Research graph
References from RIN1 regulates developmental and pain-related plasticity in spinal synapses via NMDA receptor subunit trafficking. Local targets link to admitted publications; unresolved targets remain external evidence.
NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease
10.1038/nrn3504 · 2013 · External reference
Targeting N-methyl-d-aspartate receptors in neurodegenerative diseases
10.3390/ijms25073733 · 2024 · External reference
Ionotropic glutamate receptors contribute to pain transmission and chronic pain
10.1016/j.neuropharm.2016.08.014 · 2017 · External reference
Ubiquitination and functional modification of GluN2B subunit-containing NMDA receptors by Cbl-b in the spinal cord dorsal horn
2020 · External reference
Peripheral inflammation increased the synaptic expression of NMDA receptors in spinal dorsal horn
10.1016/j.pain.2009.04.005 · 2009 · External reference
Agmatine requires GluN2B-containing NMDA receptors to inhibit the development of neuropathic pain
10.1177/17448069211029171 · 2021 · External reference
Effect of NMDA NR2B antagonist on neuropathic pain in two spinal cord injury models
10.1016/j.pain.2012.02.003 · 2012 · External reference
Disruption of SHP1/NMDA receptor signaling in spinal cord dorsal horn alleviated inflammatory pain
10.1016/j.neuropharm.2018.04.029 · 2018 · External reference
Differential expression of GluN2 NMDA receptor subunits in the dorsal horn of male and female rats
10.1080/19336950.2020.1871205 · 2021 · External reference
Heterogeneity of synaptic NMDA receptor responses within individual lamina I pain-processing neurons across sex in rats and humans
10.1113/jp285521 · 2024 · External reference
Synaptic GluN2A and GluN2B containing NMDA receptors within the superficial dorsal horn activated following primary afferent stimulation
10.1523/jneurosci.0145-14.2014 · 2014 · External reference
GluN2A and GluN2B N-methyl-D-aspartate receptor (NMDARs) subunits: their roles and therapeutic antagonists in neurological diseases
10.3390/ph16111535 · 2023 · External reference
GluN2B and GluN2D NMDARs dominate synaptic responses in the adult spinal cord
10.1038/srep04094 · 2014 · External reference
Developmental and regional expression in the rat brain and functional properties of four NMDA receptors
10.1016/0896-6273(94)90210-0 · 1994 · External reference
A developmental change in NMDA receptor-associated proteins at hippocampal synapses
10.1523/jneurosci.20-03-01260.2000 · 2000 · External reference
The Developmental shift of NMDA receptor composition proceeds independently of GluN2 subunit-specific GluN2 C-terminal sequences
10.1016/j.celrep.2018.09.089 · 2018 · External reference
Casein kinase 2 regulates the NR2 subunit composition of synaptic NMDA receptors
10.1016/j.neuron.2010.08.011 · 2010 · External reference
mGluR5 and NMDA receptors drive the experience- and activity-dependent NMDA receptor NR2B to NR2A subunit switch
10.1016/j.neuron.2011.02.045 · 2011 · External reference
Influence of GluN2 subunit identity on NMDA receptor function
10.1016/j.neuropharm.2013.01.016 · 2013 · External reference
Bidirectional, experience-dependent regulation of N-methyl-D-aspartate receptor subunit composition in the rat visual cortex during postnatal development
10.1073/pnas.96.22.12876 · 1999 · External reference
Differential trafficking of AMPA and NMDA receptors by SAP102 and PSD-95 underlies synapse development
10.1073/pnas.0811025106 · 2008 · External reference
Individual NMDA receptor GluN2 subunit signaling domains differentially regulate the postnatal maturation of hippocampal excitatory synaptic transmission and plasticity but not dendritic morphology
10.1002/syn.22292 · 2024 · External reference
The differences between GluN2A and GluN2B signaling in the brain
10.1002/jnr.24251 · 2018 · External reference
Regulation of NMDA receptor subunit expression and its implications for LTD, LTP, and metaplasticity
10.1016/j.neuropharm.2008.07.046 · 2008 · External reference
Conserved contributions of NMDA receptor subtypes to synaptic responses in lamina II spinal neurons across early postnatal development
10.1186/s13041-020-00566-9 · 2020 · External reference
Identifying functional populations among the interneurons in laminae I-III of the spinal dorsal horn
10.1177/1744806917693003 · 2017 · External reference
Recent advances in our understanding of the organization of dorsal horn neuron populations and their contribution to cutaneous mechanical allodynia
10.1007/s00702-020-02159-1 · 2020 · External reference
Parallel ascending spinal pathways for affective touch and pain
10.1038/s41586-020-2860-1 · 2020 · External reference
In Vivo Interrogation of Spinal Mechanosensory Circuits
10.1016/j.celrep.2016.10.010 · 2016 · External reference
Identification of spinal circuits transmitting and gating mechanical pain
10.1016/j.cell.2014.11.003 · 2014 · External reference
Identification of spinal circuits involved in touch-evoked dynamic mechanical pain
10.1038/nn.4549 · 2017 · External reference
GPR39 regulated spinal glycinergic inhibition and mechanical inflammatory pain
2024 · External reference
Central Nervous System Targets: Inhibitory Interneurons in the Spinal Cord
10.1007/s13311-020-00936-0 · 2020 · External reference
Chronic pain states: pharmacological strategies to restore diminished inhibitory spinal pain control
10.1146/annurev-pharmtox-010611-134636 · 2012 · External reference
The RAS effector RIN1 modulates the formation of aversive memories
10.1523/jneurosci.23-03-00748.2003 · 2003 · External reference
The Rab5 guanylate exchange factor Rin1 regulates endocytosis of the EphA4 receptor in mature excitatory neurons
10.1073/pnas.0801174105 · 2008 · External reference
Integration of transforming growth factor beta and RAS signaling silences a RAB5 guanine nucleotide exchange factor and enhances growth factor-directed cell migration
10.1128/mcb.01087-07 · 2008 · External reference
Ras and Rab interactor 1 controls neuronal plasticity by coordinating dendritic filopodial motility and AMPA receptor turnover
10.1091/mbc.e16-07-0526 · 2017 · External reference
Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1
10.1016/s1534-5807(01)00008-9 · 2001 · External reference
Activity-induced synaptic delivery of the GluN2A-containing NMDA receptor is dependent on endoplasmic reticulum chaperone Bip and involved in fear memory
10.1038/cr.2015.75 · 2015 · External reference
Diversity in NMDA receptor composition: many regulators, many consequences
10.1177/1073858411435129 · 2013 · External reference
The SRC homology 2 domain of Rin1 mediates its binding to the epidermal growth factor receptor and regulates receptor endocytosis
10.1074/jbc.m304324200 · 2003 · External reference
Efficacy of GluN2B-Containing NMDA receptor antagonist for antitumor and antidepressant therapy in non-small cell lung cancer
10.1016/j.ejphar.2024.176860 · 2024 · External reference
The GluN1/GluN2B NMDA receptor and metabotropic glutamate receptor 1 negative allosteric modulator has enhanced neuroprotection in a rat subarachnoid hemorrhage model
10.1016/j.expneurol.2017.12.005 · 2018 · External reference
Spermine reverses lipopolysaccharide-induced memory deficit in mice
10.1186/s12974-014-0220-5 · 2015 · External reference
Pyramidal and parvalbumin neurons modulate the process of electroacupuncture stimulation for stroke rehabilitation
10.1016/j.isci.2024.109695 · 2024 · External reference
The GluN2B-containing NMDA receptor alleviates neuronal apoptosis in neonatal hypoxic-ischemic encephalopathy by activating PI3K-Akt-CREB signaling pathway
10.33549/physiolres.935044 · 2023 · External reference
Regulated expression of the Ras effector Rin1 in forebrain neurons
10.1016/j.mcn.2009.09.012 · 2010 · External reference
NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders
10.1038/nrn2153 · 2007 · External reference
NR2 subunits and NMDA receptors on lamina II inhibitory and excitatory interneurons of the mouse dorsal horn
10.1186/1744-8069-6-26 · 2010 · External reference
NMDA receptor antagonists: emerging insights into molecular mechanisms and clinical applications in neurological disorders
10.3390/ph17050639 · 2024 · External reference
GluN2B-containing NMDARs in the mammalian brain: pharmacology, physiology, and pathology
10.3389/fnmol.2023.1190324 · 2023 · External reference
Regulation of NMDA glutamate receptor functions by the GluN2 subunits
10.1111/jnc.14970 · 2020 · External reference
NMDA receptor surface mobility depends on NR2A-2B subunits
10.1073/pnas.0605238103 · 2006 · External reference
AMPA and NMDA glutamate receptor trafficking: multiple roads for reaching and leaving the synapse
10.1007/s00441-006-0254-9 · 2006 · External reference
Identification of brain-to-spinal circuits controlling the laterality and duration of mechanical allodynia in mice
10.1016/j.celrep.2023.112300 · 2023 · External reference
Reduced expression of APLP2 in spinal GABAergic inhibitory neurons contributed to nerve injury-induced microglial activation and pain sensitization
10.1016/j.neuropharm.2022.109334 · 2023 · External reference
Recruitment of spinoparabrachial neurons by dorsal horn calretinin neurons
10.1016/j.celrep.2019.07.048 · 2019 · External reference
Dual electrical stimulation at spinal-muscular interface reconstructs spinal sensorimotor circuits after spinal cord injury
10.1038/s41467-024-44898-9 · 2024 · External reference
A spinal neural circuitry for converting touch to itch sensation
10.1038/s41467-020-18895-7 · 2020 · External reference
Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration
10.1016/j.cell.2021.12.041 · 2022 · External reference
Disrupting D1-NMDA or D2-NMDA receptor heteromerization prevents cocaine’s rewarding effects but preserves natural reward processing
10.1126/sciadv.abg5970 · 2021 · External reference
mGluR5/ERK signaling regulated the phosphorylation and function of glycine receptor α1ins subunit in spinal dorsal horn of mice
2019 · External reference
