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References from Cardiometabolic health and physical robustness map onto distinct patterns of brain structure and neurotransmitter systems. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
2022 · External reference
Unresolved reference
2018 · External reference
Life’s essential 8: updating and enhancing the American Heart Association’s construct of cardiovascular health: a presidential advisory from the American Heart Association
2022 · External reference
Dementia prevention, intervention, and care: 2024 report of the Lancet Standing Commission
10.1016/s0140-6736(24)01296-0 · 2024 · External reference
Next generation brain health: transforming global research and public health to promote prevention of dementia and reduce its risk in young adult populations
10.1016/j.lanhl.2024.100665 · 2024 · External reference
Chronic inflammation in the etiology of disease across the life span
10.1038/s41591-019-0675-0 · 2019 · External reference
Epidemiologic studies of modifiable factors associated with cognition and dementia: systematic review and meta-analysis
10.1186/1471-2458-14-643 · 2014 · External reference
Brain structural abnormalities in obesity: relation to age, genetic risk, and common psychiatric disorders : evidence through univariate and multivariate mega-analysis including 6420 participants from the ENIGMA MDD working group
10.1038/s41380-020-0774-9 · 2021 · External reference
Increased body mass index is associated with specific regional alterations in brain structure
10.1038/ijo.2016.42 · 2016 · External reference
Body mass index but not genetic risk is longitudinally associated with altered structural brain parameters
10.1038/s41598-021-03343-3 · 2021 · External reference
Obesity associated with increased brain age from midlife
10.1016/j.neurobiolaging.2016.07.010 · 2016 · External reference
Association between body mass index and cortical thickness: among elderly cognitively normal men and women
10.1017/s1041610214001744 · 2015 · External reference
Population-based body-brain mapping links brain morphology with anthropometrics and body composition
10.1038/s41398-021-01414-7 · 2021 · External reference
Measures of obesity are associated with MRI markers of brain aging: The Northern Manhattan Study
10.1212/wnl.0000000000007966 · 2019 · External reference
Gray matter structural networks are associated with cardiovascular risk factors in healthy older adults
10.1177/0271678x17729111 · 2018 · External reference
Effects of cerebrovascular risk factors on gray matter volume in adults aged 60-64 years: a voxel-based morphometric study
10.1016/j.pscychresns.2006.01.009 · 2006 · External reference
Aerobic exercise in people with schizophrenia: neural and neurocognitive benefits
10.1007/s40473-016-0077-2 · 2016 · External reference
Mediterranean diet and brain structure in a multiethnic elderly cohort
10.1212/wnl.0000000000002121 · 2015 · External reference
The impact of common epidemiological factors on gray and white matter volumes in magnetic resonance imaging—is prevention of brain degeneration possible?
10.3389/fneur.2021.633619 · 2021 · External reference
Effects of urban living environments on mental health in adults
10.1038/s41591-023-02365-w · 2023 · External reference
The Lancet Psychiatry Commission: a blueprint for protecting physical health in people with mental illness
10.1016/s2215-0366(19)30132-4 · 2019 · External reference
Canonical correlation analysis and partial least squares for identifying brain-behavior associations: a tutorial and a comparative study
2022 · External reference
Multiple holdouts with stability: improving the generalizability of machine learning analyses of brain-behavior relationships
10.1016/j.biopsych.2019.12.001 · 2020 · External reference
Neuroimaging contrast across the cortical hierarchy is the feature maximally linked to behavior and demographics
10.1016/j.neuroimage.2020.116853 · 2020 · External reference
Lower motor performance is linked with poor sleep quality, depressive symptoms, and grey matter volume alterations
2024 · External reference
Data-driven identification of a left anterior hippocampus’ morphological network associated with self-regulation
2024 · External reference
Brain-behaviour modes of covariation in healthy and clinically depressed young people
10.1038/s41598-019-47277-3 · 2019 · External reference
A cross-cohort replicable and heritable latent dimension linking behaviour to multi-featured brain structure
10.1038/s42003-022-04244-5 · 2022 · External reference
Evaluation of brain-body health in individuals with common neuropsychiatric disorders
10.1001/jamapsychiatry.2023.0791 · 2023 · External reference
A metabolic obesity profile is associated with decreased gray matter volume in cognitively healthy older adults
10.3389/fnagi.2019.00202 · 2019 · External reference
Association of peripheral blood pressure with gray matter volume in 19- to 40-year-old adults
10.1212/wnl.0000000000006947 · 2019 · External reference
Higher body mass index is associated with reduced posterior default mode connectivity in older adults
10.1002/hbm.23605 · 2017 · External reference
Hormonal and neural mechanisms of food reward, eating behaviour and obesity
10.1038/nrendo.2014.91 · 2014 · External reference
Mapping neurotransmitter systems to the structural and functional organization of the human neocortex
10.1038/s41593-022-01186-3 · 2022 · External reference
neuromaps: structural and functional interpretation of brain maps
10.1038/s41592-022-01625-w · 2022 · External reference
Systemic inflammation as a predictor of brain aging: contributions of physical activity, metabolic risk, and genetic risk
10.1016/j.neuroimage.2017.12.027 · 2018 · External reference
Brain morphology links systemic inflammation to cognitive function in midlife adults
10.1016/j.bbi.2015.03.015 · 2015 · External reference
Obesity and neuroinflammation: a pathway to cognitive impairment
10.1016/j.bbi.2014.04.001 · 2014 · External reference
Cardiometabolic risk factors and neurodegeneration: a review of the mechanisms underlying diabetes, obesity and hypertension in Alzheimer’s disease
10.1136/jnnp-2023-332661 · 2024 · External reference
Obesity and the cerebral cortex: underlying neurobiology in mice and humans
10.1016/j.bbi.2024.04.033 · 2024 · External reference
Linking interindividual variability in brain structure to behaviour
10.1038/s41583-022-00584-7 · 2022 · External reference
Multimodal population brain imaging in the UK Biobank prospective epidemiological study
10.1038/nn.4393 · 2016 · External reference
UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age
10.1371/journal.pmed.1001779 · 2015 · External reference
Image processing and Quality Control for the first 10,000 brain imaging datasets from UK Biobank
10.1016/j.neuroimage.2017.10.034 · 2018 · External reference
Automatic parcellation of human cortical gyri and sulci using standard anatomical nomenclature
10.1016/j.neuroimage.2010.06.010 · 2010 · External reference
Overview of leakage scenarios in supervised machine learning
10.1186/s40537-025-01193-8 · 2025 · External reference
Relations between two sets of variates
10.1093/biomet/28.3-4.321 · 1936 · External reference
On stability of canonical correlation analysis and partial least squares with application to brain-behavior associations
2023 · External reference
Canonical ridge and econometrics of joint production
10.1016/0304-4076(76)90010-5 · 1976 · External reference
Canonical correlation analysis: an overview with application to learning methods
10.1162/0899766042321814 · 2004 · External reference
Leakage and the reproducibility crisis in machine-learning-based science
10.1016/j.patter.2023.100804 · 2023 · External reference
A multiple hold-out framework for sparse partial least squares
10.1016/j.jneumeth.2016.06.011 · 2016 · External reference
On testing for spatial correspondence between maps of human brain structure and function
10.1016/j.neuroimage.2018.05.070 · 2018 · External reference
A high-resolution in vivo atlas of the human brain’s serotonin system
2017 · External reference
Normative database of the serotonergic system in healthy subjects using multi-tracer PET
10.1016/j.neuroimage.2012.07.001 · 2012 · External reference
Cerebral blood flow predicts differential neurotransmitter activity
10.1038/s41598-018-22444-0 · 2018 · External reference
Cellular and molecular signatures of in vivo imaging measures of GABAergic neurotransmission in the human brain
10.1038/s42003-022-03268-1 · 2022 · External reference
Brain cholinergic alterations in idiopathic REM sleep behaviour disorder: a PET imaging study with 18F-FEOBV
10.1016/j.sleep.2018.12.020 · 2019 · External reference
A multi-modal parcellation of human cerebral cortex
10.1038/nature18933 · 2016 · External reference
Situating the default-mode network along a principal gradient of macroscale cortical organization
10.1073/pnas.1608282113 · 2016 · External reference
Regional aerobic glycolysis in the human brain
10.1073/pnas.1010459107 · 2010 · External reference
Insights into neuroepigenetics through human histone deacetylase PET imaging
2016 · External reference
An anatomically comprehensive atlas of the adult human brain transcriptome
10.1038/nature11405 · 2012 · External reference
10.7554/elife.72129.sa2
10.7554/elife.72129.sa2 · External reference
Atlas of type 2 dopamine receptors in the human brain: age and sex dependent variability in a large PET cohort
10.1016/j.neuroimage.2022.119149 · 2022 · External reference
Quantification of dopamine transporter in human brain using PET with 18F-FE-PE2I
10.2967/jnumed.111.101626 · 2012 · External reference
Kinetic modeling of the serotonin 5-HT(1B) receptor radioligand [(11)C]P943 in humans
10.1038/jcbfm.2009.195 · 2010 · External reference
Determination of receptor occupancy in the presence of mass dose: [11C]GSK189254 PET imaging of histamine H3 receptor occupancy by PF-03654746
10.1177/0271678x16650697 · 2017 · External reference
Sex differences in [11C]ABP688 binding: a positron emission tomography study of mGlu5 receptors
10.1007/s00259-018-4252-4 · 2019 · External reference
Individual variability in functional connectivity architecture of the human brain
10.1016/j.neuron.2012.12.028 · 2013 · External reference
10.1126/science.aar2578
10.1126/science.aar2578 · External reference
Characterization of age/sex and the regional distribution of mGluR5 availability in the healthy human brain measured by high-resolution [(11)C]ABP688 PET
10.1007/s00259-015-3167-6 · 2016 · External reference
Unresolved reference
2021 · External reference
Validation of a combined image derived input function and venous sampling approach for the quantification of [18F]GE-179 PET binding in the brain
10.1016/j.neuroimage.2021.118194 · 2021 · External reference
Initial evaluation of 18F-GE-179, a putative PET Tracer for activated N-methyl D-aspartate receptors
10.2967/jnumed.113.130641 · 2014 · External reference
Interindividual variability and lateralization of μ-opioid receptors in the human brain
10.1016/j.neuroimage.2020.116922 · 2020 · External reference
Adult attachment system links with brain Mu opioid receptor availability in vivo. biological psychiatry
2021 · External reference
PET imaging reveals lower kappa opioid receptor availability in alcoholics but no effect of age
10.1038/s41386-018-0199-1 · 2018 · External reference
Sex difference in brain CB1 receptor availability in man
10.1016/j.neuroimage.2018.10.013 · 2019 · External reference
Imaging the cannabinoid CB1 receptor in humans with [11C]OMAR: assessment of kinetic analysis methods, test-retest reproducibility, and gender differences
10.1038/jcbfm.2015.46 · 2015 · External reference
Cross-species functional alignment reveals evolutionary hierarchy within the connectome
10.1016/j.neuroimage.2020.117346 · 2020 · External reference
Neurodevelopment of the association cortices: patterns, mechanisms, and implications for psychopathology
10.1016/j.neuron.2021.06.016 · 2021 · External reference
Cardiometabolic multimorbidity, genetic risk, and dementia: a prospective cohort study
2022 · External reference
Cardiometabolic determinants of early and advanced brain alterations: insights from conventional and novel MRI techniques
10.1016/j.neubiorev.2020.04.001 · 2020 · External reference
Cardiometabolic risk factors associated with brain age and accelerate brain ageing
10.1002/hbm.25680 · 2022 · External reference
Is psychosis a multisystem disorder? A meta-review of central nervous system, immune, cardiometabolic, and endocrine alterations in first-episode psychosis and perspective on potential models
10.1038/s41380-018-0058-9 · 2019 · External reference
Associations between mental health, blood pressure and the development of hypertension
10.1038/s41467-023-37579-6 · 2023 · External reference
Interplay of G-proteins and serotonin in the neuroimmunoinflammatory model of chronic stress and depression: a narrative review
10.2174/0113816128285578231218102020 · 2024 · External reference
Neurological consequences of obesity
10.1016/s1474-4422(17)30084-4 · 2017 · External reference
Neurotransmitter, peptide and cytokine processes in relation to depressive disorder: comorbidity between depression and neurodegenerative disorders
10.1016/j.pneurobio.2008.01.004 · 2008 · External reference
Genetic evidence for causal effects of immune dysfunction in psychiatric disorders: where are we?
10.1038/s41398-024-02778-2 · 2024 · External reference
Impact of inflammation on neurotransmitter changes in major depression: an insight into the action of antidepressants
10.1016/j.pnpbp.2013.10.018 · 2014 · External reference
The potential crosstalk between the brain and visceral adipose tissue in Alzheimer’s development
10.1007/s11064-022-03569-1 · 2022 · External reference
Longitudinal and concurrent C-reactive protein and diet associations with cognitive function in the population-based Tromsø study
10.1177/13872877251317624 · 2025 · External reference
Exposure to multiple ambient air pollutants changes white matter microstructure during early adolescence with sex-specific differences
10.1038/s43856-024-00576-x · 2024 · External reference
Gender difference in the effects of outdoor air pollution on cognitive function among elderly in Korea
10.3389/fpubh.2019.00375 · 2019 · External reference
Gender differences in association between air pollution and daily mortality in the capital of the green lungs of Poland-population-based study with 2,953,000 person-years of follow-up
10.3390/jcm9082351 · 2020 · External reference
Sex disparity in cognitive aging related to later-life exposure to ambient air pollution
10.1016/j.scitotenv.2023.163980 · 2023 · External reference
Extricating sex and gender in air pollution research: a community-based study on cardinal symptoms of exposure
10.3390/ijerph10093801 · 2013 · External reference
Serotonin, food intake, and obesity
10.1111/obr.13210 · 2021 · External reference
Serotonin controlling feeding and satiety
10.1016/j.bbr.2014.08.065 · 2015 · External reference
Physical exercise-induced fatigue: the role of serotonergic and dopaminergic systems
2017 · External reference
Advances from neuroimaging studies in eating disorders
10.1017/s1092852915000012 · 2015 · External reference
Immuno-metabolic depression: from concept to implementation
10.1016/j.lanepe.2024.101166 · 2024 · External reference
Where is dopamine and how do immune cells see it?: Dopamine-mediated immune cell function in health and disease
10.1007/s11481-019-09851-4 · 2020 · External reference
