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References from The cell cycle regulator PLK1 promotes murine melanoma progression by regulating the transcription factor BACH1. Local targets link to admitted publications; unresolved targets remain external evidence.
Cancer statistics, 2025
2025 · External reference
Melanoma
10.1016/s0140-6736(18)31559-9 · 2018 · External reference
A landscape of driver mutations in melanoma
10.1016/j.cell.2012.06.024 · 2012 · External reference
Genomic classification of cutaneous melanoma
10.1016/j.cell.2015.05.044 · 2015 · External reference
Classifying BRAF alterations in cancer: new rational therapeutic strategies for actionable mutations
10.1038/s41388-018-0171-x · 2018 · External reference
Improved survival with vemurafenib in melanoma with BRAF V600E mutation
10.1056/nejmoa1103782 · 2011 · External reference
Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma
10.1038/nature13121 · 2014 · External reference
Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma
10.1046/j.0022-202x.2004.22243.x · 2004 · External reference
The metabolism of cancer cells during metastasis
10.1038/s41568-020-00320-2 · 2021 · External reference
A PGC1α-mediated transcriptional axis suppresses melanoma metastasis
10.1038/nature19347 · 2016 · External reference
Oxidative stress inhibits distant metastasis by human melanoma cells
10.1038/nature15726 · 2015 · External reference
Metabolic heterogeneity confers differences in melanoma metastatic potential
10.1038/s41586-019-1847-2 · 2020 · External reference
Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy
10.1038/nrd3184 · 2010 · External reference
Targeting polo-like kinases: a promising therapeutic approach for cancer treatment
10.1016/j.tranon.2015.03.010 · 2015 · External reference
Plk1 phosphorylation of PTEN causes a tumor-promoting metabolic state
10.1128/mcb.00814-14 · 2014 · External reference
Polo-like kinase 1 induces epithelial-to-mesenchymal transition and promotes epithelial cell motility by activating CRAF/ERK signaling
2016 · External reference
BI 6727, a Polo-like kinase inhibitor with improved pharmacokinetic profile and broad antitumor activity
10.1158/1078-0432.ccr-08-2445 · 2009 · External reference
In vitro targeting of Polo-like kinase 1 in bladder carcinoma: comparative effects of four potent inhibitors
10.4161/cbt.25087 · 2013 · External reference
Efficacy and mechanism of action of volasertib, a potent and selective inhibitor of Polo-like kinases, in preclinical models of acute myeloid leukemia
10.1124/jpet.114.221150 · 2015 · External reference
Combined inhibition of MEK and Plk1 has synergistic antitumor activity in NRAS mutant melanoma
10.1038/jid.2015.198 · 2015 · External reference
Braf(V600E) cooperates with Pten loss to induce metastatic melanoma
10.1038/ng.356 · 2009 · External reference
β-catenin signaling controls metastasis in Braf-activated Pten-deficient melanomas
10.1016/j.ccr.2011.10.030 · 2011 · External reference
PLK1, a potential target for cancer therapy
10.1016/j.tranon.2016.10.003 · 2017 · External reference
Polo-like kinase 1 (Plk1) overexpression enhances ionizing radiation-induced cancer formation in mice
10.1074/jbc.m117.810960 · 2017 · External reference
Genetic depletion of Polo-like kinase 1 leads to embryonic lethality due to mitotic aberrancies
10.1002/bies.201670908 · 2016 · External reference
The Molecular Signatures Database (MSigDB) hallmark gene set collection
10.1016/j.cels.2015.12.004 · 2015 · External reference
The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression
10.1016/j.molonc.2007.02.004 · 2007 · External reference
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
10.1038/s41580-020-0230-3 · 2020 · External reference
Modulation of oxidative stress as an anticancer strategy
10.1038/nrd4002 · 2013 · External reference
Critical role of reactive oxygen species (ROS) for synergistic enhancement of apoptosis by vemurafenib and the potassium channel inhibitor TRAM-34 in melanoma cells
10.1038/cddis.2017.6 · 2017 · External reference
Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism
10.1038/s41586-019-1005-x · 2019 · External reference
BACH1 stabilization by antioxidants stimulates lung cancer metastasis
10.1016/j.cell.2019.06.005 · 2019 · External reference
Heme regulates the dynamic exchange of Bach1 and NF-E2-related factors in the Maf transcription factor network
10.1073/pnas.0308083100 · 2004 · External reference
Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site
10.1128/mcb.16.11.6083 · 1996 · External reference
The transcription factor BACH1 at the crossroads of cancer biology: from epithelial-mesenchymal transition to ferroptosis
10.1016/j.jbc.2021.101032 · 2021 · External reference
The GeneCards suite: from gene data mining to disease genome sequence analyses
10.1002/cpbi.5 · 2016 · External reference
A global transcriptional network connecting noncoding mutations to changes in tumor gene expression
10.1038/s41588-018-0091-2 · 2018 · External reference
Dual kinase-bromodomain inhibitors for rationally designed polypharmacology
10.1038/nchembio.1471 · 2014 · External reference
Drug combination studies and their synergy quantification using the Chou-Talalay method
10.1158/0008-5472.can-09-1947 · 2010 · External reference
The kinase PLK1 promotes the development of Kras/Tp53-mutant lung adenocarcinoma through transcriptional activation of the receptor RET
10.1126/scisignal.abj4009 · 2022 · External reference
Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression
10.1016/j.ccell.2014.11.019 · 2015 · External reference
Antioxidants accelerate lung cancer progression in mice
10.1126/scitranslmed.3007653 · 2014 · External reference
Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors
10.1172/jci82661 · 2016 · External reference
Targeted knockdown of polo-like kinase 1 alters metabolic regulation in melanoma
10.1016/j.canlet.2017.02.013 · 2017 · External reference
Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway
10.1038/s41467-017-01647-5 · 2017 · External reference
Bach1 inhibits oxidative stress-induced cellular senescence by impeding p53 function on chromatin
10.1038/nsmb.1516 · 2008 · External reference
The transcription factor Bach1 suppresses the developmental angiogenesis of zebrafish
10.1155/2017/2143875 · 2017 · External reference
Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1
10.1093/emboj/20.11.2835 · 2001 · External reference
Nrf2 activation promotes lung cancer metastasis by inhibiting the degradation of Bach1
10.1016/j.cell.2019.06.003 · 2019 · External reference
Antioxidant-induced phosphorylation of tyrosine 486 leads to rapid nuclear export of Bach1 that allows Nrf2 to bind to the antioxidant response element and activate defensive gene expression
10.1074/jbc.m109.040022 · 2010 · External reference
Phosphorylation of BACH1 switches its function from transcription factor to mitotic chromosome regulator and promotes its interaction with HMMR
10.1042/bcj20170520 · 2018 · External reference
Clinical development of BRAF plus MEK inhibitor combinations
10.1016/j.trecan.2020.05.009 · 2020 · External reference
Survival of patients with advanced metastatic melanoma: the impact of novel therapies-update 2017
10.1016/j.ejca.2017.06.028 · 2017 · External reference
Cobimetinib combined with vemurafenib in advanced BRAF(V600)-mutant melanoma (coBRIM): updated efficacy results from a randomised, double-blind, phase 3 trial
10.1016/s1470-2045(16)30122-x · 2016 · External reference
Three-dimensional (3D) tumor spheroid invasion assay
10.3791/52686 · 2015 · External reference
Normal cells, but not cancer cells, survive severe Plk1 depletion
10.1128/mcb.26.6.2093-2108.2006 · 2006 · External reference
In vitro cell migration and invasion assays
2014 · External reference
GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses
10.1093/nar/gkx247 · 2017 · External reference
