Research graph
References from Large-scale seroepidemiology uncovers nephro-urological pathologies in people with tau autoimmunity. Local targets link to admitted publications; unresolved targets remain external evidence.
Tau is widely expressed in rat tissues
10.1046/j.1471-4159.1996.67031235.x · 1996 · External reference
Proteomics. Tissue-based map of the human proteome
10.1126/science.1260419 · 2015 · External reference
Atypical, non-standard functions of the microtubule associated Tau protein
10.1186/s40478-017-0489-6 · 2017 · External reference
A multi-layered quantitative in vivo expression atlas of the podocyte unravels kidney disease candidate genes
10.1016/j.celrep.2018.04.059 · 2018 · External reference
Glucose regulates microtubule disassembly and the dose of insulin secretion via tau phosphorylation
10.2337/db19-1186 · 2020 · External reference
Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease
10.1073/pnas.83.11.4044 · 1986 · External reference
Tau antisera recognize neurofibrillary tangles in a range of neurodegenerative disorders
10.1002/ana.410220411 · 1987 · External reference
Association of amyloid and tau with cognition in preclinical Alzheimer disease: a longitudinal study
10.1001/jamaneurol.2019.1424 · 2019 · External reference
Plasma tau in Alzheimer disease
10.1212/wnl.0000000000003246 · 2016 · External reference
Plasma P-tau181 in Alzheimer’s disease: relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer’s dementia
10.1038/s41591-020-0755-1 · 2020 · External reference
Association of plasma total tau level with cognitive decline and risk of mild cognitive impairment or dementia in the mayo clinic study on aging
10.1001/jamaneurol.2017.1359 · 2017 · External reference
Blood biomarkers to detect Alzheimer disease in primary care and secondary care
10.1001/jama.2024.13855 · 2024 · External reference
Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements
10.1523/jneurosci.2361-07.2007 · 2007 · External reference
Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain
10.1111/j.1471-4159.2011.07337.x · 2011 · External reference
Tau-targeting therapies for Alzheimer disease
10.1038/s41582-018-0013-z · 2018 · External reference
Natural antibodies as rheostats for susceptibility to chronic diseases in the aged
10.3389/fimmu.2016.00127 · 2016 · External reference
Naturally occurring auto-antibodies in homeostasis and disease
10.1016/j.it.2008.10.002 · 2009 · External reference
Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths
10.1126/sciimmunol.abl4340 · 2021 · External reference
Decoding the autoantibody reactome
10.1126/science.abn1034 · 2024 · External reference
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis in children and adolescents
10.1002/ana.21756 · 2009 · External reference
A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis
10.1016/s0140-6736(04)17551-x · 2004 · External reference
First-in-human, double-blind, placebo-controlled, single-dose escalation study of aducanumab (BIIB037) in mild-to-moderate Alzheimer’s disease
10.1016/j.trci.2016.06.002 · 2016 · External reference
Lower serum antibodies against tau protein and heavy neurofilament in Alzheimer’s disease
10.3233/jad-180039 · 2018 · External reference
Naturally occurring autoantibodies against tau protein are reduced in Parkinson’s disease dementia
10.1371/journal.pone.0164953 · 2016 · External reference
Continuous population-level monitoring of SARS-CoV-2 seroprevalence in a large European metropolitan region
10.1016/j.isci.2023.105928 · 2023 · External reference
The cystic fibrosis transmembrane regulator controls tolerogenic responses to food allergens in mice and humans
2024 · External reference
Protective anti-prion antibodies in human immunoglobulin repertoires
10.15252/emmm.202012739 · 2020 · External reference
A simple method for estimating relative risk using logistic regression
10.1186/1471-2288-12-14 · 2012 · External reference
logbin: an R package for relative risk regression using the log-binomial model
10.18637/jss.v086.i09 · 2018 · External reference
Pathological inclusion bodies in tauopathies contain distinct complements of tau with three or four microtubule-binding repeat domains as demonstrated by new specific monoclonal antibodies
10.1046/j.1365-2990.2003.00463.x · 2003 · External reference
A common antigenic motif recognized by naturally occurring human VH5-51/VL4-1 anti-tau antibodies with distinct functionalities
10.1186/s40478-018-0543-z · 2018 · External reference
Assessment of plasma total tau level as a predictive biomarker for dementia and related endophenotypes
10.1001/jamaneurol.2018.4666 · 2019 · External reference
Tau in the brain interstitial fluid is fragmented and seeding-competent
10.1016/j.neurobiolaging.2021.09.013 · 2022 · External reference
Seroprevalence of autoantibodies against brain antigens in health and disease
10.1002/ana.24189 · 2014 · External reference
Naturally occurring antibodies to tau exists in human blood and are not changed in Alzheimer’s disease
10.1007/s12640-020-00161-9 · 2020 · External reference
Clinical features and disease haplotypes of individuals with the N279K tau gene mutation: a comparison of the pallidopontonigral degeneration kindred and a French family
10.1001/archneur.59.6.943 · 2002 · External reference
Microtubule-associated protein tau in murine kidney: role in podocyte architecture
10.1007/s00018-021-04106-z · 2022 · External reference
Tau-targeting therapies for Alzheimer disease: current status and future directions
10.1038/s41582-023-00883-2 · 2023 · External reference
Unresolved reference
External reference
Update on the TOGETHER study: a patient‐ and investigator‐blind, randomized, placebo‐controlled study evaluating the efficacy, safety and tolerability of bepranemab, UCB0107, in prodromal‐to‐mild Alzheimer’s disease
10.1002/alz.068973 · 2022 · External reference
Longitudinal associations of blood phosphorylated tau181 and neurofilament light chain with neurodegeneration in Alzheimer disease
10.1001/jamaneurol.2020.4986 · 2021 · External reference
A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease
10.1038/s41591-020-0781-z · 2020 · External reference
Blood phosphorylated tau 181 as a biomarker for Alzheimer’s disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts
10.1016/s1474-4422(20)30071-5 · 2020 · External reference
Plasma tau/amyloid-β1-42 ratio predicts brain tau deposition and neurodegeneration in Alzheimer’s disease
10.1093/brain/awy347 · 2019 · External reference
Discriminative accuracy of plasma phospho-tau217 for Alzheimer disease vs other neurodegenerative disorders
10.1001/jama.2020.12134 · 2020 · External reference
Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy
10.1126/scitranslmed.aal2029 · 2017 · External reference
Performance of plasma phosphorylated tau 181 and 217 in the community
10.1038/s41591-022-01822-2 · 2022 · External reference
Recommendations for optimal ICD codes to study neurologic conditions: a systematic review
10.1212/wnl.0b013e3182684707 · 2012 · External reference
Big tau: what we know, and we need to know
10.1523/eneuro.0052-23.2023 · 2023 · External reference
Plasma pTau181 as a biomarker for Alzheimer’s disease
10.1002/mco2.1 · 2020 · External reference
P-tau217 in Alzheimer’s disease
10.1016/j.cca.2022.03.018 · 2022 · External reference
Brain-derived tau: a novel blood-based biomarker for Alzheimer’s disease-type neurodegeneration
10.1093/brain/awac407 · 2023 · External reference
Unresolved reference
2004 · External reference
Activation of the Wnt signaling pathway: a molecular mechanism for lithium action
10.1006/dbio.1997.8552 · 1997 · External reference
Natural polyreactive IgA antibodies coat the intestinal microbiota
10.1126/science.aan6619 · 2017 · External reference
Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation
10.1038/nature09385 · 2010 · External reference
LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies
10.15252/emmm.202114745 · 2021 · External reference
The ASC inflammasome adapter governs SAA-derived protein aggregation in inflammatory amyloidosis
10.1038/s44321-024-00107-0 · 2024 · External reference
Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration
10.1016/j.neuron.2010.11.030 · 2010 · External reference
Prion seeding activity and infectivity in skin samples from patients with sporadic Creutzfeldt-Jakob disease
2017 · External reference
Estimating the relative risk in cohort studies and clinical trials of common outcomes
10.1093/aje/kwg074 · 2003 · External reference
Antiphospholipid antibodies are enriched post-acute COVID-19 but do not modulate the thrombotic risk
10.1016/j.clim.2023.109845 · 2023 · External reference
Unresolved reference
2023 · External reference
Unresolved reference
2021 · External reference
