Research graph
References from The blood–brain barrier regulates brain tumor growth through the SLC36 amino acid transporter Pathetic in Drosophila. Local targets link to admitted publications; unresolved targets remain external evidence.
Metabolic reprogramming and cancer progression
10.1126/science.aaw5473 · 2020 · External reference
Histidine is selectively required for the growth of Myc-dependent dedifferentiation tumours in the Drosophila CNS
10.15252/embj.201899895 · 2019 · External reference
Author correction: tumours with PI3K activation are resistant to dietary restriction
10.1038/s41586-020-2215-y · 2020 · External reference
Tumours with PI3K activation are resistant to dietary restriction
10.1038/nature07782 · 2009 · External reference
Dietary restriction reduces angiogenesis and growth in an orthotopic mouse brain tumour model
10.1038/sj.bjc.6600298 · 2002 · External reference
Dietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism
10.1038/s41467-023-36630-w · 2023 · External reference
Glucose influences the response of glioblastoma cells to temozolomide and dexamethasone
10.1177/10732748221075468 · 2022 · External reference
High glucose promotes human glioblastoma cell growth by increasing the expression and function of chemoattractant and growth factor receptors
10.1016/j.tranon.2019.04.016 · 2019 · External reference
Non-autonomous regulation of neurogenesis by extrinsic cues: a Drosophila perspective
2022 · External reference
Waking up quiescent neural stem cells: molecular mechanisms and implications in neurodevelopmental disorders
2020 · External reference
An interplay between cellular growth and atypical fusion defines morphogenesis of a modular glial niche in Drosophila
10.1038/s41467-022-32685-3 · 2022 · External reference
Role of DE-cadherin in neuroblast proliferation, neural morphogenesis, and axon tract formation in Drosophila larval brain development
10.1523/jneurosci.23-08-03325.2003 · 2003 · External reference
Morphogenesis and proliferation of the larval brain glia in Drosophila
10.1016/j.ydbio.2005.04.024 · 2005 · External reference
Systemic and local cues drive neural stem cell niche remodelling during neurogenesis in Drosophila
10.7554/elife.30413 · 2018 · External reference
Dilp-2-mediated PI3-kinase activation coordinates reactivation of quiescent neuroblasts with growth of their glial stem cell niche
10.1371/journal.pbio.3000721 · 2020 · External reference
Organization and function of the blood-brain barrier in Drosophila
10.1523/jneurosci.4367-07.2008 · 2008 · External reference
The Drosophila blood-brain barrier: development and function of a glial endothelium
10.3389/fnins.2014.00365 · 2014 · External reference
The Drosophila blood-brain barrier emerges as a model for understanding human brain diseases
10.1016/j.nbd.2023.106071 · 2023 · External reference
Evolutionary conservation of vertebrate blood-brain barrier chemoprotective mechanisms in Drosophila
10.1523/jneurosci.5564-08.2009 · 2009 · External reference
Plasticity of carbohydrate transport at the blood-brain barrier
10.3389/fnbeh.2020.612430 · 2021 · External reference
Evolutionarily conserved roles for blood-brain barrier xenobiotic transporters in endogenous steroid partitioning and behavior
10.1016/j.celrep.2017.10.026 · 2017 · External reference
Modulation of sleep by trafficking of lipids through the Drosophila blood-brain barrier
2023 · External reference
Prospero acts as a binary switch between self-renewal and differentiation in Drosophila neural stem cells
10.1016/j.devcel.2006.09.015 · 2006 · External reference
Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster
10.1038/ng1632 · 2005 · External reference
Anaplastic lymphoma kinase spares organ growth during nutrient restriction in Drosophila
10.1016/j.cell.2011.06.040 · 2011 · External reference
The SLC36 transporter Pathetic is required for neural stem cell proliferation and for brain growth under nutrition restriction
10.1186/s13064-020-00148-4 · 2020 · External reference
Starvation-induced regulation of carbohydrate transport at the blood-brain barrier is TGF-β-signaling dependent
10.7554/elife.62503 · 2021 · External reference
Tumour-derived gliogenesis sustains dedifferentiation-dependent tumour growth in the Drosophila CNS
2024 · External reference
Starvation selection reduces and delays larval ecdysone production and signaling
10.1242/jeb.246144 · 2023 · External reference
Lgl, Pins and aPKC regulate neuroblast self-renewal versus differentiation
10.1038/nature04299 · 2006 · External reference
The tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in Drosophila
10.1016/j.devcel.2008.03.004 · 2008 · External reference
Concerted control of gliogenesis by InR/TOR and FGF signalling in the Drosophila post-embryonic brain
10.1242/dev.074179 · 2012 · External reference
scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila
10.1093/emboj/cdg548 · 2003 · External reference
The serine protease homolog, scarface, is sensitive to nutrient availability and modulates the development of the Drosophila blood-brain barrier
10.1523/jneurosci.0452-20.2021 · 2021 · External reference
The glia of the adult Drosophila nervous system
10.1002/glia.23115 · 2017 · External reference
Fly-FUCCI: a versatile tool for studying cell proliferation in complex tissues
10.1016/j.celrep.2014.03.020 · 2014 · External reference
Dacapo, a cyclin-dependent kinase inhibitor, stops cell proliferation during Drosophila development
10.1016/s0092-8674(00)81818-8 · 1996 · External reference
Impaired G2/M cell cycle arrest induces apoptosis in pyruvate carboxylase knockdown MDA-MB-231 cells
2021 · External reference
Direct sensing of nutrients via a LAT1-like transporter in Drosophila insulin-producing cells
10.1016/j.celrep.2016.08.093 · 2016 · External reference
minidiscs encodes a putative amino acid transporter subunit required non-autonomously for imaginal cell proliferation
10.1016/s0925-4773(99)00338-x · 2000 · External reference
Drosophila expresses a CD98 transporter with an evolutionarily conserved structure and amino acid-transport properties
10.1042/bj20082198 · 2009 · External reference
Glial solute carrier transporters in Drosophila and mice
10.1002/glia.21085 · 2011 · External reference
Sensing of the non-essential amino acid tyrosine governs the response to protein restriction in Drosophila
10.1038/s42255-022-00608-7 · 2022 · External reference
A holidic medium for Drosophila melanogaster
10.1038/nmeth.2731 · 2014 · External reference
Glioblastoma and methionine addiction
10.3390/ijms23137156 · 2022 · External reference
Branched chain amino acids
10.1146/annurev-physiol-020518-114455 · 2019 · External reference
The alpha-ketoacid dehydrogenase complexes of Drosophila melanogaster
2024 · External reference
Functions of the SLC36 transporter Pathetic in growth control
10.1080/19336934.2015.1129089 · 2015 · External reference
Organization and postembryonic development of glial cells in the adult central brain of Drosophila
10.1523/jneurosci.4844-08.2008 · 2008 · External reference
The SLC36 transporter Pathetic is required for extreme dendrite growth in Drosophila sensory neurons
10.1101/gad.259119.115 · 2015 · External reference
SLC36A4 (hPAT4) is a high affinity amino acid transporter when expressed in Xenopus laevis oocytes
10.1074/jbc.m110.172403 · 2011 · External reference
PAT-related amino acid transporters regulate growth via a novel mechanism that does not require bulk transport of amino acids
10.1242/dev.01821 · 2005 · External reference
Transport of amino acids across the blood-brain barrier
10.3389/fphys.2020.00973 · 2020 · External reference
Metabolomic analysis reveals that the Drosophila melanogaster gene lysine influences diverse aspects of metabolism
10.1534/genetics.117.300201 · 2017 · External reference
Drosophila’s insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions
10.1016/s1534-5807(02)00117-x · 2002 · External reference
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
10.1016/s0092-8674(00)80595-4 · 1999 · External reference
Nutrient-dependent expression of insulin-like peptides from neuroendocrine cells in the CNS contributes to growth regulation in Drosophila
10.1016/s0960-9822(02)01043-6 · 2002 · External reference
Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes
10.1126/science.1070058 · 2002 · External reference
A fat body-derived IGF-like peptide regulates postfeeding growth in Drosophila
10.1016/j.devcel.2009.10.008 · 2009 · External reference
A Drosophila insulin-like peptide promotes growth during nonfeeding states
10.1016/j.devcel.2009.10.009 · 2009 · External reference
Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila
10.1038/nature09867 · 2011 · External reference
Drosophila insulin-like peptide-6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin-like peptide-2 from the brain
10.1111/acel.12000 · 2012 · External reference
Systemic muscle wasting and coordinated tumour response drive tumourigenesis
10.1038/s41467-020-18502-9 · 2020 · External reference
The amino acid transporter SLC36A4 regulates the amino acid pool in retinal pigmented epithelial cells and mediates the mechanistic target of rapamycin, complex 1 signaling
10.1111/acel.12561 · 2017 · External reference
Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties
10.1016/j.cell.2012.12.012 · 2013 · External reference
Dedifferentiation of neurons and astrocytes by oncogenes can induce gliomas in mice
10.1126/science.1226929 · 2012 · External reference
Targeting cancer metabolism in the era of precision oncology
10.1038/s41573-021-00339-6 · 2022 · External reference
Tumor microenvironmental nutrients, cellular responses, and cancer
10.1016/j.chembiol.2023.08.011 · 2023 · External reference
The SLC36 family of proton-coupled amino acid transporters and their potential role in drug transport
10.1111/j.1476-5381.2011.01438.x · 2011 · External reference
Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activation
10.1038/onc.2010.177 · 2010 · External reference
mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake
10.1038/nature11163 · 2012 · External reference
The Drosophila cyclin D-Cdk4 complex promotes cellular growth
10.1093/emboj/19.17.4543 · 2000 · External reference
Inhibition of cellular growth and proliferation by dTOR overexpression in Drosophila
10.1002/gene.10139 · 2002 · External reference
Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB
10.1126/science.1068094 · 2002 · External reference
Tumor-derived MMPs regulate cachexia in a Drosophila cancer model
10.1016/j.devcel.2021.08.008 · 2021 · External reference
Lessons in genome engineering: opportunities, tools and pitfalls
2019 · External reference
GLAD: an online database of gene list annotation for Drosophila
10.7150/jgen.12863 · 2015 · External reference
Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool
10.1186/1471-2105-14-128 · 2013 · External reference
Enrichr: a comprehensive gene set enrichment analysis web server 2016 update
10.1093/nar/gkw377 · 2016 · External reference
Piwi is required during Drosophila embryogenesis to license dual-strand piRNA clusters for transposon repression in adult ovaries
10.1016/j.molcel.2017.03.017 · 2017 · External reference
Epidermal tyrosine catabolism is crucial for metabolic homeostasis and survival against high-protein diets in Drosophila
10.1242/dev.202372 · 2024 · External reference
Context-dependent impact of the dietary non-essential amino acid tyrosine on Drosophila physiology and longevity
10.1126/sciadv.adn7167 · 2024 · External reference
Automatic cell counting in vivo in the larval nervous system of Drosophila
10.1111/j.1365-2818.2012.03608.x · 2012 · External reference
Partial inhibition of Cdk1 in G 2 phase overrides the SAC and decouples mitotic events
10.4161/cc.28401 · 2014 · External reference
Glial Hedgehog signalling and lipid metabolism regulate neural stem cell proliferation in Drosophila
10.15252/embr.202052130 · 2021 · External reference
