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References from Control of mitochondrial dynamics by the metabolic regulator dPGC1 limits Yorkie-induced oncogenic growth in Drosophila. Local targets link to admitted publications; unresolved targets remain external evidence.
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The AMPK-like protein kinases Sik2 and Sik3 interact with Hipk and induce synergistic tumorigenesis in a Drosophila cancer model
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A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
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Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1
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Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres
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Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice
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Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network
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New insights into PGC-1 coactivators: redefining their role in the regulation of mitochondrial function and beyond
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Mitochondrial fusion is increased by the nuclear coactivator PGC-1beta
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PGC-1α Is a master regulator of mitochondrial lifecycle and ROS stress response
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PGC-1α-mediated mitochondrial quality control: molecular mechanisms and implications for heart failure
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PGC1α promotes tumor growth by inducing gene expression programs supporting lipogenesis
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PGC-1 family coactivators and cell fate: roles in cancer, neurodegeneration, cardiovascular disease and retrograde mitochondria-nucleus signalling
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The metabolic co-regulator PGC1α suppresses prostate cancer metastasis
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From metabolism to malignancy: the multifaceted role of PGC1α in cancer
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High-resolution dynamics of the transcriptional response to nutrition in Drosophila: a key role for dFOXO
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Emerging functional similarities and divergences between Drosophila Spargel/dPGC-1 and mammalian PGC-1 protein
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The Hippo signaling pathway in development and disease
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The role of the Hippo pathway in human disease and tumorigenesis
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Regulation of the Hippo pathway in cancer biology
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Hippo pathway in cancer: aberrant regulation and therapeutic opportunities
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Control of mitochondrial structure and function by the Yorkie/YAP oncogenic pathway
10.1101/gad.183061.111 · 2012 · External reference
A cytoplasmic suppressor of a nuclear mutation affecting mitochondrial functions in Drosophila
10.1534/genetics.112.143719 · 2012 · External reference
PGC-1/spargel counteracts high-fat-diet-induced obesity and cardiac lipotoxicity downstream of TOR and brummer ATGL lipase
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Germline knockdown of spargel (PGC-1) produces embryonic lethality in Drosophila
10.1016/j.mito.2019.08.006 · 2019 · External reference
Spargel/dPGC-1 is a new downstream effector in the insulin-TOR signaling pathway in Drosophila
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Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog
10.1016/j.cmet.2011.09.013 · 2011 · External reference
Increased mitochondrial biogenesis preserves intestinal stem cell homeostasis and contributes to longevity in Indy mutant flies
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Cancer in Drosophila: imaginal discs as a model for epithelial tumor formation
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The Drosophila PGC-1 homologue Spargel coordinates mitochondrial activity to insulin signalling
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Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance
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PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis
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PGC-1beta controls mitochondrial metabolism to modulate circadian activity, adaptive thermogenesis, and hepatic steatosis
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Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance
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Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
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Yorkie and JNK control tumorigenesis in Drosophila cells with cytokinesis failure
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The miRNA bantam regulates growth and tumorigenesis by repressing the cell cycle regulator tribbles
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The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila homolog of YAP
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The bantam microRNA is a target of the hippo tumor-suppressor pathway
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The Hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Drosophila
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Warburg effect metabolism drives neoplasia in a Drosophila genetic model of epithelial cancer
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Oncogenic cooperation between SOCS family proteins and EGFR identified using a Drosophila epithelial transformation model
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dTcf/Pangolin suppresses growth and tumor formation in Drosophila
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JNK signaling is converted from anti- to pro-tumor pathway by Ras-mediated switch of Warts activity
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Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila
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Drosophila actin-Capping Protein limits JNK activation by the Src proto-oncogene
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In Drosophila, RhoGEF2 cooperates with activated Ras in tumorigenesis through a pathway involving Rho1-Rok-Myosin-II and JNK signalling
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Estrogen related receptor is required for the testicular development and for the normal sperm axoneme/mitochondrial derivatives in Drosophila males
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Drosophila Erect wing (Ewg) controls mitochondrial fusion during muscle growth and maintenance by regulation of the Opa1-like gene
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The Parkinson’s disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila
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PINK1 is selectively stabilized on impaired mitochondria to activate Parkin
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The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo
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The GTPase dMiro is required for axonal transport of mitochondria to Drosophila synapses
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Axonal transport of mitochondria to synapses depends on milton, a novel Drosophila protein
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Vimar is a novel regulator of mitochondrial fission through miro
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Ca2+-dependent regulation of mitochondrial dynamics by the Miro-Milton complex
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Miro, a Rho GTPase genetically interacts with Alzheimer’s disease-associated genes (Tau, Aβ42 and Appl) in Drosophila melanogaster
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DRP1-dependent mitochondrial fission initiates follicle cell differentiation during Drosophila oogenesis
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A hyperfused mitochondrial state achieved at G1-S regulates cyclin E buildup and entry into S phase
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An integrated view of cyclin E function and regulation
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Focusing on foci: H2AX and the recruitment of DNA-damage response factors
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Contributions of DNA repair, cell cycle checkpoints and cell death to suppressing the DNA damage-induced tumorigenic behavior of Drosophila epithelial cells
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Dacapo, a cyclin-dependent kinase inhibitor, stops cell proliferation during Drosophila development
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Hippo signaling instructs ectopic but not normal organ growth
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Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle
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Peroxisome proliferator-activated receptors (PPARs) and associated transcription factors in colon cancer: reduced expression of PPARgamma-coactivator 1 (PGC-1)
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The localisation and reduction of nuclear staining of PPARgamma and PGC-1 in human breast cancer
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PGC-1alpha mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis
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Differential regulation of cyclin E by Yorkie-Scalloped signaling in organ development
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Mitochondrial fusion regulates proliferation and differentiation in the type II neuroblast lineage in Drosophila
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Mitochondrial fusion supports increased oxidative phosphorylation during cell proliferation
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Splice variants of mitofusin 2 shape the endoplasmic reticulum and tether it to mitochondria
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Drosophila phosphatidylinositol-4 kinase fwd promotes mitochondrial fission and can suppress Pink1/parkin phenotypes
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