Research graph
References from The transcription factor SKN-1 drives lysosomal enlargement during aging to maintain function. Local targets link to admitted publications; unresolved targets remain external evidence.
Targeting lysosomes in human disease: from basic research to clinical applications
10.1038/s41392-021-00778-y · 2021 · External reference
Lysosomal storage diseases
10.1038/s41572-018-0025-4 · 2018 · External reference
An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast
10.1038/nature11654 · 2012 · External reference
Regulation of lysosomal function by the DAF-16 forkhead transcription factor couples reproduction to aging in Caenorhabditis elegans
10.1534/genetics.117.204222 · 2017 · External reference
Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans
2020 · External reference
Determinants and outcomes of mitochondrial dynamics
10.1016/j.molcel.2023.02.012 · 2023 · External reference
Dynamics of mitochondrial morphology in healthy cells and during apoptosis
10.1038/sj.cdd.4401260 · 2003 · External reference
Lysosomal size matters
10.1111/tra.12714 · 2020 · External reference
Lysosome fission: planning for an exit
10.1016/j.tcb.2019.05.003 · 2019 · External reference
Tubular lysosome induction couples animal starvation to healthy aging
10.1038/s43587-023-00470-6 · 2023 · External reference
Pathogenic LRRK2 mutations, through increased kinase activity, produce enlarged lysosomes with reduced degradative capacity and increase ATP13A2 expression
10.1093/hmg/ddv314 · 2015 · External reference
Sequential action of Caenorhabditis elegans Rab GTPases regulates phagolysosome formation during apoptotic cell degradation
10.1073/pnas.1008946107 · 2010 · External reference
LAAT-1 is the lysosomal lysine/arginine transporter that maintains amino acid homeostasis
10.1126/science.1220281 · 2012 · External reference
Oxidative stress, aging, and diseases
10.2147/cia.s158513 · 2018 · External reference
The role of redox-mediated lysosomal dysfunction and therapeutic strategies
10.1016/j.biopha.2023.115121 · 2023 · External reference
Spatiotemporal regulation of autophagy during Caenorhabditis elegans aging
10.7554/elife.18459 · 2017 · External reference
SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans
10.1016/j.freeradbiomed.2015.06.008 · 2015 · External reference
The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans
10.1038/ncomms3267 · 2013 · External reference
Proteasomal dysfunction activates the transcription factor SKN-1 and produces a selective oxidative-stress response in Caenorhabditis elegans
10.1042/bj20070521 · 2008 · External reference
Mitochondrial SKN-1/Nrf mediates a conserved starvation response
10.1016/j.cmet.2012.09.007 · 2012 · External reference
The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans
10.1128/mcb.01811-08 · 2009 · External reference
The amino acid transporter SLC-36.1 cooperates with PtdIns3P 5-kinase to control phagocytic lysosome reformation
10.1083/jcb.201901074 · 2019 · External reference
Saturated very long chain fatty acid configures glycosphingolipid for lysosome homeostasis in long-lived C. elegans
10.1038/s41467-021-25398-6 · 2021 · External reference
PIKfyve activity regulates reformation of terminal storage lysosomes from endolysosomes
10.1111/tra.12525 · 2017 · External reference
Biogenesis of lysosome-related organelles complex-1 (BORC) regulates late endosomal/lysosomal size through PIKfyve-dependent phosphatidylinositol-3,5-bisphosphate
10.1111/tra.12679 · 2019 · External reference
BORC, a multisubunit complex that regulates lysosome positioning
10.1016/j.devcel.2015.02.011 · 2015 · External reference
A BORC-dependent molecular pathway for vesiculation of cell corpse phagolysosomes
10.1016/j.cub.2022.12.041 · 2023 · External reference
BORC regulates the axonal transport of synaptic vesicle precursors by activating ARL-8
10.1016/j.cub.2017.07.013 · 2017 · External reference
Autophagy genes are essential for dauer development and life-span extension in C. elegans
10.1126/science.1087782 · 2003 · External reference
Regulation of life-span by germ-line stem cells in Caenorhabditis elegans
10.1126/science.1065768 · 2002 · External reference
Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence
10.7554/elife.07836 · 2015 · External reference
Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans
10.1016/j.cell.2008.01.030 · 2008 · External reference
Aging and SKN-1-dependent loss of 20S proteasome adaptation to oxidative stress in C. elegans
10.1093/gerona/glw093 · 2017 · External reference
Clathrin and phosphatidylinositol-4,5-bisphosphate regulate autophagic lysosome reformation
10.1038/ncb2557 · 2012 · External reference
SKN-1 and Nrf2 couples proline catabolism with lipid metabolism during nutrient deprivation
10.1038/ncomms6048 · 2014 · External reference
Autophagic lysosome reformation in health and disease
10.1080/15548627.2022.2128019 · 2023 · External reference
The genetics of Caenorhabditis elegans
10.1093/genetics/77.1.71 · 1974 · External reference
Systematic functional analysis of the Caenorhabditis elegans genome using RNAi
10.1038/nature01278 · 2003 · External reference
Proline catabolism modulates innate immunity in Caenorhabditis elegans
10.1016/j.celrep.2016.11.038 · 2016 · External reference
Guidelines for monitoring autophagy in Caenorhabditis elegans
2015 · External reference
Histone acetylation promotes long-lasting defense responses and longevity following early life heat stress
10.1371/journal.pgen.1008122 · 2019 · External reference
The impact of glucose on mitochondria and life span is determined by the integrity of proline catabolism in Caenorhabditis elegans
10.1016/j.jbc.2023.102881 · 2023 · External reference
