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References from Multi-Target Neuroprotection by Syzygium aromaticum Ethyl Acetate Fraction Against Mercuric Chloride-Induced Hippocampal Toxicity: Insights from Network Pharmacology, Molecular Docking, and In Vivo Evaluation. Local targets link to admitted publications; unresolved targets remain external evidence.
Global, regional, and national burden of Alzheimer’s disease and other dementias from 1990 to 2021: findings from the Global Burden of Disease Study 2021.
10.3389/fnagi.2025.1678212 · 2025 · External reference
Global burden of Alzheimer’s disease and other dementias (1990–2021): inequality, frontier, and decomposition analysis.
10.3389/fnagi.2025.1637029 · 2025 · External reference
Alzheimer’s and dementia: Diagnosis, assessment, and disease monitoring global, regional, and national burden of Alzheimer’s disease and other dementias (ADODs) and their risk factors, 1990-2021: A systematic analysis for the Global Burden of Disease stu ….
10.1002/dad2.70126 · External reference
The Toxicity of Mercury and Its Chemical Compounds: Molecular Mechanisms and Environmental and Human Health Implications: A Comprehensive Review.
10.1021/acsomega.3c07047 · 2024 · External reference
Early prediction of cognitive impairment in adults aged 20 years and older using machine learning and biomarkers of heavy metal exposure.
10.1016/j.crtox.2024.100198 · 2024 · External reference
Ameliorative effects of Quercetin-rich fraction of Zingiber officinale on cognitive deficit and sensory motor dysfunction in mercury chloride-induced neurotoxicity in male Wistar rats.
2026 · External reference
Upregulation of caspase-3, oxidative stress, neurobehavioural and histological alterations in mercury chloride-exposed rats: role of aqueous Allium sativum bulb extract.
10.1007/s10735-024-10318-x · 2024 · External reference
Medicinal plants with neuroprotective potential in East African countries: A systematic review.
10.1016/j.phyplu.2025.100744 · 2025 · External reference
Exploring the Neuroprotective Potentials of Flavonoid Metabolites in Syzygium aromaticum: A Review with in-silico Insight to Therapeutic Potential.
10.2147/jep.s536765 · 2025 · External reference
Multi-Targeting Neuroprotective Effects of Syzygium aromaticum Bud Extracts and Their Key Phytocompounds against Neurodegenerative Diseases.
10.3390/ijms24098148/s1 · External reference
Neuroprotective Properties of Clove (Syzygium aromaticum): State of the Art and Future Pharmaceutical Applications for Alzheimer’s Disease.
10.3390/biom15030452 · 2025 · External reference
Comparison of intranasal and intraperitoneal administration of Eugenia caryophyllata (clove) essential oil on spatial memory, anxiety-like behavior and locomotor activity in a pilocarpine-induced status epilepticus rat model.
10.1186/s12906-022-03711-0 · External reference
Exercise and Syzygium aromaticum reverse memory deficits, apoptosis and mitochondrial dysfunction of the hippocampus in Alzheimer’s disease.
10.1016/j.jep.2021.114871 · 2022 · External reference
A Method to Predict Blood-Brain Barrier Permeability of Drug-Like Compounds Using Molecular Dynamics Simulations.
10.1016/j.bpj.2014.06.024 · 2014 · External reference
Explaining Blood–Brain Barrier Permeability of Small Molecules by Integrated Analysis of Different Transport Mechanisms.
10.1021/acs.jmedchem.2c01824 · 2023 · External reference
Integration of molecular docking, molecular dynamics and network pharmacology to explore the multi-target pharmacology of fenugreek against diabetes.
10.1111/jcmm.17787 · 2023 · External reference
Research on the mechanism of eugenol in the treatment of liver cancer based on network pharmacology, molecular docking technology, and in vitro experiments.
10.1097/cad.0000000000001675 · 2025 · External reference
In vitro and In silico Network Pharmacology Analysis of Eugenol from Syzygium aromaticum Against Escherichia coli.
10.4103/ajprhc.ajprhc_56_24 · 2024 · External reference
Network pharmacology integrated with molecular docking and molecular dynamics simulations to explore the mechanism of Tongxie Yaofang in the treatment of ulcerative colitis.
10.1097/md.0000000000039569 · 2024 · External reference
Network pharmacology, pathway enrichment, and molecular docking analysis reveal the multi target therapeutic potential of phytochemicals from Eleusine coracana.
10.1007/s44371-026-00682-w · 2026 · External reference
Integrative Network Pharmacology and Molecular Docking Approaches in Herbal Medicine Research. A Systematic Review of Applications, Advances, and Translational Potential.
10.12688/f1000research.173985.1 · 2026 · External reference
Semisynthesis of Derivatives of Oleanolic Acid from Syzygium aromaticum and Their Antinociceptive and Anti-Inflammatory Properties.
10.1155/2016/8401843 · 2016 · External reference
Impact of Extraction Techniques on the Phytochemical Profile and Antibacterial Activity of Syzygium aromaticum; Bio-Guided Fractionation Reveals a Potent n-Butanol Fraction and Essential Oil Efficacy.
10.1177/1934578x251353369 · External reference
LC-MS and GC-MS Profiling of Different Fractions of Ficus platyphylla Stem Bark Ethanolic Extract.
10.1155/2022/6349332 · 2022 · External reference
Network Toxicology and Molecular Docking Analysis of Tetracycline-Induced Acute Pancreatitis: Unveiling Core Mechanisms and Targets.
10.3390/toxics12120929 · 2024 · External reference
Pharmacodynamics, Network Pharmacology, and Pharmacokinetics of Chinese Medicine Formula 9002A in the Treatment of Alzheimer’s Disease.
10.3389/fphar.2022.849994 · 2022 · External reference
Sample size calculation in animal studies using resource equation approach.
10.21315/mjms2017.24.5.11 · 2017 · External reference
How to calculate sample size in animal studies?.
10.4103/0976-500x.119726 · 2013 · External reference
Ameliorating effect of melatonin on mercuric chloride-induced neurotoxicity in rats.
10.1016/j.heliyon.2021.e07485 · 2021 · External reference
Test Guideline 425: Acute Oral Toxicity - Up-and-Down Procedure.
2022 · External reference
Mercuric chloride induced brain toxicity in mice: The protective effects of puerarin-loaded PLGA nanoparticles.
10.1002/jbt.23425 · 2023 · External reference
Electrophysiological, Behavioral and Molecular Study of Vitamin E and Ginkgo biloba in a Rat Model of Alzheimer’s Disease.
2021 · External reference
In Vivo Diuretic Activity of Hydromethanolic Extract and Solvent Fractions of the Root Bark of Clerodendrum myricoides Hochst. (Lamiaceae).
10.1155/2020/1718708 · 2020 · External reference
Effects of Aqueous Extract of Syzygium aromaticum (Clove) On Mercury Chloride-Induced Toxicity in The Hippocampus of Adult Wistar Rats.
10.4314/sokjmls.v10i1.9 · 2025 · External reference
Ameliorative Effects of Ethyl-Acetate Extract of Bidens pilosa on Oxidative Stress and Reproductive Impairment in Bisphenol A-Exposed Male Mice: Insight from In-silico, Invitro and In-vivo Studies.
10.12688/f1000research.166336.2 · 2025 · External reference
Assessment of the Impact of <em>Bidens pilosa</em> on Behavioral, Oxidative Stress and Cerebellar Cortical Histoarchitectural Alterations During Bisphenol A Exposure in Mice.
10.2147/jep.s522973 · 2025 · External reference
Examining Object Location and Object Recognition Memory in Mice.
10.1002/0471142301.ns0831s69 · 2014 · External reference
Therapeutic effects of anodal transcranial direct current stimulation in a rat model of adhd.
10.7554/elife.56359 · 2020 · External reference
Evaluation of Some Biochemical Parameters and Brain Oxidative Stress in Experimental Rats Exposed Chronically to Silver Nitrate and the Protective Role of Vitamin E and Selenium.
10.5487/tr.2016.32.4.301 · 2016 · External reference
Antioxidant enhancing ability of different solvents extractable components of Talinum triangulare in some selected Tissue homogenates of Albino Rats -In vitro.
10.7324/japs.2015.50911 · 2015 · External reference
Assessment of oxidative stress parameters of brain-derived neurotrophic factor heterozygous mice in acute stress model.
2016 · External reference
Peli1 contributions in microglial activation, neuroinflammatory responses and neurological deficits following experimental subarachnoid hemorrhage.
10.3389/fnmol.2017.00398 · 2017 · External reference
Polypharmacology: The science of multi-targeting molecules.
10.1016/j.phrs.2021.106055 · 2022 · External reference
Polypharmacology: new drugs in 2023–2024.
10.1007/s43440-025-00715-8 · 2025 · External reference
The Crucial Role of the Blood–Brain Barrier in Neurodegenerative Diseases: Mechanisms of Disruption and Therapeutic Implications.
10.3390/jcm14020386 · 2025 · External reference
Neurotherapeutics across blood-brain barrier: screening of BBB-permeable and CNS-active molecules for neurodegenerative disease.
10.3389/fphar.2025.1616144 · External reference
The neuroprotective effect of eugenol in aluminum chloride-induced Alzheimer’s rats: Insights into the role of TLR4/MyD88/NF-kB and NLRP3 inflammasome/gasdermin D signaling pathways.
10.1016/j.abb.2026.110885 · 2026 · External reference
Eugenol mitigates schizophrenia-like behavioral deficits, oxidative stress, apoptosis, neuroinflammation, and cholinergic dysfunction in ketamine-induced mice.
10.1007/s40199-026-00603-3 · 2026 · External reference
In silico and in vivo anti-inflammatory effect of eugenol and acetyleugenol.
10.1016/j.sciaf.2024.e02205 · 2024 · External reference
Multi-Target Protective Effects of β-Caryophyllene (BCP) at the Intersection of Neuroinflammation and Neurodegeneration.
10.3390/ijms26136027 · 2025 · External reference
A mechanistic review on immunomodulatory effects of selective type two cannabinoid receptor β-caryophyllene.
10.1002/biof.1869 · 2022 · External reference
Challenges and Discoveries in Polypharmacology of Neurodegenerative Diseases.
10.2174/1568026623666230126112628 · 2023 · External reference
Development of Novel Herbal Compound Formulations Targeting Neuroinflammation: Network Pharmacology, Molecular Docking, and Experimental Verification.
10.1155/2023/2558415 · 2023 · External reference
Network pharmacology approach to unravel the neuroprotective potential of natural products: a narrative review.
10.1007/s11030-025-11198-3 · External reference
Unravelling the developmental toxicity of heavy metals using zebrafish as a model: a narrative review.
10.1007/s10534-025-00671-z · 2025 · External reference
Combined Molecular Toxicity Mechanism of Heavy Metals Mixtures.
10.1002/9781394158355.ch09 · 2025 · External reference
Mercury-mediated neurological diseases: insight into molecular mechanisms, mutant proteins, and structure-based therapeutic inhibitors.
2024 · External reference
Carvacrol mitigates Mercury chloride induced neurotoxicity by regulation of NRF-2/HO-1/NF-κB expression.
10.1016/j.jtemb.2025.127715 · 2025 · External reference
Mercury-induced neurotoxicity in rat: in vivo and in silico studies of thymoquinone modulatory effect via oxidative stress and inflammation, HO-1/NRF/Trx/Trx-R trajectories.
10.1186/s12917-025-05093-0 · 2025 · External reference
Integrated network pharmacology, molecular docking and MD simulation unravel neuroprotective phytochemicals from aframomum melegueta targeting microglial neuroinflammation in Alzheimer’s disease.
10.1007/s13721-026-00776-6 · 2026 · External reference
Elucidating the therapeutic mechanism of betanin in Alzheimer’s Disease treatment through network pharmacology and bioinformatics analysis.
10.1007/s11011-024-01385-w · 2024 · External reference
Hippocampal Dysfunction Provoked by Mercury Chloride Exposure: Evaluation of Cognitive Impairment, Oxidative Stress, Tissue Injury and Nature of Cell Death.
10.1155/2018/7878050 · 2018 · External reference
Natural Products as Modulators of Nrf2 Signaling Pathway in Neuroprotection.
10.3390/ijms24043748 · External reference
Neuroprotective potential of eugenol against acrylamide-induced brain toxicity by regulating Nrf2/NQO1/HO-1 and NLRP3/NF-κB/IL-1β signaling cascades.
10.1038/s41598-025-34650-8 · 2026 · External reference
Inflammation in Metal-Induced Neurological Disorders and Neurodegenerative Diseases.
2024 · External reference
Mechanisms of Metal-Induced Mitochondrial Dysfunction in Neurological Disorders.
10.3390/toxics9060142 · 2021 · External reference
NMDA Receptor Antagonists: Emerging Insights into Molecular Mechanisms and Clinical Applications in Neurological Disorders.
10.3390/ph17050639 · External reference
Comprehensive Review Regarding Mercury Poisoning and Its Complex Involvement in Alzheimer’s Disease.
10.3390/ijms23041992 · 2022 · External reference
Mercury Exposure and Health Effects: What Do We Really Know?.
10.3390/ijms26052326 · 2025 · External reference
Inhibition of Acetylcholinesterase Modulates NMDA Receptor Antagonist Mediated Alterations in the Developing Brain.
10.3390/ijms15033784 · 2014 · External reference
NMDA Receptor Function During Senescence: Implication on Cognitive Performance.
10.3389/fnins.2015.00473 · 2015 · External reference
In Silico and in vivo Evaluation of a New Derivative from Memantine and Sinapic Acid (N-Sinapoyl-memantine) as a Candidate for the Management of Alzheimer’s Disease.
10.3390/cryst15060491 · 2025 · External reference
Mercury-induced toxicity of rat cortical neurons is mediated through N-methyl-D-Aspartate receptors.
10.1186/1756-6606-5-30 · 2012 · External reference
NMDA receptor-dependent glutamate excitotoxicity in human embryonic stem cell-derived neurons.
10.1016/j.neulet.2013.03.010 · 2013 · External reference
Memantine protects the cultured rat hippocampal neurons treated by NMDA and amyloid β1–42.
10.3389/fnins.2023.1269664 · 2023 · External reference
Pharmacological Modulation of Excitotoxicity through the Combined Use of NMDA Receptor Inhibition and Group III mGlu Activation Reduces TMT-Induced Neurodegeneration in the Rat Hippocampus.
10.3390/ijms24098249 · 2023 · External reference
Virtual Screening of Benzimidazole Derivatives as Potential Triose Phosphate Isomerase Inhibitors with Biological Activity against Leishmania mexicana.
10.3390/ph16030390 · 2023 · External reference
Computational Screening of High-Affinity Natural Product-Derived Inhibitors Targeting NF-κB Protein: A Molecular Docking Approach toward Anti-Inflammatory and Anticancer Therapeutics.
2025 · External reference
Computational investigation of phytochemicals from Withania somnifera (Indian ginseng/ashwagandha) as plausible inhibitors of GluN2B-containing NMDA receptors.
10.1080/07391102.2021.1905553 · 2022 · External reference
Ameliorative effects of egg white hydrolysate on recognition memory impairments associated with chronic exposure to low mercury concentration.
10.1016/j.neuint.2016.10.002 · 2016 · External reference
Neurocognitive and Affective Disorders Induced by Inorganic Mercury Exposure in Male Wistar Rats: Unraveling the Role of Oxidative Stress.
10.17582/journal.aavs/2025/13.2.304.315 · 2025 · External reference
Chronic Methylmercury Intoxication Induces Systemic Inflammation, Behavioral, and Hippocampal Amino Acid Changes in C57BL6J Adult Mice.
10.3390/ijms232213837 · 2022 · External reference
Neuroprotective Effects of Eugenol Acetate Against Ischemic Stroke.
10.2147/jir.s487482 · 2025 · External reference
Bioactive compounds and exercise in aging and neurodegeneration: mechanistic insights from the gut–brain–metabolic axis.
10.3389/fnut.2026.1781176 · 2026 · External reference
Andrographis paniculata protects against brain hippocampus and cerebellum from mercury chloride induced damage by attenuating oxidative stress.
10.5620/eaht.2022027 · External reference
The Toxicity of Mercury and Its Chemical Compounds: Molecular Mechanisms and Environmental and Human Health Implications: A Comprehensive Review.
10.1021/acsomega.3c07047 · 2024 · External reference
Toxic Mechanisms of Five Heavy Metals: Mercury, Lead, Chromium, Cadmium, and Arsenic.
10.3389/fphar.2021.643972 · 2021 · External reference
Interrelationship of lipid aldehydes (MDA, 4-HNE, and 4-ONE) mediated protein oxidation in muscle foods.
10.1080/10408398.2023.2245029 · 2024 · External reference
Antioxidant effects of vitamin E and risk of cardiovascular disease in women with obesity – A narrative review.
10.1016/j.clnu.2022.04.032 · 2022 · External reference
Review article vitamin E: a multi-functional ingredient for health enhancement and food preservation.
2023 · External reference
Potential Effect of Syzygium aromaticum (Cloves) Extract on Serum Antioxidant Status and Lipid Profiles in Wistar Rats with Artesunate Toxicity.
10.3390/app12168216 · 2022 · External reference
Therapeutic Potential of Clove Oil in Mitigating Cadmium-Induced Hepatorenal Toxicity Through Antioxidant, Anti-Inflammatory, and Antiapoptotic Mechanisms.
10.3390/ph18010094 · 2025 · External reference
Clove Essential Oil Enhances Antioxidant Defenses and Reduces DNA Damage in a Cellular Model of Parkinson’s Disease.
10.1155/padi/4243787 · 2025 · External reference
Hippocampal Dysfunction Provoked by Mercury Chloride Exposure: Evaluation of Cognitive Impairment, Oxidative Stress, Tissue Injury and Nature of Cell Death.
10.1155/2018/7878050 · 2018 · External reference
Andrographis paniculata protects against brain hippocampus and cerebellum from mercury chloride induced damage by attenuating oxidative stress.
10.5620/eaht.2022027 · External reference
Neuroprotective potential of eugenol against acrylamide-induced brain toxicity by regulating Nrf2/NQO1/HO-1 and NLRP3/NF-κB/IL-1β signaling cascades.
10.1038/s41598-025-34650-8 · 2026 · External reference
Neuroprotective Effects of Cloves on Albino Rats Induced with Mercury.
10.58578/ajmsphr.v3i1.7893 · 2025 · External reference
Multi-Target Neuroprotection by Syzygium aromaticum Ethyl Acetate Fraction Against Mercuric Chloride-Induced Hippocampal Toxicity: Insights from Network Pharmacology, Molecular Docking, and in vivo Evaluation.
10.6084/m9.figshare.32920373.v3 · 2026 · External reference