Research graph
References from Development of bitopic nanobody-ligand conjugates targeting G protein-coupled receptors and exhibiting logic-gated signaling. Local targets link to admitted publications; unresolved targets remain external evidence.
G protein-coupled receptors (GPCRs): advances in structures, mechanisms, and drug discovery
10.1038/s41392-024-01803-6 · 2024 · External reference
Biased allosteric modulators: new frontiers in GPCR drug discovery
10.1016/j.tips.2020.12.005 · 2021 · External reference
Strategies for targeting cell surface proteins using multivalent conjugates and chemical biology
10.1016/bs.mcb.2021.06.004 · 2021 · External reference
Common activation mechanism of class A GPCRs
10.7554/elife.50279 · 2019 · External reference
Adenosine A2A receptor antagonists: from caffeine to selective non-xanthines
10.1111/bph.15103 · 2022 · External reference
Historical and current adenosine receptor agonists in preclinical and clinical development
10.3389/fncel.2019.00124 · 2019 · External reference
Targeting strategies for tissue-specific drug delivery
10.1016/j.cell.2020.02.001 · 2020 · External reference
De novo design of protein logic gates
10.1126/science.aay2790 · 2020 · External reference
Logic-gated antibody pairs that selectively act on cells co-expressing two antigens
10.1038/s41587-022-01384-1 · 2022 · External reference
Discovery and design of G protein-coupled receptor targeting antibodies
10.1080/17460441.2023.2193389 · 2023 · External reference
The impact of nanobodies on G protein-coupled receptor structural biology and their potential as therapeutic agents
10.1124/molpharm.124.000974 · 2024 · External reference
Exploring cellular biochemistry with nanobodies
10.1074/jbc.rev120.012960 · 2020 · External reference
Engineering agonistic bispecifics to investigate the influence of distance on surface-mediated complement activation
10.4049/jimmunol.2400091 · 2024 · External reference
Improved GPCR ligands from nanobody tethering
10.1038/s41467-020-15884-8 · 2020 · External reference
Semi-synthetic nanobody-ligand conjugates exhibit tunable signaling properties and enhanced transcriptional outputs at neurokinin receptor-1
10.1002/pro.4866 · 2024 · External reference
Nanobody-mediated dualsteric engagement of the angiotensin receptor broadens biased ligand pharmacology
10.1124/molpharm.123.000797 · 2024 · External reference
Highly biased agonism for GPCR ligands via nanobody tethering
10.1038/s41467-024-49068-5 · 2024 · External reference
Characterization of a nanobody-epitope tag interaction and its application for receptor engineering
10.1021/acschembio.2c00407 · 2022 · External reference
Rapid covalent labeling of membrane proteins on living cells using a nanobody-epitope tag pair
10.1021/acs.bioconjchem.2c00334 · 2022 · External reference
Molecular determinants of CGS21680 binding to the human adenosine A2A receptor
10.1124/mol.114.097360 · 2015 · External reference
Novel alendronate-CGS21680 conjugate reduces bone resorption and induces new bone formation in post-menopausal osteoporosis and inflammatory osteolysis mouse models
10.1186/s13075-022-02961-0 · 2022 · External reference
Agonist derived molecular probes for A2 adenosine receptors
10.1002/jmr.300020406 · 1989 · External reference
The ALFA-tag is a highly versatile tool for nanobody-based bioscience applications
10.1038/s41467-019-12301-7 · 2019 · External reference
A nanobody that recognizes a 14-residue peptide epitope in the E2 ubiquitin-conjugating enzyme UBC6e modulates its activity
10.1016/j.molimm.2019.08.008 · 2019 · External reference
Peptides in headlock—a novel high-affinity and versatile peptide-binding nanobody for proteomics and microscopy
10.1038/srep19211 · 2016 · External reference
Modulation of protein properties in living cells using nanobodies
10.1038/nsmb.1727 · 2010 · External reference
Sortase-mediated labeling: expanding frontiers in site-specific protein functionalization opens new research avenues
10.1016/j.cbpa.2024.102443 · 2024 · External reference
A luminescent biosensor with increased dynamic range for intracellular cAMP
10.1021/cb200248h · 2011 · External reference
Backbone modification of a polypeptide drug alters duration of action in vivo
10.1038/nbt.2920 · 2014 · External reference
Ligand residence time at G-protein-coupled receptors-why we should take our time to study it
10.1124/mol.115.099671 · 2015 · External reference
Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs
10.7554/elife.74101 · 2022 · External reference
TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome
10.1038/s41589-020-0535-8 · 2020 · External reference
[3H]xanthine amine congener of 1,3-dipropyl-8-phenylxanthine: an antagonist radioligand for adenosine receptors
10.1073/pnas.83.11.4089 · 1986 · External reference
PTH receptor-1 signalling-mechanistic insights and therapeutic prospects
10.1038/nrendo.2015.139 · 2015 · External reference
The A(2A)-adenosine receptor: a GPCR with unique features?
2008 · External reference
Modular cytokine receptor-targeting chimeras for targeted degradation of cell surface and extracellular proteins
10.1038/s41587-022-01456-2 · 2023 · External reference
Atomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic beta2-microglobulin variant
10.1073/pnas.1008560108 · 2011 · External reference
Activation of a G protein-coupled receptor through indirect antibody-mediated tethering of ligands
10.1039/d1cb00118c · 2021 · External reference
Programming tissue-sensing T cells that deliver therapies to the brain
10.1126/science.adl4237 · 2024 · External reference
Characterization and expression of the human A2a adenosine receptor gene
10.1046/j.1471-4159.1996.66010362.x · 1996 · External reference
Genetic tagging of the adenosine A2A receptor reveals its heterogeneous expression in brain regions
10.3389/fnana.2022.978641 · 2022 · External reference
Structure-activity relationships of the sustained effects of adenosine A2A receptor agonists driven by slow dissociation kinetics
10.1124/mol.116.105551 · 2017 · External reference
2016 Philip S. Portoghese medicinal chemistry lectureship: designing bivalent or bitopic molecules for G-protein coupled receptors. the whole is greater than the sum of its parts
10.1021/acs.jmedchem.9b01105 · 2020 · External reference
Homo-oligomerization of the human adenosine A2A receptor is driven by the intrinsically disordered C-terminus
2021 · External reference
Oligomerization of G protein-coupled receptors: Still doubted?
10.1016/bs.pmbts.2019.11.006 · 2020 · External reference
GPCR heteromers: An overview of their classification, function and physiological relevance
10.3389/fendo.2022.931573 · 2022 · External reference
Receptor dimers and biased ligands: novel strategies for targeting G protein-coupled receptors
10.1016/j.pharmthera.2025.108829 · 2025 · External reference
Chemically induced dimerization via nanobody binding facilitates in situ ligand assembly and on-demand GPCR activation
10.1021/jacsau.4c00711 · 2024 · External reference
Triple-hormone-receptor agonist retatrutide for obesity—a phase 2 trial
10.1056/nejmoa2301972 · 2023 · External reference
Mechanisms of action and therapeutic application of glucagon-like peptide-1
10.1016/j.cmet.2018.03.001 · 2018 · External reference
Yeast surface display platform for rapid discovery of conformationally selective nanobodies
10.1038/s41594-018-0028-6 · 2018 · External reference
Discovery of antibodies targeting multipass transmembrane proteins using a suspension cell-based evolutionary approach
10.1016/j.crmeth.2023.100429 · 2023 · External reference
Structural basis for selectivity and antagonism in extracellular GPCR-nanobodies
10.1038/s41467-024-49000-x · 2024 · External reference
Structural basis of μ-opioid receptor targeting by a nanobody antagonist
10.1038/s41467-024-52947-6 · 2024 · External reference
Structure elucidation of a human melanocortin-4 receptor specific orthosteric nanobody agonist
10.1038/s41467-024-50827-7 · 2024 · External reference
ColabFold: making protein folding accessible to all
10.1038/s41592-022-01488-1 · 2022 · External reference
Evaluation of AlphaFold modeling for elucidation of nanobody-peptide epitope interactions
10.1016/j.jbc.2025.110268 · 2025 · External reference
