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References from The translational roadmap of the gut models, focusing on gut-on-chip. Local targets link to admitted publications; unresolved targets remain external evidence.
Fundamentals of neurogastroenterology: Basic science.
10.1053/j.gastro.2016.02.018 · 2016 · External reference
Time-of-Day-Dependent Physiological Responses to Meal and Exercise.
10.3389/fnut.2020.00018 · 2020 · External reference
“Gut health”: A new objective in medicine?
10.1186/1741-7015-9-24 · 2011 · External reference
Antibiotics as deep modulators of gut microbiota: Between good and evil.
10.1136/gutjnl-2016-312297 · 2016 · External reference
Probiotics in the gastrointestinal diseases of the elderly.
10.1007/s12603-011-0357-1 · 2012 · External reference
Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017.
10.1016/s0140-6736(18)32203-7 · 2018 · External reference
Health effects of dietary risks in 195 countries, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017.
10.1016/s0140-6736(19)30041-8 · 2019 · External reference
Global burden of 87 risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019.
10.1016/s0140-6736(20)30752-2 · 2020 · External reference
Metabolic syndrome and gastrointestinal diseases.
10.1007/s00535-007-2033-0 · 2007 · External reference
Gastrointestinal disorders and metabolic syndrome: Dysbiosis as a key link and common bioactive dietary components useful for their treatment.
10.3390/ijms21144929 · 2020 · External reference
Colon In Vivo Inner & Outer Mucus Layer Colon Chip Mucus Layer Swelling Mucus Layer Colon Organoids.
2019 · External reference
NutriChip: Nutrition analysis meets microfluidics.
10.1039/c2lc40845g · 2013 · External reference
Development of a gut-on-a-chip model for high throughput disease modeling and drug discovery.
10.3390/ijms20225661 · 2019 · External reference
Colorectal tumor-on-a-chip system: A 3D tool for precision onco-nanomedicine.
10.1126/sciadv.aaw1317 · 2019 · External reference
Microfluidic chip for culturing intestinal epithelial cell layers: Characterization and comparison of drug transport between dynamic and static models.
10.1016/j.tiv.2020.104815 · 2020 · External reference
Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids.
10.1038/s41598-018-21201-7 · 2018 · External reference
A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip.
10.1038/s41551-019-0397-0 · 2019 · External reference
A microfluidics-based in vitro model of the gastrointestinal human-microbe interface.
10.1038/ncomms11535 · 2016 · External reference
A robust longitudinal co-culture of obligate anaerobic gut microbiome with human intestinal epithelium in an anoxic-oxic interface-on-a-chip.
10.3389/fbioe.2019.00013 · 2019 · External reference
The Current Status of Drug Discovery and Development as Originated in United States Academia: The Influence of Industrial and Academic Collaboration on Drug Discovery and Development.
10.1111/cts.12577 · 2018 · External reference
Computational Modeling of Gastrointestinal Fluid Dynamics
10.1007/978-94-007-6561-0_13 · 2013 · External reference
Model intestinal microflora in computer simulation: A simulation and modeling package for host-microflora interactions.
10.1109/tbme.2002.803548 · 2002 · External reference
Mathematical modeling of transport and degradation of feedstuffs in the small intestine.
10.1016/j.jtbi.2011.10.024 · 2012 · External reference
A stochastic agent-based model of the SARS-CoV-2 epidemic in France.
10.1038/s41591-020-1001-6 · 2020 · External reference
Agent based modeling of human gut microbiome interactions and perturbations.
10.1371/journal.pone.0148386 · 2016 · External reference
In silico trials of food digestion and absorption: how far are we?
10.1016/j.cofs.2020.04.006 · 2020 · External reference
Models of the Gut for Analyzing the Impact of Food and Drugs.
10.1002/adhm.201900968 · 2019 · External reference
Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers.
10.1038/nprot.2007.303 · 2007 · External reference
Advances and Current Challenges in Intestinal in vitro Model Engineering: A Digest.
10.3389/fbioe.2019.00144 · 2019 · External reference
The Simulator of the Human Intestinal Microbial Ecosystem (SHIME®)
10.1007/978-3-319-16104-4_27 · 2015 · External reference
CoMiniGut-A small volume in vitro colon model for the screening of gut microbial fermentation processes.
10.7717/peerj.4268 · 2018 · External reference
Using bioreactors to study the effects of drugs on the human microbiota.
10.1016/j.ymeth.2018.08.003 · 2018 · External reference
A multi-chamber microfluidic intestinal barrier model using Caco-2 cells for drug transport studies.
10.1371/journal.pone.0197101 · 2018 · External reference
A systematic investigation of the effect of the fluid shear stress on Caco-2 cells towards the optimization of epithelial organ-on-chip models.
10.1016/j.biomaterials.2019.119521 · 2019 · External reference
Transcriptome comparisons of in vitro intestinal epithelia grown under static and microfluidic gut-on-chip conditions with in vivo human epithelia.
10.1038/s41598-021-82853-6 · 2021 · External reference
Long-term flow through human intestinal organoids with the gut organoid flow chip (GOFlowChip).
10.1039/c9lc00653b · 2019 · External reference
A microfluidic chip based model for the study of full thickness human intestinal tissue using dual flow.
10.1063/1.4964813 · 2016 · External reference
Intestinal enteroids/organoids: A novel platform for drug discovery in inflammatory bowel diseases.
10.3748/wjg.v25.i30.4125 · 2019 · External reference
Human Colon-on-a-Chip Enables Continuous In Vitro Analysis of Colon Mucus Layer Accumulation and Physiology.
10.1016/j.jcmgh.2019.11.008 · 2020 · External reference
Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites.
10.1186/s40168-019-0650-5 · 2019 · External reference
Human iPSC-Derived Endothelial Cells and Microengineered Organ-Chip Enhance Neuronal Development.
10.1016/j.stemcr.2018.02.012 · 2018 · External reference
An interphase microfluidic culture system for the study of ex vivo intestinal tissue.
10.3390/mi11020150 · 2020 · External reference
An Intestinal Organ Culture System Uncovers a Role for the Nervous System in Microbe-Immune Crosstalk.
10.1016/j.cell.2017.02.009 · 2017 · External reference
Integrated In Vitro and In Silico Modeling Delineates the Molecular Effects of a Synbiotic Regimen on Colorectal-Cancer-Derived Cells.
10.1016/j.celrep.2019.04.001 · 2019 · External reference
Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation.
10.1039/c3ib40126j · 2013 · External reference
Three-Dimensional Regeneration of Patient-Derived Intestinal Organoid Epithelium in a Physiodynamic Mucosal Interface-on-a-Chip.
10.3390/mi11070663 · 2020 · External reference
An integrated microfluidic system for long-term perfusion culture and on-line monitoring of intestinal tissue models.
10.1039/b717091b · 2008 · External reference
A novel dual-flow bioreactor simulates increased fluorescein permeability in epithelial tissue barriers.
10.1002/biot.201400004 · 2014 · External reference
A three-dimensional immunocompetent intestine-on-chip model as in vitro platform for functional and microbial interaction studies.
10.1016/j.biomaterials.2019.119396 · 2019 · External reference
Membrane-free culture and real-time barrier integrity assessment of perfused intestinal epithelium tubes.
10.1038/s41467-017-00259-3 · 2017 · External reference
Provisional classification and in silico study of biopharmaceutical system based on Caco-2 cell permeability and dose number.
10.1021/mp4000585 · 2013 · External reference
Prediction of solubility and permeability class membership: provisional BCS classification of the world's top oral drugs.
10.1208/s12248-009-9144-x · 2009 · External reference
Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow.
10.1039/c2lc40074j · 2012 · External reference
Bacteria and fungi respond differently to multifactorial climate change in a temperate heathland, traced with 13C-glycine and FACE CO2.
10.1371/journal.pone.0085070 · 2014 · External reference
Materials for microfluidic chip fabrication.
10.1021/ar300314s · 2013 · External reference
Organ-on-A-chip devices advance to market.
10.1039/c6lc01554a · 2017 · External reference
The origins and the future of microfluidics.
10.1038/nature05058 · 2006 · External reference
Soft lithography for micro- and nanoscale patterning.
10.1038/nprot.2009.234 · 2010 · External reference
Thin and large free-standing PDMS membrane by using polystyrene Petri dish.
10.1007/s13206-012-6211-7 · 2012 · External reference
On chip porous polymer membranes for integration of gastrointestinal tract epithelium with microfluidic 'body-on-a-chip' devices.
10.1007/s10544-012-9669-0 · 2012 · External reference
A pumpless body-on-a-chip model using a primary culture of human intestinal cells and a 3D culture of liver cells.
10.1039/c8lc00111a · 2018 · External reference
Extrusion printing of ionic-covalent entanglement hydrogels with high toughness.
10.1039/c3tb21159b · 2013 · External reference
3D Printing of Highly Stretchable and Tough Hydrogels into Complex, Cellularized Structures.
10.1002/adma.201501099 · 2015 · External reference
Photocrosslinkable hyaluronan-gelatin hydrogels for two-step bioprinting.
10.1089/ten.tea.2009.0798 · 2010 · External reference
World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects.
10.1001/jama.2013.281053 · 2013 · External reference
Beyond the 3Rs: Expanding the use of human-relevant replacement methods in biomedical research.
10.14573/altex.1907031 · 2019 · External reference
The Human Microbiome Project: A Community Resource for the Healthy Human Microbiome.
10.1371/journal.pbio.1001377 · 2012 · External reference
Mouse microbiota models: Comparing germ-free mice and antibiotics treatment as tools for modifying gut bacteria.
10.3389/fphys.2018.01534 · 2018 · External reference
10.12688/openreseurope.13335.1 · 2021 · Admitted local publication
Microfluidic platforms for mechanobiology.
10.1039/c3lc41393d · 2013 · External reference
