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References from The challenges and considerations for emerging or future entrepreneurial researchers in microphysiological systems. Local targets link to admitted publications; unresolved targets remain external evidence.
Microfluidics: the fur-free way towards personalised medicine in cancer therapy.
2016 · External reference
Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies.
10.1038/s41598-018-22749-0 · 2018 · External reference
Organs-on-a-chip engineering.
10.1016/b978-0-12-817202-5.00003-6 · 2020 · External reference
Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing.
10.14573/altex.1603161 · 2016 · External reference
First EMA workshop on non-animal approaches in support of medicinal product development: challenges and opportunities for use of micro-physiological systems.
2017 · External reference
Non-Animal Approaches the Way Forward.
10.2779/373944 · 2016 · External reference
Statement by FDA Commissioner Scott Gottlieb, M.D., on efforts to reduce animal testing through a study aimed at eliminating the use of dogs in certain trials.
External reference
Administrator Wheeler Signs Memo to Reduce Animal Testing, Awards $4.25 Million to Advance Research on Alternative Methods to Animal Testing.
External reference
Impact of organ-on-a-chip technology on pharmaceutical R&D costs.
10.1016/j.drudis.2019.06.003 · 2019 · External reference
The Emergence of Microphysiological Systems (Organs-on-chips) as Paradigm-changing Tools for Toxicologic Pathology.
10.1177/0192623318809065 · 2019 · External reference
Organ-on-chip Market Expected to reach $170 Million, Globally, by 2023.
External reference
Organ-on-Chip Market 2019 - Industry Analysis, Size, Share, Strategies and Forecast to 2023.
External reference
Organ-on-chip Market by Type (Heart-on-chip, Human-on-chip, Intestine-on-chip, Kidney-on-chip, Liver-on-chip, and Lung-on-chip) - Global Opportunity Analysis and Industry Forecast, 2017-2023.
External reference
Organ-on-Chip Market by Offering (Services, Products), by Type (Liver-on-Chip, Lung-on-Chip, Kidney-on-Chip, Heart-on-Chip, Intestine-on-Chip, Brain-on-Chip), by Application (Toxicology Research, Physiological Model Development, Drug Discovery), by End User (Pharmaceutical & Biotechnology Companies, Academic & Research Institutes), by Geography (U.S., Canada, Germany, U.K., France, China, Japan) – Global Market Size, Share, Development, Growth and Demand Forecast, 2016–2025.
External reference
Microfluidics Market Size, Share & Trends Analysis Report By Application (Lab-on-a-Chip, Organs-on-Chips, Continuous Flow), By Technology (Medical, Non-Medical), By Material, And Segment Forecasts, 2020 - 2027.
External reference
Microfluidics Market by Product (Devices, Components (Chips, Sensors, Pump, Valves, and Needles), Application (IVD [POC, Clinical, Veterinary], Research, Manufacturing, Therapeutics), End User and Region - Global Forecast to 2025.
External reference
Microfluidics Market - Growth, Trends, and Forecasts (2020 - 2025).
External reference
An introduction to drug disposition: The basic principles of absorption, distribution, metabolism, and excretion.
10.1177/019262339502300202 · 1995 · External reference
Evidence-based absorption, distribution, metabolism, excretion (ADME) and its interplay with alternative toxicity methods.
10.14573/altex.1610101 · 2016 · External reference
FDA's Woodcock: The Clinical Trials System is 'Broken'.
External reference
FDA's Woodcock: 'The clinical trial system is broken'.
External reference
Estimation of clinical trial success rates and related parameters.
10.1093/biostatistics/kxx069 · 2019 · External reference
The cost of drug development.
10.1056/nejmc1504317 · 2015 · External reference
A Tough Road: Cost To Develop One New Drug Is $2.6 Billion; Approval Rate for Drugs Entering Clinical Development is Less Than 12%.
External reference
Getting A Handle On Clinical Trial Costs.
External reference
How Can Pricing and Reimbursement Policies Improve Affordable Access to Medicines? Lessons Learned from European Countries.
10.1007/s40258-016-0300-z · 2017 · External reference
The cost of pharmaceutical innovation to patients.
10.1517/17460441.2.11.1431 · 2007 · External reference
Create a translational medicine knowledge repository--Research downsizing, mergers and increased outsourcing have reduced the depth of in-house translational medicine expertise and institutional memory at many pharmaceutical and biotech companies: How will they avoid relearning old lessons?
10.1186/1479-5876-9-56 · 2011 · External reference
Outsourcing Clinical Trials Outside of the US.
External reference
Partnering with the right CRO is a winning strategy for companies big and small.
External reference
Pharma is shuffling around jobs, but a skills gap threatens the process.
External reference
MImETIC INDiRECT-ED001.
2021 · External reference
Henrietta Lacks, HeLa cells, and cell culture contamination.
10.5858/133.9.1463 · 2009 · External reference
Validation of Alternative In Vitro Methods to Animal Testing: Concepts, Challenges, Processes and Tools.
10.1007/978-3-319-33826-2_4 · 2016 · External reference
Organ-on-Chip In Development: Towards a European roadmap for Organ-on-Chip.
2018 · External reference
Diffusion of innovations theory, principles, and practice.
10.1377/hlthaff.2017.1104 · 2018 · External reference
Horizon 2020 Work Programme 2014-2015 General Annexes.
External reference
Measuring Technology Readiness for Investment: Accelerating Technology Development and Improving Innovation Performance
2017 · External reference
An Approach for Developing Concept of Innovation Readiness Levels.
2011 · External reference
A Survey of Technology Readiness Level Users.
10.1002/j.2334-5837.2016.00283.x · 2016 · External reference
An Analysis of TRL-Based Cost and Schedule Models.
2012 · External reference
Addressing Patient Specificity in the Engineering of Tumor Models.
10.3389/fbioe.2019.00217 · 2019 · External reference
Modeling Patient-Derived Glioblastoma with Cerebral Organoids.
10.1016/j.celrep.2019.02.063 · 2019 · External reference
A novel spheroid-based co-culture model mimics loss of keratinocyte differentiation, melanoma cell invasion, and drug-induced selection of ABCB5-expressing cells.
10.1186/s12885-019-5606-4 · 2019 · External reference
CAAP48, a New Sepsis Biomarker, Induces Hepatic Dysfunction in an in vitro Liver-on-Chip Model.
10.3389/fimmu.2019.00273 · 2019 · External reference
3D Primary Hepatocyte Culture Systems for Analyses of Liver Diseases, Drug Metabolism, and Toxicity: Emerging Culture Paradigms and Applications.
10.1002/biot.201800347 · 2019 · External reference
Experimental study of tuberculosis: From animal models to complex cell systems and organoids.
10.1371/journal.ppat.1006421 · 2017 · External reference
Integrated gut/liver microphysiological systems elucidates inflammatory inter-tissue crosstalk.
10.1002/bit.26370 · 2017 · External reference
An alternative approach based on microfluidics to study drug metabolism and toxicity using liver and intestinal tissue [dissertation].
2010 · External reference
WAT-on-a-chip integrating human mature white adipocytes for mechanistic research and pharmaceutical applications.
10.1038/s41598-020-63710-4 · 2020 · External reference
A microfluidic chip based model for the study of full thickness human intestinal tissue using dual flow.
10.1063/1.4964813 · 2016 · External reference
A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents.
10.1039/c5lc00392j · 2015 · External reference
3D bioactive composite scaffolds for bone tissue engineering.
10.1016/j.bioactmat.2017.10.001 · 2017 · External reference
Bioinks and bioprinting technologies to make heterogeneous and biomimetic tissue constructs.
10.1016/j.mtbio.2019.100008 · 2019 · External reference
Hydrogels for liver tissue engineering.
10.3390/bioengineering6030059 · 2019 · External reference
Coaxial 3D bioprinting of self-assembled multicellular heterogeneous tumor fibers.
10.1038/s41598-017-01581-y · 2017 · External reference
Bioprinted 3D primary liver tissues allow assessment of organ-level response to clinical drug induced toxicity in vitro.
10.1371/journal.pone.0158674 · 2016 · External reference
Scaffold-Based or Scaffold-Free Bioprinting: Competing or Complementing Approaches?
10.1115/1.4030414 · 2015 · External reference
Advances in Hydrogels in Organoids and Organs-on-a-Chip.
10.1002/adma.201902042 · 2019 · External reference
Modular, tissue-specific, and biodegradable hydrogel cross-linkers for tissue engineering.
10.1126/sciadv.aaw7396 · 2019 · External reference
Functionalizing bioinks for 3D bioprinting applications.
10.1016/j.drudis.2018.09.012 · 2019 · External reference
Microfluidic bioprinting for engineering vascularized tissues and organoids.
10.3791/55957 · 2017 · External reference
Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function.
10.1073/pnas.1210182109 · 2012 · External reference
Human organ culture: Updating the approach to bridge the gap from in vitro to in vivo in inflammation, cancer, and stem cell biology.
10.3389/fmed.2017.00148 · 2017 · External reference
Three-Dimensional Organoids in Cancer Research: The Search for the Holy Grail of Preclinical Cancer Modeling.
10.1089/omi.2018.0172 · 2018 · External reference
A simple high-throughput approach identifies actionable drug sensitivities in patient-derived tumor organoids.
10.1038/s42003-019-0305-x · 2019 · External reference
Comparison of cancer cells in 2D vs 3D culture reveals differences in AKT-mTOR-S6K signaling and drug responses.
10.1242/jcs.188102 · 2017 · External reference
Chemoresistance of Lung Cancer Cells: 2D and 3D In Vitro Models for Anticancer Drug Screening
10.5772/intechopen.78946 · 2018 · External reference
Human tissue models in cancer research: Looking beyond the mouse.
10.1242/dmm.031260 · 2017 · External reference
Enhancing reproducibility in cancer drug screening: How do we move forward?
10.1158/0008-5472.can-14-0725 · 2014 · External reference
Preclinical experimental models of drug metabolism and disposition in drug discovery and development.
10.1016/j.apsb.2012.10.004 · 2012 · External reference
Organoids provide an important window on inflammation in cancer.
10.3390/cancers10050151 · 2018 · External reference
Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids.
10.1038/s41598-018-21201-7 · 2018 · External reference
Towards personalized computational oncology: From spatial models of tumour spheroids, to organoids, to tissues.
10.1098/rsif.2017.0703 · 2018 · External reference
Canine liver organoids for disease modeling of copper toxicosis and transplantation [master’s thesis].
2015 · External reference
A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity.
10.1016/j.cell.2017.11.010 · 2018 · External reference
Organoids as Reliable Breast Cancer Study Models: An Update.
10.23937/ijor-2017/1710008 · 2018 · External reference
Ex vivo tumor culture systems for functional drug testing and therapy response prediction.
10.4155/fsoa-2017-0003 · 2017 · External reference
Tumor slice culture system to assess drug response of primary breast cancer.
10.1186/s12885-016-2119-2 · 2016 · External reference
Mouse models of metastasis: Progress and prospects.
10.1242/dmm.030403 · 2017 · External reference
Ex vivo testing of patient-derived xenografts mirrors the clinical outcome of patients with pancreatic ductal adenocarcinoma.
10.1158/1078-0432.ccr-15-2936 · 2016 · External reference
Development of Patient-Derived Preclinical Platform for Metastatic Pancreatic Cancer: PDOX and a Subsequent Organoid Model System Using Percutaneous Biopsy Samples.
10.3389/fonc.2019.00875 · 2019 · External reference
Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies.
10.1038/nprot.2010.111 · 2010 · External reference
High-Content Biopsies Facilitate Molecular Analyses and Do Not Increase Complication Rates in Patients With Advanced Solid Tumors.
10.1200/po.17.00081 · 2017 · External reference
Use of Precision-Cut Lung Slices as an Ex Vivo Tool for Evaluating Viruses and Viral Vectors for Gene and Oncolytic Therapy.
10.1016/j.omtm.2018.07.010 · 2018 · External reference
Precision-cut human liver slice cultures as an immunological platform.
10.1016/j.jim.2018.01.012 · 2018 · External reference
Tumor Organoids as a Pre-clinical Cancer Model for Drug Discovery.
10.1016/j.chembiol.2017.06.012 · 2017 · External reference
Temperature variations within and between incubators-a prospective, observational study.
10.1007/s10815-013-0104-0 · 2013 · External reference
Oxygenation in cell culture: Critical parameters for reproducibility are routinely not reported.
10.1371/journal.pone.0204269 · 2018 · External reference
Limitations of oxygen delivery to cells in culture: An underappreciated problem in basic and translational research.
10.1016/j.freeradbiomed.2017.10.003 · 2017 · External reference
WEBINAR: What is hyperoxia, normoxia and hypoxia to cells: Why researchers should care about environmental oxygen and how it influences results
External reference
A microfluidics platform for combinatorial drug screening on cancer biopsies.
10.1038/s41467-018-04919-w · 2018 · External reference
Microfluidics as an Enabling Technology for Personalized Cancer Therapy.
10.1002/smll.201904321 · 2020 · External reference
Maintenance of head and neck tumor on-chip: Gateway to personalized treatment?
10.4155/fsoa-2016-0089 · 2017 · External reference
Development of a Microfluidic Culture Paradigm for Ex Vivo Maintenance of Human Glioblastoma Tissue: A New Glioblastoma Model?
10.1016/j.tranon.2019.09.002 · 2020 · External reference
Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms.
10.1007/s00204-018-2152-9 · 2018 · External reference
Materials for Microfluidic Chip Fabrication.
10.1021/ar300314s · 2013 · External reference
High-Performance Materials for 3D Printing in Chemical Synthesis Applications.
10.1002/adma.201805982 · 2019 · External reference
Design of Sealable Custom-Shaped Cell Mimicries Based on Self-Assembled Monolayers on CYTOP Polymer.
10.1021/acsami.9b05073 · 2019 · External reference
PDMS-based microfluidic devices for cell culture.
10.3390/inventions3030065 · 2018 · External reference
Advantages and challenges of microfluidic cell culture in polydimethylsiloxane devices.
10.1016/j.bios.2014.07.029 · 2015 · External reference
Vanderbilt researchers win an R&D100 Award for MultiWell MicroFormulator.
External reference
NCATS Supports Award-Winning Technology for Drug Development.
External reference
A 96-well microplate bioreactor platform supporting individual dual perfusion and high-throughput assessment of simple or biofabricated 3D tissue models.
10.1039/c8lc00485d · 2018 · External reference
Methods of delivering mechanical stimuli to Organ-on-a-Chip.
10.3390/mi10100700 · 2019 · External reference
Multi-organs-on-chips: Towards long-term biomedical investigations.
10.3390/molecules24040675 · 2019 · External reference
A standalone perfusion platform for drug testing and target validation in micro-vessel networks.
10.1063/1.4818837 · 2013 · External reference
Democratising Technology: the Confluence of Makers and Grassroot Innovators.
2015 · External reference
Technological Sovereignty: Democratising Technology and Innovation [green paper]. Progressive Agenda for Europe
2019 · External reference
Moving beyond the Three Rs in Biomedical Research.
External reference
ARRIVE guidelines.
External reference
The National Institutes of Health Microphysiological Systems Program focuses on a critical challenge in the drug discovery pipeline.
10.1186/scrt361 · 2013 · External reference
3S - Systematic, systemic, and systems biology and toxicology.
10.14573/altex.1804051 · 2018 · External reference
Ban on animal testing.
External reference
human Organ and Disease Model Technologies.
External reference
Organ on Chip in Development.
External reference
EUROoC.
External reference
Bad Witches: Gender and the downfall of Elizabeth Holmes of Theranos and Disney’s Maleficent.
10.3390/socsci8060175 · 2019 · External reference
EURL ECVAM Status Report on the Development, Validation and Regulatory Acceptance of Alternative Methods and Apporaches.
2018 · External reference
Applications of CRISPR technologies in research and beyond.
10.1038/nbt.3659 · 2016 · External reference
Beyond CRISPR: What’s current and upcoming in genome editing.
External reference
The commercialization of genome-editing technologies.
10.1080/07388551.2016.1271768 · 2017 · External reference
30 years of microfluidics.
10.1016/j.mne.2019.01.003 · 2019 · External reference
Microfluidics for genome-wide studies involving next generation sequencing.
10.1063/1.4978426 · 2017 · External reference
Small but Perfectly Formed? Successes, Challenges, and Opportunities for Microfluidics in the Chemical and Biological Sciences.
10.1016/j.chempr.2017.01.009 · 2017 · External reference
Rwanda is Building Africa’s Very Own Silicon Valley – Kigali Innovation City (KIC).
External reference
Rwanda is bringing tech buzz to Africa.
External reference
Africa's first 'Silicon Valley' to be built in Rwanda.
External reference
Human Genomics Research Has A Diversity Problem.
External reference
Diversity and inclusion in genomic research: why the uneven progress?
10.1007/s12687-017-0316-6 · 2017 · External reference
Building the future of health research: Proposal for a European Council for Health Research.
2018 · External reference
A New Pharmaceutical Commons: Transforming Drug Discovery.
External reference
Latest global cancer data: Cancer burden rises to 19.3 million new cases and 10.0 million cancer deaths in 2020.
External reference
Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.
10.3322/caac.21492 · 2018 · External reference
Cancer Surpasses CVD as Leading Cause of Death in High-Income Counties.
External reference
Cancer Overtakes CVD as Leading Cause of Death in Wealthy Nations.
External reference
Cancer Therapeutics Market by Application (Blood Cancer, Lung Cancer, Colorectal Cancer, Prostate Cancer, Breast Cancer, Cervical Cancer, Head & Neck Cancer, Glioblastoma, Malignant Meningioma, Mesothelioma, Melanoma, and Others) and Top Selling Drugs (Revlimid, Avastin, Herceptin, Rituxan, Opdivo, Gleevec, Velcade, Imbruvica, Ibrance, Zytiga, Alimta, Xtandi, Tarceva, Perjeta, Temodar, and Others): Global Opportunity Analysis and Industry Forecast, 2019 – 2026.
External reference
Global Cancer Therapeutics Market: Emphasis on Recurrent and Metastatic Divisions.
External reference
Global Cancer Therapeutics Market: Emphasis on Recurrent and Metastatic Divisions.
External reference
Global Cancer Therapeutics Market Size By Application, By End User, By Geographic Scope and Forecast.
External reference
Cancer Diagnostics Market Worth $249.6 Billion By 2026 CAGR: 7.0%.
External reference
Cancer Diagnostics Market by Technology (ELISA, ELFA, PCR, NGS, Immunohistochemistry, Microarray, Imaging (MRI, CT, PET, Ultrasound, Mammography), Biopsy), Application (Breast Cancer, Lung Cancer, Colorectal Cancer, Melanoma) - Forecast to 2020.
External reference
Cancer Diagnostics Market - Growth, Trends, and Forecasts (2020 - 2025).
External reference
Cancer Diagnostics Market Size By Application (Tumor Biomarkers Tests, Imaging {Ultrasound and Radiology, Mammography, MRI Scan, PET Scan, CT Scan, SPECT & Others}, Biopsy, Liquid Biopsy, Immunohistochemistry, In Situ Hybridization), By Cancer Type (Bladder Cancer, Breast Cancer, Colon and Rectal Cancer, Endometrial Cancer, Kidney Cancer, Leukemia, Liver-Lung Cancer, Melanoma, Non-Hodgkin Lymphoma, Pancreatic Cancer, Prostate Cancer, Thyroid Cancer), By End-use (Hospitals, Diagnostic Laboratories, Diagnostic Imaging Centers, Cancer Research Institutes), Industry Analysis Report, Regional Outlook, Application Potential, Price Trends, Competitive Market Share & Forecast, 2020 – 2026.
External reference
Global Personalized Medicine Market – Types, Technologies and Applications.
External reference
Personalized Medicine, Targeted Therapeutics and Companion Diagnostic Market to 2025 - Strategic Analysis of Industry Trends, Technologies, Participants, and Environment.
External reference
Companion Diagnostics - Global Market Trajectory & Analytics.
External reference
A marriage of tumor slices and microfluidics.
External reference
A microfluidic device for exposing tumor biopsy tissue to multiple drugs.
2012 · External reference
Parallel microfluidic chemosensitivity testing on individual slice cultures.
10.1039/c4lc00642a · 2014 · External reference
Microfluidic transwell inserts for generation of tissue culture-friendly gradients in well plates.
10.1039/c3lc51052b · 2014 · External reference
BaroFuse, a novel pressure-driven, adjustable-throughput perfusion system for tissue maintenance and assessment.
10.1016/j.heliyon.2016.e00210 · 2016 · External reference
Microfluidic assay apparatus and methods of use
2014 · External reference
OncoFluidics
External reference
Plant-based and Cultured Meat 2020-2030.
External reference
Organ-on-A-chip devices advance to market.
10.1039/c6lc01554a · 2017 · External reference
Hybrid business models for ‘Organ-on-a-Chip’ technology: The best of both worlds.
10.1016/j.phanu.2018.02.001 · 2018 · External reference
Organovo
External reference
Organovo exploring strategic alternatives and implementing restructuring plan
External reference
Organovo Holdings
External reference
Organovo & Merck Enter Multi-year Research Partnership for 3D Printed Human Tissue
External reference
L'Oreal's Plan to Start 3D Printing Human Skin
External reference
Media Coverage
External reference
Organovo Files Definitive Proxy Statement and Sends Letter to Stockholders
External reference
Organovo Announces Termination of Merger Agreement with Tarveda Therapeutics
External reference
Interoperability of microfluidic devices — Guidelines for pitch spacing dimensions and initial device classification
External reference
AIM Biotech
External reference
Products
External reference
Microfluidic platform for investigating cell-based interactions
2016 · External reference
3D Cell Culture Chip
External reference
AIM Biotech Overview
External reference
AIM Biotech 3D Organ-On-A-Chip Devices
External reference
ibidi at a Glance
External reference
New Market Reports
External reference
Live Cell Imaging Market to Reach USD 3.76 Billion By 2026
External reference
Live Cell Imaging Market - Growth, Trends, and Forecasts (2020 - 2025)
External reference
Live Cell Imaging Market worth $2.9 billion by 2023
External reference
World Live Cell Imaging Market - Opportunities and Forecast, 2020-2027
External reference
ISO 9000 Family
External reference
ISO 13485
External reference
Grants Awarded
External reference
CellASIC Corp
External reference
Synthetic control of mammalian-cell motility by engineering chemotaxis to an orthogonal bioinert chemical signal.
10.1073/pnas.1402087111 · 2014 · External reference
Arginine starvation-associated atypical cellular death involves mitochondrial dysfunction, nuclear DNA leakage, and chromatin autophagy.
10.1073/pnas.1404171111 · 2014 · External reference
NF-κB oscillations translate into functionally related patterns of gene expression.
10.7554/elife.09100 · 2016 · External reference
Applications of the CellASIC® ONIX Microfluidic Platform
External reference
Tutorials/Protocols for the CellASIC® ONIX Microfluidic Platform
External reference
CellASIC® ONIX Live Cell Analysis Customer Reviews
External reference
FDA signs collaborative agreement with CN Bio Innovations to use Organs-on-Chips to improve drug development and evaluation
External reference
CN Bio Innovations announces research collaboration with AstraZeneca to validate a new in vitro tool to predict optimised drug dosing regimens for multi-drug therapies
2020 · External reference
CN Bio Innovations announces license of worldwide rights to Hepatitis B programme from Bristol-Myers Squibb.
External reference
CN Bio Innovations announces licence of platform microfluidics technologies from Vanderbilt University.
External reference
PhysioMimix™ Human 3D Cell Culture wins Lab Innovation 2018 Award
External reference
Characterizing the Reproducibility in Using a Liver Microphysiological System for Assaying Drug Toxicity, Metabolism and Accumulation.
10.1111/cts.12969 · 2020 · External reference
Design, modeling and fabrication of a constant flow pneumatic micropump.
10.1088/0960-1317/17/5/007 · 2007 · External reference
Perfused multiwell plate for 3D liver tissue engineering.
10.1039/b913221j · 2010 · External reference
Bioreactor technologies to support liver function in vitro.
10.1016/j.addr.2014.02.011 · 2014 · External reference
Metabolite profiling and pharmacokinetic evaluation of hydrocortisone in a perfused three-dimensional human liver bioreactor.
10.1124/dmd.115.063495 · 2015 · External reference
Modeling therapeutic antibody-small molecule drug-drug interactions using a three-dimensional perfusable human liver coculture platform.
10.1124/dmd.116.071456 · 2016 · External reference
Three-dimensional perfused human in vitro model of non-alcoholic fatty liver disease.
10.3748/wjg.v23.i2.204 · 2017 · External reference
Integrated assessment of diclofenac biotransformation, pharmacokinetics, and omics-based toxicity in a three-dimensional human liver-immunocompetent coculture systems.
10.1124/dmd.116.074005 · 2017 · External reference
Quantitative assessment of population variability in hepatic drug metabolism using a perfused three-dimensional human liver microphysiological system.
10.1124/jpet.116.237495 · 2017 · External reference
3D microfluidic liver cultures as a physiological preclinical tool for hepatitis B virus infection.
10.1038/s41467-018-02969-8 · 2018 · External reference
A Microphysiological System for Studying Nonalcoholic Steatohepatitis.
10.1002/hep4.1450 · 2019 · External reference
Quantitative Systems Pharmacology Approaches Applied to Microphysiological Systems (MPS): Data Interpretation and Multi-MPS Integration.
10.1002/psp4.12010 · 2015 · External reference
Integrated Gut and Liver Microphysiological Systems for Quantitative In Vitro Pharmacokinetic Studies.
10.1208/s12248-017-0122-4 · 2017 · External reference
Establishing quasi-steady state operations of microphysiological systems (MPS) using tissue-specific metabolic dependencies.
10.1038/s41598-018-25971-y · 2018 · External reference
CN Bio Innovations raises $9 million USD (c. £6.9 million GBP).
External reference
CN Bio Innovations raises $9 million USD (c. £6.9 million GBP).
External reference
Women In Innovation: Developing 'Organs-On-Chips'.
External reference
BBC World Service.
External reference
Liver on a Chip.
External reference
Discovery Channel, Developmental Biology.
External reference
About Us.
External reference
Emulate.
External reference
Donald Ingber.
External reference
Reconstituting Organ-Level Lung Functions on a Chip.
10.1126/science.1188302 · 2010 · External reference
Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment.
10.1039/c3ib40049b · 2013 · External reference
Bone-chip system to monitor osteogenic differentiation using optical imaging.
10.1007/s10404-019-2261-7 · 2019 · External reference
Bone marrow-on-a-chip replicates hematopoietic niche physiology in vitro.
10.1038/nmeth.2938 · 2014 · External reference
Microfabrication of human organs-on-chips.
10.1038/nprot.2013.137 · 2013 · External reference
Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow.
10.1039/c2lc40074j · 2012 · External reference
Enhanced Utilization of Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids Using Microengineered Chips.
10.1016/j.jcmgh.2017.12.008 · 2017 · External reference
Human gut-on-a-chip supports polarized infection of coxsackie B1 virus in vitro.
10.1371/journal.pone.0169412 · 2017 · External reference
Assessment of whole blood thrombosis in a microfluidic device lined by fixed human endothelium.
10.1007/s10544-016-0095-6 · 2016 · External reference
Primary Human Lung Alveolus-on-a-chip Model of Intravascular Thrombosis for Assessment of Therapeutics.
10.1002/cpt.742 · 2018 · External reference
A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice.
10.1126/scitranslmed.3004249 · 2012 · External reference
Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro.
10.1038/nmeth.3697 · 2016 · External reference
Optimizing drug discovery by investigative toxicology: Current and future trends.
10.14573/altex.1808181 · 2019 · External reference
Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery.
10.1146/annurev-pharmtox-010617-052722 · 2018 · External reference
Emulate, Inc. and INTENZE Products, Inc. Announce Collaboration to Use Organ-Chips to Study Tattoo Ink Safety Risks.
External reference
FDA to Use Emulate's Organ-on-a-Chip Technology for Toxicology Testing.
External reference
FDA Signs Collaborative Agreement with Emulate, Inc. to Use Organs-on-Chips Technology as a Toxicology Testing Platform for Understanding How Products Affect Human Health and Safety.
External reference
Miniature liver on a chip could boost US food safety.
External reference
Emulate Announces Strategic Collaboration with Johnson & Johnson Innovation to Use Organs-on-Chips Platform to Better Predict Human Response in Drug Development Process.
External reference
New Data from Emulate’s Asthma-on-Chip Presented at American Thoracic Society Annual Meeting.
External reference
Emulate Announces Expanded Collaboration with Merck to Use Organ-Chips in Drug Discovery and Development Process for Inflammatory Diseases.
External reference
Emulate, Inc. Awarded Michael J. Fox Foundation Grant to use Organs-on-Chips to Investigate Drug Candidates for Treatment of Parkinson’s Disease.
External reference
SpaceX Dragon Heads to Space Station with NASA Science, Cargo.
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Emulate, Inc. Appoints Jim Corbett as Chief Executive Officer and Martin Madaus, PhD, as Executive Chairman.
External reference
The Design and Fabrication of Three-Chamber Microscale Cell Culture Analog Devices with Integrated Dissolved Oxygen Sensors.
10.1021/bp034077d · 2004 · External reference
Incorporation of 3T3-L1 cells to mimic bioaccumulation in a microscale cell culture analog device for toxicity studies.
10.1021/bp034238d · 2004 · External reference
Hurel.
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A dynamic in vivo surrogate assay platform for cell-based studies.
2004 · External reference
Hurel.
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Which models to use in Early Toxicology Assessment to detect Human Hepatotoxic Drugs?
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Long-term hepatitis B infection in a scalable hepatic co-culture system.
10.1038/s41467-017-00200-8 · 2017 · External reference
Persistent hepatitis B viral infection in a novel, scalable primary hepatocyte co-culture system.
2017 · External reference
Development of a Microscale Cell Culture Analog to Probe Naphthalene Toxicity.
10.1021/bp0341996 · 2004 · External reference
Real-time fluorescence detection of multiple microscale cell culture analog devices in situ.
10.1002/cyto.a.20427 · 2007 · External reference
Oxygen-mediated enhancement of primary hepatocyte metabolism, functional polarization, gene expression, and drug clearance.
10.1073/pnas.0906820106 · 2009 · External reference
Evaluation of a microfluidic based cell culture platform with primary human hepatocytes for the prediction of hepatic clearance in human.
10.1016/j.bcp.2009.05.013 · 2009 · External reference
A novel system for evaluation of drug mixtures for potential efficacy in treating multidrug resistant cancers.
10.1002/bit.22219 · 2009 · External reference
A microfluidic hepatic coculture platform for cell-based drug metabolism studies.
10.1016/j.bcp.2009.11.010 · 2010 · External reference
Assessment of a Micropatterned Hepatocyte Coculture System to Generate Major Human Excretory and Circulating Drug Metabolites.
10.1124/dmd.110.034876 · 2010 · External reference
Evaluation of the relevance of DILI predictive hypotheses in early drug development: Review of In vitro methodologies vs BDDCS classification.
10.1039/c8tx00016f · 2018 · External reference
Determination of human hepatocyte intrinsic clearance for slowly metabolized compounds: Comparison of a primary hepatocyte/stromal cell co-culture with plated primary hepatocytes and hepaRG.
10.1124/dmd.115.067769 · 2016 · External reference
Hurel Corporation And Johnson and Johnson Pharmaceutical R&D Enter Into Joint Scientific Collaboration.
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J&JPRD and Hurel enter scientific collaboration.
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Products.
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ACEA Biosciences and Hurel Corporation Announce Joint Marketing of Integrated Product Kits.
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Hurel announces partnership with Cyprotex.
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Optivia Biotechnology Forms Technology and Marketing Alliance with Hurel Corporation.
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Hurel and Sanofi enter cell-based R&D Collaboration.
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HµREL humanPool: Combining the phenotypic breadth of pooled primary hepatocytes with the stable, long-enduring cellular competency of HµREL co-culture technology.
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HUB Organoids.
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Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform.
10.1038/s41598-017-08879-x · 2017 · External reference
Development of a 3D tissue slice culture model for the study of human endometrial repair and regeneration.
10.3390/biom10010136 · 2020 · External reference
3D microfluidic Ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade.
10.1039/c8lc00322j · 2018 · External reference
Patient-derived organoid models help define personalized management of gastrointestinal cancer.
10.1002/bjs.10726 · 2018 · External reference
Method of preparing cells for 3D tissue culture.
2015 · External reference
Hanging drop plate.
2010 · External reference
A High-Throughput-Compatible 3D Microtissue Co-Culture System for Phenotypic RNAi Screening Applications.
10.1177/1087057113499071 · 2013 · External reference
Development of an Innovative 3D Cell Culture System to Study Tumour--Stroma Interactions in Non-Small Cell Lung Cancer Cells.
10.1371/journal.pone.0092511 · 2014 · External reference
The importance of inter-individual Kupffer cell variability in the governance of hepatic toxicity in a 3D primary human liver microtissue model.
10.1038/s41598-019-43870-8 · 2019 · External reference
Development and validation of an in vitro 3D model of NASH with severe fibrotic phenotype.
2019 · External reference
InSphero Announces Collaboration with NIH National Center for Advancing Translational Sciences (NCATS).
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NIH/NCATS and InSphero Host Inaugural 3D Tumor Model Standards Working Group at AACR 2017.
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Comprehensive Study by AstraZeneca and Genentech Confirms Superiority of InSphero Human Liver Microtissues for Prediction of Drug-Induced Liver Injury.
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InSphero’s CEO Jan Lichtenberg wins Entrepreneur Of The Year™ 2015.
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InSphero Scientist Receives 3Rs ward for Microtissue-based Body on a Chip System.
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Protea Biosciences and InSphero AG Enter into Collaboration and Co-marketing Agreement to Combine 3D Technologies.
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InSphero Partners with ALPCO to Advance Diabetes Research.
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InSphero Receives Additional USD 10m for Organ-on-a-Chip Disease Models.
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InSphero Announces Agreement with Pfizer to Develop Novel Assays for Predicting Drug-induced Liver Injury.
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AstraZeneca Relies on 3D Insight™ Human Islet Microtissues in Pancreatic Beta-cell Study.
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InSphero Certified for ISO 9001:2015.
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Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury.
10.1007/s00204-017-2002-1 · 2017 · External reference
Transcriptomic, Proteomic, and Functional Long-Term Characterization of Multicellular Three-Dimensional Human Liver Microtissues.
10.1089/aivt.2017.0022 · 2018 · External reference
Evaluation of assays for drug efficacy in a three-dimensional model of the lung.
10.1007/s00432-016-2198-0 · 2016 · External reference
Adding the 'heart’ to hanging drop networks for microphysiological multi-tissue experiments.
10.1039/c5lc01000d · 2015 · External reference
Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model.
10.1038/s41598-017-14815-w · 2017 · External reference
Microphysiological Systems: Engineered for Biological InSIght.
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Phaseguides: A paradigm shift in microfluidic priming and emptying.
10.1039/c0lc00643b · 2011 · External reference
Phaseguide patterns for liquid manipulation.
2010 · External reference
Phaseguide patterns for liquid manipulation.
2011 · External reference
1.6 million USD pharma funding for kidney-on-a-chip nephrotoxicity model.
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Pharma-supported pilot towards neurotox model.
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MIMETAS and Galapagos to develop human disease models on-a-chip.
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In Nature Communications: gut-on-a-chip in high throughput leak-tight intestinal tubules to study toxicology, transport, and disease.
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Molecular Devices and MIMETAS sign co-marketing agreement.
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Barrier function measurements.
2017 · External reference
Development of a gut-on-a-chip model for high throughput disease modeling and drug discovery.
10.3390/ijms20225661 · 2019 · External reference
Meet us.
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MIMETAS And Hubrecht Organoid Technologies Partner To Market Organoids-On-A-Chip.
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Snake Venom Gland Organoids.
10.1016/j.cell.2019.11.038 · 2020 · External reference
A glomerulus-on-a-chip to recapitulate the human glomerular filtration barrier.
10.1038/s41467-019-11577-z · 2019 · External reference
Membrane-free culture and real-time barrier integrity assessment of perfused intestinal epithelium tubes.
10.1038/s41467-017-00259-3 · 2017 · External reference
Screening of Drug-Transporter Interactions in a 3D Microfluidic Renal Proximal Tubule on a Chip.
10.1208/s12248-018-0247-0 · 2018 · External reference
Combining Extracellular miRNA Determination with Microfluidic 3D Cell Cultures for the Assessment of Nephrotoxicity: a Proof of Concept Study.
10.1208/s12248-018-0245-2 · 2018 · External reference
Flow stimulates drug transport in a human kidney proximal tubule-on-a-chip independent of primary cilia.
10.1016/j.bbagen.2019.129433 · 2020 · External reference
Nephrotoxicity and Kidney Transport Assessment on 3D Perfused Proximal Tubules.
10.1208/s12248-018-0248-z · 2018 · External reference
On-chip three-dimensional cell culture in phaseguides improves hepatocyte functions in vitro.
10.1063/1.4922863 · 2015 · External reference
3D Cultures of Parkinson’s Disease-Specific Dopaminergic Neurons for High Content Phenotyping and Drug Testing.
10.1002/advs.201800927 · 2018 · External reference
High-throughput compound evaluation on 3D networks of neurons and glia in a microfluidic platform.
10.1038/srep38856 · 2016 · External reference
Three-dimensional (3D) tetra-culture brain on chip platform for organophosphate toxicity screening.
10.1038/s41598-018-20876-2 · 2018 · External reference
A perfused human blood-brain barrier on-a-chip for high-throughput assessment of barrier function and antibody transport.
10.1186/s12987-018-0108-3 · 2018 · External reference
3D human microvessel-on-a-chip model for studying monocyte-to-endothelium adhesion under flow - application in systems toxicology.
10.14573/altex.1811301 · 2020 · External reference
Acoustic Characterization of a Vessel-on-a-Chip Microfluidic System for Ultrasound-Mediated Drug Delivery.
10.1109/tuffc.2018.2803137 · 2018 · External reference
96 perfusable blood vessels to study vascular permeability in vitro.
10.1038/s41598-017-14716-y · 2017 · External reference
Therapy response testing of breast cancer in a 3D high-throughput perfused microfluidic platform.
10.1186/s12885-017-3709-3 · 2017 · External reference
Interstitial flow recapitulates gemcitabine chemoresistance in a 3D microfluidic pancreatic ductal adenocarcinoma model by induction of multidrug resistance proteins.
10.3390/ijms20184647 · 2019 · External reference
MIMETAS Opens New Laboratory Facilities and Offices in the USA.
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Jos Joore: "Personalized Medicine - Going for the Sure Cure" | TEDxBinnenhof 2016.
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Channeling chip power: Tissue chips are being put to the test by industry.
10.1038/nm0217-138 · 2017 · External reference
OrganoPlate®.
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MIMETAS: High-throughput 3D perfused tissue models.
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Y and Z Generations at Workplaces.
10.7441/joc.2016.03.06 · 2016 · External reference
Generational differences in workplace behavior.
10.1111/jasp.12208 · 2014 · External reference
Different Generations’ Attitudes Towards Work and Management in the Business Organizations.
2017 · External reference
Pioneer Advantage: Marketing Logic or Marketing Legend?
10.2307/3172825 · 1993 · External reference
First-mover advantages from pioneering new markets: A Survey of Empirical Evidence.
10.1007/bf01024216 · 1994 · External reference
Pioneer-Migrator-Settler (PMS) Map.
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Excavating The Video-Game Industry’s Past.
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Down Many Times, but Still Playing the Game.
2006 · External reference
Company Information.
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What is search engine optimization: SEO?
10.1016/j.sbspro.2010.12.185 · 2010 · External reference
Understanding Search-Engine Optimization.
10.1109/mc.2015.297 · 2015 · External reference
External Communication Strategy 2020.
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Communication tips for ERC grantees.
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Social Media & Outreach.
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Use of social media to enhance the impact of published papers.
2018 · External reference
Announcing PETA’s 2014 Company of the Year.
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Hurel Wins Proggy for Groundbreaking Non-Animal Testing Method.
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Hurel Receives Funding From The Humane Society.
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Evolution of coopetition in a cluster: the case of Waipara in the wine sector.
10.1080/08276331.2013.822144 · 2013 · External reference
Expanding the networks of disadvantaged entrepreneurs.
2015 · External reference
Hepatocellular Carcinoma.
10.15586/hepatocellularcarcinoma.2019 · 2019 · External reference
Comprehensive Evaluation of Organotypic and Microphysiological Liver Models for Prediction of Drug-Induced Liver Injury.
10.3389/fphar.2019.01093 · 2019 · External reference
Theranos Case Study: What Went Wrong?
2019 · External reference
The Theranos saga and the consequences.
10.1515/cclm-2018-0392 · 2018 · External reference
SEC v Holmes et al. [legal document].
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5 Top Emerging Organ-on-a-Chip (OOC) Startups Impacting The Pharma Sector.
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Global Cell Therapy Technologies Market 2021 Size, Development Status, Type and Application, Segmentation, Forecast 2030.
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