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References from Chromosome duplication causes premature aging via defects in ribosome quality control. Local targets link to admitted publications; unresolved targets remain external evidence.
Mortality associated with Down’s syndrome in the USA from 1983 to 1997: a population-based study
10.1016/s0140-6736(02)08092-3 · 2002 · External reference
Down syndrome
10.1038/s41572-019-0143-7 · 2020 · External reference
Precocious aging and dementia in patients with Down’s syndrome
1978 · External reference
Occurrence of neuropathological changes and dementia of Alzheimer’s disease in Down’s syndrome
10.1002/ana.410170310 · 1985 · External reference
Cognitive impairment and age-related vision disorders: their possible relationship and the evaluation of the use of aspirin and statins in a 65 years-and-over Sardinian population
10.3389/fnagi.2014.00309 · 2014 · External reference
Aging in Down syndrome and the development of Alzheimer’s disease neuropathology
10.2174/1567205012666151020114607 · 2016 · External reference
Effects of aneuploidy on cellular physiology and cell division in haploid yeast
10.1126/science.1142210 · 2007 · External reference
Aneuploidy causes proteotoxic stress in yeast
10.1101/gad.207407.112 · 2012 · External reference
Aneuploidy: implications for protein homeostasis and disease
10.1242/dmm.013391 · 2014 · External reference
Aneuploid proliferation defects in yeast are not driven by copy number changes of a few dosage-sensitive genes
10.1101/gad.261743.115 · 2015 · External reference
Aneuploidy-induced cellular stresses limit autophagic degradation
10.1101/gad.269118.115 · 2015 · External reference
Hypo-osmotic-like stress underlies general cellular defects of aneuploidy
10.1038/s41586-019-1187-2 · 2019 · External reference
The genetic basis of aneuploidy tolerance in wild yeast
10.7554/elife.52063 · 2020 · External reference
Dosage compensation can buffer copy-number variation in wild yeast
10.7554/elife.05462 · 2015 · External reference
Further support for aneuploidy tolerance in wild yeast and effects of dosage compensation on gene copy-number evolution
10.7554/elife.14409 · 2016 · External reference
The MCS1/SSD1/SRK1/SSL1 gene is involved in stable maintenance of the chromosome in yeast
10.1016/0378-1119(94)90618-1 · 1994 · External reference
Cbk1 regulation of the RNA-binding protein Ssd1 integrates cell fate with translational control
10.1016/j.cub.2009.10.071 · 2009 · External reference
Nucleocytoplasmic shuttling of Ssd1 defines the destiny of its bound mRNAs
10.1111/j.1365-2958.2011.07731.x · 2011 · External reference
The yeast Cbk1 kinase regulates mRNA localization via the mRNA-binding protein Ssd1
10.1083/jcb.201011061 · 2011 · External reference
Ssd1 and Gcn2 suppress global translation efficiency in replicatively aged yeast while their activation extends lifespan
2018 · External reference
Diverse RNA-binding proteins interact with functionally related sets of RNAs, suggesting an extensive regulatory system
10.1371/journal.pbio.0060255 · 2008 · External reference
The response to single-gene duplication implicates translation as a key vulnerability in aneuploid yeast
10.1371/journal.pgen.1011454 · 2024 · External reference
Comparative modeling reveals the molecular determinants of aneuploidy fitness cost in a wild yeast model
10.1016/j.xgen.2024.100656 · 2024 · External reference
Investigating the role of RNA-binding protein Ssd1 in aneuploidy tolerance through network analysis
10.1261/rna.080199.124 · 2024 · External reference
The response to single-gene duplication implicates translation as a key vulnerability in aneuploid yeast
2024 · External reference
The pleiotropic deubiquitinase Ubp3 confers aneuploidy tolerance
10.1101/gad.287474.116 · 2016 · External reference
Molecular pathways: stem cell quiescence
10.1158/1078-0432.ccr-10-1499 · 2011 · External reference
Mechanisms, hallmarks, and implications of stem cell quiescence
10.1016/j.stemcr.2019.05.012 · 2019 · External reference
The budding yeast transition to quiescence
10.1002/yea.3546 · 2021 · External reference
Cellular quiescence in budding yeast
10.1002/yea.3545 · 2021 · External reference
Starvation signals in yeast are integrated to coordinate metabolic reprogramming and stress response to ensure longevity
10.1007/s00294-017-0697-4 · 2017 · External reference
Mechanisms that link chronological aging to cellular quiescence in budding yeast
10.3390/ijms21134717 · 2020 · External reference
Regulation of adult stem cell quiescence and its functions in the maintenance of tissue integrity
10.1038/s41580-022-00568-6 · 2023 · External reference
Defective hematopoietic stem cell and lymphoid progenitor development in the Ts65Dn mouse model of Down syndrome: potential role of oxidative stress
10.1089/ars.2010.3798 · 2011 · External reference
Usp16 contributes to somatic stem-cell defects in Down’s syndrome
10.1038/nature12530 · 2013 · External reference
Transcriptome and proteome profiling of neural induced pluripotent stem cells from individuals with Down syndrome disclose dynamic dysregulations of key pathways and cellular functions
10.1007/s12035-019-1585-3 · 2019 · External reference
Quiescence in Saccharomyces cerevisiae
10.1146/annurev-genet-080320-023632 · 2022 · External reference
A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress
10.1016/j.cell.2012.10.044 · 2012 · External reference
Cdc48-associated complex bound to 60S particles is required for the clearance of aberrant translation products
10.1073/pnas.1221724110 · 2013 · External reference
Ribosome-associated quality-control mechanisms from bacteria to humans
10.1016/j.molcel.2022.03.038 · 2022 · External reference
Role of a ribosome-associated E3 ubiquitin ligase in protein quality control
10.1038/nature09371 · 2010 · External reference
Protein synthesis. Rqc2p and 60S ribosomal subunits mediate mRNA-independent elongation of nascent chains
10.1126/science.1259724 · 2015 · External reference
The Rqc2/Tae2 subunit of the ribosome-associated quality control (RQC) complex marks ribosome-stalled nascent polypeptide chains for aggregation
10.7554/elife.11794 · 2016 · External reference
Failure of RQC machinery causes protein aggregation and proteotoxic stress
10.1038/nature16973 · 2016 · External reference
Aggregation of CAT tails blocks their degradation and causes proteotoxicity in S. cerevisiae
10.1371/journal.pone.0227841 · 2020 · External reference
Threonine-rich carboxyl-terminal extension drives aggregation of stalled polypeptides
10.1016/j.molcel.2024.10.011 · 2024 · External reference
Ageing exacerbates ribosome pausing to disrupt cotranslational proteostasis
10.1038/s41586-021-04295-4 · 2022 · External reference
Protein translation paradox: Implications in translational regulation of aging
10.3389/fcell.2023.1129281 · 2023 · External reference
Translational control in cell ageing: an update
10.1042/bst20210844 · 2021 · External reference
A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration
10.1073/pnas.0812819106 · 2009 · External reference
RNA function. Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration
10.1126/science.1249749 · 2014 · External reference
NEMF mutations that impair ribosome-associated quality control are associated with neuromuscular disease
10.1038/s41467-020-18327-6 · 2020 · External reference
Inefficient quality control of ribosome stalling during APP synthesis generates CAT-tailed species that precipitate hallmarks of Alzheimer’s disease
10.1186/s40478-021-01268-6 · 2021 · External reference
Failure to degrade CAT-tailed proteins disrupts neuronal morphogenesis and cell survival
10.1016/j.celrep.2020.108599 · 2021 · External reference
Dysregulation of ribosome-associated quality control elicits cognitive disorders via overaccumulation of TTC3
10.1073/pnas.2211522120 · 2023 · External reference
Poly-alanine-tailing is a modifier of neurodegeneration caused by Listerin mutation
2024 · External reference
Comparative modeling reveals the molecular determinants of aneuploidy fitness cost in a wild yeast model
2024 · External reference
Metabolic status rather than cell cycle signals control quiescence entry and exit
10.1083/jcb.201009028 · 2011 · External reference
Xbp1 directs global repression of budding yeast transcription during the transition to quiescence and is important for the longevity and reversibility of the quiescent state
10.1371/journal.pgen.1003854 · 2013 · External reference
Ssd1 and the cell wall integrity pathway promote entry, maintenance, and recovery from quiescence in budding yeast
10.1091/mbc.e19-04-0190 · 2019 · External reference
Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells
10.1016/j.cell.2012.09.019 · 2012 · External reference
Transcriptional reprogramming in cellular quiescence
10.1080/15476286.2017.1327510 · 2017 · External reference
Global promoter targeting of a conserved lysine deacetylase for transcriptional shutoff during quiescence entry
10.1016/j.molcel.2015.07.014 · 2015 · External reference
Extension of chronological life span in yeast by decreased TOR pathway signaling
10.1101/gad.1381406 · 2006 · External reference
Chronological lifespan in yeast is dependent on the accumulation of storage carbohydrates mediated by Yak1, Mck1 and Rim15 kinases
2016 · External reference
Aneuploidy shortens replicative lifespan in Saccharomyces cerevisiae
10.1111/acel.12443 · 2016 · External reference
A common SSD1 truncation is toxic to cells entering quiescence and promotes sporulation
2022 · External reference
Key events during the transition from rapid growth to quiescence in budding yeast require posttranscriptional regulators
10.1091/mbc.e13-05-0241 · 2013 · External reference
A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds
10.1038/nbt.1534 · 2009 · External reference
Genomic analysis of stationary-phase and exit in Saccharomyces cerevisiae: gene expression and identification of novel essential genes
10.1091/mbc.e03-11-0856 · 2004 · External reference
Defective mitochondrial gene expression results in reactive oxygen species-mediated inhibition of respiration and reduction of yeast life span
10.1128/mcb.02360-05 · 2006 · External reference
Mitochondrial dysfunction leads to reduced chronological lifespan and increased apoptosis in yeast
10.1016/j.febslet.2008.11.028 · 2009 · External reference
The proteomics of quiescent and nonquiescent cell differentiation in yeast stationary-phase cultures
10.1091/mbc.e10-06-0499 · 2011 · External reference
Aneuploidy-induced proteostasis disruption impairs mitochondrial functions and mediates aggregation of mitochondrial precursor proteins through SQSTM1/p62
2024 · External reference
Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells
10.1126/science.1160058 · 2008 · External reference
Mitochondrial dysfunction in Down syndrome: from pathology to therapy
10.1016/j.neuroscience.2022.12.003 · 2023 · External reference
HST2 mediates SIR2-independent life-span extension by calorie restriction
10.1126/science.1113611 · 2005 · External reference
Comment on “HST2 mediates SIR2-independent life-span extension by calorie restriction”
10.1126/science.1124608 · 2006 · External reference
Yeast sirtuins and the regulation of aging
10.1111/1567-1364.12115 · 2014 · External reference
Porin 1 modulates autophagy in yeast
10.3390/cells10092416 · 2021 · External reference
The role of autophagy in the regulation of yeast life span
10.1111/nyas.13549 · 2018 · External reference
A role for the actin cytoskeleton in cell death and aging in yeast
10.1083/jcb.200310148 · 2004 · External reference
An Hsp90 co-chaperone links protein folding and degradation and is part of a conserved protein quality control
10.1016/j.celrep.2021.109328 · 2021 · External reference
Rqc1 and Ltn1 prevent C-terminal Alanine-Threonine Tail (CAT-tail)-induced protein aggregation by efficient recruitment of Cdc48 on stalled 60S subunits
10.1074/jbc.m116.722264 · 2016 · External reference
The ribosome-associated quality control factor TCF25 imposes K48 specificity on Listerin-mediated ubiquitination of nascent chains by binding and specifically orienting the acceptor ubiquitin
2024 · External reference
Streptothricin F, an inhibitor of protein synthesis with miscoding activity
10.7164/antibiotics.31.1137 · 1978 · External reference
Streptothricin F is a bactericidal antibiotic effective against highly drug-resistant gram-negative bacteria that interacts with the 30S subunit of the 70S ribosome
10.1371/journal.pbio.3002091 · 2023 · External reference
Protein aggregation caused by aminoglycoside action is prevented by a hydrogen peroxide scavenger
10.1016/j.molcel.2012.10.001 · 2012 · External reference
Structure and assembly pathway of the ribosome quality control complex
10.1016/j.molcel.2014.12.015 · 2015 · External reference
The ribosome as a hub for protein quality control
10.1016/j.molcel.2013.01.020 · 2013 · External reference
CAT tails drive degradation of stalled polypeptides on and off the ribosome
10.1038/s41594-019-0230-1 · 2019 · External reference
Translation of CGA codon repeats in yeast involves quality control components and ribosomal protein L1
10.1261/rna.039446.113 · 2013 · External reference
Asc1, Hel2, and Slh1 couple translation arrest to nascent chain degradation
10.1261/rna.060897.117 · 2017 · External reference
Ubiquitination of stalled ribosome triggers ribosome-associated quality control
10.1038/s41467-017-00188-1 · 2017 · External reference
The Cdc34/SCF ubiquitination complex mediates Saccharomyces cerevisiae cell wall integrity
10.1534/genetics.106.059154 · 2006 · External reference
New insight into the role of the Cdc34 ubiquitin-conjugating enzyme in cell cycle regulation via Ace2 and Sic1
10.1534/genetics.110.125302 · 2011 · External reference
An auxiliary, membrane-based mechanism for nuclear migration in budding yeast
10.1091/mbc.e12-08-0602 · 2013 · External reference
Identification of a positive regulator of the cell cycle ubiquitin-conjugating enzyme Cdc34 (Ubc3)
10.1128/mcb.16.2.677 · 1996 · External reference
Yeast Ran-binding protein Yrb1p is required for efficient proteolysis of cell cycle regulatory proteins Pds1p and Sic1p
10.1074/jbc.m007925200 · 2000 · External reference
SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex
10.1016/s1097-2765(00)80184-7 · 1999 · External reference
Overexpression of two transcriptional factors, Kin28 and Pog1, suppresses the stress sensitivity caused by the rsp5 mutation in Saccharomyces cerevisiae
10.1111/j.1574-6968.2007.00947.x · 2007 · External reference
POG1, a novel yeast gene, promotes recovery from pheromone arrest via the G1 cyclin CLN2
10.1093/genetics/151.2.531 · 1999 · External reference
The transcriptional activator Pog1 controls cell cycle, and its phosphorylated form is downregulated by the ubiquitin ligase Dma2 in Saccharomyces cerevisiae
2014 · External reference
Identification of aneuploidy-tolerating mutations
10.1016/j.cell.2010.08.038 · 2010 · External reference
Quantitative proteomic analysis reveals posttranslational responses to aneuploidy in yeast
10.7554/elife.03023 · 2014 · External reference
Unresolved reference
External reference
Deubiquitinating enzyme Ubp6 functions noncatalytically to delay proteasomal degradation
10.1016/j.cell.2006.07.038 · 2006 · External reference
In vivo disassembly of free polyubiquitin chains by yeast Ubp14 modulates rates of protein degradation by the proteasome
10.1093/emboj/16.16.4826 · 1997 · External reference
Ubiquitin signaling in neurodegenerative diseases: an autophagy and proteasome perspective
10.1038/s41418-020-00667-x · 2021 · External reference
Free ubiquitin: a novel therapeutic target for neurodegenerative diseases
10.4103/1673-5374.306075 · 2021 · External reference
Reduced free ubiquitin levels and proteasome activity in cultured neurons and brain tissues treated with amyloid beta aggregates
10.1186/s13041-020-00632-2 · 2020 · External reference
The Doa4 deubiquitinating enzyme is required for ubiquitin homeostasis in yeast
10.1091/mbc.10.8.2583 · 1999 · External reference
Defects arising from whole-genome duplications in Saccharomyces cerevisiae
10.1534/genetics.104.029256 · 2004 · External reference
Elimination of protein aggregates prevents premature senescence in human trisomy 21 fibroblasts
10.1371/journal.pone.0219592 · 2019 · External reference
4-Phenylbutyrate ameliorates apoptotic neural cell death in Down syndrome by reducing protein aggregates
10.1038/s41598-020-70362-x · 2020 · External reference
The proteostasis network and its decline in ageing
10.1038/s41580-019-0101-y · 2019 · External reference
Aging as an event of proteostasis collapse
10.1101/cshperspect.a004440 · 2011 · External reference
Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast
10.1038/nature09529 · 2010 · External reference
mTOR hyperactivation in Down syndrome underlies deficits in autophagy induction, autophagosome formation, and mitophagy
10.1038/s41419-019-1752-5 · 2019 · External reference
SNARE proteins rescue impaired autophagic flux in Down syndrome
10.1371/journal.pone.0223254 · 2019 · External reference
Ubiquitin orchestrates proteasome dynamics between proliferation and quiescence in yeast
10.1091/mbc.e17-03-0162 · 2017 · External reference
Ubiquitin-mediated sequestration of normal cellular proteins into polyglutamine aggregates
10.1073/pnas.1530212100 · 2003 · External reference
Ubiquitin signalling in neurodegeneration: mechanisms and therapeutic opportunities
10.1038/s41418-020-00706-7 · 2021 · External reference
Strategies to investigate ubiquitination in Huntington’s disease
10.3389/fchem.2020.00485 · 2020 · External reference
Trisomy 21-induced dysregulation of microglial homeostasis in Alzheimer’s brains is mediated by USP25
10.1126/sciadv.abe1340 · 2021 · External reference
Muscle stem cell dysfunction impairs muscle regeneration in a mouse model of Down syndrome
10.1038/s41598-018-22342-5 · 2018 · External reference
Ubiquitin depletion as a key mediator of toxicity by translational inhibitors
10.1128/mcb.23.24.9251-9261.2003 · 2003 · External reference
Rsp5 ubiquitin ligase modulates translation accuracy in yeast Saccharomyces cerevisiae
10.1261/rna.2131605 · 2005 · External reference
Expanding role of ubiquitin in translational control
10.3390/ijms21031151 · 2020 · External reference
Aneuploidy causes non-genetic individuality
10.1016/j.cell.2017.03.021 · 2017 · External reference
Targeting the adaptability of heterogeneous aneuploids
10.1016/j.cell.2015.01.026 · 2015 · External reference
Divergent aging of isogenic yeast cells revealed through single-cell phenotypic dynamics
2019 · External reference
A programmable fate decision landscape underlies single-cell aging in yeast
10.1126/science.aax9552 · 2020 · External reference
Aging with Down syndrome-where are we now and where are we going?
10.3390/jcm10204687 · 2021 · External reference
Genetic dissection of down syndrome-associated alterations in APP/amyloid-β biology using mouse models
10.1038/s41598-021-85062-3 · 2021 · External reference
Dyrk1a from gene function in development and physiology to dosage correction across life span in Down syndrome
10.3390/genes12111833 · 2021 · External reference
Dose imbalance of DYRK1A kinase causes systemic progeroid status in Down syndrome by increasing the un-repaired DNA damage and reducing LaminB1 levels
10.1016/j.ebiom.2023.104692 · 2023 · External reference
Global analysis of protein localization in budding yeast
10.1038/nature02026 · 2003 · External reference
Single-cell RNA sequencing reveals intrinsic and extrinsic regulatory heterogeneity in yeast responding to stress
10.1371/journal.pbio.2004050 · 2017 · External reference
Isolation of quiescent and nonquiescent cells from yeast stationary-phase cultures
10.1083/jcb.200604072 · 2006 · External reference
Yeast genomic expression studies using DNA microarrays
10.1016/s0076-6879(02)50976-9 · 2002 · External reference
Genome-wide association across Saccharomyces cerevisiae strains reveals substantial variation in underlying gene requirements for toxin tolerance
10.1371/journal.pgen.1007217 · 2018 · External reference
Fast and accurate short read alignment with Burrows-Wheeler transform
10.1093/bioinformatics/btp324 · 2009 · External reference
HTSeq—a Python framework to work with high-throughput sequencing data
10.1093/bioinformatics/btu638 · 2015 · External reference
edgeR: a Bioconductor package for differential expression analysis of digital gene expression data
10.1093/bioinformatics/btp616 · 2010 · External reference
Cluster analysis and display of genome-wide expression patterns
10.1073/pnas.95.25.14863 · 1998 · External reference
Java Treeview--extensible visualization of microarray data
10.1093/bioinformatics/bth349 · 2004 · External reference
Dosage suppression genetic interaction networks enhance functional wiring diagrams of the cell
10.1038/nbt.1855 · 2011 · External reference
Chemical genomic profiling via barcode sequencing to predict compound mode of action
10.1007/978-1-4939-2269-7_23 · 2015 · External reference
Quantitative proteomic comparison of stationary/G0 phase cells and tetrads in budding yeast
10.1038/srep32031 · 2016 · External reference
Start codon-associated ribosomal frameshifting mediates nutrient stress adaptation
10.1038/s41594-023-01119-z · 2023 · External reference
eIF5A functions globally in translation elongation and termination
10.1016/j.molcel.2017.03.003 · 2017 · External reference
Cutadapt removes adapter sequences from high-throughput sequencing reads
10.14806/ej.17.1.200 · 2011 · External reference
Fast gapped-read alignment with Bowtie 2
10.1038/nmeth.1923 · 2012 · External reference
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