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References from Hydroxyurea induces an oxidative stress response that triggers ER expansion and cytoplasmic protein aggregation. Local targets link to admitted publications; unresolved targets remain external evidence.
Membrane protein insertion at the endoplasmic reticulum
10.1146/annurev-cellbio-092910-154125 · 2011 · External reference
High capacity of the endoplasmic reticulum to prevent secretion and aggregation of amyloidogenic proteins
10.15252/embj.201695841 · 2018 · External reference
Protein folding in the endoplasmic reticulum
10.1101/cshperspect.a013201 · 2013 · External reference
Protein quality control in the secretory pathway
10.1083/jcb.201906047 · 2019 · External reference
The unfolded protein response: controlling cell fate decisions under ER stress and beyond
10.1038/nrm3270 · 2012 · External reference
Human protein-disulfide isomerase is a redox-regulated chaperone activated by oxidation of domain a’
10.1074/jbc.m111.303149 · 2012 · External reference
Role of the ERO1-PDI interaction in oxidative protein folding and disease
10.1016/j.pharmthera.2020.107525 · 2020 · External reference
The unfolded protein response: an overview
2021 · External reference
Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease
10.1089/ars.2014.5851 · 2014 · External reference
Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response
10.1083/jcb.200907074 · 2009 · External reference
The role of glutathione in disulphide bond formation and endoplasmic-reticulum-generated oxidative stress
10.1038/sj.embor.7400645 · 2006 · External reference
Glutathione directly reduces an oxidoreductase in the endoplasmic reticulum of mammalian cells
10.1074/jbc.m411409200 · 2004 · External reference
Glutathione revisited: a vital function in iron metabolism and ancillary role in thiol-redox control
10.1038/emboj.2011.105 · 2011 · External reference
The thioredoxin antioxidant system
10.1016/j.freeradbiomed.2013.07.036 · 2014 · External reference
Glutathione limits Ero1-dependent oxidation in the endoplasmic reticulum
10.1074/jbc.m404992200 · 2004 · External reference
Maturation of cytosolic iron-sulfur proteins requires glutathione
10.1074/jbc.m200677200 · 2002 · External reference
Oxidized redox state of glutathione in the endoplasmic reticulum
10.1126/science.1523409 · 1992 · External reference
Glutathione: overview of its protective roles, measurement, and biosynthesis
10.1016/j.mam.2008.08.006 · 2009 · External reference
Molecular mechanisms and potential clinical significance of S-glutathionylation
10.1089/ars.2007.1716 · 2008 · External reference
Redox characteristics of the eukaryotic cytosol
10.1016/j.bbamcr.2007.10.013 · 2008 · External reference
Oxidative protein folding and unfolded protein response elicit differing redox regulation in endoplasmic reticulum and cytosol of yeast
10.1016/j.freeradbiomed.2012.02.048 · 2012 · External reference
Oxygen stress: a regulator of apoptosis in yeast
10.1083/jcb.145.4.757 · 1999 · External reference
Hydroxyurea-the good, the bad and the ugly
10.3390/genes12071096 · 2021 · External reference
Targeting matrix metallopeptidase 2 by hydroxyurea selectively kills acute myeloid mixed-lineage leukemia
10.1038/s41420-022-00989-4 · 2022 · External reference
Hydroxyurea modulates thiol-disulfide homeostasis in the yeast endoplasmic reticulum
10.26508/lsa.202503225 · 2025 · External reference
Cell-cycle synchrony for analysis of S. pombe DNA replication
10.1007/978-1-60327-815-7_24 · 2009 · External reference
Fission yeast cell cycle synchronization methods
10.1007/978-1-4939-3145-3_20 · 2016 · External reference
The transcription factors Pap1 and Prr1 collaborate to activate antioxidant, but not drug tolerance, genes in response to H2O2
10.1093/nar/gks141 · 2012 · External reference
Regulation of the fission yeast transcription factor Pap1 by oxidative stress: requirement for the nuclear export factor Crm1 (Exportin) and the stress-activated MAP kinase Sty1/Spc1
10.1101/gad.12.10.1453 · 1998 · External reference
Activation of the redox sensor Pap1 by hydrogen peroxide requires modulation of the intracellular oxidant concentration
10.1111/j.1365-2958.2004.04065.x · 2004 · External reference
Cop9/signalosome subunits and Pcu4 regulate ribonucleotide reductase by both checkpoint-dependent and -independent mechanisms
10.1101/gad.1090803 · 2003 · External reference
Spd2 assists Spd1 in the modulation of ribonucleotide reductase architecture but does not regulate deoxynucleotide pools
2014 · External reference
Checkpoint regulation of nuclear Tos4 defines S phase arrest in fission yeast
10.1534/g3.119.400726 · 2020 · External reference
Cell division cycle mutants altered in DNA replication and mitosis in the fission yeast Schizosaccharomyces pombe
10.1007/bf00422777 · 1981 · External reference
The fission yeast Nup107-120 complex functionally interacts with the small GTPase Ran/Spi1 and is required for mRNA export, nuclear pore distribution, and proper cell division
10.1128/mcb.24.14.6379-6392.2004 · 2004 · External reference
Heh2/Man1 may be an evolutionarily conserved sensor of NPC assembly state
10.1091/mbc.e20-09-0584 · 2021 · External reference
Nuclear envelope: membrane bending for pore formation?
10.1016/j.cub.2009.03.053 · 2009 · External reference
The nuclear envelope
10.1101/cshperspect.a000539 · 2010 · External reference
LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells
2017 · External reference
Surveillance of nuclear pore complex assembly by ESCRT-III/Vps4
10.1016/j.cell.2014.09.012 · 2014 · External reference
Nuclear membrane protein Lem2 regulates nuclear size through membrane flow
10.1038/s41467-019-09623-x · 2019 · External reference
Lem2 and Lnp1 maintain the membrane boundary between the nuclear envelope and endoplasmic reticulum
10.1038/s42003-020-0999-9 · 2020 · External reference
Mechanisms of hydroxyurea-induced cellular senescence: an oxidative stress connection?
10.1155/2021/7753857 · 2021 · External reference
The cell killing mechanisms of hydroxyurea
10.3390/genes7110099 · 2016 · External reference
Monitoring cytosolic H2O2 fluctuations arising from altered plasma membrane gradients or from mitochondrial activity
10.1038/s41467-019-12475-0 · 2019 · External reference
Adaptive response of Schizosaccharomyces pombe to hydrogen peroxide and menadione
10.1099/13500872-141-12-3127 · 1995 · External reference
Diamide, a new reagent for the intracellular oxidation of glutathione to the disulfide
10.1016/0006-291x(69)90850-x · 1969 · External reference
The disulfide proteome and other reactive cysteine proteomes: analysis and functional significance
10.1089/ars.2010.3551 · 2011 · External reference
Membrane thiol-disulfide status in glucose-6-phosphate dehydrogenase deficient red cells. Relationship to cellular glutathione
10.1016/0005-2736(82)90424-2 · 1982 · External reference
Decreases in GSH:GSSG activate vascular endothelial growth factor receptor 2 (VEGFR2) in human aortic endothelial cells
10.1016/j.redox.2018.07.015 · 2018 · External reference
Manipulating disulfide bond formation and protein folding in the endoplasmic reticulum
10.1002/j.1460-2075.1992.tb05223.x · 1992 · External reference
Dithiothreitol, a new protective reagent for SH groups
10.1021/bi00892a002 · 1964 · External reference
Inhibition of eIF2α dephosphorylation accelerates pterostilbene-induced cell death in human hepatocellular carcinoma cells in an ER stress and autophagy-dependent manner
10.1038/s41419-019-1639-5 · 2019 · External reference
Norcantharidin combined with paclitaxel induces endoplasmic reticulum stress mediated apoptotic effect in prostate cancer cells by targeting SIRT7 expression
10.1002/tox.23334 · 2021 · External reference
CPY* and the power of yeast genetics in the elucidation of quality control and associated protein degradation of the endoplasmic reticulum
2005 · External reference
N-glycans are not required for the efficient degradation of the mutant Saccharomyces cerevisiae CPY* in Schizosaccharomyces pombe
10.1007/s00253-011-3662-z · 2012 · External reference
Processing and maturation of carboxypeptidase Y and alkaline phosphatase in Schizosaccharomyces pombe
10.1007/s00253-010-3031-3 · 2011 · External reference
Vacuolar protein sorting in fission yeast: cloning, biosynthesis, transport, and processing of carboxypeptidase Y from Schizosaccharomyces pombe
10.1128/jb.179.13.4179-4189.1997 · 1997 · External reference
ER-golgi traffic is a prerequisite for efficient ER degradation
10.1091/mbc.01-08-0399 · 2002 · External reference
Localization of an alpha 1,2 galactosyltransferase activity to the Golgi apparatus of Schizosaccharomyces pombe
10.1091/mbc.5.5.519 · 1994 · External reference
Sbg1 is a novel regulator for the localization of the β-glucan synthase Bgs1 in fission yeast
10.1371/journal.pone.0167043 · 2016 · External reference
Drc1p/Cps1p, a 1,3-beta-glucan synthase subunit, is essential for division septum assembly in Schizosaccharomyces pombe
10.1093/genetics/153.3.1193 · 1999 · External reference
Involvement of Smi1 in cell wall integrity and glucan synthase Bgs4 localization during fission yeast cytokinesis
2022 · External reference
Overview of fission yeast septation
10.1111/cmi.12611 · 2016 · External reference
Sec61p and BiP directly facilitate polypeptide translocation into the ER
10.1016/0092-8674(92)90415-9 · 1992 · External reference
Binding protein BiP is required for translocation of secretory proteins into the endoplasmic reticulum in Saccharomyces cerevisiae
10.1073/pnas.88.4.1565 · 1991 · External reference
BiP/Kar2p serves as a molecular chaperone during carboxypeptidase Y folding in yeast
10.1083/jcb.130.1.41 · 1995 · External reference
Sec63p and Kar2p are required for the translocation of SRP-dependent precursors into the yeast endoplasmic reticulum in vivo
10.1093/emboj/20.1.262 · 2001 · External reference
BiP and Sec63p are required for both co- and posttranslational protein translocation into the yeast endoplasmic reticulum
10.1073/pnas.92.21.9643 · 1995 · External reference
Stress-induced protein disaggregation in the endoplasmic reticulum catalysed by BiP
10.1038/s41467-022-30238-2 · 2022 · External reference
Chaperone-facilitated aggregation of thermo-sensitive proteins shields them from degradation during heat stress
10.1016/j.celrep.2020.01.077 · 2020 · External reference
Formation of transient protein aggregate-like centers is a general strategy postponing degradation of misfolded intermediates
10.3390/ijms241311202 · 2023 · External reference
Vgl1, a multi-KH domain protein, is a novel component of the fission yeast stress granules required for cell survival under thermal stress
10.1093/nar/gkq555 · 2010 · External reference
Inhibition of protein synthesis disrupts the Golgi apparatus in the fission yeast, Schizosaccharomyces pombe
10.1002/yea.320100102 · 1994 · External reference
Effect of cycloheximide on the reaction of puromycin with polysome-bound peptidyl-tRNA
10.1016/0014-5793(70)80278-2 · 1970 · External reference
Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin
10.1038/nchembio.304 · 2010 · External reference
Mechanism of puromycin action: fate of ribosomes after release of nascent protein chains from polysomes
10.1073/pnas.70.12.3866 · 1973 · External reference
Puromycin reaction of the A-site bound peptidyl-tRNA
10.1016/0300-9084(92)90080-x · 1992 · External reference
Inhibitors of protein biosynthesis. II. Mode of action of anisomycin
10.1016/s0021-9258(18)95953-3 · 1967 · External reference
Cysteine sulfenylation directs IRE-1 to activate the SKN-1/Nrf2 antioxidant response
10.1016/j.molcel.2016.07.019 · 2016 · External reference
Regulation of the unfolded protein response in yeast by oxidative stress
10.1002/1873-3468.13389 · 2019 · External reference
The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis
10.7554/elife.00048 · 2012 · External reference
Endoplasmic reticulum stress response in yeast and humans
2014 · External reference
Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response
10.1371/journal.pbio.0040423 · 2006 · External reference
Effect of protein S-glutathionylation on Ca2+ homeostasis in cultured aortic endothelial cells
2011 · External reference
Diamide: an oxidant probe for thiols
10.1016/0076-6879(95)51116-4 · 1995 · External reference
Diamide triggers mainly S Thiolations in the cytoplasmic proteomes of Bacillus subtilis and Staphylococcus aureus
10.1128/jb.00937-09 · 2009 · External reference
Protein disulfide bond formation in the cytoplasm during oxidative stress
10.1074/jbc.m312267200 · 2004 · External reference
The effect of disulfide bonds on protein folding, unfolding, and misfolding investigated by FT–Raman spectroscopy
10.1002/jrs.4935 · 2016 · External reference
Disulfide bonding in neurodegenerative misfolding diseases
10.1155/2013/318319 · 2013 · External reference
S-glutathionylation of cryptic cysteines enhances titin elasticity by blocking protein folding
10.1016/j.cell.2014.01.056 · 2014 · External reference
The role of s-nitrosylation and s-glutathionylation of protein disulphide isomerase in protein misfolding and neurodegeneration
10.1155/2013/797914 · 2013 · External reference
Glutathione metabolism and its implications for health
10.1093/jn/134.3.489 · 2004 · External reference
KEGG: kyoto encyclopedia of genes and genomes
10.1093/nar/28.1.27 · 2000 · External reference
Enzymes catalysing conjugations of glutathione with alpha-beta-unsaturated carbonyl compounds
10.1042/bj1090651 · 1968 · External reference
Endoplasmic reticulum stress and oxidative stress in the pathogenesis of non-alcoholic fatty liver disease
10.3109/10715762.2015.1078461 · 2015 · External reference
Endoplasmic reticulum stress links oxidative stress to impaired pancreatic beta-cell function caused by human oxidized LDL
10.1371/journal.pone.0163046 · 2016 · External reference
PI3Kδ contributes to ER stress-associated asthma through ER-redox disturbances: the involvement of the RIDD-RIG-I-NF-κB axis
2018 · External reference
The unfolded protein response: from stress pathway to homeostatic regulation
10.1126/science.1209038 · 2011 · External reference
The unfolded protein response coordinates the production of endoplasmic reticulum protein and endoplasmic reticulum membrane
10.1091/mbc.8.9.1805 · 1997 · External reference
XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum
10.1083/jcb.200406136 · 2004 · External reference
TMX4-driven LINC complex disassembly and asymmetric autophagy of the nuclear envelope upon acute ER stress
10.1038/s41467-023-39172-3 · 2023 · External reference
Endoplasmic reticulum stress in human chronic wound healing: rescue by 4-phenylbutyrate
10.1111/iwj.13525 · 2021 · External reference
Endoplasmic reticulum pathology and stress response in neurons precede programmed necrosis after neonatal hypoxia-ischemia
10.1016/j.ijdevneu.2015.11.007 · 2016 · External reference
Nuclear mechanics and mechanotransduction in health and disease
10.1016/j.cub.2013.11.009 · 2013 · External reference
Mechanical control of tissue and organ development
10.1242/dev.024166 · 2010 · External reference
Computational analyses reveal spatial relationships between nuclear pore complexes and specific lamins
10.1083/jcb.202007082 · 2021 · External reference
Nuclear pore complexes cluster in dysmorphic nuclei of normal and progeria cells during replicative senescence
10.3390/cells10010153 · 2021 · External reference
Insertional mutation of the Drosophila nuclear lamin Dm0 gene results in defective nuclear envelopes, clustering of nuclear pore complexes, and accumulation of annulate lamellae
10.1083/jcb.137.5.1001 · 1997 · External reference
10.4161/nucl.18824 · 2012 · Admitted local publication
Nuclear mechanics in the fission yeast
10.3390/cells8101285 · 2019 · External reference
The hyaluronidase, TMEM2, promotes ER homeostasis and longevity independent of the UPRER
10.1016/j.cell.2019.10.018 · 2019 · External reference
Endoplasmic reticulum stress and reactive oxygen species in plants
10.3390/antiox11071240 · 2022 · External reference
Unfolding the Interactions between endoplasmic reticulum stress and oxidative stress
10.3390/antiox12050981 · 2023 · External reference
Hydroxyurea facilitates manifestation of disease relevant phenotypes in patients-derived IPSCs-based modeling of late-onset Parkinson’s disease
10.14336/ad.2018.1216 · 2019 · External reference
The unfolded protein response pathway in the yeast Kluyveromyces lactis. A comparative view among yeast species
10.3390/cells7080106 · 2018 · External reference
Organelle-based aggregation and retention of damaged proteins in asymmetrically dividing cells
10.1016/j.cell.2014.09.026 · 2014 · External reference
Molecular genetic analysis of fission yeast Schizosaccharomyces pombe
10.1016/0076-6879(91)94059-l · 1991 · External reference
A toolbox of stable integration vectors in the fission yeast Schizosaccharomyces pombe
10.1242/jcs.240754 · 2020 · External reference
Extending the Schizosaccharomyces pombe molecular genetic toolbox
10.1371/journal.pone.0097683 · 2014 · External reference
The fission yeast nucleoporin Alm1 is required for proteasomal degradation of kinetochore components
10.1083/jcb.201612194 · 2017 · External reference
Mapping RNA-seq reads with STAR
10.1002/0471250953.bi1114s51 · 2015 · External reference
The sequence alignment/map format and SAMtools
10.1093/bioinformatics/btp352 · 2009 · External reference
HTSeq--a Python framework to work with high-throughput sequencing data
10.1093/bioinformatics/btu638 · 2015 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update)
10.1093/nar/gkac194 · 2022 · External reference
ShinyGO: a graphical gene-set enrichment tool for animals and plants
10.1093/bioinformatics/btz931 · 2020 · External reference
The mitochondria-to-cytosol H2O2 gradient is caused by peroxiredoxin-dependent cytosolic scavenging
10.3390/antiox10050731 · 2021 · External reference
Fiji: an open-source platform for biological-image analysis
10.1038/nmeth.2019 · 2012 · External reference
High pressure freezing and freeze substitution of Schizosaccharomyces pombe and Saccharomyces cerevisiae for TEM
10.1016/s0091-679x(08)00401-9 · 2008 · External reference
Freeze-substitution protocols for improved visualization of membranes in high-pressure frozen samples
10.1046/j.1365-2818.2003.01228.x · 2003 · External reference
A low-viscosity epoxy resin embedding medium for electron microscopy
10.1016/s0022-5320(69)90033-1 · 1969 · External reference
PomBase: a global core biodata resource-growth, collaboration, and sustainability
10.1093/genetics/iyae007 · 2024 · External reference