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References from Identification of intestinal enteroendocrine cell subtypes and their associated hormones in zebrafish. Local targets link to admitted publications; unresolved targets remain external evidence.
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2019 · External reference
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2021 · External reference
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Requirement of Math1 for secretory cell lineage commitment in the mouse intestine
10.1126/science.1065718 · 2001 · External reference
Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium
10.1093/emboj/cdf649 · 2002 · External reference
Intestinal neurogenin 3 directs differentiation of a bipotential secretory progenitor to endocrine cell rather than goblet cell fate
10.1016/j.ydbio.2007.07.015 · 2007 · External reference
Neurogenin 3-expressing progenitor cells in the gastrointestinal tract differentiate into both endocrine and non-endocrine cell types
10.1016/j.ydbio.2004.03.013 · 2004 · External reference
Neurogenin 3 and the enteroendocrine cell lineage in the adult mouse small intestinal epithelium
10.1016/j.ydbio.2006.07.040 · 2006 · External reference
Loss of enteroendocrine cells in mice alters lipid absorption and glucose homeostasis and impairs postnatal survival
10.1172/jci40794 · 2010 · External reference
Cyclin D1 represses the basic helix-loop-helix transcription factor, BETA2/NeuroD
10.1074/jbc.m110747200 · 2002 · External reference
Intestinal Neurod1 expression impairs paneth cell differentiation and promotes enteroendocrine lineage specification
10.1038/s41598-019-55292-7 · 2019 · External reference
Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice
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Regulation of the pancreatic islet-specific gene BETA2 (neuroD) by neurogenin 3
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Identification of enteroendocrine regulators by real-time single-cell differentiation mapping
10.1016/j.cell.2018.12.029 · 2019 · External reference
Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation
2024 · External reference
Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient
10.1038/s41556-018-0143-y · 2018 · External reference
Ghrelin expression in the mouse pancreas defines a unique multipotent progenitor population
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10.1038/nature24489 · 2017 · External reference
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Rfx6 promotes the differentiation of peptide-secreting enteroendocrine cells while repressing genetic programs controlling serotonin production
10.1016/j.molmet.2019.08.007 · 2019 · External reference
High fat diet induces microbiota-dependent silencing of enteroendocrine cells
2019 · External reference
Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways
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Ascl1b and Neurod1, instead of Neurog3, control pancreatic endocrine cell fate in zebrafish
10.1186/1741-7007-11-78 · 2013 · External reference
Pancreatic and intestinal endocrine cells in zebrafish share common transcriptomic signatures and regulatory programmes
10.1186/s12915-020-00840-1 · 2020 · External reference
Identification of an evolutionarily conserved domain in Neurod1 favouring enteroendocrine versus goblet cell fate
10.1371/journal.pgen.1010109 · 2022 · External reference
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Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites
10.1038/nature16527 · 2016 · External reference
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10.1126/sciadv.abq2403 · 2022 · External reference
OCA-T1 and OCA-T2 are coactivators of POU2F3 in the tuft cell lineage
10.1038/s41586-022-04842-7 · 2022 · External reference
Sprouty2 limits intestinal tuft and goblet cell numbers through GSK3β-mediated restriction of epithelial IL-33
10.1038/s41467-021-21113-7 · 2021 · External reference
Antigen sampling by intestinal M cells is the principal pathway initiating mucosal IgA production to commensal enteric bacteria
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Dll1- and Dll4-mediated notch signaling are required for homeostasis of intestinal stem cells.
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Delta-Notch signalling controls commitment to a secretory fate in the zebrafish intestine
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Sox4 promotes Atoh1-independent intestinal secretory differentiation toward tuft and enteroendocrine fates
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Loss of ascl1a prevents secretory cell differentiation within the zebrafish intestinal epithelium resulting in a loss of distal intestinal motility
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The Ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium
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Zebrafish Agr2 is required for terminal differentiation of intestinal goblet cells
2012 · External reference
The protein disulfide isomerase AGR2 is essential for production of intestinal mucus
10.1073/pnas.0808722106 · 2009 · External reference
Fxr signaling and microbial metabolism of bile salts in the zebrafish intestine
2021 · External reference
Single-cell resolution of the adult zebrafish intestine under conventional conditions and in response to an acute Vibrio cholerae infection
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2011 · External reference
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10.1016/j.jcmgh.2022.02.007 · 2022 · External reference
Enteroendocrine cell lineages that differentially control feeding and gut motility
10.7554/elife.78512 · 2023 · External reference
Enteroendocrine cell types that drive food reward and aversion
2022 · External reference
Single-cell transcriptomic atlas of enteroendocrine cells along the murine gastrointestinal tract
10.1371/journal.pone.0308942 · 2024 · External reference
Description and functional validation of human enteroendocrine cell sensors
10.1126/science.adl1460 · 2024 · External reference
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The bHLH transcription factor ASCL1 promotes differentiation of endocrine cells in the stomach and is regulated by Notch signaling
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Mash1 is required for neuroendocrine cell development in the glandular stomach
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2020 · External reference
sox4b is a key player of pancreatic alpha cell differentiation in zebrafish
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Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development
10.1242/dev.041673 · 2010 · External reference
The zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cells
10.1101/gad.381806 · 2006 · External reference
Nkx2.2 regulates cell fate choice in the enteroendocrine cell lineages of the intestine
10.1016/j.ydbio.2007.09.047 · 2008 · External reference
The novel enterochromaffin marker Lmx1a regulates serotonin biosynthesis in enteroendocrine cell lineages downstream of Nkx2.2
2016 · External reference
Homeodomain transcription factor NKX2.2 functions in immature cells to control enteroendocrine differentiation and is expressed in gastrointestinal neuroendocrine tumors
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Review article: transcriptional events controlling the terminal differentiation of intestinal endocrine cells
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Pax6 and Pdx1 are required for production of glucose-dependent insulinotropic polypeptide in proglucagon-expressing L cells
10.1152/ajpendo.90440.2008 · 2008 · External reference
PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum
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Pdx1 inactivation restricted to the intestinal epithelium in mice alters duodenal gene expression in enterocytes and enteroendocrine cells
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Lmx1b, Pet-1, and Nkx2.2 coordinately specify serotonergic neurotransmitter phenotype
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Lmx1b is essential for the development of serotonergic neurons
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2020 · External reference
Targeted mutation of secretogranin-2 disrupts sexual behavior and reproduction in zebrafish
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10.1038/45230 · 1999 · External reference
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10.1126/science.1117255 · 2005 · External reference
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10.1016/j.peptides.2008.12.016 · 2009 · External reference
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Ghrelin enhances appetite and increases food intake in humans
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In vivo drug discovery for increasing incretin-expressing cells identifies DYRK inhibitors that reinforce the enteroendocrine system
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