11132055 · 2022 · External reference
Dysfunction of guinea-pig pulmonary surfactant and type II pneumocytes after repetitive challenge with aerosolized ovalbumin
10.1046/j.1365-2222.1997.420885.x · 1997 · External reference
Amino acid-mediated metabolism: a new power to influence properties of stem cells
10.1155/2019/6919463 · 2019 · External reference
Transcriptomics analysis identifies the decline in the alveolar type II stem cell niche in aged human lungs
10.1165/rcmb.2023-0363oc · 2024 · External reference
Dysregulated ITGA3/FAK/YAP axis mediates impaired alveolar type II epithelial cells function in COPD
10.2991/978-94-6463-932-2 · 2025 · External reference
Mitochondrial dysfunction and alveolar type II epithelial cell senescence: The destroyer and rescuer of idiopathic pulmonary fibrosis
10.3389/fcell.2025.1535601 · 2025 · External reference
Alveolar type II cells maintain bioenergetic homeostasis in hypoxia through metabolic and molecular adaptation
10.1152/ajplung.00298.2013 · 2014 · External reference
Reactive oxygen species regulate hematopoietic stem cell self-renewal, migration and development, as well as their bone marrow microenvironment
10.1089/ars.2014.5941 · 2014 · External reference
Aerobic glycolysis: meeting the metabolic requirements of cell proliferation
10.1146/annurev-cellbio-092910-154237 · 2011 · External reference
Rapamycin enhances long-term hematopoietic reconstitution of ex vivo expanded mouse hematopoietic stem cells by inhibiting senescence
10.1097/tp.0b013e3182a7fcf8 · 2014 · External reference
αCGRP deficiency aggravates pulmonary fibrosis by promoting senescence in alveolar type 2 cells
10.1038/s41435-025-00361-3 · 2025 · External reference
B vitamins and one-carbon metabolism: implications in human health and disease
10.3390/nu12092867 · 2020 · External reference
Ferroptotic alveolar epithelial type II cells drive TH2 and TH17 mixed asthma triggered by birch pollen allergen Bet v 1
10.1038/s41420-024-01861-3 · 2024 · External reference
Impaired wingless and int-1(WNT) signaling in type 2 alveolar epithelial cells drives senescence and inefficient alveolar repair in alpha-1 antitrypsin deficient lungs
10.1164/ajrccm.2025.211.abstracts.a3061 · 2025 · External reference
Polymerized Z-α-1 antitrypsin leads to lung injury in a murine model of emphysema
10.1172/jci.insight.199029 · 2026 · External reference
Effects of exogenous fatty acids and inhibition of de novo fatty acid synthesis on disaturated phosphatidylcholine production by fetal lung cells and adult type II cells
10.3109/01902148909087872 · 1989 · External reference
An MTCH2 pathway repressing mitochondria metabolism regulates haematopoietic stem cell fate
10.1038/ncomms8901 · 2015 · External reference
Lung oxygen consumption and mitochondria of alveolar epithelial and endothelial cells
10.1152/jappl.1975.38.4.588 · 1975 · External reference
Iron accumulation drives fibrosis, senescence and the senescence-associated secretory phenotype
10.1038/s42255-023-00928-2 · 2023 · External reference
Hypoxia, oxidative stress and inflammation
10.1016/j.freeradbiomed.2018.03.042 · 2018 · External reference
mTOR signaling in stem and progenitor cells
10.1242/dev.152595 · 2018 · External reference
N-acetylcysteine protects murine alveolar type II cells from cigarette smoke injury in a nuclear erythroid 2-related factor-2-independent manner
10.1165/rcmb.2012-0295oc · 2013 · External reference
Proteolytic cleavage of Opa1 stimulates mitochondrial inner membrane fusion and couples fusion to oxidative phosphorylation
10.1016/j.cmet.2014.03.011 · 2014 · External reference
Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD
10.1172/jci74985 · 2014 · External reference
The mitochondrial unfolded protein response is activated upon hematopoietic stem cell exit from quiescence
10.1111/acel.12756 · 2018 · External reference
Pathogenic mechanisms underlying idiopathic pulmonary fibrosis
10.1146/annurev-pathol-042320-030240 · 2022 · External reference
NAD+ metabolism, stemness, the immune response, and cancer
10.1038/s41392-020-00354-w · 2021 · External reference
Trained immunity: a program of innate immune memory in health and disease
10.1126/science.aaf1098 · 2016 · External reference
Dysfunctional lactate metabolism in human alveolar type II cells from idiopathic pulmonary fibrosis lung explant tissue
10.1186/s12931-021-01866-x · 2021 · External reference
The ferroptosis inhibitor NUPR1 coordinates the mitochondrial response to oxidative stress and cell metabolism during COPD pathogenesis in the lung
10.1152/ajplung.00098.2026 · 2026 · External reference
Glucose and glutamine metabolism regulate human hematopoietic stem cell lineage specification
10.1016/j.stem.2014.06.002 · 2014 · External reference
Mitochondrial role in stemness and differentiation of hematopoietic stem cells
10.1155/2019/4067162 · 2019 · External reference
Alveolar epithelial type II cells as drivers of lung fibrosis in idiopathic pulmonary fibrosis
10.3390/ijms21072269 · 2020 · External reference
Epithelial cell mitochondrial dysfunction and PINK1 are induced by transforming growth factor-beta1 in pulmonary fibrosis
10.1371/journal.pone.0121246 · 2015 · External reference
Regulation of fetal lung disaturated phosphatidylcholine synthesis by de novo palmitate supply
10.1016/0005-2760(88)90246-9 · 1988 · External reference
Dynamic changes in intracellular ROS levels regulate airway basal stem cell homeostasis through Nrf2-dependent Notch signaling
10.1016/j.stem.2014.05.009 · 2014 · External reference
10.4199/c00067ed1v01y201210isp037
10.4199/c00067ed1v01y201210isp037 · 2012 · External reference
Mitochondrial dysfunction-associated alveolar epithelial senescence is involved in CdCl2-induced COPD-like lung injury
10.1016/j.jhazmat.2024.135103 · 2024 · External reference
Cooperation and competition in the evolution of ATP-producing pathways
10.1126/science.1058079 · 2001 · External reference
Beyond inflammation: alarmins as critical drivers of pulmonary fibrosis
10.1183/23120541.00747-2025 · 2026 · External reference
Early ERK1/2 activation promotes DRP1-dependent mitochondrial fission necessary for cell reprogramming
10.1038/ncomms11124 · 2016 · External reference
Age-dependent inflammatory microenvironment mediates alveolar regeneration
10.3390/ijms25063476 · 2024 · External reference
Mitochondrial iron-sulfur clusters: structure, function, and an emerging role in vascular biology
10.1016/j.redox.2021.102164 · 2021 · External reference
Regulation of stem cell aging by metabolism and epigenetics
10.1016/j.cmet.2017.07.019 · 2017 · External reference
Alveolar injury and regeneration following deletion of ABCA3
10.1172/jci.insight.97381 · 2017 · External reference
Senescence: pathogenic driver in chronic obstructive pulmonary disease
10.3390/medicina58060817 · 2022 · External reference
Impaired AMPK control of alveolar epithelial cell metabolism promotes pulmonary fibrosis
10.1172/jci.insight.182578 · 2025 · External reference
Molecular and cellular processing of lung surfactant
10.1096/fasebj.8.12.8088461 · 1994 · External reference
The regulation and function of the L-type amino acid transporter 1 (LAT1) in cancer
10.3390/ijms19082373 · 2018 · External reference
New insights into the alveolar epithelium as a driver of acute respiratory distress syndrome
10.3390/biom12091273 · 2022 · External reference
Glutamine drives glutathione synthesis and contributes to radiation sensitivity of A549 and H460 lung cancer cell lines
10.1016/j.bbagen.2016.01.021 · 2016 · External reference
Role of adipocyte differentiation-related protein in surfactant phospholipid synthesis by type II cells
10.1152/ajplung.00204.2001 · 2002 · External reference
Hypoxia-inducible factors in physiology and medicine
10.1016/j.cell.2012.01.021 · 2012 · External reference
Abnormal mitochondrial iron metabolism damages alveolar type II epithelial cells involved in bleomycin-induced pulmonary fibrosis
10.7150/thno.94072 · 2024 · External reference
Regeneration-associated transitional state cells in pulmonary fibrosis
10.3390/ijms23126757 · 2022 · External reference
Methionine metabolism regulates maintenance and differentiation of human pluripotent stem cells
10.1016/j.cmet.2014.03.017 · 2014 · External reference
Influence of threonine metabolism on S-adenosylmethionine and histone methylation
10.1126/science.1226603 · 2013 · External reference
Randomised controlled trial for emphysema with a selective agonist of the γ-type retinoic acid receptor
10.1183/09031936.00161911 · 2012 · External reference
Alpha1-antitrypsin deficiency
10.1056/nejmra1910234 · 2020 · External reference
Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis
10.1038/s41467-020-17358-3 · 2020 · External reference
YAP1 inhibits the senescence of alveolar epithelial cells by targeting Prdx3 to alleviate pulmonary fibrosis
10.1038/s12276-024-01277-0 · 2024 · External reference
Activated DRP1 promotes mitochondrial fission and induces glycolysis in ATII cells under hyperoxia
10.1186/s12931-024-03083-8 · 2024 · External reference
Environmental allergens house dust mite-induced asthma is associated with ferroptosis in the lungs
10.3892/etm.2021.10918 · 2021 · External reference
Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis
10.1038/nm1748 · 2008 · External reference
Glutamine oxidation is indispensable for survival of human pluripotent stem cells
10.1016/j.cmet.2016.03.001 · 2016 · External reference
Metabolism. AMP-activated protein kinase mediates mitochondrial fission in response to energy stress
10.1126/science.aab4138 · 2016 · External reference
Cigarette smoke induces senescence in alveolar epithelial cells
10.1165/rcmb.2003-0290oc · 2004 · External reference
Alveolar cell senescence in patients with pulmonary emphysema
10.1164/rccm.200509-1374oc · 2006 · External reference
Exposure to cigarette smoke enhances the stemness of alveolar type 2 cells
10.1165/rcmb.2019-0188oc · 2020 · External reference
Alveolar inflammation in cystic fibrosis
10.1016/j.jcf.2010.03.001 · 2010 · External reference
Single-cell analysis reveals fibroblast heterogeneity and myofibroblasts in systemic sclerosis-associated interstitial lung disease
10.1136/annrheumdis-2018-214865 · 2019 · External reference
Cigarette smoke-induced blockade of the mitochondrial respiratory chain switches lung epithelial cell apoptosis into necrosis
10.1152/ajplung.00291.2006 · 2007 · External reference
New perspectives on the aberrant alveolar repair of idiopathic pulmonary fibrosis
10.3389/fcell.2020.580026 · 2020 · External reference
Relationship between ACSL4-mediated ferroptosis and chronic obstructive pulmonary disease
10.2147/copd.s391129 · 2023 · External reference
ZIP8 is an iron and zinc transporter whose cell-surface expression is up-regulated by cellular iron loading
10.1074/jbc.m112.367284 · 2012 · External reference
Characterizing cellular heterogeneity in fibrotic hypersensitivity pneumonitis by single-cell transcriptional analysis
10.1038/s41420-022-00831-x · 2022 · External reference
Glutamine Metabolism Is Required for Alveolar Regeneration during Lung Injury
10.3390/biom12050728 · 2022 · External reference
Enhanced glycolysis-mediated energy production in alveolar stem cells is required for alveolar regeneration
10.1016/j.stem.2023.07.007 · 2023 · External reference
Repair and regeneration of the alveolar epithelium in lung injury
10.1096/fj.202400088r · 2024 · External reference
Cuproptosis of bronchial epithelial cells triggers airway remodeling in chronic asthma
10.1038/s41598-025-34574-3 · 2026 · External reference
Hypoxia. 2. Hypoxia regulates cellular metabolism
10.1152/ajpcell.00485.2010 · 2011 · External reference
From ancient pathways to aging cells-connecting metabolism and cellular senescence
10.1016/j.cmet.2016.05.010 · 2016 · External reference
The metabolic roots of senescence: mechanisms and opportunities for intervention
10.1038/s42255-021-00483-8 · 2021 · External reference
Mitochondrial dysfunction induces senescence with a distinct secretory phenotype
10.1016/j.cmet.2015.11.011 · 2016 · External reference
Mitophagy promotes lung repair and regeneration by restoring epithelial metabolic fitness
10.1038/s41467-026-71728-x · 2026 · External reference
The pathogenesis of pulmonary fibrosis: a moving target
10.1183/09031936.00073012 · 2013 · External reference
The ATF4-glutamine axis: a central node in cancer metabolism, stress adaptation, and therapeutic targeting
10.1038/s41420-025-02683-7 · 2025 · External reference
Next-generation regenerative therapies for alpha-1 antitrypsin deficiency: molecular pathogenesis to clinical translation
10.3390/ijms26178504 · 2025 · External reference
Downregulation of HMGCS2 mediated AECIIs lipid metabolic alteration promotes pulmonary fibrosis by activating fibroblasts
10.1186/s12931-024-02816-z · 2024 · External reference
Senescence of alveolar type 2 cells drives progressive pulmonary fibrosis
10.1164/rccm.202004-1274oc · 2021 · External reference
Neonatal hyperoxia activates activating transcription factor 4 to stimulate folate metabolism and alveolar epithelial type 2 cell proliferation
10.1165/rcmb.2021-0363oc · 2022 · External reference
Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis
10.1038/s41467-019-10991-7 · 2019 · External reference
Impaired AT2 to AT1 cell transition in PM2.5-induced mouse model of chronic obstructive pulmonary disease
10.1186/s12931-022-01996-w · 2022 · External reference
Metabolic control of stem cell function: insights into amino acid-driven mechanisms
10.1007/s12015-025-10967-9 · 2025 · External reference
Essential functions of iron-requiring proteins in DNA replication, repair and cell cycle control
10.1007/s13238-014-0083-7 · 2014 · External reference
Impaired autophagy-accelerated senescence of alveolar type II epithelial cells drives pulmonary fibrosis induced by single-walled carbon nanotubes
10.1186/s12951-023-01821-6 · 2023 · External reference
NLRP3 regulates ferroptosis via the JAK2/STAT3 pathway in asthma inflammation: Insights from in vivo and in vitro studies
10.1016/j.intimp.2024.113416 · 2024 · External reference
CYP1B1 mediates cigarette smoke-induced lipid accumulation in alveolar type 2 cells
10.1096/fj.202501439rr · 2025 · External reference
Ageing limits stemness and tumorigenesis by reprogramming iron homeostasis
10.1038/s41586-024-08285-0 · 2025 · External reference