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References from PRMT5 regulates alternative splicing of TCF3 under hypoxia to promote EMT and invasion in breast cancer. Local targets link to admitted publications; unresolved targets remain external evidence.
Multi-omics analysis reveals contextual tumor suppressive and oncogenic gene modules within the acute hypoxic response
10.1038/s41467-021-21687-2 · 2021 · External reference
Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions
10.1038/s41392-023-01332-8 · 2023 · External reference
Hypoxia-induced alternative splicing: the 11th Hallmark of Cancer
10.1186/s13046-020-01616-9 · 2020 · External reference
Hypoxia-induced CTCF promotes EMT in breast cancer
10.1016/j.celrep.2024.114367 · 2024 · External reference
Unresolved reference
External reference
Hypoxia-induced loss of SRSF2-dependent DNA methylation promotes CTCF-mediated alternative splicing of VEGFA in breast cancer
10.1016/j.isci.2023.106804 · 2023 · External reference
Hypoxia-induced TGF-β-RBFOX2-ESRP1 axis regulates human MENA alternative splicing and promotes EMT in breast cancer
10.1093/narcan/zcaa021 · 2020 · External reference
Epigenetic crosstalk between hypoxia and tumor driven by HIF regulation
2020 · External reference
Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth
10.1038/ncomms10539 · 2016 · External reference
Hypoxia-Induced Epigenetic Regulation and Silencing of the BRCA1 Promoter
10.1128/mcb.01121-10 · 2011 · External reference
JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1α–mediated glucose metabolism
2013 · External reference
Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells
2018 · External reference
Hypoxia causes epigenetic gene regulation in macrophages by attenuating Jumonji histone demethylase activity
2010 · External reference
Regulation of alternative splicing by histone modifications
10.1126/science.1184208 · 2010 · External reference
CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing
10.1038/nature10442 · 2011 · External reference
Histone marks regulate the epithelial-to-mesenchymal transition via alternative splicing
10.1016/j.celrep.2022.110357 · 2022 · External reference
Protein arginine methyltransferases: promising targets for cancer therapy
10.1038/s12276-021-00613-y · 2021 · External reference
PRMT5 function and targeting in cancer
10.15698/cst2020.08.228 · 2020 · External reference
Arginine methyltransferases in normal and malignant hematopoiesis
10.1016/j.exphem.2016.03.009 · 2016 · External reference
PRMT5-mediated histone arginine methylation antagonizes transcriptional repression by polycomb complex PRC2
10.1093/nar/gkaa065 · 2020 · External reference
PRMT5 Is a Critical Regulator of Breast Cancer Stem Cell Function via Histone Methylation and FOXP1 Expression
2018 · External reference
Snail/PRMT5/NuRD complex contributes to DNA hypermethylation in cervical cancer by TET1 inhibition
10.1038/s41418-021-00786-z · 2021 · External reference
PRMT5 promotes cell proliferation by inhibiting BTG2 expression via the ERK signaling pathway in hepatocellular carcinoma
10.1002/cam4.1360 · 2018 · External reference
Oxygen-sensitive methylation of ULK1 is required for hypoxia-induced autophagy
10.1038/s41467-022-28831-6 · 2022 · External reference
Activation of PRMT1 and PRMT5 mediates hypoxia- and ischemia-induced apoptosis in human lung epithelial cells and the lung of miniature pigs: the role of p38 and JNK mitogen-activated protein kinases
10.1016/j.bbrc.2013.09.136 · 2013 · External reference
Endothelial PRMT5 plays a crucial role in angiogenesis after acute ischemic injury
2022 · External reference
The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer
10.1093/nar/gkx727 · 2017 · External reference
PRMT5 inhibition disrupts splicing and stemness in glioblastoma
2021 · External reference
PRMT5 Promotes Symmetric Dimethylation of RNA Processing Proteins and Modulates Activated T Cell Alternative Splicing and Ca2+/NFAT Signaling
10.4049/immunohorizons.2100076 · 2021 · External reference
PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing
10.1038/nsmb.1568 · 2009 · External reference
Hypoxia-induced CTCF mediates alternative splicing via coupling chromatin looping and RNA Pol II pause to promote EMT in breast cancer
10.1016/j.celrep.2025.115267 · 2025 · External reference
Integration of gene expression and DNA methylation data across different experiments
10.1093/nar/gkad566 · 2023 · External reference
Acquired RAD51C Promoter Methylation Loss Causes PARP Inhibitor Resistance in High-Grade Serous Ovarian Carcinoma
10.1158/0008-5472.can-21-0774 · 2021 · External reference
DNA hypermethylation associated with upregulated gene expression in prostate cancer demonstrates the diversity of epigenetic regulation
2020 · External reference
Widespread plasticity in CTCF occupancy linked to DNA methylation
10.1101/gr.136101.111 · 2012 · External reference
Cancer Metastasis: Building a Framework
10.1016/j.cell.2006.11.001 · 2006 · External reference
A Perspective on Cancer Cell Metastasis
10.1126/science.1203543 · 2011 · External reference
The lingering mysteries of metastatic recurrence in breast cancer
2020 · External reference
A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models
10.1038/nchembio.1810 · 2015 · External reference
Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666
2015 · External reference
The landscape of human mutually exclusive splicing
10.15252/msb.20177728 · 2017 · External reference
Biological impact of mutually exclusive exon switching
2021 · External reference
Alternative splicing of mutually exclusive exons—a review
10.1016/j.biosystems.2013.07.003 · 2013 · External reference
Modulation of PKM alternative splicing by PTBP1 promotes gemcitabine resistance in pancreatic cancer cells
10.1038/onc.2015.270 · 2015 · External reference
Expression of the FGFR2 mesenchymal splicing variant in epithelial cells drives epithelial-mesenchymal transition
10.18632/oncotarget.6706 · 2016 · External reference
Intragenic DNA methylation and BORIS-mediated cancer-specific splicing contribute to the Warburg effect
10.1073/pnas.1708447114 · 2017 · External reference
Prognostic Value of EMT-inducing Transcription Factors (EMT-TFs) in Metastatic Breast Cancer: A Systematic Review and Meta-analysis
10.1038/srep28587 · 2016 · External reference
The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis
2022 · External reference
Transcriptional Regulation of EMT Transcription Factors in Cancer
10.1016/j.semcancer.2023.10.001 · 2023 · External reference
Epithelial–mesenchymal transition and its transcription factors
2021 · External reference
TCF3 alternative splicing controlled by hnRNP H/F regulates E-cadherin expression and hESC pluripotency
10.1101/gad.316984.118 · 2018 · External reference
Transcription factor 3 promotes migration and invasion potential and maintains cancer stemness by activating ID1 expression in esophageal squamous cell carcinoma
2023 · External reference
HN1L-mediated transcriptional axis AP-2γ/METTL13/TCF3-ZEB1 drives tumor growth and metastasis in hepatocellular carcinoma
10.1038/s41418-019-0301-1 · 2019 · External reference
E2A modulates stemness, metastasis, and therapeutic resistance of breast cancer
10.1158/0008-5472.can-20-2685 · 2021 · External reference
Unresolved reference
External reference
Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition
10.1038/cr.2013.110 · 2013 · External reference
MeCP2 gates spatial learning-induced alternative splicing events in the mouse hippocampus
2020 · External reference
The in vivo kinetics of RNA polymerase II elongation during co-transcriptional splicing
10.1371/journal.pbio.1000573 · 2011 · External reference
How Slow RNA Polymerase II Elongation Favors Alternative Exon Skipping
10.1016/j.molcel.2014.03.044 · 2014 · External reference
The roles of HLH transcription factors in epithelial mesenchymal transition and multiple molecular mechanisms
2013 · External reference
A New Role for E12/E47 in the Repression ofE-cadherin Expression and Epithelial-Mesenchymal Transitions
2002 · External reference
G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer
10.1172/jci57349 · 2012 · External reference
The Snail repressor recruits EZH2 to specific genomic sites through the enrollment of the lncRNA HOTAIR in epithelial-to-mesenchymal transition
2016 · External reference
Unresolved reference
External reference
An EMT–Driven Alternative Splicing Program Occurs in Human Breast Cancer and Modulates Cellular Phenotype
2011 · External reference
SET8 promotes epithelial-mesenchymal transition and confers TWIST dual transcriptional activities
2011 · External reference
Genome-wide CRISPR screen identifies PRC2 and KMT2D-COMPASS as regulators of distinct EMT trajectories that contribute differentially to metastasis
10.1038/s41556-022-00877-0 · 2022 · External reference
G9a drives hypoxia-mediated gene repression for breast cancer cell survival and tumorigenesis
10.1073/pnas.1618706114 · 2017 · External reference
A hypoxia-responsive TRAF6–ATM–H2AX signalling axis promotes HIF1α activation, tumorigenesis and metastasis
2016 · External reference
Epigenetic regulation of hypoxia‐responsive gene expression: Focusing on chromatin and DNA modifications
2013 · External reference
CTCF and BORIS-mediated autophagy regulation via alternative splicing of BNIP3L in breast cancer
10.1016/j.jbc.2024.107416 · 2024 · External reference
A TGFβ-PRMT5-MEP50 axis regulates cancer cell invasion through histone H3 and H4 arginine methylation coupled transcriptional activation and repression
2016 · External reference
PRMT5 Promotes EMT Through Regulating Akt Activity in Human Lung Cancer
2021 · External reference
PRMT5 methylome profiling uncovers a direct link to splicing regulation in acute myeloid leukemia
10.1038/s41594-019-0313-z · 2019 · External reference
Protein Arginine Methyltransferase 5 (PRMT5) and the ERK1/2 & PI3K Pathways: A Case for PRMT5 Inhibition and Combination Therapies in Cancer
2020 · External reference
Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln
2002 · External reference
Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms
10.1128/mcb.20.2.429-440.2000 · 2000 · External reference
A new DNA binding and dimerization motif in lmmunoglobulin enhancer binding, daughterless, MyoD, a&i myc proteins
1989 · External reference
Distinct roles for E12 and E47 in B cell specification and the sequential rearrangement of immunoglobulin light chain loci
10.1084/jem.20090756 · 2009 · External reference
The protein Id: a negative regulator of helix-loop-helix DNA binding proteins
10.1016/0092-8674(90)90214-y · 1990 · External reference
Repurposing the CRISPR-Cas9 system for targeted DNA methylation
10.1093/nar/gkw159 · 2016 · External reference
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
2002 · External reference
PAR-CLIP (Photoactivatable Ribonucleoside-Enhanced Crosslinking and Immunoprecipitation)
10.1016/b978-0-12-420120-0.00008-6 · 2014 · External reference
Hypoxia-induced changes in intragenic DNA methylation correlate with alternative splicing in breast cancer
2020 · External reference
STAR: ultrafast universal RNA-seq aligner
2012 · External reference
rMATS: Robust and flexible detection of differential alternative splicing from replicate RNA-Seq data
2014 · External reference
ShinyGO: a graphical gene-set enrichment tool for animals and plants
2019 · External reference
GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis
2019 · External reference
Control of breast cancer growth and initiation by the stem cell-associated transcription factor TCF3
10.1158/0008-5472.can-12-0119 · 2012 · External reference
Optimized protocol to create deletion in adherent cell lines using CRISPR/Cas9 system
10.1016/j.xpro.2021.100857 · 2021 · External reference
ChIP-Atlas 2021 update: a data-mining suite for exploring epigenomic landscapes by fully integrating ChIP-seq, ATAC-seq and Bisulfite-seq data
2022 · External reference
Trimmomatic: a flexible trimmer for Illumina sequence data
10.1093/bioinformatics/btu170 · 2014 · External reference
The Sequence Alignment/Map format and SAMtools
10.1093/bioinformatics/btp352 · 2009 · External reference
Model-based Analysis of ChIP-Seq (MACS)
2008 · External reference
