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References from Estrogen and Lysyl Oxidase: How Crosslink Changes Increase Biological Female Athlete ACL Injury Risk. Local targets link to admitted publications; unresolved targets remain external evidence.
Non-contact anterior cruciate ligament injury epidemiology in team-ball sports: a systematic review with meta-analysis by sex, age, sport, participation level, and exposure type.
10.1007/s40279-022-01697-w · 2022 · External reference
Sex differences in injury rates in team-sport athletes: a systematic review and meta-regression analysis.
10.1016/j.jshs.2021.04.003 · 2022 · External reference
Why female athletes injure their ACL’s more frequently? What can we do to mitigate their risk?
10.26603/001c.25467 · 2021 · External reference
Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell.
10.1002/jcb.10413 · 2003 · External reference
Lysyl oxidase: an oxidative enzyme and effector of cell function.
10.1007/s00018-006-6149-9 · 2006 · External reference
Enzymatic and non-enzymatic functions of the lysyl oxidase family in bone.
10.1016/j.matbio.2016.01.001 · 2016 · External reference
Lysyl oxidase (LOX): functional contributions to signaling pathways.
10.3390/biom10081093 · 2020 · External reference
Lysyl oxidases: from enzyme activity to extracellular matrix cross-links.
10.1042/ebc20180050 · 2019 · External reference
Anterior cruciate ligament injuries in female athletes: part 1, mechanisms and risk factors.
10.1177/0363546505284183 · 2006 · External reference
The G-protein-coupled estrogen receptor GPER in health and disease.
10.1038/nrendo.2011.122 · 2011 · External reference
The rationale for targeting the LOX family in cancer.
10.1038/nrc3319 · 2012 · External reference
Effect of estrogen on musculoskeletal performance and injury risk.
10.3389/fphys.2018.01834 · 2018 · External reference
17β-Estradiol and estrogen receptor α protect right ventricular function in pulmonary hypertension via BMPR2 and apelin.
10.1172/jci129433 · 2021 · External reference
The combined regulation of estrogen and cyclic tension on fibroblast biosynthesis derived from anterior cruciate ligament.
10.1016/j.matbio.2004.07.004 · 2004 · External reference
Dysregulation of lysyl oxidase expression in lesions and endometrium of women with endometriosis.
10.1177/1933719115585144 · 2015 · External reference
LOX family enzymes expression in vaginal tissue of premenopausal women with severe pelvic organ prolapse.
10.1007/s00192-010-1199-9 · 2010 · External reference
Estradiol plays a role in regulating the expression of lysyl oxidase family genes in mouse urogenital tissues and human Ishikawa cells.
10.1631/jzus.b1500048 · 2015 · External reference
The effect of estrogen on tendon and ligament metabolism and function.
10.1016/j.jsbmb.2017.06.008 · 2017 · External reference
Estrogen inhibits lysyl oxidase and decreases mechanical function in engineered ligaments.
10.1152/japplphysiol.00823.2014 · 2015 · External reference
Menopause-related estrogen decrease and the pathogenesis of HFpEF: JACC review topic of the week.
10.1016/j.jacc.2019.12.049 · 2020 · External reference
Molecular characterization of lysyl oxidase-mediated extracellular matrix remodeling during mouse decidualization.
10.1002/1873-3468.12645 · 2017 · External reference
Lysyl oxidase gene expression and enzyme activity in the rat ovary: regulation by follicle-stimulating hormone, androgen, and transforming growth factor-beta superfamily members in vitro.
10.1210/en.2002-220652 · 2003 · External reference
Effect of estrogen on cellular metabolism of the human anterior cruciate ligament.
10.1097/00003086-199909000-00030 · 1999 · External reference
Effect of estrogen on tendon collagen synthesis, tendon structural characteristics, and biomechanical properties in postmenopausal women.
10.1152/japplphysiol.90935.2008 · 2009 · External reference
Differential expressions of lysyl oxidase family in ACL and MCL fibroblasts after mechanical injury.
10.1016/j.injury.2012.08.046 · 2013 · External reference
Lysyl oxidase activity is required for ordered collagen fibrillogenesis by tendon cells.
10.1074/jbc.m115.641670 · 2015 · External reference
Combined effects of tumor necrosis factor-α and interleukin-1β on lysyl oxidase and matrix metalloproteinase expression in human knee synovial fibroblasts in vitro.
2017 · External reference
The effect of estrogen on anterior cruciate ligament structure and function: a systematic review.
2023 · External reference
Mechanical injury and IL-1β regulated LOXs and MMP-1, 2, 3 expression in ACL fibroblasts co-cultured with synoviocytes.
10.1007/s10529-020-02870-9 · 2020 · External reference
The role of the lysyl oxidases in tissue repair and remodeling: a concise review.
10.1007/s13770-016-0007-0 · 2017 · External reference
Cyclic loading induces anabolic gene expression in ACLs in a load-dependent and sex-specific manner.
10.1002/jor.25677 · 2024 · External reference
The effect of the menstrual cycle on collagen metabolism, growth hormones and strength in young physically active women.
10.5114/biolsport.2021.107314 · 2021 · External reference
The effect of enzymatic crosslink degradation on the mechanics of the anterior cruciate ligament: a hybrid multi-domain model.
10.3390/app11188580 · 2021 · External reference
An anterior cruciate ligament failure mechanism.
10.1177/0363546519854450 · 2019 · External reference
Regulators of collagen crosslinking in developing and adult tendons.
10.22203/ecm.v043a11 · 2022 · External reference
Tendon mechanical properties are enhanced via recombinant lysyl oxidase treatment.
10.3389/fbioe.2022.945639 · 2022 · External reference
The ACL injury response: a collagen-based analysis.
10.1016/j.knee.2017.01.013 · 2017 · External reference
Ligament cell biology: effect of mechanical loading.
10.33594/000000773 · 2025 · External reference
Uterine collagen cross-linking: biology, role in disorders, and therapeutic implications.
10.1007/s43032-023-01386-7 · 2024 · External reference
Bone stress injuries in runners.
10.1016/j.pmr.2015.08.008 · 2016 · External reference
Energy availability and the female athlete triad in elite endurance athletes.
10.1111/sms.12261 · 2015 · External reference
Cross-species analysis of genetic architecture and polygenic risk scores for non-contact ACL rupture in dogs and humans.
10.1038/s42003-024-07395-9 · 2025 · External reference
