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References from Lhx3/4 initiates a cardiopharyngeal-specific transcriptional program in response to widespread FGF signaling. Local targets link to admitted publications; unresolved targets remain external evidence.
Gene regulatory networks for development
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Modularity and design principles in the sea urchin embryo gene regulatory network
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Global regulatory logic for specification of an embryonic cell lineage
10.1073/pnas.0711220105 · 2008 · External reference
Structure and function of the feed-forward loop network motif
10.1073/pnas.2133841100 · 2003 · External reference
Genomic control of patterning
10.1387/ijdb.072495ip · 2009 · External reference
Assessing regulatory information in developmental gene regulatory networks
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Unresolved reference
2015 · External reference
Signaling in cell differentiation and morphogenesis
10.1101/cshperspect.a008151 · 2012 · External reference
Signaling mechanisms controlling cell fate and embryonic patterning
10.1101/cshperspect.a005975 · 2012 · External reference
Editorial: Signaling Pathways in Embryonic Development.
10.3389/fcell.2017.00076 · 2017 · External reference
Neural tissue in ascidian embryos is induced by FGF9/16/20, acting via a combination of maternal GATA and Ets transcription factors
10.1016/s0092-8674(03)00928-0 · 2003 · External reference
An Ets transcription factor, HrEts, is target of FGF signaling and involved in induction of notochord, mesenchyme, and brain in ascidian embryos
10.1016/s0012-1606(03)00246-x · 2003 · External reference
The ETS-domain transcription factor family
10.1016/s1357-2725(97)00086-1 · 1997 · External reference
Genomic and biochemical insights into the specificity of ETS transcription factors
10.1146/annurev.biochem.79.081507.103945 · 2011 · External reference
Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration
10.1016/j.cell.2011.09.044 · 2011 · External reference
Towards an understanding of cell-specific functions of signal-dependent transcription factors
10.1530/jme-13-0216 · 2013 · External reference
The Ets family of proteins: weak modulators of gene expression in quest for transcriptional partners
1994 · External reference
Regulation of Ets function by protein—protein interactions
10.1038/sj.onc.1204035 · 2000 · External reference
When Ets transcription factors meet their partners
10.1002/bies.10068 · 2002 · External reference
Field identification of ’types’ A and B of the ascidian in a region of sympatry.
10.1007/s00227-012-1898-5 · 2012 · External reference
Morphological evidence that the molecularly determined type A and type B are different species: and
10.1111/jzs.12101 · 2015 · External reference
Tunicates and not cephalochordates are the closest living relatives of vertebrates
10.1038/nature04336 · 2006 · External reference
The draft genome of Ciona intestinalis: insights into chordate and vertebrate origins
10.1126/science.1080049 · 2002 · External reference
Heart genetics in a small package, exploiting the condensed genome of Ciona intestinalis.
10.1093/bfgp/elt034 · 2014 · External reference
Ciona as a Simple Chordate Model for Heart Development and Regeneration.
2016 · External reference
The ascidian Mesp gene specifies heart precursor cells
10.1242/dev.01145 · 2004 · External reference
Spatio-temporal intersection of Lhx3 and Tbx6 defines the cardiac field through synergistic activation of Mesp
10.1016/j.ydbio.2009.01.033 · 2009 · External reference
Uncoupling heart cell specification and migration in the simple chordate Ciona intestinalis
10.1242/dev.02051 · 2005 · External reference
FGF signaling delineates the cardiac progenitor field in the simple chordate, Ciona intestinalis
10.1101/gad.1467706 · 2006 · External reference
The transcription/migration interface in heart precursors of Ciona intestinalis
10.1126/science.1158170 · 2008 · External reference
Cytoskeletal polarity mediates localized induction of the heart progenitor lineage
10.1038/ncb2291 · 2011 · External reference
Initial deployment of the cardiogenic gene regulatory network in the basal chordate, Ciona intestinalis
10.1016/j.ydbio.2012.05.002 · 2012 · External reference
FoxF is essential for FGF-induced migration of heart progenitor cells in the ascidian Ciona intestinalis
10.1242/dev.010140 · 2007 · External reference
Surrounding tissues canalize motile cardiopharyngeal progenitors towards collective polarity and directed migration
2015 · External reference
Evolutionary origins of the vertebrate heart: Specification of the cardiac lineage in Ciona intestinalis
10.1073/pnas.1634991100 · 2003 · External reference
Collier/OLF/EBF-dependent transcriptional dynamics control pharyngeal muscle specification from primed cardiopharyngeal progenitors
10.1016/j.devcel.2014.04.001 · 2014 · External reference
Regulation and evolution of cardiopharyngeal cell identity and behavior: insights from simple chordates
10.1016/j.gde.2015.02.008 · 2015 · External reference
Early chordate origins of the vertebrate second heart field
10.1126/science.1190181 · 2010 · External reference
Ascidians and the plasticity of the chordate developmental program
10.1016/j.cub.2008.05.039 · 2008 · External reference
Sequential and combinatorial inputs from Nodal, Delta2/Notch and FGF/MEK/ERK signalling pathways establish a grid-like organisation of distinct cell identities in the ascidian neural plate
10.1242/dev.002352 · 2007 · External reference
Diverse ETS transcription factors mediate FGF signaling in the Ciona anterior neural plate
10.1016/j.ydbio.2014.12.032 · 2015 · External reference
An FGF-driven feed-forward circuit patterns the cardiopharyngeal mesoderm in space and time.
10.7554/elife.29656 · 2018 · External reference
Direct activation by Ets and Zic is required for initial expression of the Brachyury gene in the ascidian notochord
10.1016/j.ydbio.2007.03.034 · 2007 · External reference
A combinatorial code of maternal GATA, Ets and β-catenin-TCF transcription factors specifies and patterns the early ascidian ectoderm
10.1242/dev.010850 · 2007 · External reference
Induction of anterior neural fates in the ascidian Ciona intestinalis
10.1016/s0925-4773(00)00528-1 · 2001 · External reference
The Sequence Specificity of Homeodomain-DNA Interaction
10.1016/0092-8674(88)90123-7 · 1988 · External reference
Divergent homeo box proteins recognize similar DNA sequences in Drosophila
10.1038/332858a0 · 1988 · External reference
A genomewide survey of developmentally relevant genes in Ciona intestinalis. II. Genes for homeobox transcription factors
10.1007/s00427-003-0321-0 · 2003 · External reference
Tissue-specific genome editing in Ciona embryos by CRISPR/Cas9
10.1242/dev.114488 · 2014 · External reference
A Manually Curated Gene Model Set for an Ascidian, Ciona robusta (Ciona intestinalis Type A).
10.2108/zs210102 · 2022 · External reference
Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences
10.1016/j.cell.2008.05.024 · 2008 · External reference
DNA-binding specificities of human transcription factors
10.1016/j.cell.2012.12.009 · 2013 · External reference
High-Throughput Protein Production Combined with High- Throughput SELEX Identifies an Extensive Atlas of Ciona robusta Transcription Factor DNA-Binding Specificities
10.1007/978-1-4939-9624-7_23 · 2019 · External reference
Spatial and temporal expression of two transcriptional isoforms of Lhx3, a LIM class homeobox gene, during embryogenesis of two phylogenetically remote ascidians, Halocynthia roretzi and Ciona intestinalis
10.1016/j.gep.2010.01.004 · 2010 · External reference
Gene expression profiles of transcription factors and signaling molecules in the ascidian embryo: towards a comprehensive understanding of gene networks
10.1242/dev.01270 · 2004 · External reference
Characterization of a notochord-specific enhancer from the Brachyury promoter region of the ascidian, Ciona intestinalis
10.1242/dev.124.3.589 · 1997 · External reference
Predictable mosaic transgene expression in ascidian embryos produced with a simple electroporation device.
10.1002/dvdy.20815 · 2006 · External reference
Development of Ciona intestinalis juveniles (through 2nd ascidian stage).
10.2108/zsj.21.285 · 2004 · External reference
Tfap2 and Sox1/2/3 cooperatively specify ectodermal fates in ascidian embryos
2017 · External reference
Identification of a novel inhibitor of mitogen-activated protein kinase kinase
10.1074/jbc.273.29.18623 · 1998 · External reference
Role of the FGF and MEK signaling pathway in the ascidian embryo
10.1046/j.1440-169x.2001.00594.x · 2001 · External reference
Signaling and transcriptional regulation in neural crest specification and migration: lessons from xenopus embryos
10.1002/wdev.76 · 2013 · External reference
Comprehensive single-cell transcriptome lineages of a proto-vertebrate
10.1038/s41586-019-1385-y · 2019 · External reference
Cell lineage analysis in ascidian embryos by intracellular injection of a tracer enzyme. III. Up to the tissue restricted stage
10.1016/0012-1606(87)90188-6 · 1987 · External reference
The role of pigment cells in the brain of ascidian larva
10.1002/cne.20142 · 2004 · External reference
Variable levels of drift in tunicate cardiopharyngeal gene regulatory elements
10.1186/s13227-019-0137-2 · 2019 · External reference
Combinatorial chromatin dynamics foster accurate cardiopharyngeal fate choices.
10.7554/elife.49921 · 2019 · External reference
Neuronal subtype specification in the spinal cord of a protovertebrate
10.1242/dev.061507 · 2011 · External reference
Neural tube patterning by Ephrin, FGF and Notch signaling relays
10.1242/dev.072108 · 2011 · External reference
A LIM-homeodomain combinatorial code for motor-neuron pathway selection
10.1038/16275 · 1999 · External reference
LIM factor Lhx3 contributes to the specification of motor neuron and interneuron identity through cell-type-specific protein-protein interactions
10.1016/s0092-8674(02)00823-1 · 2002 · External reference
A regulatory network to segregate the identity of neuronal subtypes
10.1016/j.devcel.2008.03.021 · 2008 · External reference
Misregulation of cell adhesion molecules in the Ciona neural tube closure mutant bugeye
10.1016/j.ydbio.2021.08.006 · 2021 · External reference
ANISEED 2017: extending the integrated ascidian database to the exploration and evolutionary comparison of genome-scale datasets
10.1093/nar/gkx1108 · 2018 · External reference
A genomewide survey of developmentally relevant genes in Ciona intestinalis. VII. Molecules involved in the regulation of cell polarity and actin dynamics
10.1007/s00427-003-0325-9 · 2003 · External reference
Onecut is a direct neural-specific transcriptional activator of Rx in Ciona intestinalis
10.1016/j.ydbio.2011.05.584 · 2011 · External reference
FGF/MAPK/Ets signaling renders pigment cell precursors competent to respond to Wnt signal by directly controlling Ci-Tcf transcription
10.1242/dev.057323 · 2011 · External reference
Transcriptional regulation of the Ciona Gsx gene in the neural plate
10.1016/j.ydbio.2018.12.013 · 2019 · External reference
Ci-POU-IV expression identifies PNS neurons in embryos and larvae of the ascidian Ciona intestinalis
10.1007/s00427-004-0444-y · 2005 · External reference
Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance
10.1083/jcb.201005060 · 2010 · External reference
GLIPR-2 overexpression in HK-2 cells promotes cell EMT and migration through ERK1/2 activation.
10.1371/journal.pone.0058574 · 2013 · External reference
Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly
10.1242/jcs.00241 · 2003 · External reference
Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation
10.1074/jbc.m202447200 · 2002 · External reference
Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling
10.1242/jcs.115.5.1059 · 2002 · External reference
A critical role for the EphA3 receptor tyrosine kinase in heart development
10.1016/j.ydbio.2006.08.058 · 2007 · External reference
Soluble THSD7A is an N-glycoprotein that promotes endothelial cell migration and tube formation in angiogenesis
10.1371/journal.pone.0029000 · 2011 · External reference
Autoantibodies against thrombospondin type 1 domain-containing 7A induce membranous nephropathy
10.1172/jci85265 · 2016 · External reference
Noise propagation with interlinked feed-forward pathways
10.1038/srep23607 · 2016 · External reference
Pharyngeal mesoderm regulatory network controls cardiac and head muscle morphogenesis
10.1073/pnas.1208690109 · 2012 · External reference
The logic of gene regulatory networks in early vertebrate forebrain patterning
10.1016/j.mod.2012.10.004 · 2013 · External reference
Gene regulatory networks in the evolution and development of the heart
10.1126/science.1132292 · 2006 · External reference
The bilaterian head patterning gene six3/6 controls aboral domain development in a cnidarian
10.1371/journal.pbio.1001488 · 2013 · External reference
FGF and canonical Wnt signaling cooperate to induce paraxial mesoderm from tailbud neuromesodermal progenitors through regulation of a two-step epithelial to mesenchymal transition
10.1242/dev.143578 · 2017 · External reference
The gene regulatory networks underlying formation of the auditory hindbrain
10.1007/s00018-014-1759-0 · 2015 · External reference
The genomic regulatory control of skeletal morphogenesis in the sea urchin
10.1242/dev.073049 · 2012 · External reference
Relative importance of composition structures and biologically meaningful logics in bipartite Boolean models of gene regulation
10.1038/s41598-022-22654-7 · 2022 · External reference
A genome-wide relay of signalling-responsive enhancers drives hematopoietic specification
10.1038/s41467-023-35910-9 · 2023 · External reference
Suboptimization of developmental enhancers
10.1126/science.aac6948 · 2015 · External reference
Diverse logics and grammar encode notochord enhancers
10.1016/j.celrep.2023.112052 · 2023 · External reference
Single-nucleotide variants within heart enhancers increase binding affinity and disrupt heart development
2023 · External reference
Alimentary tract of Kowalevskiidae (Appendicularia, Tunicata) and evolutionary implications
10.1002/jmor.10145 · 2003 · External reference
Massive Gene Loss and Function Shuffling in Appendicularians Stretch the Boundaries of Chordate Wnt Family Evolution.
10.3389/fcell.2021.700827 · 2021 · External reference
Cardiopharyngeal deconstruction and ancestral tunicate sessility
10.1038/s41586-021-04041-w · 2021 · External reference
Thaliaceans, the neglected pelagic relatives of Ascidians: a developmental and evolutionary enigma
10.1086/681440 · 2015 · External reference
Transcriptional regulation of the peripheral nervous system in Ciona intestinalis
10.1016/j.ydbio.2013.03.016 · 2013 · External reference
Gene expression profiles in Ciona intestinalis tailbud embryos
10.1242/dev.128.15.2893 · 2001 · External reference
NIH Image to ImageJ: 25 years of image analysis.
10.1038/nmeth.2089 · 2012 · External reference
Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown.
10.1038/nprot.2016.095 · 2016 · External reference
An integrated database of the ascidian, Ciona intestinalis: towards functional genomics
10.2108/zsj.22.837 · 2005 · External reference
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10.1093/bioinformatics/btu638 · 2015 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
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