Research graph
References from AMPK modulates a DEAH box RNA-helicase to attenuate TOR signaling and establish developmental quiescence in Caenorhabditis elegans. Local targets link to admitted publications; unresolved targets remain external evidence.
Genomics of developmental plasticity in animals
10.3389/fgene.2019.00720 · 2019 · External reference
Developmental plasticity and the evolution of animal complex life cycles
10.1098/rstb.2009.0268 · 2010 · External reference
Suspended animation, diapause and quiescence: arresting the cell cycle in C. elegans
10.4161/cc.19444 · 2012 · External reference
Developmental plasticity and the response to nutrient stress in Caenorhabditis elegans
10.1016/j.ydbio.2021.01.015 · 2021 · External reference
Starvation protects germline stem cells and extends reproductive longevity in C. elegans
10.1126/science.1178343 · 2009 · External reference
To grow or not to grow: nutritional control of development during Caenorhabditis elegans L1 arrest
10.1534/genetics.113.150847 · 2013 · External reference
Lessons from C. elegans: signaling pathways for longevity
10.1016/j.tem.2012.07.007 · 2012 · External reference
C. elegans dauer formation and the molecular basis of plasticity
10.1101/gad.1701508 · 2008 · External reference
Nutrient sensing pathways regulating adult reproductive diapause in C. elegans
10.1371/journal.pone.0274076 · 2022 · External reference
Sensory control of dauer larva formation in Caenorhabditis elegans
10.1002/cne.901980305 · 1981 · External reference
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
10.1038/40194 · 1997 · External reference
Lifespan and dauer regulation by tissue-specific activities of Caenorhabditis elegans DAF-18
10.1016/j.ydbio.2005.07.010 · 2005 · External reference
The dauerlarva, a post-embryonic developmental variant of the nematode Caenorhabditis elegans
10.1016/0012-1606(75)90109-8 · 1975 · External reference
Dauer
2007 · External reference
A cellular memory of developmental history generates phenotypic diversity in C. elegans
10.1016/j.cub.2009.11.035 · 2010 · External reference
Transgenerational effects of extended dauer diapause on starvation survival and gene expression plasticity in Caenorhabditis elegans
10.1534/genetics.118.301250 · 2018 · External reference
Inhibition of germline proliferation during C. elegans dauer development requires PTEN, LKB1 and AMPK signalling
10.1242/dev.02232 · 2006 · External reference
The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span
10.1242/dev.01255 · 2004 · External reference
AMPK regulates germline stem cell quiescence and integrity through an endogenous small RNA pathway
10.1371/journal.pbio.3000309 · 2019 · External reference
The putative RNA helicase HELZ promotes cell proliferation, translation initiation and ribosomal protein S6 phosphorylation
10.1371/journal.pone.0022107 · 2011 · External reference
HELZ directly interacts with CCR4-NOT and causes decay of bound mRNAs
10.26508/lsa.201900405 · 2019 · External reference
AMP-activated protein kinase in metabolic control and insulin signaling
10.1161/01.res.0000256090.42690.05 · 2007 · External reference
WormBase 2016: expanding to enable helminth genomic research
2016 · External reference
WormBase ParaSite—a comprehensive resource for helminth genomics
10.1016/j.molbiopara.2016.11.005 · 2017 · External reference
The ZGRF1 helicase promotes recombinational repair of replication-blocking DNA damage in human cells
10.1016/j.celrep.2020.107849 · 2020 · External reference
Mouse ZGRF1 helicase facilitates DNA repair and maintains efficient fertility
2025 · External reference
Caenorhabditis elegans DNA-2 helicase/endonuclease plays a vital role in maintaining genome stability, morphogenesis, and life span
10.1016/j.bbrc.2011.03.045 · 2011 · External reference
ZNFX-1 functions within perinuclear nuage to balance epigenetic signals
10.1016/j.molcel.2018.04.009 · 2018 · External reference
26G endo-siRNAs regulate spermatogenic and zygotic gene expression in Caenorhabditis elegans
10.1073/pnas.0906378106 · 2009 · External reference
A small-RNA-mediated feedback loop maintains proper levels of 22G-RNAs in C. elegans
10.1016/j.celrep.2020.108279 · 2020 · External reference
Meiotic recombination in C. elegans initiates by a conserved mechanism and is dispensable for homologous chromosome synapsis
10.1016/s0092-8674(00)81481-6 · 1998 · External reference
AMPK phosphorylation of raptor mediates a metabolic checkpoint
10.1016/j.molcel.2008.03.003 · 2008 · External reference
Germline stem cell integrity and quiescence are controlled by an AMPK-dependent neuronal trafficking pathway
10.1371/journal.pgen.1010716 · 2023 · External reference
Analysis of protein phosphorylation using Phos-Tag gels
10.1002/cpps.64 · 2018 · External reference
Protein charge and mass contribute to the spatio-temporal dynamics of protein-protein interactions in a minimal proteome
10.1002/pmic.201100540 · 2013 · External reference
Role of electrostatics in protein-RNA binding: the global vs the local energy landscape
10.1021/acs.jpcb.7b04318 · 2017 · External reference
Highly accurate protein structure prediction with AlphaFold
10.1038/s41586-021-03819-2 · 2021 · External reference
Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB
10.1038/nature09706 · 2011 · External reference
Identification of AMP-activated protein kinase targets by a consensus sequence search of the proteome
10.1186/s12918-015-0156-0 · 2015 · External reference
AMP-activated kinase regulates lipid droplet localization and stability of adipose triglyceride lipase in C. elegans dauer larvae
2015 · External reference
RNA helicases regulate RNA condensates
10.1038/s41422-020-0296-7 · 2020 · External reference
Modulation of RNA condensation by the DEAD-Box protein eIF4A
10.1016/j.cell.2019.12.031 · 2020 · External reference
Sexually dimorphic RNA helicases DDX3X and DDX3Y differentially regulate RNA metabolism through phase separation
10.1016/j.molcel.2022.04.022 · 2022 · External reference
IUPred3: prediction of protein disorder enhanced with unambiguous experimental annotation and visualization of evolutionary conservation
10.1093/nar/gkab408 · 2021 · External reference
Deep structural insights into RNA-binding disordered protein regions
10.1002/wrna.1714 · 2022 · External reference
Tissue enrichment analysis for C. elegans genomics
10.1186/s12859-016-1229-9 · 2016 · External reference
Two new functions in the WormBase Enrichment Suite
2018 · External reference
The C. elegans intestine: organogenesis, digestion, and physiology
10.1007/s00441-019-03036-4 · 2019 · External reference
Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival
10.1038/nature07536 · 2009 · External reference
C. elegans S6K mutants require a creatine-kinase-like effector for lifespan extension
10.1016/j.celrep.2016.02.012 · 2016 · External reference
RNA helicase proteins as chaperones and remodelers
10.1146/annurev-biochem-060713-035546 · 2014 · External reference
MOV10 Is a 5’ to 3’ RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3’ UTRs
10.1016/j.molcel.2014.03.017 · 2014 · External reference
SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast
10.1128/mcb.19.9.5943 · 1999 · External reference
Caenorhabditis elegans SMG-2 selectively marks mRNAs containing premature translation termination codons
10.1128/mcb.00410-07 · 2007 · External reference
DEAD-box helicases as integrators of RNA, nucleotide and protein binding
10.1016/j.bbagrm.2013.02.002 · 2013 · External reference
H+/myo-inositol transporter genes, hmit-1.1 and hmit-1.2, have roles in the osmoprotective response in Caenorhabditis elegans
10.1016/j.bbrc.2011.06.001 · 2011 · External reference
Modulation of RNA-binding properties of the RNA helicase UPF1 by its activator UPF2
10.1261/rna.079188.122 · 2023 · External reference
C. elegans AMPKs promote survival and arrest germline development during nutrient stress
10.1242/bio.2012836 · 2012 · External reference
Neuronal TORC1 modulates longevity via AMPK and cell nonautonomous regulation of mitochondrial dynamics in C. elegans
10.7554/elife.49158 · 2019 · External reference
The opposing actions of target of rapamycin and AMP-activated protein kinase in cell growth control
10.1101/cshperspect.a019141 · 2015 · External reference
A shift of the TOR adaptor from Rictor towards Raptor by semaphorin in C. elegans
10.1038/ncomms1495 · 2011 · External reference
AMPK blocks starvation-inducible transgenerational defects in Caenorhabditis elegans
10.1073/pnas.1616171114 · 2017 · External reference
The auxin-inducible degradation (AID) system enables versatile conditional protein depletion in C. elegans
2015 · External reference
The Rheb-TORC1 signaling axis functions as a developmental checkpoint
10.1242/dev.181727 · 2020 · External reference
Knockdown of neuronal DAF-15/Raptor promotes healthy aging in C. elegans
10.1016/j.jgg.2023.11.002 · 2024 · External reference
Mobilization of cholesterol induces the transition from quiescence to growth in Caenorhabditis elegans through steroid hormone and mTOR signaling
10.1038/s42003-024-05804-7 · 2024 · External reference
Intestine-to-germline transmission of epigenetic information intergenerationally ensures systemic stress resistance in C. elegans
10.1016/j.celrep.2020.02.050 · 2020 · External reference
10.1016/j.isci.2021.102706
10.1016/j.isci.2021.102706 · External reference
An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans
10.1016/j.cub.2007.08.047 · 2007 · External reference
Sequence determinants of in cell condensate morphology, dynamics, and oligomerization as measured by number and brightness analysis
10.1186/s12964-021-00744-9 · 2021 · External reference
Increased levels of hydrogen peroxide induce a HIF-1-dependent modification of lipid metabolism in AMPK compromised C. elegans dauer larvae
10.1016/j.cmet.2012.07.016 · 2012 · External reference
TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation
10.1016/s0960-9822(02)01091-6 · 2002 · External reference
Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks
10.1042/bj20110892 · 2012 · External reference
Regulation of mitochondrial respiration in heart cells analyzed by reaction-diffusion model of energy transfer
10.1152/ajpcell.2000.278.4.c747 · 2000 · External reference
ATP flux through creatine kinase in the normal, stressed, and failing human heart
10.1073/pnas.0408962102 · 2005 · External reference
Creatine kinase brain overexpression protects colorectal cells from various metabolic and non-metabolic stresses
10.1002/jcb.23020 · 2011 · External reference
Creatine transport and creatine kinase activity is required for CD8+ T cell immunity
10.1016/j.celrep.2022.110446 · 2022 · External reference
Genetics: influence of TOR kinase on lifespan in C. elegans
10.1038/426620a · 2003 · External reference
Deletion of the intestinal peptide transporter affects insulin and TOR signaling in Caenorhabditis elegans
10.1074/jbc.m403415200 · 2004 · External reference
TOR signaling in Caenorhabditis elegans development, metabolism, and aging
10.1534/genetics.119.302504 · 2019 · External reference
Role of mTOR signaling in female reproduction
10.3389/fendo.2019.00692 · 2019 · External reference
A double negative feedback loop between mTORC1 and AMPK kinases guarantees precise autophagy induction upon cellular stress
10.3390/ijms20225543 · 2019 · External reference
Basic Caenorhabditis elegans methods: synchronization and observation
2012 · External reference
GPS 6.0: an updated server for prediction of kinase-specific phosphorylation sites in proteins
10.1093/nar/gkad383 · 2023 · External reference
RNA interference in Caenorhabditis elegans
2015 · External reference
Enzymatic assembly of DNA molecules up to several hundred kilobases
10.1038/nmeth.1318 · 2009 · External reference
Microinjection for precision genome editing in Caenorhabditis elegans
10.1016/j.xpro.2021.100748 · 2021 · External reference
Purification of RNA using TRIzol (TRI reagent)
2010 · External reference
SRplot: a free online platform for data visualization and graphing
10.1371/journal.pone.0294236 · 2023 · External reference
