Research graph
References from Distinct S-adenosylmethionine synthases link phosphatidylcholine to mitochondrial function and stress survival. Local targets link to admitted publications; unresolved targets remain external evidence.
Controlling gene expression in response to stress
10.1038/nrg3055 · 2011 · External reference
Linking cellular stress responses to systemic homeostasis
10.1038/s41580-018-0068-0 · 2018 · External reference
s-adenosylmethionine levels govern innate immunity through distinct methylation-dependent pathways
10.1016/j.cmet.2015.07.013 · 2015 · External reference
Stress-responsive and metabolic gene regulation are altered in low S-adenosylmethionine
10.1371/journal.pgen.1007812 · 2018 · External reference
S-adenosylmethionine synthases specify distinct H3K4me3 populations and gene expression patterns during heat stress
10.7554/elife.79511 · 2023 · External reference
Eight kinetically stable but thermodynamically activated molecules that power cell metabolism
2017 · External reference
Worm Perturb-Seq: massively parallel whole-animal RNAi and RNA-seq
10.1038/s41467-025-60154-0 · 2025 · External reference
A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans
10.1016/j.cell.2011.09.045 · 2011 · External reference
New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen
10.1371/journal.pgen.0010017 · 2005 · External reference
Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation
10.1073/pnas.091016398 · 2001 · External reference
Conserved SAMS function in regulating egg-laying in C. elegans
10.3109/10799893.2012.756896 · 2013 · External reference
Influence of threonine metabolism on S-adenosylmethionine and histone methylation
10.1126/science.1226603 · 2013 · External reference
Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity
10.1038/nature13198 · 2014 · External reference
Mutations in the S-adenosylmethionine synthetase genes, SAM1 and SAM2, differentially impact genome stability in Saccharomyces cerevisiae
10.1534/genetics.119.302435 · 2019 · External reference
Methionine metabolism and liver disease
10.1146/annurev.nutr.28.061807.155438 · 2008 · External reference
Methionine synthase is essential for cancer cell proliferation in physiological folate environments
10.1038/s42255-021-00486-5 · 2021 · External reference
WormPaths: Caenorhabditis elegans metabolic pathway annotation and visualization
10.1093/genetics/iyab089 · 2021 · External reference
Methylthioadenosine
10.1016/j.biocel.2003.11.016 · 2004 · External reference
Metabolic network rewiring of propionate flux compensates vitamin B12 deficiency in C. elegans
10.7554/elife.17670 · 2016 · External reference
Caenorhabditis elegans methionine/S-adenosylmethionine cycle activity is sensed and adjusted by a nuclear hormone receptor
10.7554/elife.60259 · 2020 · External reference
Interspecies systems biology uncovers metabolites affecting C. elegans gene expression and life history traits
10.1016/j.cell.2014.01.047 · 2014 · External reference
Hallmarks of aging: an expanding universe
10.1016/j.cell.2022.11.001 · 2023 · External reference
WormCat: an online tool for annotation and visualization of Caenorhabditis elegans genome-scale data
2019 · External reference
Defining characteristics and conservation of poorly annotated genes in Caenorhabditis elegans using WormCat 2.0
2022 · External reference
Mitochondrial UPR: a double-edged sword
10.1016/j.tcb.2016.06.006 · 2016 · External reference
Mitophagy and the mitochondrial unfolded protein response in neurodegeneration and bacterial infection
10.1186/s12915-015-0129-1 · 2015 · External reference
High confidence ATFS-1 target genes for quantifying activation of the mitochondrial unfolded protein response
2021 · External reference
Activation of the endoplasmic reticulum unfolded protein response by lipid disequilibrium without disturbed proteostasis in vivo
2014 · External reference
Mitochondrial S-adenosylmethionine deficiency induces mitochondrial unfolded protein response and extends lifespan in Caenorhabditis elegans
2024 · External reference
Lysosomal activity regulates Caenorhabditis elegans mitochondrial dynamics through vitamin B12 metabolism
10.1073/pnas.2008021117 · 2020 · External reference
Rates of behavior and aging specified by mitochondrial function during development
10.1126/science.1077780 · 2002 · External reference
Defining the role of phosphomethylethanolamine N-methyltransferase from Caenorhabditis elegans in phosphocholine biosynthesis by biochemical and kinetic analysis
10.1021/bi060199d · 2006 · External reference
Phosphoethanolamine N-methyltransferase (PMT-1) catalyses the first reaction of a new pathway for phosphocholine biosynthesis in Caenorhabditis elegans
10.1042/bj20061815 · 2007 · External reference
Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans
10.1038/ncomms4483 · 2014 · External reference
Publisher Correction: affinity purification of cell-specific mitochondria from whole animals resolves patterns of genetic mosaicism
10.1038/s41556-018-0055-x · 2018 · External reference
Greater loss of mitochondrial function with ageing is associated with earlier onset of sarcopenia in C. elegans
10.18632/aging.101654 · 2018 · External reference
Neuronal TORC1 modulates longevity via AMPK and cell nonautonomous regulation of mitochondrial dynamics in C. elegans
10.7554/elife.49158 · 2019 · External reference
How and when to measure mitochondrial inner membrane potentials
10.1016/j.bpj.2024.03.011 · 2024 · External reference
Seahorse Xfe 24 extracellular flux analyzer-based analysis of cellular respiration in Caenorhabditis elegans
2015 · External reference
Measurement of respiration rate in live Caenorhabditis elegans
2019 · External reference
Guidelines for the measurement of oxygen consumption rate in Caenorhabditis elegans
10.1016/j.redox.2025.103723 · 2025 · External reference
The critical role of phosphatidylcholine and phosphatidylethanolamine metabolism in health and disease
10.1016/j.bbamem.2017.04.006 · 2017 · External reference
Immunity-linked genes are stimulated by a membrane stress pathway linked to Golgi function and the ARF-1 GTPase
10.1126/sciadv.adi5545 · 2023 · External reference
Cholesterol-independent SREBP-1 maturation is linked to ARF1 inactivation
2016 · External reference
Lipid landscapes and pipelines in membrane homeostasis
10.1038/nature13474 · 2014 · External reference
Phosphatidylcholine affects inner membrane protein translocases of mitochondria
10.1074/jbc.m116.722694 · 2016 · External reference
VPS13D promotes peroxisome biogenesis
10.1083/jcb.202001188 · 2021 · External reference
Vmp1, Vps13D, and Marf/Mfn2 function in a conserved pathway to regulate mitochondria and ER contact in development and disease
2021 · External reference
Vps13D encodes a ubiquitin-binding protein that is required for the regulation of mitochondrial size and clearance
10.1016/j.cub.2017.11.064 · 2018 · External reference
Vps13D functions in a Pink1-dependent and Parkin-independent mitophagy pathway
2021 · External reference
Insights into VPS13 properties and function reveal a new mechanism of eukaryotic lipid transport
10.1016/j.bbalip.2021.159003 · 2021 · External reference
VPS13D mutations affect mitochondrial homeostasis and locomotion in Caenorhabditis elegans
2025 · External reference
VPS13D movement disorder
1993 · External reference
VPS13D affects epileptic seizures by regulating mitochondrial fission and autophagy in epileptic rats
10.1016/j.gendis.2024.101266 · 2024 · External reference
The phosphatidylcholine transfer protein Stard7 is required for mitochondrial and epithelial cell homeostasis
10.1038/srep46416 · 2017 · External reference
StarD7 deficiency switches on glycolysis and promotes mitophagy flux in C2C12 myoblasts
10.1111/febs.16979 · 2024 · External reference
Role of the lipid transport protein StarD7 in mitochondrial dynamics
10.1016/j.bbalip.2021.159029 · 2021 · External reference
The phosphatidylcholine transfer protein StarD7 is important for myogenic differentiation in mouse myoblast C2C12 cells and human primary skeletal myoblasts
10.1038/s41598-020-59444-y · 2020 · External reference
StarD7 protein deficiency adversely affects the phosphatidylcholine composition, respiratory activity, and cristae structure of mitochondria
10.1074/jbc.m116.736793 · 2016 · External reference
WormBase 2024: status and transitioning to alliance infrastructure
10.1093/genetics/iyae050 · 2024 · External reference
The mechanisms and roles of mitochondrial dynamics in C. elegans
10.1016/j.semcdb.2023.10.006 · 2024 · External reference
Disruption of mitochondrial dynamics increases stress resistance through activation of multiple stress response pathways
10.1096/fj.201903235r · 2020 · External reference
A DRP-1 dependent autophagy process facilitates rebuilding of the mitochondrial network and modulates adaptation capacity in response to acute heat stress during C. elegans development
10.1080/15548627.2021.1953821 · 2021 · External reference
The mitochondrial intermembrane space protein mitofissin drives mitochondrial fission required for mitophagy
10.1016/j.molcel.2023.04.022 · 2023 · External reference
Functional genomic screen reveals genes involved in lipid-droplet formation and utilization
10.1038/nature06928 · 2008 · External reference
Nonselective autophagy reduces mitochondrial content during starvation in Caenorhabditis elegans
10.1152/ajpcell.00109.2018 · 2018 · External reference
SAMS-1 coordinates HLH-30/TFEB and PHA-4/FOXA activities through histone methylation to mediate dietary restriction-induced autophagy and longevity
10.1080/15548627.2022.2068267 · 2023 · External reference
A fluorescent reporter for rapid assessment of autophagic flux reveals unique autophagy signatures during C. elegans post-embryonic development and identifies compounds that modulate autophagy
10.1080/27694127.2024.2371736 · 2024 · External reference
Tissue-specific autophagy responses to aging and stress in C. elegans
10.18632/aging.100765 · 2015 · External reference
Fuel oxidation under the control of mitochondrial shape and dynamics
10.15252/embj.2023114129 · 2023 · External reference
Mitochondrial morphology controls fatty acid utilization by changing CPT1 sensitivity to malonyl-CoA
2023 · External reference
Depletion of mitochondrial methionine adenosyltransferase α1 triggers mitochondrial dysfunction in alcohol-associated liver disease
10.1038/s41467-022-28201-2 · 2022 · External reference
Muscle choline kinase beta defect causes mitochondrial dysfunction and increased mitophagy
10.1093/hmg/ddr305 · 2011 · External reference
Organelle-selective click labeling coupled with flow cytometry allows pooled CRISPR screening of genes involved in phosphatidylcholine metabolism
10.1016/j.cmet.2023.02.014 · 2023 · External reference
Mitochondrial membrane lipids in the regulation of bioenergetic flux
10.1016/j.cmet.2024.07.024 · 2024 · External reference
A D-2-hydroxyglutarate dehydrogenase mutant reveals a critical role for ketone body metabolism in Caenorhabditis elegans development
10.1371/journal.pbio.3002057 · 2023 · External reference
A persistence detector for metabolic network rewiring in an animal
10.1016/j.celrep.2018.12.064 · 2019 · External reference
A feedback loop engaging propionate catabolism intermediates controls mitochondrial morphology
10.1038/s41556-022-00883-2 · 2022 · External reference
SIN-3 transcriptional coregulator maintains mitochondrial homeostasis and polyamine flux
10.1016/j.isci.2024.109789 · 2024 · External reference
Early embryonic lethality caused by disruption of the gene for choline kinase alpha, the first enzyme in phosphatidylcholine biosynthesis
10.1074/jbc.m708766200 · 2008 · External reference
Glycerolipid synthesis and lipid droplet formation in the endoplasmic reticulum
2023 · External reference
Phospholipid methylation controls Atg32-mediated mitophagy and Atg8 recycling
10.15252/embj.201591440 · 2015 · External reference
Methionine inhibits autophagy and promotes growth by inducing the SAM-responsive methylation of PP2A
10.1016/j.cell.2013.06.041 · 2013 · External reference
Membrane lipid composition: effect on membrane and organelle structure, function and compartmentalization and therapeutic avenues
10.3390/ijms20092167 · 2019 · External reference
The small GTPase Arf1 modulates mitochondrial morphology and function
10.15252/embj.201489039 · 2014 · External reference
Arf1 coordinates fatty acid metabolism and mitochondrial homeostasis
10.1038/s41556-023-01180-2 · 2023 · External reference
Mitochondria regulate intracellular coenzyme Q transport and ferroptotic resistance via STARD7
2023 · External reference
Calorie restriction prevents age-related changes in the intestinal microbiota
10.18632/aging.202753 · 2021 · External reference
Metabolomic profiling for juvenile Chinook salmon exposed to contaminants of emerging concern
10.1016/j.scitotenv.2020.141097 · 2020 · External reference
The importance of experimental design and QC samples in large-scale and MS-driven untargeted metabolomic studies of humans
10.4155/bio.12.204 · 2012 · External reference
Using MetaboAnalyst 5.0 for LC-HRMS spectra processing, multi-omics integration and covariate adjustment of global metabolomics data
10.1038/s41596-022-00710-w · 2022 · External reference
Data normalization strategies in metabolomics: current challenges, approaches, and tools
10.1177/1469066720918446 · 2020 · External reference
DEBrowser: interactive differential expression analysis and visualization tool for count data
10.1186/s12864-018-5362-x · 2019 · External reference
BioVenn—a web application for the comparison and visualization of biological lists using area-proportional Venn diagrams
10.1186/1471-2164-9-488 · 2008 · External reference
Dietary restriction and AMPK increase lifespan via mitochondrial network and peroxisome remodeling
2017 · External reference
ClassyFire: automated chemical classification with a comprehensive, computable taxonomy
10.1186/s13321-016-0174-y · 2016 · External reference
RefMet: a reference nomenclature for metabolomics
10.1038/s41592-020-01009-y · 2020 · External reference
