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References from Dual transcriptional activities of PAX3 and PAX7 spatially encode spinal cell fates through distinct gene networks. Local targets link to admitted publications; unresolved targets remain external evidence.
Parsing patterns: Emerging roles of tissue self-organization in health and disease
10.1016/j.cell.2024.05.016 · 2024 · External reference
Making sense out of spinal cord somatosensory development
10.1242/dev.139592 · 2016 · External reference
Transcription factors: from enhancer binding to developmental control
10.1038/nrg3207 · 2012 · External reference
Establishing neuronal diversity in the spinal cord: a time and a place
10.1242/dev.182154 · 2019 · External reference
Broadly expressed repressors integrate patterning across orthogonal axes in embryos
10.1073/pnas.1703001114 · 2017 · External reference
Pax-3, a novel murine DNA binding protein expressed during early neurogenesis
10.1002/j.1460-2075.1991.tb08054.x · 1991 · External reference
Distinct regulatory mechanisms act to establish and maintain Pax3 expression in the developing neural tube
10.1371/journal.pgen.1003811 · 2013 · External reference
Coordination of progenitor specification and growth in mouse and chick spinal cord
10.1126/science.1254927 · 2014 · External reference
The murine paired box gene, Pax7, is expressed specifically during the development of the nervous and muscular system
10.1016/0925-4773(90)90132-6 · 1990 · External reference
Pax3- and Pax7-mediated Dbx1 regulation orchestrates the patterning of intermediate spinal interneurons
10.1016/j.ydbio.2017.06.014 · 2017 · External reference
Pax3 and Pax7 are expressed in commissural neurons and restrict ventral neuronal identity in the spinal cord
10.1016/s0925-4773(98)00168-3 · 1998 · External reference
Dysgenesis of cephalic neural crest derivatives in Pax7−/− mutant mice
10.1242/dev.122.3.831 · 1996 · External reference
Key basic helix-loop-helix transcription factor genes Hes1 and Ngn2 are regulated by Pax3 during mouse embryonic development
10.1016/j.ydbio.2008.01.008 · 2008 · External reference
Role of Pax3 acetylation in the regulation of Hes1 and Neurog2
10.1091/mbc.e10-06-0541 · 2011 · External reference
Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral neural tube
10.1016/s0092-8674(01)00283-5 · 2001 · External reference
Pax factors in transcription and epigenetic remodelling
10.1016/j.semcdb.2015.07.007 · 2015 · External reference
The selector gene Pax7 dictates alternate pituitary cell fates through its pioneer action on chromatin remodeling
10.1101/gad.200436.112 · 2012 · External reference
Pioneer factor Pax7 initiates two-step cell-cycle-dependent chromatin opening
10.1038/s41594-023-01152-y · 2024 · External reference
Carm1 regulates Pax7 transcriptional activity through MLL1/2 recruitment during asymmetric satellite stem cell divisions
10.1016/j.stem.2012.07.001 · 2012 · External reference
Pax7 activates myogenic genes by recruitment of a histone methyltransferase complex
10.1038/ncb1671 · 2008 · External reference
Pax3/7BP is a Pax7- and Pax3-binding protein that regulates the proliferation of muscle precursor cells by an epigenetic mechanism
10.1016/j.stem.2012.05.022 · 2012 · External reference
Pioneer and nonpioneer factor cooperation drives lineage specific chromatin opening
10.1038/s41467-019-11791-9 · 2019 · External reference
Pax3 cooperates with Ldb1 to direct local chromosome architecture during myogenic lineage specification
10.1038/s41467-019-10318-6 · 2019 · External reference
The transcriptional activator PAX3-FKHR rescues the defects of Pax3 mutant mice but induces a myogenic gain-of-function phenotype with ligand-independent activation of Met signaling in vivo
10.1101/gad.281203 · 2003 · External reference
Temporal control of BMP signalling determines neuronal subtype identity in the dorsal neural tube
10.1242/dev.090118 · 2013 · External reference
Bmp and Wnt/beta-catenin signals control expression of the transcription factor Olig3 and the specification of spinal cord neurons
10.1016/j.ydbio.2006.10.045 · 2007 · External reference
BMP4 patterns Smad activity and generates stereotyped cell fate organization in spinal organoids
10.1242/dev.175430 · 2019 · External reference
Canonical BMP7 activity is required for the generation of discrete neuronal populations in the dorsal spinal cord
10.1242/dev.074948 · 2012 · External reference
BMPs direct sensory interneuron identity in the developing spinal cord using signal-specific not morphogenic activities
10.7554/elife.30647 · 2017 · External reference
Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter
10.1074/jbc.m111023200 · 2002 · External reference
The activin signaling pathway promotes differentiation of dI3 interneurons in the spinal neural tube
10.1016/j.ydbio.2005.05.039 · 2005 · External reference
Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor
10.1101/gad.12.2.186 · 1998 · External reference
A novel genetic hierarchy functions during hypaxial myogenesis: Pax3 directly activates Myf5 in muscle progenitor cells in the limb
10.1101/gad.382806 · 2006 · External reference
Pax3 and Pax7 play essential safeguard functions against environmental stress-induced birth defects
10.1016/j.devcel.2015.02.006 · 2015 · External reference
Cellular mechanisms underlying Pax3-related neural tube defects and their prevention by folic acid
2019 · External reference
Unresolved reference
External reference
Transcriptome analyses based on genetic screens for Pax3 myogenic targets in the mouse embryo
10.1186/1471-2164-11-696 · 2010 · External reference
Wnt canonical pathway restricts graded Shh/Gli patterning activity through the regulation of Gli3 expression
10.1242/dev.012054 · 2008 · External reference
Retinoic acid, an essential component of the roof plate organizer, promotes the spatiotemporal segregation of dorsal neural fates
10.1242/dev.202973 · 2024 · External reference
Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord
10.1242/dev.173807 · 2019 · External reference
The bHLH factor Olig3 coordinates the specification of dorsal neurons in the spinal cord
10.1101/gad.326105 · 2005 · External reference
Crossinhibitory activities of Ngn1 and Math1 allow specification of distinct dorsal interneurons
10.1016/s0896-6273(01)00367-1 · 2001 · External reference
Msx1 and Msx2 act as essential activators of Atoh1 expression in the murine spinal cord
10.1242/dev.099002 · 2014 · External reference
A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube
10.1016/s0092-8674(00)80853-3 · 2000 · External reference
Sequential roles for Mash1 and Ngn2 in the generation of dorsal spinal cord interneurons
10.1242/dev.01859 · 2005 · External reference
Prdm13 mediates the balance of inhibitory and excitatory neurons in somatosensory circuits
10.1016/j.devcel.2013.02.015 · 2013 · External reference
Prdm12 specifies V1 interneurons through cross-repressive interactions with Dbx1 and Nkx6 genes in Xenopus
10.1242/dev.121871 · 2015 · External reference
Control of interneuron fate in the developing spinal cord by the progenitor homeodomain protein Dbx1
10.1016/s0896-6273(01)00212-4 · 2001 · External reference
GREAT improves functional interpretation of cis-regulatory regions
10.1038/nbt.1630 · 2010 · External reference
Pax genes: regulators of lineage specification and progenitor cell maintenance
10.1242/dev.091785 · 2014 · External reference
ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif
10.1093/nar/gkr572 · 2011 · External reference
Characterization of a bone morphogenetic protein-responsive Smad-binding element
10.1091/mbc.11.2.555 · 2000 · External reference
Drosophila mad binds to DNA and directly mediates activation of vestigial by decapentaplegic
10.1038/40906 · 1997 · External reference
Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors
10.1038/s41467-017-02054-6 · 2017 · External reference
Impact of cytosine methylation on DNA binding specificities of human transcription factors
2017 · External reference
PRDM16 functions as a co-repressor in the BMP pathway to suppress neural stem cell proliferation
2025 · External reference
“Stripe” transcription factors provide accessibility to co-binding partners in mammalian genomes
10.1016/j.molcel.2022.06.029 · 2022 · External reference
A global genomic transcriptional code associated with CNS-expressed genes
10.1016/j.yexcr.2006.06.017 · 2006 · External reference
Mechanistic differences in the transcriptional interpretation of local and long-range Shh morphogen signaling
10.1016/j.devcel.2012.09.015 · 2012 · External reference
SoxB1-driven transcriptional network underlies neural-specific interpretation of morphogen signals
10.1073/pnas.1220010110 · 2013 · External reference
A direct fate exclusion mechanism by Sonic hedgehog-regulated transcriptional repressors
2015 · External reference
A transcription factor network specifying inhibitory versus excitatory neurons in the dorsal spinal cord
10.1242/dev.105866 · 2014 · External reference
SOX2 co-occupies distal enhancer elements with distinct POU factors in ESCs and NPCs to specify cell state
10.1371/journal.pgen.1003288 · 2013 · External reference
Mouse Zic5 deficiency results in neural tube defects and hypoplasia of cephalic neural crest derivatives
10.1016/j.ydbio.2004.02.017 · 2004 · External reference
Mapping and analysis of chromatin state dynamics in nine human cell types
10.1038/nature09906 · 2011 · External reference
H3K4me2 reliably defines transcription factor binding regions in different cells
10.1016/j.ygeno.2014.02.002 · 2014 · External reference
Pioneer factor Pax7 deploys a stable enhancer repertoire for specification of cell fate
10.1038/s41588-017-0035-2 · 2018 · External reference
The yin and yang of pioneer transcription factors: dual roles in repression and activation
10.1002/bies.202400138 · 2024 · External reference
From pioneer to repressor: bimodal foxd3 activity dynamically remodels neural crest regulatory landscape in vivo
10.1016/j.devcel.2018.11.009 · 2018 · External reference
Transcriptional dominance of Pax7 in adult myogenesis is due to high-affinity recognition of homeodomain motifs
10.1016/j.devcel.2012.03.014 · 2012 · External reference
Divergent transcriptional and transforming properties of PAX3-FOXO1 and PAX7-FOXO1 paralogs
10.1371/journal.pgen.1009782 · 2022 · External reference
Neural progenitors adopt specific identities by directly repressing all alternative progenitor transcriptional programs
10.1016/j.devcel.2016.02.013 · 2016 · External reference
Decoding of position in the developing neural tube from antiparallel morphogen gradients
10.1126/science.aam5887 · 2017 · External reference
Integration of signals along orthogonal axes of the vertebrate neural tube controls progenitor competence and increases cell diversity
10.1371/journal.pbio.1001907 · 2014 · External reference
A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord
10.1016/s0092-8674(00)80802-8 · 1999 · External reference
HDAC4 promotes Pax7-dependent satellite cell activation and muscle regeneration
10.15252/embr.201439195 · 2014 · External reference
TLE4 regulates muscle stem cell quiescence and skeletal muscle differentiation
10.1242/jcs.256008 · 2022 · External reference
Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family
10.1093/emboj/19.10.2292 · 2000 · External reference
Epigenetic mechanisms of Groucho/Grg/TLE mediated transcriptional repression
10.1016/j.molcel.2011.11.007 · 2012 · External reference
Functional dissection of Pax3 in paraxial mesoderm development and myogenesis
10.1002/stem.1254 · 2013 · External reference
Uncoupling dorsal-mediated activation from dorsal-mediated repression in the Drosophila embryo
10.1242/dev.02643 · 2006 · External reference
Pax3 synergizes with Gli2 and Zic1 in transactivating the Myf5 epaxial somite enhancer
10.1016/j.ydbio.2013.09.006 · 2013 · External reference
SUMOylation of Pax7 is essential for neural crest and muscle development
10.1007/s00018-012-1220-1 · 2013 · External reference
Phosphorylation of PAX3 contributes to melanoma phenotypes by affecting proliferation, invasion, and transformation
10.1111/pcmr.12277 · 2014 · External reference
PAX3 gene structure, alternative splicing and evolution
10.1016/s0378-1119(99)00339-x · 1999 · External reference
Chromatin opening ability of pioneer factor Pax7 depends on unique isoform and C-terminal domain
10.1093/nar/gkad520 · 2023 · External reference
Multiple conserved regulatory elements with overlapping functions determine Sox10 expression in mouse embryogenesis
10.1093/nar/gkm727 · 2007 · External reference
Maternally expressed PGK-Cre transgene as a tool for early and uniform activation of the Cre site-specific recombinase
10.1023/a:1008868325009 · 1998 · External reference
A retrospective clonal analysis of the myocardium reveals two phases of clonal growth in the developing mouse heart
10.1242/dev.00580 · 2003 · External reference
Nonpermissiveness for mouse embryonic stem (ES) cell derivation circumvented by a single backcross to 129/Sv strain: establishment of ES cell lines bearing the Omd conditional lethal mutation
10.1007/s003359900914 · 1998 · External reference
High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP
10.1038/75973 · 2000 · External reference
Establishment of ES cells from inbred strain mice by dual inhibition (2i)
10.1262/jrd.10-178a · 2012 · External reference
The PAX-FOXO1s trigger fast trans-differentiation of chick embryonic neural cells into alveolar rhabdomyosarcoma with tissue invasive properties limited by S phase entry inhibition
10.1371/journal.pgen.1009164 · 2020 · External reference
BMP signaling patterns the dorsal and intermediate neural tube via regulation of homeobox and helix-loop-helix transcription factors
10.1242/dev.129.10.2459 · 2002 · External reference
Combinatorial analysis of developmental cues efficiently converts human pluripotent stem cells into multiple neuronal subtypes
10.1038/nbt.3049 · 2015 · External reference
Gene regulatory logic for reading the Sonic Hedgehog signaling gradient in the vertebrate neural tube
10.1016/j.cell.2011.10.047 · 2012 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
Data Analysis
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Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position
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Efficient low-cost chromatin profiling with CUT&Tag
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Unresolved reference
2014 · External reference
Fast gapped-read alignment with Bowtie 2
10.1038/nmeth.1923 · 2012 · External reference
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10.1093/nar/gkw257 · 2016 · External reference
Model-based analysis of ChIP-Seq (MACS)
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10.1093/bioinformatics/btt637 · 2014 · External reference
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10.1093/nar/gkab1113 · 2022 · External reference
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