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References from Bridging integrator 1 fragment accelerates tau aggregation and propagation by enhancing clathrin-mediated endocytosis in mice. Local targets link to admitted publications; unresolved targets remain external evidence.
Dementia in China: epidemiology, clinical management, and research advances
10.1016/s1474-4422(19)30290-x · 2020 · External reference
Four distinct trajectories of tau deposition identified in Alzheimer’s disease
10.1038/s41591-021-01309-6 · 2021 · External reference
Development of a novel tau propagation mouse model endogenously expressing 3 and 4 repeat tau isoforms
10.1093/brain/awab289 · 2022 · External reference
A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity
10.1007/s00401-014-1254-6 · 2014 · External reference
LRP1 is a master regulator of tau uptake and spread
10.1038/s41586-020-2156-5 · 2020 · External reference
Seeding of normal Tau by pathological Tau conformers drives pathogenesis of Alzheimer-like tangles
10.1074/jbc.m110.209296 · 2011 · External reference
Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons
10.1074/jbc.m112.394528 · 2013 · External reference
A novel role for the late-onset Alzheimer’s disease (LOAD)-associated protein Bin1 in regulating postsynaptic trafficking and glutamatergic signaling.
10.1038/s41380-019-0407-3 · 2020 · External reference
Amphiphysin 2 (BIN1) in physiology and diseases.
10.1007/s00109-014-1138-1 · 2014 · External reference
Tandem arrangement of the clathrin and AP-2 binding domains in amphiphysin 1 and disruption of clathrin coat function by amphiphysin fragments comprising these sites
10.1074/jbc.m910430199 · 2000 · External reference
Multiple amphiphysin II splice variants display differential clathrin binding: identification of two distinct clathrin-binding sites
10.1046/j.1471-4159.1998.70062369.x · 1998 · External reference
The BIN1 rs744373 Alzheimer’s disease risk SNP is associated with faster Aβ-associated tau accumulation and cognitive decline.
10.1002/alz.12371 · 2022 · External reference
BIN1 rs744373 located in enhancers of brain tissues upregulates BIN1 mRNA expression, thereby leading to Alzheimer’s disease.
10.1002/alz.12548 · 2022 · External reference
Bridging integrator 1 (BIN1) protein expression increases in the Alzheimer’s disease brain and correlates with neurofibrillary tangle pathology
10.3233/jad-132450 · 2014 · External reference
Cloning and expression of mouse legumain, a lysosomal endopeptidase
10.1042/bj3350111 · 1998 · External reference
Structure and function of legumain in health and disease
10.1016/j.biochi.2015.09.022 · 2016 · External reference
Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer’s disease
10.1038/nm.3700 · 2014 · External reference
Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer’s disease
10.1038/ncomms9762 · 2015 · External reference
Distinct tau prion strains propagate in cells and mice and define different tauopathies
10.1016/j.neuron.2014.04.047 · 2014 · External reference
Clathrin interacts specifically with amphiphysin and is displaced by dynamin
10.1016/s0014-5793(97)00928-9 · 1997 · External reference
SH3 domain-dependent interactions of endophilin with amphiphysin
10.1016/s0014-5793(97)01016-8 · 1997 · External reference
Loss of Bin1 Promotes the Propagation of Tau Pathology
10.1016/j.celrep.2016.09.063 · 2016 · External reference
Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson’s disease
10.1038/nsmb.3433 · 2017 · External reference
Activation of asparaginyl endopeptidase leads to Tau hyperphosphorylation in Alzheimer disease
10.1074/jbc.m112.446070 · 2013 · External reference
BIN1 protein isoforms are differentially expressed in astrocytes, neurons, and microglia: neuronal and astrocyte BIN1 are implicated in tau pathology.
10.1186/s13024-020-00387-3 · 2020 · External reference
Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds
10.1073/pnas.1301440110 · 2013 · External reference
RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway
10.1242/jcs.00718 · 2003 · External reference
BIN1/M-Amphiphysin2 induces clustering of phosphoinositides to recruit its downstream partner dynamin
10.1038/ncomms6647 · 2014 · External reference
Role of Clathrin and Dynamin in Clathrin Mediated Endocytosis/Synaptic Vesicle Recycling and Implications in Neurological Diseases.
10.3389/fncel.2021.754110 · 2021 · External reference
Neuronal BIN1 Regulates Presynaptic Neurotransmitter Release and Memory Consolidation
10.1016/j.celrep.2020.02.026 · 2020 · External reference
A mechanistic model of tau amyloid aggregation based on direct observation of oligomers
10.1038/ncomms8025 · 2015 · External reference
Self-propagation of pathogenic protein aggregates in neurodegenerative diseases
10.1038/nature12481 · 2013 · External reference
V363I and V363A mutated tau affect aggregation and neuronal dysfunction differently in C. elegans
10.1016/j.nbd.2018.06.018 · 2018 · External reference
Polymerization of tau peptides into fibrillar structures. The effect of FTDP-17 mutations
10.1016/s0014-5793(99)00210-0 · 1999 · External reference
Disease-Associated Tau Phosphorylation Hinders Tubulin Assembly within Tau Condensates
10.1002/anie.202011157 · 2021 · External reference
α-Synuclein modulates tau spreading in mouse brains
10.1084/jem.20192193 · 2021 · External reference
Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice
10.1007/s00401-015-1413-4 · 2015 · External reference
Brain banking as a cornerstone of neuroscience in China.
10.1016/s1474-4422(14)70259-5 · 2015 · External reference
Extracellular Sortilin Proteopathy Relative to β-Amyloid and Tau in Aged and Alzheimer’s Disease Human Brains.
10.3389/fnagi.2020.00093 · 2020 · External reference
National Institute on Aging-Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach.
10.1007/s00401-011-0910-3 · 2012 · External reference
Amphiphysin II (SH3P9; BIN1), a member of the amphiphysin/Rvs family, is concentrated in the cortical cytomatrix of axon initial segments and nodes of ranvier in brain and around T tubules in skeletal muscle
10.1083/jcb.137.6.1355 · 1997 · External reference
Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction
10.7554/elife.65301 · 2021 · External reference
