Research graph
References from Cellular arrangement impacts metabolic activity and antibiotic tolerance in Pseudomonas aeruginosa biofilms. Local targets link to admitted publications; unresolved targets remain external evidence.
Gradients and consequences of heterogeneity in biofilms
10.1038/s41579-022-00692-2 · 2022 · External reference
The biogeography of infection revisited
10.1038/s41579-022-00683-3 · 2022 · External reference
Bacterial biofilms: from the natural environment to infectious diseases
10.1038/nrmicro821 · 2004 · External reference
Biofilm formation as microbial development
10.1146/annurev.micro.54.1.49 · 2000 · External reference
’Toole GA. Mechanisms of biofilm resistance to antimicrobial agents
10.1016/s0966-842x(00)01913-2 · 2001 · External reference
Bacterial biofilms: a common cause of persistent infections
10.1126/science.284.5418.1318 · 1999 · External reference
Unresolved reference
2011 · External reference
The plant vascular system: evolution, development and functions
10.1111/jipb.12041 · 2013 · External reference
Biofilms: an emergent form of bacterial life
10.1038/nrmicro.2016.94 · 2016 · External reference
Fungal biofilm architecture produces hypoxic microenvironments that drive antifungal resistance
10.1073/pnas.2003700117 · 2020 · External reference
Spatial patterns of DNA replication, protein synthesis, and oxygen concentration within bacterial biofilms reveal diverse physiological states
10.1128/jb.00107-07 · 2007 · External reference
Spatial alanine metabolism determines local growth dynamics of Escherichia coli colonies
2021 · External reference
Micron Scale Spatial Measurement of the O2 Gradient Surrounding a Bacterial Biofilm in Real Time.
10.1128/mbio.02536-20 · 2020 · External reference
Microsensor and transcriptomic signatures of oxygen depletion in biofilms associated with chronic wounds.
10.1111/wrr.12401 · 2016 · External reference
Diffusion in biofilms
10.1128/jb.185.5.1485-1491.2003 · 2003 · External reference
Microanatomy at cellular resolution and spatial order of physiological differentiation in a bacterial biofilm
10.1128/mbio.00103-13 · 2013 · External reference
’Toole GA. The developmental model of microbial biofilms: ten years of a paradigm up for review
10.1016/j.tim.2008.11.001 · 2009 · External reference
Vertical stratification of matrix production is essential for physical integrity and architecture of macrocolony biofilms of Escherichia coli: Biofilm integrity requires matrix stratification
10.1111/1462-2920.12991 · 2015 · External reference
Architectural transitions in Vibrio cholerae biofilms at single-cell resolution
10.1073/pnas.1601702113 · 2016 · External reference
Vibrio cholerae biofilm growth program and architecture revealed by single-cell live imaging
2016 · External reference
Mechanisms Underlying Vibrio cholerae Biofilm Formation and Dispersion
10.1146/annurev-micro-111021-053553 · 2022 · External reference
Shared biophysical mechanisms determine early biofilm architecture development across different bacterial species
10.1371/journal.pbio.3001846 · 2022 · External reference
The biofilm life cycle: expanding the conceptual model of biofilm formation
2022 · External reference
Evolution of the complex transcription network controlling biofilm formation in Candida species
2021 · External reference
Evidence of a possible multicellular life cycle in Escherichia coli.
10.1016/j.isci.2022.105795 · 2023 · External reference
Large-scale orientational order in bacterial colonies during inward growth.
2022 · External reference
Physiological heterogeneity in biofilms
10.1038/nrmicro1838 · 2008 · External reference
Inoculation density and nutrient level determine the formation of mushroom-shaped structures in Pseudomonas aeruginosa biofilms.
10.1038/srep32097 · 2016 · External reference
Liquid transport facilitated by channels in Bacillus subtilis biofilms
10.1073/pnas.1216376110 · 2013 · External reference
Intra-colony channels in E. coli function as a nutrient uptake system.
10.1038/s41396-020-0700-9 · 2020 · External reference
Water in bacterial biofilms: pores and channels, storage and transport functions
10.1080/1040841x.2021.1962802 · 2022 · External reference
Matrix-trapped viruses can prevent invasion of bacterial biofilms by colonizing cells.
2021 · External reference
Understanding the Complex Phage-Host Interactions in Biofilm Communities.
10.1146/annurev-virology-091919-074222 · 2021 · External reference
AccretionTrapping and Binding of Sediment in Archean Stromatolites—Morphological Expression of the Antiquity of Life.
10.1007/s11214-007-9292-1 · 2008 · External reference
Stromatolites as Biosignatures of Atmospheric Oxygenation: Carbonate Biomineralization and UV-C Resilience in a Geitlerinema sp.—Dominated Culture.
10.3389/fmicb.2020.00948 · 2020 · External reference
Extracellular matrix structure governs invasion resistance in bacterial biofilms
10.1038/ismej.2014.246 · 2015 · External reference
Bacterial predation transforms the landscape and community assembly of biofilms
10.1016/j.cub.2021.03.036 · 2021 · External reference
Antimicrobial Tolerance in Biofilms.
2015 · External reference
Nutrient Gradients Mediate Complex Colony-Level Antibiotic Responses in Structured Microbial Populations.
10.3389/fmicb.2022.740259 · 2022 · External reference
Carbon Sources Tune Antibiotic Susceptibility in Pseudomonas aeruginosa via Tricarboxylic Acid Cycle Control
10.1016/j.chembiol.2016.12.015 · 2017 · External reference
Antimicrobial Tolerance and Metabolic Adaptations in Microbial Biofilms
10.1016/j.tim.2019.05.003 · 2019 · External reference
Biofilm-related infections: bridging the gap between clinical management and fundamental aspects of recalcitrance toward antibiotics
10.1128/mmbr.00013-14 · 2014 · External reference
Microbial biofilms.
10.1146/annurev.mi.49.100195.003431 · 1995 · External reference
Pseudomonas aeruginosa biofilm infections: Community structure, antimicrobial tolerance and immune response
10.1016/j.jmb.2015.08.016 · 2015 · External reference
Model Systems to Study the Chronic, Polymicrobial Infections in Cystic Fibrosis: Current Approaches and Exploring Future Directions.
10.1128/mbio.01763-21 · 2021 · External reference
Genes involved in matrix formation in Pseudomonas aeruginosa PA14 biofilms
10.1046/j.1365-2958.2003.03877.x · 2004 · External reference
Growing and analyzing static biofilms.
2005 · External reference
Fitness of isogenic colony morphology variants of Pseudomonas aeruginosa in murine airway infection.
10.1371/journal.pone.0001685 · 2008 · External reference
Phenazines affect biofilm formation by Pseudomonas aeruginosa in similar ways at various scales
10.1016/j.resmic.2010.01.003 · 2010 · External reference
Biosynthesis of the Pseudomonas aeruginosa Extracellular Polysaccharides, Alginate, Pel, and Psl.
10.3389/fmicb.2011.00167 · 2011 · External reference
Microtiter dish biofilm formation assay.
2011 · External reference
A semi-quantitative approach to assess biofilm formation using wrinkled colony development
2012 · External reference
Electron-shuttling antibiotics structure bacterial communities by modulating cellular levels of c-di-GMP
10.1073/pnas.1700264114 · 2017 · External reference
10.1016/b978-0-12-815499-1.00055-7
10.1016/b978-0-12-815499-1.00055-7 · 2020 · External reference
Machine learning identification of Pseudomonas aeruginosa strains from colony image data.
2022 · External reference
Bacterial Multicellularity: The Biology of Escherichia coli Building Large-Scale Biofilm Communities
10.1146/annurev-micro-031921-055801 · 2021 · External reference
Spatial organization of different sigma factor activities and c-di-GMP signalling within the three-dimensional landscape of a bacterial biofilm.
10.1098/rsob.180066 · 2018 · External reference
Heterogeneity in Pseudomonas aeruginosa biofilms includes expression of ribosome hibernation factors in the antibiotic-tolerant subpopulation and hypoxia-induced stress response in the metabolically active population
10.1128/jb.00022-12 · 2012 · External reference
Redundant phenazine operons in Pseudomonas aeruginosa exhibit environment-dependent expression and differential roles in pathogenicity
10.1073/pnas.1213901109 · 2012 · External reference
Phenazine production promotes antibiotic tolerance and metabolic heterogeneity in Pseudomonas aeruginosa biofilms.
10.1038/s41467-019-08733-w · 2019 · External reference
Deletion mutant library for investigation of functional outputs of cyclic diguanylate metabolism in Pseudomonas aeruginosa PA14
10.1128/aem.00299-14 · 2014 · External reference
Facultative control of matrix production optimizes competitive fitness in Pseudomonas aeruginosa PA14 biofilm models
10.1128/aem.02628-15 · 2015 · External reference
Colony-morphology screening uncovers a role for the Pseudomonas aeruginosa nitrogen-related phosphotransferase system in biofilm formation
10.1111/mmi.13250 · 2016 · External reference
Electrochemical camera chip for simultaneous imaging of multiple metabolites in biofilms.
10.1038/ncomms10535 · 2016 · External reference
Bifunctionality of a biofilm matrix protein controlled by redox state
10.1073/pnas.1707687114 · 2017 · External reference
An orphan cbb3-type cytochrome oxidase subunit supports Pseudomonas aeruginosa biofilm growth and virulence.
2017 · External reference
Rare and localized events stabilize microbial community composition and patterns of spatial self-organization in a fluctuating environment.
10.1038/s41396-022-01189-9 · 2022 · External reference
Emergence of active nematics in chaining bacterial biofilms.
10.1038/s41467-019-10311-z · 2019 · External reference
Novel multicellular prokaryote discovered next to an underground stream.
10.7554/elife.71920 · 2022 · External reference
Microscopic cords, a virulence-related characteristic of Mycobacterium tuberculosis, are also present in nonpathogenic mycobacteria
10.1128/jb.01485-09 · 2010 · External reference
Biotropic liquid crystal phase transformations in cellulose-producing bacterial communities
10.1073/pnas.2200930119 · 2022 · External reference
Mechanical forces drive a reorientation cascade leading to biofilm self-patterning.
10.1038/s41467-021-26869-6 · 2021 · External reference
Biofilms as self-shaping growing nematics.
2023 · External reference
Paraffin Embedding and Thin Sectioning of Microbial Colony Biofilms for Microscopic Analysis.
2018 · External reference
Pseudomonas aeruginosa PA14 produces R-bodies, extendable protein polymers with roles in host colonization and virulence.
2021 · External reference
Biofilm formation at the air-liquid interface by the Pseudomonas fluorescens SBW25 wrinkly spreader requires an acetylated form of cellulose
10.1046/j.1365-2958.2003.03670.x · 2003 · External reference
Glycoside hydrolase processing of the Pel polysaccharide alters biofilm biomechanics and Pseudomonas aeruginosa virulence.
10.1038/s41522-023-00375-7 · 2023 · External reference
Scalable projected Light Sheet Microscopy for high-resolution imaging of living and cleared samples.
2023 · External reference
Stratified Growth in Pseudomonas aeruginosa Biofilms
10.1128/aem.70.10.6188-6196.2004 · 2004 · External reference
Spatial heterogeneity in biofilm metabolism elicited by local control of phenazine methylation
2023 · External reference
Phenazines Regulate Nap-Dependent Denitrification in Pseudomonas aeruginosa Biofilms
2018 · External reference
Photosensing and quorum sensing are integrated to control Pseudomonas aeruginosa collective behaviors
10.1371/journal.pbio.3000579 · 2019 · External reference
Regulation of Biofilm Exopolysaccharide Biosynthesis and Degradation in Pseudomonas aeruginosa
10.1146/annurev-micro-041320-111355 · 2022 · External reference
c-di-GMP and its Effects on Biofilm Formation and Dispersion: a Pseudomonas Aeruginosa Review.
2015 · External reference
A chemosensory system that regulates biofilm formation through modulation of cyclic diguanylate levels
10.1073/pnas.0507170102 · 2005 · External reference
The phosphodiesterase DipA (PA5017) is essential for Pseudomonas aeruginosa biofilm dispersion.
10.1128/jb.05346-11 · 2012 · External reference
Formation of pilin in Pseudomonas aeruginosa requires the alternative sigma factor (RpoN) of RNA polymerase.
10.1073/pnas.86.6.1954 · 1989 · External reference
Pseudomonas aeruginosa twitching motility: type IV pili in action
10.1146/annurev-micro-092611-150055 · 2012 · External reference
Functional conservation of the polysaccharide biosynthetic protein WbpM and its homologues in Pseudomonas aeruginosa and other medically significant bacteria
10.1128/iai.68.2.931-936.2000 · 2000 · External reference
Ssg, a putative glycosyltransferase, functions in lipo- and exopolysaccharide biosynthesis and cell surface-related properties in Pseudomonas alkylphenolia
10.1111/j.1574-6968.2010.02172.x · 2011 · External reference
Rhamnosyltransferase genes migA and wapR are regulated in a differential manner to modulate the quantities of core oligosaccharide glycoforms produced by Pseudomonas aeruginosa
10.1128/jb.05741-11 · 2012 · External reference
Biosynthesis of the Pseudomonas aeruginosa common polysaccharide antigen by D-Rhamnosyltransferases WbpX and WbpY
10.1007/s10719-022-10040-4 · 2022 · External reference
O-Specific Antigen-Dependent Surface Hydrophobicity Mediates Aggregate Assembly Type in Pseudomonas aeruginosa.
10.1128/mbio.00860-21 · 2021 · External reference
Roadmap on emerging concepts in the physical biology of bacterial biofilms: from surface sensing to community formation.
2021 · External reference
Nonmotile Subpopulations of Pseudomonas aeruginosa Repress Flagellar Motility in Motile Cells through a Type IV Pilus- and Pel-Dependent Mechanism
10.1128/jb.00528-21 · 2022 · External reference
Characterization of a gene, pilU, required for twitching motility but not phage sensitivity in Pseudomonas aeruginosa
10.1111/j.1365-2958.1994.tb00499.x · 1994 · External reference
Characterisation of a Pseudomonas aeruginosa twitching motility gene and evidence for a specialised protein export system widespread in eubacteria
10.1016/0378-1119(91)90221-v · 1991 · External reference
PilM/N/O/P proteins form an inner membrane complex that affects the stability of the Pseudomonas aeruginosa type IV pilus secretin
10.1016/j.jmb.2009.09.034 · 2009 · External reference
The Power of Touch: Type 4 Pili, the von Willebrand A Domain, and Surface Sensing by Pseudomonas aeruginosa
10.1128/jb.00084-22 · 2022 · External reference
Evidence for the Type IV Pili Retraction Motor PilT as a Component of the Surface Sensing System in Pseudomonas aeruginosa.
2023 · External reference
Novel proteins that modulate type IV pilus retraction dynamics in Pseudomonas aeruginosa
10.1128/jb.00938-08 · 2008 · External reference
The Escherichia coli rhaSR-PrhaBAD Inducible Promoter System Allows Tightly Controlled Gene Expression over a Wide Range in Pseudomonas aeruginosa
10.1128/aem.02041-16 · 2016 · External reference
Cautionary Notes on the Use of Arabinose- and Rhamnose-Inducible Expression Vectors in Pseudomonas aeruginosa
2021 · External reference
A mini-review: environmental and metabolic factors affecting aminoglycoside efficacy
10.1007/s11274-022-03445-8 · 2022 · External reference
Collective polarization dynamics in bacterial colonies signify the occurrence of distinct subpopulations
10.1371/journal.pbio.3001960 · 2023 · External reference
Contributions of antibiotic penetration, oxygen limitation, and low metabolic activity to tolerance of Pseudomonas aeruginosa biofilms to ciprofloxacin and tobramycin
10.1128/aac.47.1.317-323.2003 · 2003 · External reference
Precise spatial structure impacts antimicrobial susceptibility of S. aureus in polymicrobial wound infections
10.1073/pnas.2212340119 · 2022 · External reference
Tolerance and resistance of microbial biofilms
10.1038/s41579-022-00682-4 · 2022 · External reference
Chemical Induction of Aminoglycoside Uptake Overcomes Antibiotic Tolerance and Resistance in Staphylococcus aureus
10.1016/j.chembiol.2019.07.009 · 2019 · External reference
Tolerance to the antimicrobial peptide colistin in Pseudomonas aeruginosa biofilms is linked to metabolically active cells, and depends on the pmr and mexAB-oprM genes
10.1111/j.1365-2958.2008.06152.x · 2008 · External reference
Tolerance and Resistance of Pseudomonas aeruginosa Biofilms to Antimicrobial Agents-How P. aeruginosa Can Escape Antibiotics.
10.3389/fmicb.2019.00913 · 2019 · External reference
Tolerance of dormant and active cells in Pseudomonas aeruginosa PA01 biofilm to antimicrobial agents
10.1093/jac/dkn462 · 2009 · External reference
Entropically driven aggregation of bacteria by host polymers promotes antibiotic tolerance in Pseudomonas aeruginosa
10.1073/pnas.1806005115 · 2018 · External reference
Lysogeny at mid-twentieth century: P1, P2, and other experimental systems
10.1128/jb.186.3.595-600.2004 · 2004 · External reference
Saccharomyces cerevisiae-based molecular tool kit for manipulation of genes from gram-negative bacteria
10.1128/aem.00682-06 · 2006 · External reference
Fiji: an open-source platform for biological-image analysis.
10.1038/nmeth.2019 · 2012 · External reference
A fast algorithm for multilevel thresholding.
2001 · External reference
A Threshold Selection Method from Gray-Level Histograms
10.1109/tsmc.1979.4310076 · 1979 · External reference
SciPy 1.0: fundamental algorithms for scientific computing
10.1038/s41592-019-0686-2 · 2020 · External reference
Light sheet theta microscopy for rapid high-resolution imaging of large biological samples.
10.1186/s12915-018-0521-8 · 2018 · External reference
Advanced CLARITY for rapid and high-resolution imaging of intact tissues.
10.1038/nprot.2014.123 · 2014 · External reference
TeraStitcher—a tool for fast automatic 3D-stitching of teravoxel-sized microscopy images
10.1186/1471-2105-13-316 · 2012 · External reference
The platform protein is essential for type IV pilus biogenesis
10.1074/jbc.m113.453506 · 2013 · External reference
Cyclic-di-GMP-mediated repression of swarming motility by Pseudomonas aeruginosa: the pilY1 gene and its impact on surface-associated behaviors
10.1128/jb.01642-09 · 2010 · External reference
