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References from Structures of G-protein coupled receptor HCAR3 in complex with selective agonists reveal the basis for ligand recognition and selectivity. Local targets link to admitted publications; unresolved targets remain external evidence.
International Union of Basic and Clinical Pharmacology. LXXXII: nomenclature and classification of hydroxy-carboxylic acid receptors (GPR81, GPR109A, and GPR109B)
10.1124/pr.110.003301 · 2011 · External reference
Structural basis for ligand recognition and signaling of hydroxy-carboxylic acid receptor 2
10.1038/s41467-023-42764-8 · 2023 · External reference
GPR109A, GPR109B and GPR81, a family of hydroxy-carboxylic acid receptors
10.1016/j.tips.2009.09.001 · 2009 · External reference
GPCR screening reveals that the metabolite receptor HCAR3 regulates epithelial proliferation, migration, and cellular respiration
10.1016/j.jid.2023.12.002 · 2024 · External reference
Metabolite sensing GPCRs: promising therapeutic targets for cancer treatment?
10.3390/cells9112345 · 2020 · External reference
Hydroxycarboxylic acid receptor ligands modulate proinflammatory cytokine expression in human macrophages and adipocytes without affecting adipose differentiation
10.1248/bpb.b18-00301 · 2018 · External reference
Deorphanization of GPR109B as a receptor for the beta-oxidation intermediate 3-OH-octanoic acid and its role in the regulation of lipolysis
10.1074/jbc.m109.019455 · 2009 · External reference
Influence of nicotinic acid on serum cholesterol in man
10.1016/0003-9861(55)90070-9 · 1955 · External reference
HCAR3: an underexplored metabolite sensor
10.1038/d41573-020-00173-2 · 2020 · External reference
Hydroxycarboxylic acid receptors are essential for breast cancer cells to control their lipid/fatty acid metabolism
10.18632/oncotarget.3565 · 2015 · External reference
Identification and verification of HCAR3 and INSL5 as new potential therapeutic targets of colorectal cancer
10.1186/s12957-021-02335-x · 2021 · External reference
(D)-beta-hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G
10.1074/jbc.c500213200 · 2005 · External reference
Activation of HCAR2 by niacin: benefits beyond lipid lowering
10.2217/pgs-2019-0092 · 2019 · External reference
Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice
10.1172/jci42273 · 2010 · External reference
The niacin receptor HCAR2 modulates microglial response and limits disease progression in a mouse model of Alzheimer’s disease
10.1126/scitranslmed.abl7634 · 2022 · External reference
1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b
10.1021/jm051099t · 2006 · External reference
5-N,N-disubstituted 5-aminopyrazole-3-carboxylic acids are highly potent agonists of GPR109b
10.1016/j.bmcl.2009.05.108 · 2009 · External reference
Analogues of acifran: agonists of the high and low affinity niacin receptors, GPR109a and GPR109b
10.1021/jm070022x · 2007 · External reference
Hydroxy-carboxylic acid receptor actions in metabolism
10.1016/j.tem.2016.11.007 · 2017 · External reference
Metabolites of lactic acid bacteria present in fermented foods are highly potent agonists of human hydroxycarboxylic acid receptor 3
10.1371/journal.pgen.1008145 · 2019 · External reference
Structural basis for ligand recognition of the human hydroxycarboxylic acid receptor HCAR3
10.1016/j.celrep.2024.114895 · 2024 · External reference
Structural basis of hydroxycarboxylic acid receptor signaling mechanisms through ligand binding
10.1038/s41467-023-41650-7 · 2023 · External reference
Structures of G-protein coupled receptor HCAR1 in complex with Gi1 protein reveal the mechanistic basis for ligand recognition and agonist selectivity
2025 · External reference
High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor
10.1126/science.1150577 · 2007 · External reference
Structural insights into µ-opioid receptor activation
10.1038/nature14886 · 2015 · External reference
Structural basis of ligand recognition and self-activation of orphan GPR52
10.1038/s41586-020-2019-0 · 2020 · External reference
Structural insights into ligand recognition and activation of the medium-chain fatty acid-sensing receptor GPR84
10.1038/s41467-023-38985-6 · 2023 · External reference
Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2
10.1038/s41421-023-00610-7 · 2023 · External reference
Structural insights into the human niacin receptor HCA2-Gi signalling complex
10.1038/s41467-023-37177-6 · 2023 · External reference
Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs
10.1126/sciadv.aax2518 · 2019 · External reference
Role of the conserved NPxxY motif of the 5-HT2A receptor in determining selective interaction with isoforms of ADP-ribosylation factor (ARF)
10.1016/j.cellsig.2006.02.002 · 2006 · External reference
Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution
10.1038/s41467-024-46239-2 · 2024 · External reference
Structural genomics of the human dopamine receptor system
10.1038/s41422-023-00808-0 · 2023 · External reference
Molecular basis for lipid recognition by the prostaglandin D2 receptor CRTH2
2021 · External reference
Ligand recognition, unconventional activation, and G protein coupling of the prostaglandin E2 receptor EP2 subtype
2021 · External reference
Dominant negative G proteins enhance formation and purification of agonist-GPCR-G protein complexes for structure determination
10.1021/acsptsci.8b00017 · 2018 · External reference
Structure of the µ-opioid receptor-Gi protein complex
10.1038/s41586-018-0219-7 · 2018 · External reference
cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination
10.1038/nmeth.4169 · 2017 · External reference
Structure of formylpeptide receptor 2-Gi complex reveals insights into ligand recognition and signaling
10.1038/s41467-020-14728-9 · 2020 · External reference
Features and development of Coot
10.1107/s0907444910007493 · 2010 · External reference
PHENIX: a comprehensive Python-based system for macromolecular structure solution
10.1107/s0907444909052925 · 2010 · External reference
UCSF Chimera—a visualization system for exploratory research and analysis
10.1002/jcc.20084 · 2004 · External reference
UCSF ChimeraX: meeting modern challenges in visualization and analysis
10.1002/pro.3235 · 2018 · External reference
UCSF ChimeraX: Structure visualization for researchers, educators, and developers
10.1002/pro.3943 · 2021 · External reference
Structural basis of Gs and Gi recognition by the human glucagon receptor
10.1126/science.aaz5346 · 2020 · External reference
Activation and signaling mechanism revealed by cannabinoid receptor-Gi complex structures
2020 · External reference
CHARMM-GUI: a web-based graphical user interface for CHARMM
10.1002/jcc.20945 · 2008 · External reference
OPM database and PPM web server: resources for positioning of proteins in membranes
10.1093/nar/gkr703 · 2012 · External reference
CHARMM36 all-atom additive protein force field: validation based on comparison to NMR data
10.1002/jcc.23354 · 2013 · External reference
CHARMM general force field: a force field for drug-like molecules compatible with the CHARMM all-atom additive biological force fields
10.1002/jcc.21367 · 2010 · External reference
GROMACS: high performance molecular simulations through multi-level parallelism from laptops to supercomputers
10.1016/j.softx.2015.06.001 · 2015 · External reference
Particle mesh Ewald: an N⋅log(N) method for Ewald sums in large systems
10.1063/1.464397 · 1993 · External reference
LINCS: a linear constraint solver for molecular simulations
10.1002/(sici)1096-987x(199709)18:12<1463::aid-jcc4>3.0.co;2-h · 1997 · External reference
MDAnalysis: a toolkit for the analysis of molecular dynamics simulations
10.1002/jcc.21787 · 2011 · External reference
