References

Global burden of bacterial antimicrobial resistance 1990-2021: a systematic analysis with forecasts to 2050

10.1016/s0140-6736(24)01867-1 · 2024 · External reference

Unresolved reference

2021 · External reference

Intrinsic, adaptive and acquired antimicrobial resistance in Gram-negative bacteria

10.1042/ebc20160063 · 2017 · External reference

Reservoirs of antimicrobial resistance in the context of One Health

10.1016/j.mib.2023.102291 · 2023 · External reference

Antibiotic resistance breakers: can repurposed drugs fill the antibiotic discovery void?

10.1038/nrd4675 · 2015 · External reference

Antibiotic potentiators against multidrug-resistant bacteria: discovery, development, and clinical relevance

10.3389/fmicb.2022.887251 · 2022 · External reference

Antibiotic resistance breakers: current approaches and future directions

10.1093/femsre/fuz014 · 2019 · External reference

Amoxicillin-potassium clavulanate: a novel beta-lactamase inhibitor

1985 · External reference

Antibiotic adjuvants: a versatile approach to combat antibiotic resistance

10.1021/acsomega.3c00312 · 2023 · External reference

Overcoming intrinsic and acquired resistance mechanisms associated with the cell wall of Gram-negative bacteria

10.3390/antibiotics9090623 · 2020 · External reference

Advances in the discovery of efflux pump inhibitors as novel potentiators to control antimicrobial-resistant pathogens

10.3390/antibiotics12091417 · 2023 · External reference

Genetic architecture of intrinsic antibiotic susceptibility

10.1371/journal.pone.0005629 · 2009 · External reference

Antibiotic sensitivity profiles determined with an Escherichia coli gene knockout collection: generating an antibiotic bar code

10.1128/aac.00906-09 · 2010 · External reference

The intrinsic macrolide resistome of Escherichia coli

2024 · External reference

Complex ciprofloxacin resistome revealed by screening a Pseudomonas aeruginosa mutant library for altered susceptibility

10.1128/aac.00222-08 · 2008 · External reference

Novel genetic determinants of low-level aminoglycoside resistance in Pseudomonas aeruginosa

10.1128/aac.00507-08 · 2008 · External reference

The intrinsic resistome of bacterial pathogens

10.3389/fmicb.2013.00103 · 2013 · External reference

Critical discussion on drug efflux in Mycobacterium tuberculosis

10.1093/femsre/fuab050 · 2022 · External reference

Chlorpromazine inhibits the plasmid-mediated oqxAB multidrug efflux pump in Escherichia coli isolates of Egyptian patients with utis

10.1186/s12866-025-03850-7 · 2025 · External reference

Chlorpromazine and amitriptyline are substrates and inhibitors of the AcrB multidrug efflux pump

10.1128/mbio.00465-20 · 2020 · External reference

Verapamil increases the bactericidal activity of bedaquiline against Mycobacterium tuberculosis in a mouse model

10.1128/aac.04019-14 · 2015 · External reference

Antimicrobial and synergistic effects of commercial piperine and piperlongumine in combination with conventional antimicrobials

10.3390/antibiotics8020055 · 2019 · External reference

Synergistic combinations of polymyxins

10.1016/j.ijantimicag.2016.09.014 · 2016 · External reference

Synergy of polymyxin B and minocycline against KPC-3- and OXA-48-producing Klebsiella pneumoniae in dynamic time-kill experiments: agreement with in silico predictions

10.1093/jac/dkad394 · 2024 · External reference

Synergistic action of antimicrobial peptides and antibiotics: current understanding and future directions

10.3389/fmicb.2024.1390765 · 2024 · External reference

Synergy by perturbing the Gram-negative outer membrane: opening the door for Gram-positive specific antibiotics

10.1021/acsinfecdis.2c00193 · 2022 · External reference

Antibiotics re-booted-time to kick back against drug resistance

10.1038/s44259-025-00096-1 · 2025 · External reference

Resistance-proof antimicrobial drug discovery to combat global antimicrobial resistance threat

10.1016/j.drup.2022.100890 · 2023 · External reference

Quantifying the determinants of evolutionary dynamics leading to drug resistance

10.1371/journal.pbio.1002299 · 2015 · External reference

Highly parallel lab evolution reveals that epistasis can curb the evolution of antibiotic resistance

10.1038/s41467-020-16932-z · 2020 · External reference

Efflux-linked accelerated evolution of antibiotic resistance at a population edge

10.1016/j.molcel.2022.10.024 · 2022 · External reference

Efflux pump activity potentiates the evolution of antibiotic resistance across S. aureus isolates

10.1038/s41467-020-17735-y · 2020 · External reference

Targeting efflux pumps prevents the multi-step evolution of high-level resistance to fluoroquinolone in Pseudomonas aeruginosa

2025 · External reference

Conserved evolutionary trajectory can be perturbed to prevent resistance evolution under norfloxacin pressure by forcing Mycobacterium smegmatis on alternate evolutionary paths

10.1021/acsinfecdis.3c00605 · 2024 · External reference

Delayed commitment to evolutionary fate in antibiotic resistance fitness landscapes

10.1038/ncomms8385 · 2015 · External reference

Evolutionary paths to antibiotic resistance under dynamically sustained drug selection

10.1038/ng.1034 · 2011 · External reference

Spatiotemporal microbial evolution on antibiotic landscapes

10.1126/science.aag0822 · 2016 · External reference

Adaptation and compensation in a bacterial gene regulatory network evolving under antibiotic selection

10.7554/elife.70931 · 2021 · External reference

Pervasive gene deregulation underlies adaptation and maladaptation in trimethoprim-resistant E. coli

10.1128/mbio.02119-23 · 2023 · External reference

Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection

10.1038/msb4100050 · 2006 · External reference

The EcoCyc database (2025)

2025 · External reference

Proteostasis modulates gene dosage evolution in antibiotic-resistant bacteria

10.7554/elife.99785 · 2025 · External reference

The antibiotic trimethoprim displays strong mutagenic synergy with 2-aminopurine

10.1128/aac.01577-18 · 2019 · External reference

Why is DsbA such an oxidizing disulfide catalyst?

10.1016/0092-8674(95)90210-4 · 1995 · External reference

Roles of cysteine residues of DsbB in its activity to reoxidize DsbA, the protein disulphide bond catalyst of Escherichia coli

10.1046/j.1365-2443.1996.d01-233.x · 1996 · External reference

DsbA and MgrB regulate steA expression through the two-component system PhoQ/PhoP in Salmonella enterica

10.1128/jb.00110-13 · 2013 · External reference

Characterization of PitA and PitB from Escherichia coli

10.1128/jb.183.17.5008-5014.2001 · 2001 · External reference

Identification of AcrAB-TolC efflux pump genes and detection of mutation in efflux repressor AcrR from omeprazole responsive multidrug-resistant Escherichia coli isolates causing urinary tract infections

10.1177/1178636119889629 · 2019 · External reference

Evolutionary action of mutations reveals antimicrobial resistance genes in Escherichia coli

10.1038/s41467-022-30889-1 · 2022 · External reference

In vitro synergy of 5-nitrofurans, vancomycin and sodium deoxycholate against Gram-negative pathogens

10.1099/jmm.0.001304 · 2021 · External reference

Vancomyxins: vancomycin-polymyxin nonapeptide conjugates that retain anti-Gram-positive activity with enhanced potency against Gram-negative strains

10.1021/acsinfecdis.1c00318 · 2021 · External reference

Systematic discovery of drug interaction mechanisms

10.15252/msb.20156098 · 2015 · External reference

A new antibiotic selectively kills Gram-negative pathogens

10.1038/s41586-019-1791-1 · 2019 · External reference

Research progress of LpxC inhibitor on Gram-negative bacteria

10.1016/j.ejmech.2025.117440 · 2025 · External reference

Exploring the principles behind antibiotics with limited resistance

10.1038/s41467-025-56934-3 · 2025 · External reference

AcrAB-TolC, a major efflux pump in Gram negative bacteria: toward understanding its operation mechanism

10.5483/bmbrep.2023-0070 · 2023 · External reference

Absence, loss-of-function, or inhibition of Escherichia coli AcrB does not increase expression of other efflux pump genes supporting the discovery of AcrB inhibitors as antibiotic adjuvants

10.1093/jac/dkab452 · 2022 · External reference

Antibiotic susceptibility profiles of Escherichia coli strains lacking multidrug efflux pump genes

10.1128/aac.45.4.1126-1136.2001 · 2001 · External reference

Drug export pathway of multidrug exporter AcrB revealed by DARPin inhibitors

10.1371/journal.pbio.0050007 · 2007 · External reference

Multiple entry pathways within the efflux transporter AcrB contribute to multidrug recognition

10.1038/s41467-017-02493-1 · 2018 · External reference

Mapping the role of AcrAB-TolC efflux pumps in the evolution of antibiotic resistance reveals near-MIC treatments facilitate resistance acquisition

10.1128/msphere.01056-20 · 2020 · External reference

Enhanced expression of the multidrug efflux pumps AcrAB and AcrEF associated with insertion element transposition in Escherichia coli mutants selected with a fluoroquinolone

10.1128/aac.45.5.1467-1472.2001 · 2001 · External reference

Understanding functional redundancy and promiscuity of multidrug transporters in E. coli under lipophilic cation stress

10.3390/membranes12121264 · 2022 · External reference

Redundancy in the periplasmic adaptor proteins AcrA and AcrE provides resilience and an ability to export substrates of multidrug efflux

10.1093/jac/dkt481 · 2014 · External reference

Antivirulence DsbA inhibitors attenuate Salmonella enterica serovar Typhimurium fitness without detectable resistance

10.1096/fba.2020-00100 · 2021 · External reference

Small molecule inhibitors of disulfide bond formation by the bacterial DsbA-DsbB dual enzyme system

10.1021/cb500988r · 2015 · External reference

Alternate genetic paths of adaptation to spectinomycin in Escherichia coli

2025 · External reference

pH plays a role in the mode of action of trimethoprim on Escherichia coli

10.1371/journal.pone.0200272 · 2018 · External reference

Resistance-resistant antibacterial treatment strategies

10.3389/frabi.2023.1093156 · 2023 · External reference

Resistance-resistant antibiotics

10.1016/j.tips.2014.10.007 · 2014 · External reference

Acquired bedaquiline resistance during the treatment of drug-resistant tuberculosis: a systematic review

2022 · External reference

Targeting evolution to inhibit antibiotic resistance

10.1111/febs.15370 · 2020 · External reference

Antimicrobial resistance in Acinetobacter spp. and Pseudomonas spp

10.1128/microbiolspec.arba-0007-2017 · 2018 · External reference

New multidrug efflux inhibitors for Gram-negative bacteria

10.1128/mbio.01340-20 · 2020 · External reference

Drug efflux pump inhibitors: a promising approach to counter multidrug resistance in Gram-negative pathogens by targeting AcrB protein from AcrAB-TolC multidrug efflux pump from Escherichia coli

2022 · External reference

Update on the discovery of efflux pump inhibitors against critical priority Gram-negative bacteria

10.3390/antibiotics12010180 · 2023 · External reference

Bacterial efflux pump inhibitors reduce antibiotic resistance

10.3390/pharmaceutics16020170 · 2024 · External reference

Adaptive laboratory evolution of antimicrobial resistance in bacteria for genetic and phenotypic analyses

10.1016/j.xpro.2022.102005 · 2023 · External reference

Antibiotic marker modifications of lambda Red and FLP helper plasmids, pKD46 and pCP20, for inactivation of chromosomal genes using PCR products in multidrug-resistant strains

10.1016/j.mimet.2008.06.010 · 2008 · External reference

Identifying structural variation in haploid microbial genomes from short-read resequencing data using breseq

10.1186/1471-2164-15-1039 · 2014 · External reference

Identification of mutations in laboratory-evolved microbes from next-generation sequencing data using breseq

10.1007/978-1-4939-0554-6_12 · 2014 · External reference

A comprehensive library of fluorescent transcriptional reporters for Escherichia coli

10.1038/nmeth895 · 2006 · External reference

Highly contingent phenotypes of lon protease deficiency in Escherichia coli upon antibiotic challenge

10.1128/jb.00561-19 · 2020 · External reference

Trade-offs with stability modulate innate and mutationally acquired drug resistance in bacterial dihydrofolate reductase enzymes

10.1042/bcj20180249 · 2018 · External reference

Synergy, antagonism, and what the chequerboard puts between them

10.1093/jac/dkg301 · 2003 · External reference