Research graph
References from Glia-to-glia serotonin signaling directs MMP-dependent infiltration for experience-dependent synapse pruning. Local targets link to admitted publications; unresolved targets remain external evidence.
Neuron-to-glia and glia-to-glia signaling directs critical period experience-dependent synapse pruning
10.3389/fcell.2025.1540052 · 2025 · External reference
The period of susceptibility to the physiological effects of unilateral eye closure in kittens
10.1113/jphysiol.1970.sp009022 · 1970 · External reference
Critical period regulation across multiple timescales
10.1073/pnas.1820836117 · 2020 · External reference
Shifting developmental trajectories during critical periods of brain formation
10.3389/fncel.2020.00283 · 2020 · External reference
Glial regulation of critical period plasticity
10.3389/fncel.2023.1247335 · 2023 · External reference
Synapse formation in developing neural circuits
10.1016/s0070-2153(09)01202-2 · 2009 · External reference
Glial modulation of synapse development and plasticity: oligodendrocyte precursor cells as a new player in the synaptic quintet
10.3389/fcell.2024.1418100 · 2024 · External reference
A critical period for activity-dependent synaptic development during olfactory bulb adult neurogenesis
10.1523/jneurosci.2406-09.2009 · 2009 · External reference
Impaired activity-dependent neural circuit assembly and refinement in autism spectrum disorder genetic models
2014 · External reference
Glia control experience-dependent plasticity in an olfactory critical period
10.7554/elife.100989.3 · 2025 · External reference
Mechanisms governing activity-dependent synaptic pruning in the developing mammalian CNS
10.1038/s41583-021-00507-y · 2021 · External reference
A novel phagocytic role of astrocytes in activity-dependent elimination of mature excitatory synapses
10.1007/s12264-021-00690-z · 2021 · External reference
Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways
10.1038/nature12776 · 2013 · External reference
Glial phagocytosis in developing and mature Drosophila CNS: tight regulation for a healthy brain
10.1016/j.coi.2019.11.010 · 2020 · External reference
Experience-dependent glial pruning of synaptic glomeruli during the critical period
10.1038/s41598-024-59942-3 · 2024 · External reference
Neuron-glia interaction in the Drosophila nervous system
10.1002/dneu.22737 · 2021 · External reference
Serotonin modulates excitatory synapse maturation in the developing prefrontal cortex
10.1038/s41467-024-45734-w · 2024 · External reference
Monoamine-sensitive developmental periods impacting adult emotional and cognitive behaviors
10.1038/npp.2014.231 · 2015 · External reference
Developmental role of tryptophan hydroxylase in the nervous system
10.1007/bf02700623 · 2007 · External reference
Distinguishing characteristics of serotonin and non-serotonin-containing cells in the dorsal raphe nucleus: electrophysiological and immunohistochemical studies
10.1016/s0306-4522(02)00584-5 · 2003 · External reference
10.1371/journal.pbio.3002822 · 2024 · Admitted local publication
5-HT-dependent synaptic plasticity of the prefrontal cortex in postnatal development
10.1038/s41598-022-23767-9 · 2022 · External reference
G protein-specific mechanisms in the serotonin 5-HT2A receptor regulate psychosis-related effects and memory deficits
10.1038/s41467-024-48196-2 · 2024 · External reference
Sustained activation of postsynaptic 5-HT2A receptors gates plasticity at prefrontal cortex synapses
10.1093/cercor/bhy064 · 2019 · External reference
The role of serotonin 5-HT2A receptors in memory and cognition
10.3389/fphar.2015.00225 · 2015 · External reference
Dysfunctional serotonergic neuron-astrocyte signaling in depressive-like states
10.1038/s41380-023-02269-8 · 2023 · External reference
Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors
10.1126/science.adf0435 · 2023 · External reference
Critical period plasticity as a framework for psychedelic-assisted psychotherapy
10.3389/fnins.2021.710004 · 2021 · External reference
Psychedelic-inspired approaches for treating neurodegenerative disorders
10.1111/jnc.15544 · 2022 · External reference
Psychedelics in psychiatry: neuroplastic, immunomodulatory, and neurotransmitter mechanisms
10.1124/pharmrev.120.000056 · 2021 · External reference
Serotonergic neuromodulation of synaptic plasticity
10.1016/j.neuropharm.2024.110036 · 2024 · External reference
Two classes of matrix metalloproteinases reciprocally regulate synaptogenesis
2016 · External reference
From molecules to behavior: implications for perineuronal net remodeling in learning and memory
10.1111/jnc.16036 · 2024 · External reference
The brain’s extracellular matrix and its role in synaptic plasticity
10.1007/978-3-7091-0932-8_7 · 2012 · External reference
Extracellular matrix recycling as a novel plasticity mechanism with a potential role in disease
10.3389/fncel.2022.854897 · 2022 · External reference
The dual role of the extracellular matrix in synaptic plasticity and homeostasis
10.1038/nrn2898 · 2010 · External reference
Serotonin 2A (5-HT2A) receptor affects cell-matrix adhesion and the formation and maintenance of stress fibers in HEK293 cells
10.1038/s41598-020-78595-6 · 2020 · External reference
A glial perspective on the extracellular matrix and perineuronal net remodeling in the central nervous system
10.3389/fncel.2022.1022754 · 2022 · External reference
Serotonin-induced MMP-13 production is mediated via phospholipase C, protein kinase C, and ERK1/2 in rat uterine smooth muscle cells
10.1074/jbc.m205094200 · 2002 · External reference
The roles of matrix metalloproteinases and their inhibitors in human diseases
10.3390/ijms21249739 · 2020 · External reference
A novel Drosophila injury model reveals severed axons are cleared through a Draper/MMP-1 signaling cascade
10.7554/elife.23611 · 2017 · External reference
Structural and functional changes in the olfactory pathway of adult Drosophila take place at a critical age
10.1002/neu.10215 · 2003 · External reference
Critical periods in Drosophila neural network development: importance to network tuning and therapeutic potential
10.3389/fphys.2022.1073307 · 2022 · External reference
Neuron-specific FMRP roles in experience-dependent remodeling of olfactory brain innervation during an early-life critical period
10.1523/jneurosci.2167-20.2020 · 2021 · External reference
Activity-dependent remodeling of Drosophila olfactory sensory neuron brain innervation during an early-life critical period
10.1523/jneurosci.2223-18.2019 · 2019 · External reference
Fragile X mental retardation protein coordinates neuron-to-glia communication for clearance of developmentally transient brain neurons
10.1073/pnas.2216887120 · 2023 · External reference
Neuronal fragile X mental retardation protein activates glial insulin receptor mediated PDF-Tri neuron developmental clearance
10.1038/s41467-021-21429-4 · 2021 · External reference
The wiring logic of an identified serotonergic neuron that spans sensory networks
10.1523/jneurosci.0552-20.2020 · 2020 · External reference
DoOR 2.0--comprehensive mapping of Drosophila melanogaster odorant responses
10.1038/srep21841 · 2016 · External reference
Genetic and functional subdivision of the Drosophila antennal lobe
10.1016/j.cub.2005.07.066 · 2005 · External reference
Cell-specific genetic expression profile of antennal glia in Drosophila reveals candidate genes in neuron-glia interactions
10.1038/s41598-025-87834-7 · 2025 · External reference
Functional integration of a serotonergic neuron in the Drosophila antennal lobe
10.7554/elife.16836 · 2016 · External reference
10.1523/jneurosci.0192-17.2017
10.1523/jneurosci.0192-17.2017 · External reference
Distribution of two isoforms of tryptophan hydroxylase in the brain of rainbow trout (Oncorhynchus mykiss). An in situ hybridization study
10.1007/s00429-021-02322-8 · 2021 · External reference
Serotonin receptor 4 regulates hippocampal astrocyte morphology and function
10.1002/glia.23933 · 2021 · External reference
Astrocytes
10.1016/j.cub.2021.01.056 · 2021 · External reference
Microglia function in the central nervous system during health and neurodegeneration
10.1146/annurev-immunol-051116-052358 · 2017 · External reference
Role of microglia and astrocytes in Alzheimer’s disease: from neuroinflammation to Ca2+ homeostasis dysregulation
10.3390/cells11172728 · 2022 · External reference
Inter-species rescue of mutant phenotype-the standard for genetic analysis of human genetic disorders in Drosophila melanogaster model
10.3390/ijms23052613 · 2022 · External reference
Large-scale transgenic Drosophila resource collections for loss- and gain-of-function studies
10.1534/genetics.119.302964 · 2020 · External reference
Chemoconnectomics: mapping chemical transmission in Drosophila
10.1016/j.neuron.2019.01.045 · 2019 · External reference
Psychedelics reopen the social reward learning critical period
10.1038/s41586-023-06204-3 · 2023 · External reference
Resolving and rescuing developmental miswiring in a mouse model of cognitive impairment
10.1016/j.neuron.2019.09.042 · 2020 · External reference
α-Tubulin acetylation at lysine 40 regulates dendritic arborization and larval locomotion by promoting microtubule stability in Drosophila
2023 · External reference
Neuronal wiring diagram of an adult brain
10.1038/s41586-024-07558-y · 2024 · External reference
Engulfed by glia: glial pruning in development, function, and injury across species
10.1523/jneurosci.1660-20.2020 · 2021 · External reference
Molecular mechanisms underlying microglial sensing and phagocytosis in synaptic pruning
10.4103/1673-5374.385854 · 2024 · External reference
Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development
10.1126/science.aal3589 · 2018 · External reference
Less is more: a critical role of synapse pruning in neural circuit wiring
10.1038/s41583-022-00665-7 · 2023 · External reference
Role of glia and extracellular matrix in controlling neuroplasticity in the central nervous system
10.1007/s00281-023-00989-1 · 2023 · External reference
Insulin-like signaling promotes glial phagocytic clearance of degenerating axons through regulation of draper
10.1016/j.celrep.2016.07.022 · 2016 · External reference
Antagonistic regulation by insulin-like peptide and activin ensures the elaboration of appropriate dendritic field sizes of amacrine neurons
2020 · External reference
Refining the role of 5-HT in postnatal development of brain circuits
10.3389/fncel.2017.00139 · 2017 · External reference
Involvement of serotonin in developmental plasticity of kitten visual cortex
10.1111/j.1460-9568.1995.tb01104.x · 1995 · External reference
Engulfed by glia: glial pruning in development, function, and injury across species
10.1523/jneurosci.1660-20.2020 · 2021 · External reference
Experience-dependent MAPK/ERK signaling in glia regulates critical period remodeling of synaptic glomeruli
10.1016/j.cellsig.2024.111224 · 2024 · External reference
Glial phagocytosis in developing and mature Drosophila CNS: tight regulation for a healthy brain
10.1016/j.coi.2019.11.010 · 2020 · External reference
Neuronal cytoskeleton in synaptic plasticity and regeneration
10.1111/jnc.12502 · 2014 · External reference
Glial cells in the mammalian olfactory bulb
10.3389/fncel.2024.1426094 · 2024 · External reference
Inhibition of the kynurenine pathway protects against reactive microglial-associated reductions in the complexity of primary cortical neurons
10.1016/j.ejphar.2017.07.008 · 2017 · External reference
The role of glial and neuronal Eph/ephrin signaling in Drosophila mushroom body development and sleep and circadian behavior
10.1016/j.bbrc.2024.150072 · 2024 · External reference
Microglia-astrocyte interaction in neural development and neural pathogenesis
10.3390/cells12151942 · 2023 · External reference
Astrocytes and microglia in the coordination of CNS development and homeostasis
2024 · External reference
Glia and immune cell signaling in bipolar disorder: insights from neuropharmacology and molecular imaging to clinical application
10.1038/tp.2013.119 · 2014 · External reference
Microglia-secreted factors enhance dopaminergic differentiation of tissue- and iPSC-derived human neural stem cells
10.1016/j.stemcr.2020.12.011 · 2021 · External reference
Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets
10.1038/s41392-023-01588-0 · 2023 · External reference
Neuroinflammation: an astrocyte perspective
2023 · External reference
5-HT2A receptor dysregulation in a schizophrenia relevant mouse model of NMDA receptor hypofunction
10.1038/s41398-022-01930-0 · 2022 · External reference
Serotonin regulation of behavior via large-scale neuromodulation of serotonin receptor networks
10.1038/s41593-022-01213-3 · 2023 · External reference
The role of serotonin 5-HT2A receptors in memory and cognition
2015 · External reference
Serotonin 2A receptors are a stress response system: implications for post-traumatic stress disorder
10.1097/fbp.0000000000000459 · 2019 · External reference
Altered serotonin 2A (5-HT2A) receptor signaling underlies mild TBI-elicited deficits in social dominance
10.3389/fphar.2022.930346 · 2022 · External reference
Circuit formation in the adult brain
10.1111/ejn.15742 · 2022 · External reference
Serotonin receptor 5-HT7 in Drosophila mushroom body neurons mediates larval appetitive olfactory learning
10.1038/s41598-020-77910-5 · 2020 · External reference
Local potentiation of excitatory synapses by serotonin and its alteration in rodent models of depression
10.1038/nn.3355 · 2013 · External reference
The critical period: neurochemical and synaptic mechanisms shared by the visual cortex and the brain stem respiratory system
2021 · External reference
A critical period plasticity framework for the sensorimotor-association axis of cortical neurodevelopment
10.1016/j.tins.2023.07.007 · 2023 · External reference
A critical period for development of cerebellar-mediated autism-relevant social behavior
10.1523/jneurosci.1230-21.2021 · 2022 · External reference
Rejuvenation of plasticity in the brain: opening the critical period
10.1016/j.conb.2018.09.003 · 2019 · External reference
Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors
10.1126/science.adf0435 · 2023 · External reference
Extracellular matrix recycling as a novel plasticity mechanism with a potential role in disease
2022 · External reference
Microglial remodeling of the extracellular matrix promotes synapse plasticity
10.1016/j.cell.2020.05.050 · 2020 · External reference
Microglia as hackers of the matrix: sculpting synapses and the extracellular space
10.1038/s41423-021-00751-3 · 2021 · External reference
Macrophage invasion into the Drosophila brain requires JAK/STAT-dependent MMP activation in the blood-brain barrier
10.1371/journal.pbio.3003035 · 2025 · External reference
Optimal level activity of matrix metalloproteinases is critical for adult visual plasticity in the healthy and stroke-affected brain
2015 · External reference
Astrocytes close the mouse critical period for visual plasticity
10.1126/science.abf5273 · 2021 · External reference
Matrix metalloproteinase-9 overexpression in the hippocampus reduces alcohol-induced conditioned-place preference by regulating synaptic plasticity in mice
10.1016/j.bbr.2023.114330 · 2023 · External reference
Synaptic circuit remodelling by matrix metalloproteinases in health and disease
10.1038/nrn3320 · 2012 · External reference
The homeobox gene repo is required for the differentiation and maintenance of glia function in the embryonic nervous system of Drosophila melanogaster
10.1242/dev.121.2.317 · 1995 · External reference
The glia of the adult Drosophila nervous system
10.1002/glia.23115 · 2017 · External reference
Diet-induced glial insulin resistance impairs the clearance of neuronal debris in Drosophila brain
10.1371/journal.pbio.3002359 · 2023 · External reference
A GAL4-driver line resource for Drosophila neurobiology
10.1016/j.celrep.2012.09.011 · 2012 · External reference
Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis
10.1016/s0896-6273(00)80701-1 · 1999 · External reference
A toolkit for converting Gal4 into LexA and Flippase transgenes in Drosophila
10.1093/g3journal/jkad003 · 2023 · External reference
A hormone receptor-based transactivator bridges different binary systems to precisely control spatial-temporal gene expression in Drosophila
2012 · External reference
Constitutive and conditional epitope tagging of endogenous G-protein-coupled receptors in Drosophila
10.1523/jneurosci.2377-23.2024 · 2024 · External reference
Small molecule drug screening in Drosophila identifies the 5HT2A receptor as a feeding modulation target
10.1038/srep02120 · 2013 · External reference
Drosophila matrix metalloproteinases are required for tissue remodeling, but not embryonic development
10.1016/s1534-5807(02)00400-8 · 2003 · External reference
Pathogenic tau-induced transposable element–derived dsRNA drives neuroinflammation
10.1126/sciadv.abq5423 · 2023 · External reference
Drosophila Psidin regulates olfactory neuron number and axon targeting through two distinct molecular mechanisms
10.1523/jneurosci.3116-12.2012 · 2012 · External reference
Serotonin distinctly controls behavioral states in restrained and freely moving Drosophila
10.1016/j.isci.2022.105886 · 2022 · External reference
Experience-dependent remodeling of juvenile brain olfactory sensory neuron synaptic connectivity in an early-life critical period
10.3791/66629 · 2024 · External reference
Neuronal activity drives FMRP- and HSPG-dependent matrix metalloproteinase function required for rapid synaptogenesis
2017 · External reference
