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References from The deubiquitinating enzyme Cezanne stabilizes BRCA1 by counteracting APC/C and Ube2S-dependent Lys11-linked ubiquitination. Local targets link to admitted publications; unresolved targets remain external evidence.
Ubiquitination and proteasomal degradation of the BRCA1 tumor suppressor is regulated during cell cycle progression
10.1074/jbc.m403646200 · 2004 · External reference
BRCA1 is a cell cycle-regulated nuclear phosphoprotein
10.1073/pnas.94.14.7138 · 1997 · External reference
Physiological modulation of endogenous BRCA1 p220 abundance suppresses DNA damage during the cell cycle
10.1101/gad.225045.113 · 2013 · External reference
HERC2 is an E3 ligase that targets BRCA1 for degradation
10.1158/0008-5472.can-10-1304 · 2010 · External reference
The F-box protein FBXO44 mediates BRCA1 ubiquitination and degradation
10.1074/jbc.m112.407106 · 2012 · External reference
HUWE1 interacts with BRCA1 and promotes its degradation in the ubiquitin-proteasome pathway
10.1016/j.bbrc.2014.01.075 · 2014 · External reference
Breaking the chains: structure and function of the deubiquitinases
10.1038/nrm2731 · 2009 · External reference
OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis
10.1016/j.cell.2013.05.046 · 2013 · External reference
Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne
10.1038/nature19836 · 2016 · External reference
Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne
10.1038/nsmb.1873 · 2010 · External reference
TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling
10.1038/nature22344 · 2017 · External reference
NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signaling
10.1074/jbc.m708690200 · 2008 · External reference
RNF8- and Ube2S-dependent ubiquitin lysine 11-linkage modification in response to dna damage
10.1016/j.molcel.2017.04.013 · 2017 · External reference
Crosstalk between Lys63- and Lys11-polyubiquitin signaling at DNA damage sites is driven by Cezanne
10.1101/gad.332395.119 · 2019 · External reference
Cezanne/OTUD7B is a cell cycle-regulated deubiquitinase that antagonizes the degradation of APC/C substrates
10.15252/embj.201798701 · 2018 · External reference
Novel multiubiquitin chain linkages catalyzed by the conjugating enzymes E2EPF and RAD6 are recognized by 26 S proteasome subunit 5
10.1074/jbc.271.5.2823 · 1996 · External reference
Assembly of k11-linked ubiquitin chains by the anaphase-promoting complex
10.1007/978-1-4419-6676-6_9 · 2010 · External reference
The anaphase promoting complex/cyclosome: a machine designed to destroy
10.1038/nrm1988 · 2006 · External reference
UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit
10.1038/ncb1983 · 2009 · External reference
Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex
10.1016/j.cell.2008.04.012 · 2008 · External reference
The mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2
10.1016/j.cell.2011.01.035 · 2011 · External reference
Identification of a physiological E2 module for the human anaphase-promoting complex
10.1073/pnas.0907887106 · 2009 · External reference
UBE2S drives elongation of K11-linked ubiquitin chains by the anaphase-promoting complex
10.1073/pnas.0912802107 · 2010 · External reference
The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1
10.1101/gad.14.6.655 · 2000 · External reference
Building a regulatory network with short linear sequence motifs: lessons from the degrons of the anaphase-promoting complex
10.1016/j.molcel.2016.09.006 · 2016 · External reference
Cyclin is degraded by the ubiquitin pathway
10.1038/349132a0 · 1991 · External reference
Methylation of the BRCA1 promoter region in sporadic breast and ovarian cancer: correlation with disease characteristics
10.1038/sj.onc.1202509 · 1999 · External reference
Epigenetic factors controlling the BRCA1 and BRCA2 genes in sporadic ovarian cancer
2002 · External reference
Frequent loss of BRCA1 mRNA and protein expression in sporadic ovarian cancers
10.1002/1097-0215(20000801)87:3<317::aid-ijc2>3.0.co;2-b · 2000 · External reference
Reduction of BRCA1 protein expression in Japanese sporadic breast carcinomas and its frequent loss in BRCA1-associated cases
1999 · External reference
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
10.1038/nature03443 · 2005 · External reference
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
10.1038/nature03445 · 2005 · External reference
PARP inhibitors: synthetic lethality in the clinic
10.1126/science.aam7344 · 2017 · External reference
PARP inhibitors: extending benefit beyond BRCA-mutant cancers
10.1158/1078-0432.ccr-18-0968 · 2019 · External reference
Hallmarks of “BRCAness” in sporadic cancers
10.1038/nrc1457 · 2004 · External reference
BRCAness revisited
10.1038/nrc.2015.21 · 2016 · External reference
Identification of a RING protein that can interact in vivo with the BRCA1 gene product
10.1038/ng1296-430 · 1996 · External reference
The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation
10.1074/jbc.c000881200 · 2001 · External reference
The anaphase-promoting complex: it’s not just for mitosis any more
10.1101/gad.1013102 · 2002 · External reference
mSignatureDB: a database for deciphering mutational signatures in human cancers
2018 · External reference
Landscape of somatic mutations in 560 breast cancer whole-genome sequences
10.1038/nature17676 · 2016 · External reference
Signatures of mutational processes in human cancer
10.1038/nature12477 · 2013 · External reference
A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer
10.1038/ng.3934 · 2017 · External reference
Gene expression profile of BRCAness that correlates with responsiveness to chemotherapy and with outcome in patients with epithelial ovarian cancer
10.1200/jco.2009.27.5719 · 2010 · External reference
An integrated TCGA pan-cancer clinical data resource to drive high-quality survival outcome analytics
2018 · External reference
Survival analysis across the entire transcriptome identifies biomarkers with the highest prognostic power in breast cancer
10.1016/j.csbj.2021.07.014 · 2021 · External reference
Online survival analysis software to assess the prognostic value of biomarkers using transcriptomic data in non-small-cell lung cancer
10.1371/journal.pone.0082241 · 2013 · External reference
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
10.1038/nature11003 · 2012 · External reference
DNA repair function scores for 2172 variants in the BRCA1 amino-terminus
10.1371/journal.pgen.1010739 · 2023 · External reference
Spatiotemporal regulation of the anaphase-promoting complex in mitosis
10.1038/nrm3934 · 2015 · External reference
Who guards the guardian? Mechanisms that restrain APC/C during the cell cycle
10.1016/j.bbamcr.2018.09.011 · 2018 · External reference
Repair of strand breaks by homologous recombination
10.1101/cshperspect.a012740 · 2013 · External reference
Push back to respond better: regulatory inhibition of the DNA double-strand break response
10.1038/nrm3659 · 2013 · External reference
BRCA1 expression is induced before DNA synthesis in both normal and tumor-derived breast cells
1996 · External reference
Cell cycle regulation of BRCA1 messenger RNA in human breast epithelial cells
1996 · External reference
A transcription-independent mechanism determines rapid periodic fluctuations of BRCA1 expression
2023 · External reference
A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice
10.1016/j.molcel.2013.01.001 · 2013 · External reference
Structure of BRCA1-BRCT/Abraxas complex reveals phosphorylation-dependent BRCT dimerization at DNA damage sites
2016 · External reference
Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage
10.1073/pnas.0710061104 · 2007 · External reference
NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control
10.1101/gad.1770309 · 2009 · External reference
Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response
10.1126/science.1139476 · 2007 · External reference
RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites
10.1126/science.1139516 · 2007 · External reference
Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response
10.1126/science.1139621 · 2007 · External reference
Pathologic features and immunophenotype of estrogen receptor-positive breast cancers in BRCA1 mutation carriers
10.1097/pas.0b013e31825789ed · 2012 · External reference
Prevalence and predictors of loss of wild type BRCA1 in estrogen receptor positive and negative BRCA1-associated breast cancers
10.1186/bcr2776 · 2010 · External reference
Refined histopathological predictors of BRCA1 and BRCA2 mutation status: a large-scale analysis of breast cancer characteristics from the BCAC, CIMBA, and ENIGMA consortia
10.1186/s13058-014-0474-y · 2014 · External reference
NBA1/MERIT40 and BRE interaction is required for the integrity of two distinct deubiquitinating enzyme BRCC36-containing complexes
10.1074/jbc.m110.200857 · 2011 · External reference
