Research graph
References from The extracellular matrix supports breast cancer cell growth under amino acid starvation by promoting tyrosine catabolism. Local targets link to admitted publications; unresolved targets remain external evidence.
Progression from ductal carcinoma in situ to invasive breast cancer: revisited
10.1016/j.molonc.2013.07.005 · 2013 · External reference
Collagen density promotes mammary tumor initiation and progression.
10.1186/1741-7015-6-11 · 2008 · External reference
Role of secreted type i collagen derived from stromal cells in two breast cancer cell lines
10.3892/ol.2014.2199 · 2014 · External reference
Accessories to the crime: functions of cells recruited to the tumor microenvironment
10.1016/j.ccr.2012.02.022 · 2012 · External reference
Extracellular matrix signature identifies breast cancer subgroups with different clinical outcome
10.1002/path.2278 · 2008 · External reference
The extracellular matrix in breast cancer
10.1016/j.addr.2015.12.017 · 2016 · External reference
Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein
10.1158/0008-5472.can-14-2211 · 2015 · External reference
Hallmarks of cancer: the next generation
10.1016/j.cell.2011.02.013 · 2011 · External reference
Starved epithelial cells uptake extracellular matrix for survival
10.1038/ncomms13989 · 2017 · External reference
The utilization of extracellular proteins as nutrients is suppressed by mtorc1
10.1016/j.cell.2015.06.017 · 2015 · External reference
Ligand-occupied integrin internalization links nutrient signaling to invasive migration
2015 · External reference
Macropinocytosis of protein is an amino acid supply route in ras-transformed cells
10.1038/nature12138 · 2013 · External reference
Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions
10.1038/ncomms16031 · 2017 · External reference
Taking cell-matrix adhesions to the third dimension
10.1126/science.1064829 · 2001 · External reference
Cancer-associated fibroblasts induce a collagen cross-link switch in tumor stroma
10.1158/1541-7786.mcr-15-0307 · 2016 · External reference
A subset of myofibroblastic cancer-associated fibroblasts regulate collagen fiber elongation, which is prognostic in multiple cancers.
10.18632/oncotarget.6740 · 2016 · External reference
Fibroblast-derived matrix models desmoplastic properties and forms a prognostic signature in cancer progression
10.3389/fimmu.2023.1154528 · 2023 · External reference
Improving the metabolic fidelity of cancer models with a physiological cell culture medium
10.1126/sciadv.aau7314 · 2019 · External reference
Molecular signatures associated with transformation and progression to breast cancer in the isogenic mcf10 model
10.1016/j.ygeno.2008.08.005 · 2008 · External reference
Quantitation of apoptosis and necrosis by annexin V binding, propidium iodide uptake, and flow cytometry.
10.1101/pdb.prot087288 · 2016 · External reference
mtor signalling and cellular metabolism are mutual determinants in cancer
10.1038/s41568-018-0074-8 · 2018 · External reference
Inhibitory effect of mTOR activator MHY1485 on autophagy: suppression of lysosomal fusion.
10.1371/journal.pone.0043418 · 2012 · External reference
Amino acids and mTORC1: from lysosomes to disease
10.1016/j.molmed.2012.05.007 · 2012 · External reference
uPARAP/endo180 directs lysosomal delivery and degradation of collagen IV
10.1016/j.yexcr.2003.10.008 · 2004 · External reference
Ecm cross-linking regulates invadopodia dynamics
10.1016/j.bpj.2018.01.027 · 2018 · External reference
Extracellular matrix endocytosis in controlling matrix turnover and beyond: emerging roles in cancer
10.1042/bst20160159 · 2016 · External reference
Properdin deficiency impairs phagocytosis and enhances injury at kidney repair phase post ischemiareperfusion.
10.3389/fimmu.2021.697760 · 2021 · External reference
Method for measurement of antibody-dependent cellular phagocytosis
10.1007/978-1-0716-1450-1_19 · 2022 · External reference
Regulation of macropinocytosis by p21-activated kinase-1
10.1091/mbc.11.10.3341 · 2000 · External reference
Tyrosine phosphorylation of paxillin and pp125fak accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly
10.1083/jcb.119.4.893 · 1992 · External reference
Cell matrix adhesions in cancer: The proteins that form the glue
10.18632/oncotarget.17265 · 2017 · External reference
Therapeutic potential of focal adhesion kinase inhibition in small cell lung cancer
10.1158/1535-7163.mct-18-0328 · 2019 · External reference
Modulation of FAK and src adhesion signaling occurs independently of adhesion complex composition
10.1083/jcb.201508080 · 2016 · External reference
Src kinases catalytic activity regulates proliferation, migration and invasiveness of MDA-MB231 breast cancer cells
10.1016/j.cellsig.2012.02.011 · 2012 · External reference
Extracellular matrix stiffness: New areas affecting cell metabolism
10.3389/fonc.2021.631991 · 2021 · External reference
Imaging of human cancer cells in 3D collagen matrices.
10.21769/bioprotoc.3889 · 2021 · External reference
4-hydroxyphenylpyruvate dioxygenase promotes lung cancer growth via pentose phosphate pathway (ppp) flux mediated by lkb1-ampk/hdac10/g6pd axis.
10.1038/s41419-019-1756-1 · 2019 · External reference
Biallelic variants in hpdl, encoding 4-hydroxyphenylpyruvate dioxygenase-like protein, lead to an infantile neurodegenerative condition
10.1038/s41436-020-01010-y · 2021 · External reference
Metabolic flux analysis of 3D spheroids reveals significant differences in glucose metabolism from matched 2D cultures of colorectal cancer and pancreatic ductal adenocarcinoma cell lines.
10.1186/s40170-022-00285-w · 2022 · External reference
Starvation and pseudo-starvation as drivers of cancer metastasis through translation reprogramming
10.1016/j.cmet.2018.11.018 · 2019 · External reference
Nutrient metabolism and cancer in the in vivo context: a metabolic game of give and take
10.15252/embr.202050635 · 2020 · External reference
Remodeling the ECM: Implications for metastasis and tumor dormancy.
10.3390/cancers13194916 · 2021 · External reference
Diacylglycerol kinase a controls RCP-dependent integrin trafficking to promote invasive migration
10.1083/jcb.201109112 · 2012 · External reference
Cell-matrix interactions in mammary gland development and breast cancer
10.1101/cshperspect.a003202 · 2010 · External reference
Secreted clic3 drives cancer progression through its glutathione-dependent oxidoreductase activity
10.1038/ncomms14206 · 2017 · External reference
Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension
10.1172/jci86387 · 2016 · External reference
mtor repression in response to amino acid starvation promotes ecm degradation through mt1-mmp endocytosis arrest.
2021 · External reference
Uptake of collagen type i via macropinocytosis cause mtor activation and anti-cancer drug resistance
10.1016/j.bbrc.2020.03.067 · 2020 · External reference
mtor inhibition restores amino acid balance in cells dependent on catabolism of extracellular protein
10.1016/j.molcel.2017.08.011 · 2017 · External reference
P21-Activated kinase 1: Emerging biological functions and potential therapeutic targets in cancer
10.7150/thno.46913 · 2020 · External reference
Current trends and opportunities in targeting p21 activated kinase-1(pak1) for therapeutic management of breast cancers.
10.1016/j.gene.2020.144991 · 2020 · External reference
Metabolomic alterations in invasive ductal carcinoma of breast: A comprehensive metabolomic study using tissue and serum samples.
10.18632/oncotarget.23626 · 2018 · External reference
Hpd overexpression predicts poor prognosis in breast cancer
10.1016/j.prp.2019.152524 · 2019 · External reference
Collagen matrix density drives the metabolic shift in breast cancer cells
10.1016/j.ebiom.2016.10.012 · 2016 · External reference
The emerging role of fumarate as an oncometabolite.
10.3389/fonc.2012.00085 · 2012 · External reference
Glutamine depletion regulates slug to promote EMT and metastasis in pancreatic cancer
2020 · External reference
Extracellular matrix signals as drivers of mitochondrial bioenergetics and metabolic plasticity of cancer cells during metastasis
10.3389/fcell.2021.751301 · 2021 · External reference
The rac GTPase in cancer: From old concepts to new paradigms
10.1158/0008-5472.can-17-1456 · 2017 · External reference
RCP-driven a5b1 recycling suppresses rac and promotes RhoA activity via the RacGAP1-IQGAP1 complex
10.1083/jcb.201302041 · 2013 · External reference
Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition
10.1038/nature19353 · 2016 · External reference
Processing of type I collagen gels using nonenzymatic glycation
10.1002/jbm.a.32231 · 2010 · External reference
An automated method to quantify and visualize colocalized fluorescent signals
10.1016/j.jneumeth.2005.01.012 · 2005 · External reference
Fiji: an open-source platform for biological-image analysis.
10.1038/nmeth.2019 · 2012 · External reference
Determining the macropinocytic index of cells through a quantitative image-based assay.
10.1038/nprot.2014.004 · 2014 · External reference
MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification
10.1038/nbt.1511 · 2008 · External reference
Survival analysis across the entire transcriptome identifies biomarkers with the highest prognostic power in˝ breast cancer
10.1016/j.csbj.2021.07.014 · 2021 · External reference
SuperPlots: Communicating reproducibility and variability in cell biology
2020 · External reference
