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References from Post-transcriptional suppression of the pioneer factor Zelda protects the adult Drosophila testis from activation of the ovary program. Local targets link to admitted publications; unresolved targets remain external evidence.
The sexual identity of adult intestinal stem cells controls organ size and plasticity
10.1038/nature16953 · 2016 · External reference
Y chromosome loss in cancer drives growth by evasion of adaptive immunity
10.1038/s41586-023-06234-x · 2023 · External reference
Histone demethylase KDM5D upregulation drives sex differences in colon cancer
10.1038/s41586-023-06254-7 · 2023 · External reference
Sex differences in cancer mechanisms
10.1186/s13293-020-00291-x · 2020 · External reference
Sex-dimorphic tumor growth is regulated by tumor microenvironmental and systemic signals
10.1126/sciadv.ads4229 · 2024 · External reference
Sexual differentiation of brain and other tissues: five questions for the next 50 years
10.1016/j.yhbeh.2020.104691 · 2020 · External reference
Developmental mechanisms of sex differences: from cells to organisms
2021 · External reference
Cellular sex throughout the organism underlies somatic sexual differentiation
10.1038/s41467-024-51228-6 · 2024 · External reference
Sex-specific regulation of development, growth and metabolism
10.1016/j.semcdb.2022.04.017 · 2023 · External reference
Molecular and cellular origins of behavioral sex differences: a tiny little fly tells a lot
10.3389/fnmol.2023.1284367 · 2023 · External reference
Evolution of sexual development and sexual dimorphism in insects
10.1016/j.gde.2021.02.011 · 2021 · External reference
Sex Differences in intestinal carbohydrate metabolism promote food intake and sperm maturation
10.1016/j.cell.2019.07.029 · 2019 · External reference
Fitness trade-offs incurred by ovary-to-gut steroid signalling in Drosophila
10.1038/s41586-020-2462-y · 2020 · External reference
The Jak-STAT target Chinmo prevents sex transformation of adult stem cells in the Drosophila testis niche
10.1016/j.devcel.2014.10.004 · 2014 · External reference
Chinmo prevents transformer alternative splicing to maintain male sex identity
10.1371/journal.pgen.1007203 · 2018 · External reference
Sex determination in Drosophila: the view from the top
10.4161/fly.4.1.11277 · 2010 · External reference
Binding of the Drosophila sex-lethal gene product to the alternative splice site of transformer primary transcript
10.1038/344461a0 · 1990 · External reference
Regulation of sexual differentiation in D. melanogaster via alternative splicing of RNA from the transformer gene
10.1016/0092-8674(87)90332-1 · 1987 · External reference
Drosophila doublesex gene controls somatic sexual differentiation by producing alternatively spliced mRNAs encoding related sex-specific polypeptides
10.1016/0092-8674(89)90633-8 · 1989 · External reference
Assembly of specific SR protein complexes on distinct regulatory elements of the Drosophila doublesex splicing enhancer
10.1101/gad.10.16.2089 · 1996 · External reference
Regulation of sex-specific RNA splicing at the Drosophila doublesex gene: cis-acting mutations in exon sequences alter sex-specific RNA splicing patterns
10.1101/gad.4.1.89 · 1990 · External reference
The doublesex proteins of Drosophila melanogaster bind directly to a sex-specific yolk protein gene enhancer
10.1002/j.1460-2075.1991.tb07798.x · 1991 · External reference
The regulation and evolution of a genetic switch controlling sexually dimorphic traits in Drosophila
10.1016/j.cell.2008.06.052 · 2008 · External reference
Sex and the singular DM domain: insights into sexual regulation, evolution and plasticity
10.1038/nrg3161 · 2012 · External reference
Genetic control of germline sexual dimorphism in Drosophila
10.1016/s0074-7696(02)19010-3 · 2002 · External reference
Germ cell sex determination in mammals
10.1093/molehr/gap008 · 2009 · External reference
DMRT1 prevents female reprogramming in the postnatal mammalian testis
10.1038/nature10239 · 2011 · External reference
Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation
10.1016/j.cell.2009.11.021 · 2009 · External reference
Genetics of gonadal stem cell renewal
10.1146/annurev-cellbio-100913-013344 · 2015 · External reference
Doublesex controls specification and maintenance of the gonad stem cell niches in Drosophila
2019 · External reference
Doublesex regulates fruitless expression to promote sexual dimorphism of the gonad stem cell niche
10.1371/journal.pgen.1009468 · 2021 · External reference
Chinmo is sufficient to induce male fate in somatic cells of the adult Drosophila ovary
2016 · External reference
Differential control of yolk protein gene expression in fat bodies and gonads by the sex-determining gene tra-2 of Drosophila
10.1002/j.1460-2075.1990.tb07618.x · 1990 · External reference
Transcriptomic analysis of feminizing somatic stem cells in the Drosophila testis reveals putative downstream effectors of the transcription factor Chinmo
10.1093/g3journal/jkab067 · 2021 · External reference
Sex-converted testis somatic cells acquire female-specific behaviors and alter XY germline identity
10.1242/dev.204785 · 2025 · External reference
Conversion of somatic sex identity in the testis induces female-specific cellular behaviors in the soma and early oocyte specification in the germline
2024 · External reference
Direct cell reprogramming: approaches, mechanisms and progress
10.1038/s41580-021-00335-z · 2021 · External reference
Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons
10.1016/j.cell.2013.09.028 · 2013 · External reference
Continued activity of the pioneer factor zelda is required to drive zygotic genome activation
10.1016/j.molcel.2019.01.014 · 2019 · External reference
Structural features of transcription factors associating with nucleosome binding
10.1016/j.molcel.2019.06.009 · 2019 · External reference
The zinc-finger protein Zelda is a key activator of the early zygotic genome in Drosophila
10.1038/nature07388 · 2008 · External reference
Chromatin accessibility in the Drosophila embryo is determined by transcription factor pioneering and enhancer activation
10.1016/j.devcel.2023.07.007 · 2023 · External reference
Zelda overcomes the high intrinsic nucleosome barrier at enhancers during Drosophila zygotic genome activation
10.1101/gr.192542.115 · 2015 · External reference
Zelda potentiates morphogen activity by increasing chromatin accessibility
10.1016/j.cub.2014.04.032 · 2014 · External reference
6mA-DNA-binding factor Jumu controls maternal-to-zygotic transition upstream of Zelda
10.1038/s41467-019-10202-3 · 2019 · External reference
Steroid signaling within Drosophila ovarian epithelial cells sex-specifically modulates early germ cell development and meiotic entry
10.1371/journal.pone.0046109 · 2012 · External reference
An update on ecdysone signaling during insect oogenesis
10.1016/j.cois.2018.07.003 · 2019 · External reference
Ecdysteroids affect Drosophila ovarian stem cell niche formation and early germline differentiation
10.1038/emboj.2011.73 · 2011 · External reference
Cell survival and polarity of Drosophila follicle cells require the activity of ecdysone receptor B1 isoform
10.1534/genetics.108.096008 · 2009 · External reference
Steroid signaling in mature follicles is important for Drosophila ovulation
10.1073/pnas.1614383114 · 2017 · External reference
Steroid signaling controls sex-specific development in an invertebrate
2024 · External reference
iRegulon: from a gene list to a gene regulatory network using large motif and track collections
10.1371/journal.pcbi.1003731 · 2014 · External reference
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
10.1038/nprot.2008.211 · 2009 · External reference
Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists
10.1093/nar/gkn923 · 2009 · External reference
A conserved maternal-specific repressive domain in Zelda revealed by Cas9-mediated mutagenesis in Drosophila melanogaster
2017 · External reference
Dynamic multifactor hubs interact transiently with sites of active transcription in Drosophila embryos
2018 · External reference
Spatiotemporal gene expression targeting with the TARGET and gene-switch systems in Drosophila
10.1126/stke.2202004pl6 · 2004 · External reference
chinmo-mutant spermatogonial stem cells cause mitotic drive by evicting non-mutant neighbors from the niche
2022 · External reference
Predicting microRNA targeting efficacy in Drosophila
10.1186/s13059-018-1504-3 · 2018 · External reference
A transgenic resource for conditional competitive inhibition of conserved Drosophila microRNAs
10.1038/ncomms8279 · 2015 · External reference
GLAD: an online database of gene list annotation for Drosophila
10.7150/jgen.12863 · 2015 · External reference
Regulation of alternative splicing in Drosophila by 56 RNA binding proteins
10.1101/gr.192518.115 · 2015 · External reference
Two distinct mechanisms silence chinmo in Drosophila neuroblasts and neuroepithelial cells to limit their self-renewal
2018 · External reference
Sex-specific regulation of yolk protein gene expression in Drosophila
10.1016/0092-8674(85)90148-5 · 1985 · External reference
Observations on cell lineage of internal organs of Drosophila
1986 · External reference
Ablation of the Sam68 gene impairs female fertility and gonadotropin-dependent follicle development
10.1093/hmg/ddq422 · 2010 · External reference
A novel mutation in KHDRBS1 in a patient affected by primary ovarian insufficiency
10.1111/cen.13749 · 2018 · External reference
New mutations in non-syndromic primary ovarian insufficiency patients identified via whole-exome sequencing
10.1093/humrep/dex089 · 2017 · External reference
Sequence variants of KHDRBS1 as high penetrance susceptibility risks for primary ovarian insufficiency by mis-regulating mRNA alternative splicing
10.1093/humrep/dex263 · 2017 · External reference
Steroid signaling promotes stem cell maintenance in the Drosophila testis
10.1016/j.ydbio.2014.07.016 · 2014 · External reference
Ecdysone signaling opposes epidermal growth factor signaling in regulating cyst differentiation in the male gonad of Drosophila melanogaster
10.1016/j.ydbio.2014.08.019 · 2014 · External reference
Mating-induced Ecdysone in the testis disrupts soma-germline contacts and stem cell cytokinesis
10.1242/dev.202542 · 2024 · External reference
Direct and widespread role for the nuclear receptor EcR in mediating the response to ecdysone in Drosophila
10.1073/pnas.1900343116 · 2019 · External reference
Chinmo is the larval member of the molecular trinity that directs Drosophila metamorphosis
10.1073/pnas.2201071119 · 2022 · External reference
Antagonistic role of the BTB-zinc finger transcription factors Chinmo and Broad-Complex in the juvenile/pupal transition and in growth control
10.7554/elife.84648 · 2023 · External reference
Let-7-complex microRNAs regulate the temporal identity of Drosophila mushroom body neurons via chinmo
10.1016/j.devcel.2012.05.013 · 2012 · External reference
Age-related declines in niche self-renewal factors controls testis aging and spermatogonial stem cell competition through Hairless, Imp, and Chinmo
2025 · External reference
A single-cell atlas and lineage analysis of the adult Drosophila ovary
10.1038/s41467-020-19361-0 · 2020 · External reference
MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation
10.1038/nature07299 · 2008 · External reference
MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells
10.1016/j.cell.2009.02.038 · 2009 · External reference
The pioneer transcription factor Zelda controls the exit from regeneration and restoration of patterning in Drosophila
10.1126/sciadv.ads5743 · 2025 · External reference
Cell-type-specific chromatin occupancy by the pioneer factor Zelda drives key developmental transitions in Drosophila
10.1038/s41467-021-27506-y · 2021 · External reference
Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
10.1242/dev.118.2.401 · 1993 · External reference
Analysis of Gal4 expression patterns in adult Drosophila females
10.1534/g3.120.401676 · 2020 · External reference
A genome-scale shRNA resource for transgenic RNAi in Drosophila
10.1038/nmeth.1592 · 2011 · External reference
A hydrophilic lamin-binding domain from the Drosophila YA protein can target proteins to the nuclear envelope
10.1242/jcs.00402 · 2003 · External reference
chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila
10.1016/j.devcel.2010.02.006 · 2010 · External reference
Optimized RNA ISH, RNA FISH and protein-RNA double labeling (IF/FISH) in Drosophila ovaries
10.1038/nprot.2013.136 · 2013 · External reference
Third-generation in situ hybridization chain reaction: multiplexed, quantitative, sensitive, versatile, robust
2018 · External reference
Emergent dynamics of adult stem cell lineages from single nucleus and single cell RNA-Seq of Drosophila testes
2023 · External reference
