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References from Targeting mitochondrial structure and dynamics for therapeutic intervention in cancer. Local targets link to admitted publications; unresolved targets remain external evidence.
Mitochondrial DNA variation and cancer
10.1038/s41568-021-00358-w · 2021 · External reference
Mitochondrial signal transduction
10.1016/j.cmet.2022.10.008 · 2022 · External reference
SnapShot: mitochondrial dynamics
10.1016/j.cell.2011.06.018 · 2011 · External reference
Mito-morphosis: mitochondrial fusion, fission, and cristae remodeling as key mediators of cellular function
10.1146/annurev-physiol-021115-105011 · 2016 · External reference
Function and regulation of the divisome for mitochondrial fission
10.1038/s41586-021-03214-x · 2021 · External reference
The mitochondria-endoplasmic reticulum contact sites: a signalling platform for cell death
10.1016/j.ceb.2017.03.007 · 2017 · External reference
Mechanisms of mitochondrial fission and fusion
10.1101/cshperspect.a011072 · 2013 · External reference
Mitochondrial division, fusion and degradation
10.1093/jb/mvz106 · 2020 · External reference
Metabolism and innate immunity meet at the mitochondria
10.3389/fcell.2021.720490 · 2021 · External reference
Mitochondrial DNA stress primes the antiviral innate immune response
10.1038/nature14156 · 2015 · External reference
Regulation of cGAS-STING signalling and its diversity of cellular outcomes
10.1038/s41577-024-01112-7 · 2025 · External reference
Loss of hepatic DRP1 exacerbates alcoholic hepatitis by inducing megamitochondria and mitochondrial maladaptation
10.1002/hep.32604 · 2023 · External reference
Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal
10.1038/s41556-023-01343-1 · 2024 · External reference
Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency
10.15252/embj.201796553 · 2018 · External reference
Disruption of mitochondrial dynamics triggers muscle inflammation through interorganellar contacts and mitochondrial DNA mislocation
10.1038/s41467-022-35732-1 · 2023 · External reference
Mitochondrial cristae architecture protects against mtDNA release and inflammation
10.1016/j.celrep.2022.111774 · 2022 · External reference
Dual regulation of mitochondrial fusion by Parkin-PINK1 and OMA1
10.1038/s41586-025-08590-2 · 2025 · External reference
VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease
10.1126/science.aav4011 · 2019 · External reference
BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis
10.1126/science.aao6047 · 2018 · External reference
Apoptotic stress causes mtDNA release during senescence and drives the SASP
10.1038/s41586-023-06621-4 · 2023 · External reference
The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation
10.1016/j.molcel.2022.01.008 · 2022 · External reference
Neuro-immune cross-talk in cancer
10.1038/s41568-025-00831-w · 2025 · External reference
Regulatory T cells in the tumour microenvironment
10.1038/s41568-025-00832-9 · 2025 · External reference
Natural killer cell therapies
10.1038/s41586-023-06945-1 · 2024 · External reference
The balance of STING signaling orchestrates immunity in cancer
10.1038/s41590-024-01872-3 · 2024 · External reference
The constriction and scission machineries involved in mitochondrial fission
10.1242/jcs.199562 · 2017 · External reference
Mitochondrial dynamics: the dynamin superfamily and execution by collusion
10.1016/j.semcdb.2017.07.039 · 2018 · External reference
Cristae shaping and dynamics in mitochondrial function
10.1242/jcs.260986 · 2024 · External reference
Molecular machineries shaping the mitochondrial inner membrane
10.1038/s41580-025-00854-z · 2025 · External reference
Mitochondrial dynamics at different levels: from cristae dynamics to interorganellar cross talk
10.1146/annurev-biophys-030822-020736 · 2024 · External reference
Slc25a3-dependent copper transport controls flickering-induced Opa1 processing for mitochondrial safeguard
10.1016/j.devcel.2024.06.008 · 2024 · External reference
Mitochondrial safeguard: a stress response that offsets extreme fusion and protects respiratory function via flickering-induced Oma1 activation
10.15252/embj.2020105074 · 2020 · External reference
The mechanisms and roles of selective autophagy in mammals
10.1038/s41580-022-00542-2 · 2023 · External reference
Mitochondrial fission—changing perspectives for future progress
10.1242/jcs.263640 · 2025 · External reference
Hallmarks of aging: an expanding universe
10.1016/j.cell.2022.11.001 · 2023 · External reference
Molecular mechanisms of mitochondrial dynamics
10.1038/s41580-024-00785-1 · 2025 · External reference
An actin-dependent step in mitochondrial fission mediated by the ER-associated formin INF2
10.1126/science.1228360 · 2013 · External reference
Distinct fission signatures predict mitochondrial degradation or biogenesis
10.1038/s41586-021-03510-6 · 2021 · External reference
Food perception promotes phosphorylation of MFFS131 and mitochondrial fragmentation in liver
10.1126/science.adk1005 · 2024 · External reference
Metabolism. AMP-activated protein kinase mediates mitochondrial fission in response to energy stress
10.1126/science.aab4138 · 2016 · External reference
Fatty acyl-coenzyme A activates mitochondrial division through oligomerization of MiD49 and MiD51
10.1038/s41556-024-01400-3 · 2024 · External reference
Structural basis of mitochondrial receptor binding and constriction by DRP1
10.1038/s41586-018-0211-2 · 2018 · External reference
Functionally conserved inner mitochondrial membrane proteins CCDC51 and Mdm33 demarcate a subset of fission events
10.1083/jcb.202403140 · 2025 · External reference
Mitofissin: a novel mitochondrial fission protein that facilitates mitophagy
10.1080/15548627.2023.2237343 · 2023 · External reference
Completion of mitochondrial division requires the intermembrane space protein Mdi1/Atg44
10.1083/jcb.202303147 · 2023 · External reference
Interaction of MDM33 with mitochondrial inner membrane homeostasis pathways in yeast
10.1038/srep18344 · 2015 · External reference
The inner membrane protein Mdm33 controls mitochondrial morphology in yeast
10.1083/jcb.200211113 · 2003 · External reference
Identification of an ATP-sensitive potassium channel in mitochondria
10.1038/s41586-019-1498-3 · 2019 · External reference
Determinants and outcomes of mitochondrial dynamics
10.1016/j.molcel.2023.02.012 · 2023 · External reference
The dynamin family of mechanoenzymes: pinching in new places
10.1016/s0968-0004(99)01538-8 · 2000 · External reference
Mitochondrial dynamics in health and disease
10.1002/1873-3468.14077 · 2021 · External reference
Emerging roles of mitochondrial membrane dynamics in health and disease
10.1515/bc.2009.086 · 2009 · External reference
Mitochondrial dynamics in mammalian health and disease
10.1152/physrev.00030.2008 · 2009 · External reference
Mitochondrial stasis reveals p62-mediated ubiquitination in Parkin-independent mitophagy and mitigates nonalcoholic fatty liver disease
10.1016/j.cmet.2018.06.014 · 2018 · External reference
Mitochondrial proteases: multifaceted regulators of mitochondrial plasticity
10.1146/annurev-biochem-062917-012739 · 2020 · External reference
Phosphatidic acid and cardiolipin coordinate mitochondrial dynamics
10.1016/j.tcb.2017.08.011 · 2018 · External reference
MICOS assembly controls mitochondrial inner membrane remodeling and crista junction redistribution to mediate cristae formation
10.15252/embj.2019104105 · 2020 · External reference
Individual cristae within the same mitochondrion display different membrane potentials and are functionally independent
2019 · External reference
Super-resolution microscopies, technological breakthrough to decipher mitochondrial structure and dynamic
10.1016/j.semcdb.2024.01.006 · 2024 · External reference
Mechanisms of mitochondrial respiratory adaptation
10.1038/s41580-022-00506-6 · 2022 · External reference
Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency
10.1016/j.cell.2013.08.032 · 2013 · External reference
OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion
10.1016/j.cell.2006.06.025 · 2006 · External reference
Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling
10.1016/j.cell.2006.06.021 · 2006 · External reference
Opa1-mediated cristae opening is Bax/Bak and BH3 dependent, required for apoptosis, and independent of Bak oligomerization
10.1016/j.molcel.2008.07.010 · 2008 · External reference
Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis
10.1074/jbc.c200677200 · 2003 · External reference
A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis
10.1016/s1534-5807(01)00116-2 · 2002 · External reference
mCAUSE: Prioritizing mitochondrial targets that alleviate pancreatic cancer cell phenotypes
10.1016/j.isci.2024.110880 · 2024 · External reference
Mitochondria and MICOS - function and modeling
10.1515/revneuro-2024-0004 · 2024 · External reference
Pathways shaping the mitochondrial inner membrane
10.1098/rsob.210238 · 2021 · External reference
The MICOS complex of human mitochondria
10.1007/s00441-016-2433-7 · 2017 · External reference
OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand
10.15252/embj.201488349 · 2014 · External reference
Optic Atrophy 1 is epistatic to the core MICOS component MIC60 in mitochondrial cristae shape control
10.1016/j.celrep.2016.11.049 · 2016 · External reference
Formation of cristae and crista junctions in mitochondria depends on antagonism between Fcj1 and Su e/g
10.1083/jcb.200811099 · 2009 · External reference
The cristae modulator Optic atrophy 1 requires mitochondrial ATP synthase oligomers to safeguard mitochondrial function
10.1038/s41467-018-05655-x · 2018 · External reference
Mitochondrial dynamics in cancer stem cells
10.1007/s00018-021-03773-2 · 2021 · External reference
Mitochondrial dynamics as regulators of cancer biology
10.1007/s00018-016-2451-3 · 2017 · External reference
A century of the Warburg effect
10.1038/s42255-023-00927-3 · 2023 · External reference
100 years of the Warburg effect: a cancer metabolism endeavor
10.1016/j.cell.2024.06.026 · 2024 · External reference
What is cancer metabolism?
10.1016/j.cell.2023.01.038 · 2023 · External reference
Deciphering breast cancer: from biology to the clinic
10.1016/j.cell.2023.01.040 · 2023 · External reference
Mitochondrial elongation impairs breast cancer metastasis
10.1126/sciadv.adm8212 · 2024 · External reference
MIEF2 over-expression promotes tumor growth and metastasis through reprogramming of glucose metabolism in ovarian cancer
10.1186/s13046-020-01802-9 · 2020 · External reference
Mitochondrial dynamics regulates migration and invasion of breast cancer cells
10.1038/onc.2012.494 · 2013 · External reference
Orchestration of lymphocyte chemotaxis by mitochondrial dynamics
10.1084/jem.20061877 · 2006 · External reference
Limiting mitochondrial plasticity by targeting DRP1 induces metabolic reprogramming and reduces breast cancer brain metastases
10.1038/s43018-023-00563-6 · 2023 · External reference
Activation of Drp1 promotes fatty acids-induced metabolic reprograming to potentiate Wnt signaling in colon cancer
10.1038/s41418-022-00974-5 · 2022 · External reference
Inhibition of mitochondrial fission activates glycogen synthesis to support cell survival in colon cancer
10.1038/s41419-023-06202-3 · 2023 · External reference
Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth
10.1016/j.molcel.2015.01.002 · 2015 · External reference
Mitochondrial division is requisite to RAS-induced transformation and targeted by oncogenic MAPK pathway inhibitors
10.1016/j.molcel.2015.01.003 · 2015 · External reference
Drp1 promotes KRas-driven metabolic changes to drive pancreatic tumor growth
10.1016/j.celrep.2019.07.031 · 2019 · External reference
Systemic phospho-defective and phospho-mimetic Drp1 mice exhibit normal growth and development with altered anxiety-like behavior
10.1016/j.isci.2024.109874 · 2024 · External reference
Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors
10.1038/s41467-018-04033-x · 2018 · External reference
The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis
10.1016/s1534-5807(01)00055-7 · 2001 · External reference
DRP1, fission and apoptosis
10.1038/s41420-025-02458-0 · 2025 · External reference
Mitochondria and cancer
10.1016/j.molcel.2016.02.011 · 2016 · External reference
The power and potential of mitochondria transfer
10.1038/s41586-023-06537-z · 2023 · External reference
The role of PINK1-Parkin in mitochondrial quality control
10.1038/s41556-024-01513-9 · 2024 · External reference
The cell biology of Parkinson’s disease
10.1083/jcb.202012095 · 2021 · External reference
No Parkin zone: mitophagy without Parkin
10.1016/j.tcb.2018.07.004 · 2018 · External reference
Parkinson’s disease-associated protein Parkin: an unusual player in cancer
2018 · External reference
Unravelling the genetic links between Parkinson’s disease and lung cancer
10.1515/hsz-2022-0228 · 2023 · External reference
Parkin gene mutations are not common, but its epigenetic inactivation is a frequent event and predicts poor survival in advanced breast cancer patients
10.1186/s12885-019-6013-6 · 2019 · External reference
A cancer ubiquitome landscape identifies metabolic reprogramming as target of Parkin tumor suppression
10.1126/sciadv.abg7287 · 2021 · External reference
Inhibition of the mitochondrial protein Opa1 curtails breast cancer growth
10.1186/s13046-022-02304-6 · 2022 · External reference
Opa1 and Drp1 reciprocally regulate cristae morphology, ETC function, and NAD+ regeneration in KRas-mutant lung adenocarcinoma
10.1016/j.celrep.2022.111818 · 2022 · External reference
Developmental and tumor angiogenesis requires the mitochondria-shaping protein opa1
10.1016/j.cmet.2020.04.007 · 2020 · External reference
Small molecule OPA1 inhibitors amplify cytochrome c release and reverse cancer cells resistance to Bcl-2 inhibitors
10.1126/sciadv.adx4562 · 2025 · External reference
Metastatic breast cancer cells are selectively dependent on the mitochondrial cristae-shaping protein OPA1
10.1038/s41419-025-07878-5 · 2025 · External reference
Mitochondrial structure and function adaptation in residual triple negative breast cancer cells surviving chemotherapy treatment
10.1038/s41388-023-02596-8 · 2023 · External reference
Tetrahydrobenzimidazole TMQ0153 targets OPA1 and restores drug sensitivity in AML via ROS-induced mitochondrial metabolic reprogramming
10.1186/s13046-025-03372-0 · 2025 · External reference
Mitochondrial fusion is a therapeutic vulnerability of acute myeloid leukemia
10.1038/s41375-023-01835-x · 2023 · External reference
Targeting mitochondrial structure sensitizes acute myeloid leukemia to venetoclax treatment
10.1158/2159-8290.cd-19-0117 · 2019 · External reference
Inhibition of the mitochondria-shaping protein Opa1 restores sensitivity to Gefitinib in a lung adenocarcinomaresistant cell line
10.1038/s41419-023-05768-2 · 2023 · External reference
Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1
10.1083/jcb.200906084 · 2009 · External reference
Inducible proteolytic inactivation of OPA1 mediated by the OMA1 protease in mammalian cells
10.1083/jcb.200906083 · 2009 · External reference
OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development
2021 · External reference
Inhibition of mitochondrial OMA1 ameliorates osteosarcoma tumorigenesis
10.1038/s41419-024-07127-1 · 2024 · External reference
Selective killing of human T-ALL cells: an integrated approach targeting redox homeostasis and the OMA1/OPA1 axis
10.1038/s41419-018-0870-9 · 2018 · External reference
Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice
10.1038/emboj.2012.70 · 2012 · External reference
Ghost mitochondria drive metastasis through adaptive GCN2/Akt therapeutic vulnerability
10.1073/pnas.2115624119 · 2022 · External reference
Cellular ATP demand creates metabolically distinct subpopulations of mitochondria
10.1038/s41586-024-08146-w · 2024 · External reference
Mitochondrial dynamin-related protein Drp1: a new player in cardio-oncology
10.1007/s11912-022-01333-w · 2022 · External reference
