Research graph
References from The RNA-binding protein RBM39 scaffolds an m⁶A-dependent RNA decay complex that destabilizes Tat transcripts and restricts HIV-1 reactivation. Local targets link to admitted publications; unresolved targets remain external evidence.
Early establishment of a pool of latently infected, resting CD4(+) T cells during primary HIV-1 infection
10.1073/pnas.95.15.8869 · 1998 · External reference
Recent advances in CD8+ T cell-based immune therapies for HIV cure
10.1016/j.heliyon.2023.e17481 · 2023 · External reference
HIV “shock and kill” therapy: in need of revision
10.1016/j.antiviral.2019.03.008 · 2019 · External reference
HIV-1 Tat protein promotes formation of more-processive elongation complexes
10.1002/j.1460-2075.1991.tb04997.x · 1991 · External reference
Controlling the elongation phase of transcription with P-TEFb
10.1016/j.molcel.2006.06.014 · 2006 · External reference
Enhanced NF-κB activation via HIV-1 Tat-TRAF6 cross-talk
2024 · External reference
Potent latency reversal by Tat RNA-containing nanoparticle enables multi-omic analysis of the HIV-1 reservoir
10.1038/s41467-023-44020-5 · 2023 · External reference
The RNA binding proteins YTHDC1 and FMRP regulate the nuclear export of N6-methyladenosine-modified hepatitis B virus transcripts and affect the viral life cycle
2021 · External reference
Unmasking the U2AF homology motif family: a bona fide protein-protein interaction motif in disguise
10.1261/rna.057950.116 · 2016 · External reference
U2AF65 assemblies drive sequence-specific splice site recognition
10.15252/embr.201847604 · 2019 · External reference
RNA-binding motif protein 39 (RBM39): An emerging cancer target
10.1111/bph.15331 · 2022 · External reference
Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors
10.1074/jbc.m110417200 · 2002 · External reference
CAPER is vital for energy and redox homeostasis by integrating glucose-induced mitochondrial functions via ERR-α-Gabpa and stress-induced adaptive responses via NF-κB-cMYC
2015 · External reference
N6-methyladenosine reader protein YTHDC1 regulates influenza A virus NS segment splicing and replication
2023 · External reference
The functions of N-methyladenosine (m6A) modification on HIV-1 mRNA
10.1007/s12013-024-01280-2 · 2024 · External reference
YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs
10.7554/elife.31311 · 2017 · External reference
YTHDC1 regulates distinct post-integration steps of HIV-1 replication and is important for viral infectivity
10.1186/s12977-022-00589-1 · 2022 · External reference
Epitranscriptomic addition of m6A regulates HIV-1 RNA stability and alternative splicing
10.1101/gad.348508.121 · 2021 · External reference
Metabolic reprogramming in HIV-associated neurocognitive disorders
10.3389/fncel.2022.812887 · 2022 · External reference
Human immunodeficiency virus type 1 hnRNP A/B-dependent exonic splicing silencer ESSV antagonizes binding of U2AF65 to viral polypyrimidine tracts
10.1128/mcb.23.23.8762-8772.2003 · 2003 · External reference
Insights on the biological functions and diverse regulation of RNA-binding protein 39 and their implication in human diseases
10.1016/j.bbagrm.2022.194902 · 2023 · External reference
Dynamics of the human and viral m(6)A RNA methylomes during HIV-1 infection of T cells
10.1038/nmicrobiol.2016.11 · 2016 · External reference
Posttranscriptional m(6)A editing of HIV-1 mRNAs enhances viral gene expression
10.1016/j.chom.2016.04.002 · 2016 · External reference
Epitranscriptomic addition of m5C to HIV-1 transcripts regulates viral gene expression
10.1016/j.chom.2019.07.005 · 2019 · External reference
Epitranscriptomics: correlation of N6-methyladenosine RNA methylation and pathway dysregulation in the hippocampus of HIV transgenic rats
2019 · External reference
HIV modifies the m6A and m5C epitranscriptomic landscape of the host cell
2021 · External reference
Epitranscriptomic regulation of HIV-1 full-length RNA packaging
10.1093/nar/gkac062 · 2022 · External reference
The role of m6A modification in physiology and disease
10.1038/s41419-020-03143-z · 2020 · External reference
m(6)A RNA methylation promotes XIST-mediated transcriptional repression
10.1038/nature19342 · 2016 · External reference
Structural insights into N6-methyladenosine (m6A) modification in the transcriptome
10.1016/j.gpb.2018.03.001 · 2018 · External reference
DDX5 plays essential transcriptional and post-transcriptional roles in the maintenance and function of spermatogonia
10.1038/s41467-019-09972-7 · 2019 · External reference
The RNA helicase DDX5 promotes viral infection via regulating N6-methyladenosine levels on the DHX58 and NFκB transcripts to dampen antiviral innate immunity
2021 · External reference
RNA helicase DDX5 participates in oxLDL-induced macrophage scavenger receptor 1 expression by suppressing mRNA degradation
10.1016/j.yexcr.2018.03.003 · 2018 · External reference
The m6A reader YTHDC1 and the RNA helicase DDX5 control the production of rhabdomyosarcoma-enriched circRNAs
10.1038/s41467-023-37578-7 · 2023 · External reference
Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15
2017 · External reference
Arginine reprograms metabolism in liver cancer via RBM39
10.1016/j.cell.2023.09.011 · 2023 · External reference
N6-Methyladenosine-binding proteins suppress HIV-1 infectivity and viral production
10.1074/jbc.ra118.004215 · 2018 · External reference
The Tat inhibitor didehydro-cortistatin A prevents HIV-1 reactivation from latency
10.1128/mbio.00465-15 · 2015 · External reference
In vivo suppression of HIV rebound by didehydro-cortistatin A, a “Block-and-Lock” strategy for HIV-1 treatment
10.1016/j.celrep.2017.09.080 · 2017 · External reference
Tat inhibition by didehydro-Cortistatin A promotes heterochromatin formation at the HIV-1 long terminal repeat
10.1186/s13072-019-0267-8 · 2019 · External reference
Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure
10.1016/j.cell.2013.09.020 · 2013 · External reference
Stochastic gene expression in a lentiviral positive-feedback loop: HIV-1 Tat fluctuations drive phenotypic diversity
10.1016/j.cell.2005.06.006 · 2005 · External reference
A hardwired HIV latency program
10.1016/j.cell.2015.02.009 · 2015 · External reference
A post-transcriptional feedback mechanism for noise suppression and fate stabilization
2018 · External reference
HIV replication is increased by RNA methylation METTL3/METTL14/WTAP complex activators
10.1021/acsomega.1c01626 · 2021 · External reference
Selective degradation of splicing factor CAPERα by anticancer sulfonamides
10.1038/nchembio.2363 · 2017 · External reference
Functional impacts of epitranscriptomic m6A modification on HIV-1 infection
10.3390/v16010127 · 2024 · External reference
The race between host antiviral innate immunity and the immune evasion strategies of herpes simplex virus 1
2020 · External reference
RNA binding protein TIAR modulates HBV replication by tipping the balance of pgRNA translation
10.1038/s41392-023-01573-7 · 2023 · External reference
Circular RNA circEsyt2 regulates vascular smooth muscle cell remodeling via splicing regulation
10.1172/jci147031 · 2021 · External reference
clusterProfiler: an R package for comparing biological themes among gene clusters
10.1089/omi.2011.0118 · 2012 · External reference
STRING: a database of predicted functional associations between proteins
10.1093/nar/gkg034 · 2003 · External reference
The use of Gene Ontology terms for predicting highly-connected “hub” nodes in protein-protein interaction networks
10.1186/1752-0509-2-80 · 2008 · External reference
cytoHubba: identifying hub objects and sub-networks from complex interactome
2014 · External reference
Development of an attenuated tat protein as a highly-effective agent to specifically activate HIV-1 latency
10.1038/mt.2016.117 · 2016 · External reference
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
10.1093/nar/22.22.4673 · 1994 · External reference
MEGA12: molecular evolutionary genetic analysis version 12 for adaptive and green computing
10.1093/molbev/msae263 · 2024 · External reference
Interactive Tree Of Life (iTOL) v5: an online tool for phylogenetic tree display and annotation
10.1093/nar/gkab301 · 2021 · External reference
