Research graph
References from Super-resolution mapping in rod photoreceptors identifies rhodopsin trafficking through the inner segment plasma membrane as an essential subcellular pathway. Local targets link to admitted publications; unresolved targets remain external evidence.
Rhodopsin signaling and organization in heterozygote rhodopsin knockout mice
10.1074/jbc.m408362200 · 2004 · External reference
Absolute quantification of photoreceptor outer segment proteins
2023 · External reference
From candelas to photoisomerizations in the mouse eye by rhodopsin bleaching in situ and the light-rearing dependence of the major components of the mouse ERG
10.1016/j.visres.2004.09.019 · 2004 · External reference
Three-dimensional architecture of murine rod outer segments determined by cryoelectron tomography
2007 · External reference
The renewal of photoreceptor cell outer segments
10.1083/jcb.33.1.61 · 1967 · External reference
Phagocytosis of Retinal Rod and Cone Photoreceptors
10.1152/physiol.00038.2009 · 2010 · External reference
Structural and molecular bases of rod photoreceptor morphogenesis and disease
10.1016/j.preteyeres.2016.06.002 · 2016 · External reference
Cilia—The sensory antennae in the eye.
10.1016/j.preteyeres.2017.05.001 · 2017 · External reference
Three-dimensional architecture of the rod sensory cilium and its disruption in retinal neurodegeneration
10.1016/j.cell.2012.10.038 · 2012 · External reference
Retinitis pigmentosa
10.1186/1750-1172-1-40 · 2006 · External reference
A rhodopsin gene mutation responsible for autosomal dominant retinitis pigmentosa results in a protein that is defective in localization to the photoreceptor outer segment
10.1523/jneurosci.14-10-05818.1994 · 1994 · External reference
Structural and functional impairment of endocytic pathways by retinitis pigmentosa mutant rhodopsin-arrestin complexes
10.1172/jci200421136 · 2004 · External reference
Characterization of rhodopsin P23H-induced retinal degeneration in a Xenopus laevis model of retinitis pigmentosa.
10.1167/iovs.06-0213 · 2006 · External reference
A Zebrafish Model of Retinitis Pigmentosa Shows Continuous Degeneration and Regeneration of Rod Photoreceptors
10.3390/cells9102242 · 2020 · External reference
Subcellular localization of mutant P23H rhodopsin in an RFP fusion knock-in mouse model of retinitis pigmentosa.
2022 · External reference
Retinal degeneration in tulp1-/- mice: vesicular accumulation in the interphotoreceptor matrix
1999 · External reference
Early Synaptic Defects in tulp1 −/− Mice.
10.1167/iovs.08-3190 · 2009 · External reference
A frameshift mutation in RPGR exon ORF15 causes photoreceptor degeneration and inner retina remodeling in a model of X-linked retinitis pigmentosa.
10.1167/iovs.05-0845 · 2006 · External reference
Gelsolin dysfunction causes photoreceptor loss in induced pluripotent cell and animal retinitis pigmentosa models
10.1038/s41467-017-00111-8 · 2017 · External reference
Impaired photoreceptor protein transport and synaptic transmission in a mouse model of Bardet-Biedl syndrome
10.1016/j.visres.2007.09.016 · 2007 · External reference
BBSome function is required for both the morphogenesis and maintenance of the photoreceptor outer segment.
10.1371/journal.pgen.1007057 · 2017 · External reference
ARL13B, a Joubert Syndrome-Associated Protein, Is Critical for Retinogenesis and Elaboration of Mouse Photoreceptor Outer Segments
10.1523/jneurosci.1761-18.2018 · 2019 · External reference
Spata7 is a retinal ciliopathy gene critical for correct RPGRIP1 localization and protein trafficking in the retina
10.1093/hmg/ddu573 · 2015 · External reference
Super-resolution microscopy reveals photoreceptor-specific subciliary location and function of ciliopathy-associated protein CEP290
2021 · External reference
Rhodopsin Trafficking and Mistrafficking: Signals, Molecular Components, and
10.1016/bs.pmbts.2015.02.007 · 2015 · External reference
Rhodopsin’s carboxy-terminal cytoplasmic tail acts as a membrane receptor for cytoplasmic dynein by binding to the dynein light chain Tctex-1
10.1016/s0092-8674(00)80800-4 · 1999 · External reference
Analysis of a zebrafish dync1h1 mutant reveals multiple functions for cytoplasmic dynein 1 during retinal photoreceptor development
10.1186/1749-8104-5-12 · 2010 · External reference
Effect of conditional deletion of cytoplasmic dynein heavy chain DYNC1H1 on postnatal photoreceptors.
2021 · External reference
Conditional deletion of cytoplasmic dynein heavy chain in postnatal photoreceptors.
2021 · External reference
Structure and dynamics of photoreceptor sensory cilia
10.1007/s00424-021-02564-9 · 2021 · External reference
The structure and distribution of the cross-striated fibril and associated membranes in guinea pig photoreceptors
10.1002/aja.1001550304 · 1979 · External reference
Fine structure of a periciliary ridge complex of frog retinal rod cells revealed by ultrahigh resolution scanning electron microscopy
10.1083/jcb.96.1.265 · 1983 · External reference
Vesicular transport of newly synthesized opsin from the Golgi apparatus toward the rod outer segment. Ultrastructural immunocytochemical and autoradiographic evidence in Xenopus retinas
1985 · External reference
Biosynthesis and vectorial transport of opsin on vesicles in retinal rod photoreceptors
10.1177/34.1.2934469 · 1986 · External reference
Ultrastructural localization of rhodopsin in the vertebrate retina
10.1083/jcb.62.2.257 · 1974 · External reference
Binding pattern of anti-rhodopsin monoclonal antibodies to photoreceptor cells: an immunocytochemical study
10.1016/s0014-4835(89)80022-3 · 1989 · External reference
Myosin VIIa participates in opsin transport through the photoreceptor cilium
10.1523/jneurosci.19-15-06267.1999 · 1999 · External reference
Rhodopsin transport in the membrane of the connecting cilium of mammalian photoreceptor cells
10.1002/1097-0169(200006)46:2<95::aid-cm2>3.0.co;2-q · 2000 · External reference
A role for the Tubby-like protein 1 in rhodopsin transport
2001 · External reference
Rod disc renewal occurs by evagination of the ciliary plasma membrane that makes cadherin-based contacts with the inner segment
10.1073/pnas.1509285113 · 2015 · External reference
Tmem138 is localized to the connecting cilium essential for rhodopsin localization and outer segment biogenesis
2022 · External reference
The route of the visual receptor, rhodopsin, along the cilium
10.1242/jcs.229526 · 2019 · External reference
Knock-in human rhodopsin-GFP fusions as mouse models for human disease and targets for gene therapy
10.1073/pnas.0403149101 · 2004 · External reference
Rhodopsin C terminus, the site of mutations causing retinal disease, regulates trafficking by binding to ADP-ribosylation factor 4 (ARF4).
10.1073/pnas.0500095102 · 2005 · External reference
Identification of an outer segment targeting signal in the COOH terminus of rhodopsin using transgenic Xenopus laevis
10.1083/jcb.151.7.1369 · 2000 · External reference
Transgenic expression of a GFP-rhodopsin COOH-terminal fusion protein in zebrafish rod photoreceptors
10.1017/s0952523802192030 · 2002 · External reference
Ciliary targeting motif VxPx directs assembly of a trafficking module through Arf4
10.1038/emboj.2008.267 · 2009 · External reference
The Arf GAP ASAP1 provides a platform to regulate Arf4-and Rab11-Rab8-mediated ciliary receptor targeting
10.1038/emboj.2012.253 · 2012 · External reference
rab8 in retinal photoreceptors may participate in rhodopsin transport and in rod outer segment disk morphogenesis
10.1242/jcs.108.1.215 · 1995 · External reference
Mutant rab8 Impairs Docking and Fusion of Rhodopsin-bearing Post-Golgi Membranes and Causes Cell Death of Transgenic Xenopus Rods. Scheller RH, editor
10.1091/mbc.12.8.2341 · 2001 · External reference
A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis
10.1016/j.cell.2007.03.053 · 2007 · External reference
Small GTPases Rab8a and Rab11a are dispensable for rhodopsin transport in mouse photoreceptors.
10.1371/journal.pone.0161236 · 2016 · External reference
Loss of Arf4 causes severe degeneration of the exocrine pancreas but not cystic kidney disease or retinal degeneration
10.1371/journal.pgen.1006740 · 2017 · External reference
Syntaxin 3 and SNAP-25 pairing, regulated by omega-3 docosahexaenoic acid, controls the delivery of rhodopsin for the biogenesis of cilia-derived sensory organelles, the rod outer segments
10.1242/jcs.039982 · 2009 · External reference
Syntaxin 3 is essential for photoreceptor outer segment protein trafficking and survival
10.1073/pnas.2010751117 · 2020 · External reference
SNAREs interact with retinal degeneration slow and rod outer segment membrane protein-1 during conventional and unconventional outer segment targeting
10.1371/journal.pone.0138508 · 2015 · External reference
Defining the layers of a sensory cilium with STORM and cryoelectron nanoscopy
10.1073/pnas.1902003116 · 2019 · External reference
Rapid 3D-STORM imaging of diverse molecular targets in tissue
10.1016/j.crmeth.2022.100253 · 2022 · External reference
Differential immunogold-dextran labeling of bovine and frog rod and cone cells using monoclonal antibodies against bovine rhodopsin
10.1016/0014-4835(86)90017-5 · 1986 · External reference
Monoclonal antibodies to rhodopsin: characterization, cross-reactivity, and application as structural probes
10.1021/bi00272a020 · 1983 · External reference
Discs of mammalian rod photoreceptors form through the membrane evagination mechanism
10.1083/jcb.201508093 · 2015 · External reference
Signals governing the trafficking and mistrafficking of a ciliary GPCR, rhodopsin
10.1523/jneurosci.1520-13.2013 · 2013 · External reference
A simple, versatile method for GFP-based super-resolution microscopy via nanobodies.
10.1038/nmeth.1991 · 2012 · External reference
Centrins in retinal photoreceptor cells: regulators in the connecting cilium
10.1016/j.preteyeres.2008.01.003 · 2008 · External reference
Separation of photoreceptor cell compartments in mouse retina for protein analysis
10.1186/s13024-017-0171-2 · 2017 · External reference
Two Peeling Methods for the Isolation of Photoreceptor Cell Compartments in the Mouse Retina for Protein Analysis.
2021 · External reference
SARA-regulated vesicular targeting underlies formation of the light-sensing organelle in mammalian rods
10.1016/j.cell.2007.06.030 · 2007 · External reference
Accumulation of non-outer segment proteins in the outer segment underlies photoreceptor degeneration in Bardet–Biedl syndrome
10.1073/pnas.1510111112 · 2015 · External reference
Proteomics of photoreceptor outer segments identifies a subset of SNARE and Rab proteins implicated in membrane vesicle trafficking and fusion
10.1074/mcp.m700571-mcp200 · 2008 · External reference
Phosducin facilitates light-driven transducin translocation in rod photoreceptors: Evidence from the phosducin knockout mouse
10.1074/jbc.m311058200 · 2004 · External reference
Characterization of a cis-Golgi matrix protein, GM130
10.1083/jcb.131.6.1715 · 1995 · External reference
Intraflagellar transport molecules in ciliary and nonciliary cells of the retina
10.1083/jcb.200911095 · 2010 · External reference
Immunocytochemical evidence of Tulp1-dependent outer segment protein transport pathways in photoreceptor cells
10.1016/j.exer.2011.08.005 · 2011 · External reference
MosaicIA: An ImageJ/Fiji plugin for spatial pattern and interaction analysis.
2013 · External reference
Cytoskeletal-membrane interactions: A stable interaction between cell surface glycoconjugates and doublet microtubules of the photoreceptor connecting cilium
10.1083/jcb.105.6.2973 · 1987 · External reference
Immunocytochemical localization of opsin in the cell membrane of developing rat retinal photoreceptors
10.1083/jcb.98.5.1788 · 1984 · External reference
Artefacts and morphological changes during chemical fixation
10.1111/j.1365-2818.1992.tb03260.x · 1992 · External reference
Pre-embedding immunolabeling for electron microscopy: an evaluation of permeabilization methods and markers
10.1002/(sici)1097-0029(19980701)42:1<43::aid-jemt6>3.0.co;2-s · 1998 · External reference
Preparation, use, and enlargement of ultrasmall gold particles in immunoelectron microscopy
10.1002/(sici)1097-0029(19980701)42:1<66::aid-jemt8>3.0.co;2-p · 1998 · External reference
Guanylate cyclase 1 relies on rhodopsin for intracellular stability and ciliary trafficking.
10.7554/elife.12058 · 2015 · External reference
Super-resolution architecture of mammalian centriole distal appendages reveals distinct blade and matrix functional components
10.1038/s41467-018-04469-1 · 2018 · External reference
Nucleotide Bound to rab11a Controls Localization in Rod Cells But Not Interaction with Rhodopsin
10.1523/jneurosci.1943-14.2014 · 2014 · External reference
Multiple phosphatidylinositol(3)phosphate roles in retinal pigment epithelium membrane recycling.
2020 · External reference
An Unconventional Secretory Pathway Mediates the Cilia Targeting of Peripherin/rds
10.1523/jneurosci.3437-13.2014 · 2014 · External reference
Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium
10.1083/jcb.200907126 · 2009 · External reference
Dopamine receptors reveal an essential role of IFT-B, KIF17, and Rab23 in delivering specific receptors to primary cilia.
10.7554/elife.06996 · 2015 · External reference
Q344ter mutation causes mislocalization of rhodopsin molecules that are catalytically active: A mouse model of Q344ter-induced retinal degeneration
2010 · External reference
Evidence from normal and degenerating photoreceptors that two outer segment integral membrane proteins have separate transport pathways
10.1002/(sici)1096-9861(19971013)387:1<148::aid-cne12>3.0.co;2-q · 1997 · External reference
The ins and outs of the Arf4-based ciliary membrane-targeting complex
10.1080/21541248.2019.1616355 · 2021 · External reference
Protein sorting, targeting and trafficking in photoreceptor cells
10.1016/j.preteyeres.2013.03.002 · 2013 · External reference
Polarized sorting of rhodopsin on post-Golgi membranes in frog retinal photoreceptor cells
10.1083/jcb.113.6.1281 · 1991 · External reference
Microvesicle release from inner segments of healthy photoreceptors is a conserved phenomenon in mammalian species
10.1242/dmm.049871 · 2022 · External reference
The outer segment serves as a default destination for the trafficking of membrane proteins in photoreceptors
10.1083/jcb.200806009 · 2008 · External reference
An interaction network between the SNARE VAMP7 and Rab GTPases within a ciliary membrane-targeting complex
10.1242/jcs.222034 · 2018 · External reference
Deletion of CEP164 in mouse photoreceptors post-ciliogenesis interrupts ciliary intraflagellar transport (IFT).
10.1371/journal.pgen.1010154 · 2022 · External reference
Heterotrimeric Kinesin-2 (KIF3) mediates transition zone and axoneme formation of mouse photoreceptors
10.1074/jbc.m115.638437 · 2015 · External reference
Deletion of PrBP/δ impedes transport of GRK1 and PDE6 catalytic subunits to photoreceptor outer segments
10.1073/pnas.0701681104 · 2007 · External reference
IFT20 is required for opsin trafficking and photoreceptor outer segment development
10.1091/mbc.e10-09-0792 · 2011 · External reference
Direct interaction of the Usher syndrome 1G protein SANS and myomegalin in the retina
10.1016/j.bbamcr.2011.05.015 · 2011 · External reference
The giant spectrin βV couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route
10.1093/hmg/ddt228 · 2013 · External reference
Fiji—an Open platform for biological image analysis
2009 · External reference
PlotsOfData-A web app for visualizing data together with their summaries
10.1371/journal.pbio.3000202 · 2019 · External reference