Research graph
References from RNA-binding protein IMP1/ZBP1 directs local translation in microglial processes to regulate motility and phagocytosis during inflammation. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
2024 · External reference
Quantitative assessment of microglial morphology and density reveals remarkable consistency in the distribution and morphology of cells within the healthy prefrontal cortex of the rat
10.1186/s12974-014-0182-7 · 2014 · External reference
Remote control of gene function by local translation
10.1016/j.cell.2014.03.005 · 2014 · External reference
mRNA localization: gene expression in the spatial dimension
10.1016/j.cell.2009.01.044 · 2009 · External reference
Axonal mRNA localization and local protein synthesis in nervous system assembly, maintenance and repair
10.1038/nrn3210 · 2012 · External reference
Intra-axonal synthesis of SNAP25 is required for the formation of presynaptic terminals
10.1016/j.celrep.2017.08.097 · 2017 · External reference
The prevalence and specificity of local protein synthesis during neuronal synaptic plasticity
2021 · External reference
RNA localization and local translation in glia in neurological and neurodegenerative diseases: lessons from neurons
10.3390/cells10030632 · 2021 · External reference
AstroDot—a new method for studying the spatial distribution of mRNA in astrocytes
10.1242/jcs.239756 · 2020 · External reference
Local translation in microglial processes is required for efficient phagocytosis
10.1038/s41593-023-01353-0 · 2023 · External reference
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
10.1126/science.1110647 · 2005 · External reference
Molecular mechanisms of microglial motility: changes in ageing and Alzheimer’s disease
10.3390/cells8060639 · 2019 · External reference
Physiology of microglia
10.1152/physrev.00011.2010 · 2011 · External reference
Nanoscale surveillance of the brain by microglia via cAMP-regulated filopodia
10.1016/j.celrep.2019.05.010 · 2019 · External reference
Adenosine A(2A) receptor mediates microglial process retraction
10.1038/nn.2341 · 2009 · External reference
Age-related alterations in the dynamic behavior of microglia
10.1111/j.1474-9726.2010.00660.x · 2011 · External reference
Exacerbated glial response in the aged mouse hippocampus following controlled cortical impact injury
10.1016/j.expneurol.2008.06.013 · 2008 · External reference
Dystrophic microglia in the aging human brain
10.1002/glia.10319 · 2004 · External reference
Plaque-dependent morphological and electrophysiological heterogeneity of microglia in an Alzheimer’s disease mouse model
10.1002/glia.23318 · 2018 · External reference
The relationship between the morphological subtypes of microglia and Alzheimer’s disease neuropathology
10.1111/bpa.12717 · 2019 · External reference
The organization of myosin and actin in rapid frozen nerve growth cones
10.1083/jcb.108.1.95 · 1989 · External reference
beta-Actin messenger RNA localization and protein synthesis augment cell motility
10.1083/jcb.136.6.1263 · 1997 · External reference
Glutamate-induced RNA localization and translation in neurons
2016 · External reference
Characterization of a beta-actin mRNA zipcode-binding protein
10.1128/mcb.17.4.2158 · 1997 · External reference
Zipcode binding protein 1 regulates the development of dendritic arbors in hippocampal neurons
10.1523/jneurosci.2387-10.2011 · 2011 · External reference
Limited availability of ZBP1 restricts axonal mRNA localization and nerve regeneration capacity
10.1038/emboj.2011.347 · 2011 · External reference
Tagged actin mRNA dysregulation in IGF2BP1[Formula: see text] mice
10.1073/pnas.2208465119 · 2022 · External reference
SUnSET, a nonradioactive method to monitor protein synthesis
10.1038/nmeth.1314 · 2009 · External reference
Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis
10.1016/j.stem.2010.08.014 · 2010 · External reference
A role for huntington disease protein in dendritic RNA granules
10.1074/jbc.m110.114561 · 2010 · External reference
Object-based analyses in FIJI/ImageJ to measure local RNA translation sites in neurites in response to Aβ1-42 oligomers
10.3389/fnins.2020.00547 · 2020 · External reference
Aβ1-42 triggers the generation of a retrograde signaling complex from sentinel mRNAs in axons
10.15252/embr.201745435 · 2018 · External reference
Axonally synthesized ATF4 transmits a neurodegenerative signal across brain regions
10.1016/j.cell.2014.07.001 · 2014 · External reference
Microglia derived from aging mice exhibit an altered inflammatory profile
10.1002/glia.20468 · 2007 · External reference
Asymmetrical beta-actin mRNA translation in growth cones mediates attractive turning to netrin-1
10.1038/nn1775 · 2006 · External reference
Axonal elongation triggered by stimulus-induced local translation of a polarity complex protein
10.1038/ncb1916 · 2009 · External reference
Microglial migration mediated by ATP-induced ATP release from lysosomes
10.1038/cr.2012.10 · 2012 · External reference
Direct visualization of newly synthesized target proteins in situ
10.1038/nmeth.3319 · 2015 · External reference
Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype
10.1038/s41587-019-0201-4 · 2019 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
Metascape provides a biologist-oriented resource for the analysis of systems-level datasets
10.1038/s41467-019-09234-6 · 2019 · External reference
Protocol for identification and validation of IGF2BP1 target genes in pluripotent human embryonic carcinoma cells
10.1016/j.xpro.2023.102338 · 2023 · External reference
The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest
10.1093/nar/gkac1000 · 2023 · External reference
Local mRNA translation and cytoskeletal reorganization: Mechanisms that tune neuronal responses
10.3389/fnmol.2022.949096 · 2022 · External reference
Ibrutinib suppresses LPS-induced neuroinflammatory responses in BV2 microglial cells and wild-type mice
10.1186/s12974-018-1308-0 · 2018 · External reference
Blueberry counteracts BV-2 microglia morphological and functional switch after LPS challenge
10.3390/nu12061830 · 2020 · External reference
Microglial phagocytosis dysfunction in the dentate gyrus is related to local neuronal activity in a genetic model of epilepsy
10.1111/epi.16692 · 2020 · External reference
Axonal transcription factors signal retrogradely in lesioned peripheral nerve
10.1038/emboj.2011.494 · 2012 · External reference
Dynamic landscape of the local translation at activated synapses
10.1038/mp.2017.245 · 2018 · External reference
Locally translated mTOR controls axonal local translation in nerve injury
10.1126/science.aan1053 · 2018 · External reference
The role of TSC1 and TSC2 proteins in neuronal axons
10.1038/s41380-023-02402-7 · 2024 · External reference
Alternative 3’ UTRs modify the localization, regulatory potential, stability, and plasticity of mRNAs in neuronal compartments
10.1016/j.neuron.2018.03.030 · 2018 · External reference
Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders
10.1016/j.xgen.2022.100250 · 2023 · External reference
Directed evolution of adeno-associated virus for efficient gene delivery to microglia
10.1038/s41592-022-01547-7 · 2022 · External reference
Modeling sepsis in the laboratory: merging sound science with animal well-being
2008 · External reference
InteractiVenn: a web-based tool for the analysis of sets through Venn diagrams
10.1186/s12859-015-0611-3 · 2015 · External reference
WikiPathways 2024: next generation pathway database
10.1093/nar/gkad960 · 2024 · External reference
The reactome pathway knowledgebase 2024
10.1093/nar/gkad1025 · 2024 · External reference
KEGG for taxonomy-based analysis of pathways and genomes
10.1093/nar/gkac963 · 2023 · External reference
Quantifying microglial phagocytosis of apoptotic cells in the brain in health and disease
2018 · External reference
