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References from Derepression of the epithelial transcription factor GRHL2 promotes direct hepatocyte-to-cholangiocyte transdifferentiation. Local targets link to admitted publications; unresolved targets remain external evidence.
Transcription control of liver development
10.3390/cells10082026 · 2021 · External reference
Gene regulatory networks in differentiation and direct reprogramming of hepatic cells
10.1016/j.semcdb.2016.12.003 · 2017 · External reference
Control of cell identity by the nuclear receptor HNF4 in organ pathophysiology
10.3390/cells9102185 · 2020 · External reference
Cholangiocyte pathobiology
10.1038/s41575-019-0125-y · 2019 · External reference
Epithelial morphogenesis during liver development
10.1101/cshperspect.a027862 · 2017 · External reference
Liquid-crystal organization of liver tissue
10.7554/elife.44860 · 2019 · External reference
Structural and functional hepatocyte polarity and liver disease
10.1016/j.jhep.2015.06.015 · 2015 · External reference
The special case of hepatocytes: unique tissue architecture calls for a distinct mode of cell division
10.4161/bioa.29012 · 2014 · External reference
Epithelial plasticity during liver injury and regeneration
10.1016/j.stem.2020.08.016 · 2020 · External reference
Distinct hepatocyte identities in liver homeostasis and regeneration
10.1016/j.jhepr.2023.100779 · 2023 · External reference
Acquisition of epithelial plasticity in human chronic liver disease
10.1038/s41586-024-07465-2 · 2024 · External reference
De novo formation of the biliary system by TGFβ-mediated hepatocyte transdifferentiation
10.1038/s41586-018-0075-5 · 2018 · External reference
Progenitor cell expansion and impaired hepatocyte regeneration in explanted livers from alcoholic hepatitis
10.1136/gutjnl-2014-308410 · 2015 · External reference
Loss of hepatocyte identity following aberrant YAP activation: a key mechanism in alcoholic hepatitis
10.1016/j.jhep.2021.05.041 · 2021 · External reference
Single-cell, single-nucleus, and spatial transcriptomics characterization of the immunological landscape in the healthy and PSC human liver
10.1016/j.jhep.2023.12.023 · 2024 · External reference
Ductular reaction in liver diseases: pathological mechanisms and translational significances
10.1002/hep.30150 · 2019 · External reference
Kupffer-cell-derived IL-6 is repurposed for hepatocyte dedifferentiation via activating progenitor genes from injury-specific enhancers
2023 · External reference
A Homeostatic Arid1a-dependent permissive chromatin state licenses hepatocyte responsiveness to liver-injury-associated YAP signaling
2019 · External reference
Bipotential adult liver progenitors are derived from chronically injured mature hepatocytes
10.1016/j.stem.2014.09.008 · 2014 · External reference
Comparative analysis of cell lineage differentiation during hepatogenesis in humans and mice at the single-cell transcriptome level
10.1038/s41422-020-0378-6 · 2020 · External reference
Temporal analyses of postnatal liver development and maturation by single-cell transcriptomics
10.1016/j.devcel.2022.01.004 · 2022 · External reference
The spatiotemporal program of zonal liver regeneration following acute injury
10.1016/j.stem.2022.04.008 · 2022 · External reference
Functional compensation precedes recovery of tissue mass following acute liver injury
10.1038/s41467-020-19558-3 · 2020 · External reference
Transcriptional switch of hepatocytes initiates macrophage recruitment and T-cell suppression in endotoxemia
10.1016/j.jhep.2022.02.028 · 2022 · External reference
Dynamic transcriptional and epigenetic changes drive cellular plasticity in the liver
10.1002/hep.31704 · 2021 · External reference
Single-cell analysis of the liver epithelium reveals dynamic heterogeneity and an essential role for YAP in homeostasis and regeneration
2019 · External reference
Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches
10.1016/j.cell.2021.12.018 · 2022 · External reference
Cellular plasticity balances the metabolic and proliferation dynamics of a regenerating liver
10.1101/gr.267013.120 · 2021 · External reference
Single-cell omics analysis reveals functional diversification of hepatocytes during liver regeneration
10.1172/jci.insight.141024 · 2020 · External reference
3,5-Diethoxycarbonyl-1,4-Dihydrocollidine diet: a rodent model in cholestasis research
10.1007/978-1-4939-9420-5_16 · 2019 · External reference
Diverse functions of SOX9 in liver development and homeostasis and hepatobiliary diseases
10.1016/j.gendis.2023.03.035 · 2023 · External reference
CellRank 2: unified fate mapping in multiview single-cell data
10.1038/s41592-024-02303-9 · 2024 · External reference
A time- and space-resolved nuclear receptor atlas in mouse liver
10.1530/jme-23-0017 · 2023 · External reference
10.1101/2023.01.10.520698
10.1101/2023.01.10.520698 · 2023 · External reference
DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update)
10.1093/nar/gkac194 · 2022 · External reference
A limited set of transcriptional programs define major cell types
10.1101/gr.263186.120 · 2020 · External reference
A single-cell type transcriptomics map of human tissues
10.1126/sciadv.abh2169 · 2021 · External reference
Genome-wide midrange transcription profiles reveal expression level relationships in human tissue specification
10.1093/bioinformatics/bti042 · 2005 · External reference
Organizing combinatorial transcription factor recruitment at cis-regulatory modules
10.1080/21541264.2017.1394424 · 2018 · External reference
The ploidy conveyor of mature hepatocytes as a source of genetic variation
10.1038/nature09414 · 2010 · External reference
Simultaneous transcriptional and epigenomic profiling from specific cell types within heterogeneous tissues in vivo
10.1016/j.celrep.2016.12.087 · External reference
Spark: a navigational paradigm for genomic data exploration
10.1101/gr.140665.112 · 2012 · External reference
Decoding the function of bivalent chromatin in development and cancer
10.1101/gr.275736.121 · 2021 · External reference
Single-cell spatial multi-omics and deep learning dissect enhancer-driven gene regulatory networks in liver zonation
10.1038/s41556-023-01316-4 · 2024 · External reference
Chromatin states shaped by an epigenetic code confer regenerative potential to the mouse liver
10.1038/s41467-021-24466-1 · 2021 · External reference
DNA methylation pathways and their crosstalk with histone methylation
10.1038/nrm4043 · 2015 · External reference
Polycomb repressive complex 2 proteins EZH1 and EZH2 regulate timing of postnatal hepatocyte maturation and fibrosis by repressing gene expression at promoter regions in euchromatin in mice
2019 · External reference
Genomic and proteomic resolution of heterochromatin and its restriction of alternate fate genes
10.1016/j.molcel.2017.11.030 · 2017 · External reference
The NIH roadmap epigenomics mapping consortium
10.1038/nbt1010-1045 · 2010 · External reference
An integrated encyclopedia of DNA elements in the human genome
10.1038/nature11247 · 2012 · External reference
Molecular architecture of polycomb repressive complexes
10.1042/bst20160173 · 2017 · External reference
Mechanisms regulating PRC2 recruitment and enzymatic activity
10.1016/j.tibs.2017.04.003 · 2017 · External reference
A hyper-quiescent chromatin state formed during aging is reversed by regeneration
10.1016/j.molcel.2023.04.005 · 2023 · External reference
OVOL2 induces mesenchymal-to-epithelial transition in fibroblasts and enhances cell-state reprogramming towards epithelial lineages
10.1038/s41598-019-43021-z · 2019 · External reference
Dual roles of the transcription factor grainyhead-like 2 (GRHL2) in breast cancer
10.1074/jbc.m113.456293 · 2013 · External reference
A grainyhead-like 2/Ovo-Like 2 pathway regulates renal epithelial barrier function and lumen expansion
10.1681/asn.2014080759 · 2015 · External reference
GRHL2-controlled gene expression networks in luminal breast cancer
10.1186/s12964-022-01029-5 · 2023 · External reference
GRHL2-dependent enhancer switching maintains a pluripotent stem cell transcriptional subnetwork after exit from naive pluripotency
2018 · External reference
The transcription factor Grainy head primes epithelial enhancers for spatiotemporal activation by displacing nucleosomes
10.1038/s41588-018-0140-x · 2018 · External reference
Inducible differentiation and morphogenesis of bipotential liver cell lines from wild-type mouse embryos
10.1053/jhep.2002.36123 · 2002 · External reference
Control of cell death/survival balance by the MET dependence receptor
10.7554/elife.50041 · 2020 · External reference
Grainyhead-like 2 regulates epithelial morphogenesis by establishing functional tight junctions through the organization of a molecular network among claudin3, claudin4, and Rab25
10.1091/mbc.e12-02-0097 · 2012 · External reference
Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids
10.1016/j.stem.2021.04.005 · 2021 · External reference
Evidence for multiple roles for grainyhead-like 2 in the establishment and maintenance of human mucociliary airway epithelium.[corrected]
10.1073/pnas.1307589110 · 2013 · External reference
Novel androgen receptor coregulator GRHL2 exerts both oncogenic and antimetastatic functions in prostate cancer
10.1158/0008-5472.can-16-1616 · 2017 · External reference
VULCAN integrates ChIP-seq with patient-derived co-expression networks to identify GRHL2 as a key co-regulator of ERa at enhancers in breast cancer
10.1186/s13059-019-1698-z · 2019 · External reference
GRHL2-miR-200-ZEB1 maintains the epithelial status of ovarian cancer through transcriptional regulation and histone modification
10.1038/srep19943 · 2016 · External reference
The transcription factor Grainy head primes epithelial enhancers for spatiotemporal activation by displacing nucleosomes
10.1038/s41588-018-0140-x · 2018 · External reference
Cistrome-GO: a web server for functional enrichment analysis of transcription factor ChIP-seq peaks
2019 · External reference
Varying mechanical forces drive sensory epithelium formation
2023 · External reference
Laminin-binding integrins are essential for the maintenance of functional mammary secretory epithelium in lactation
2020 · External reference
Apical-basal polarity and the control of epithelial form and function
10.1038/s41580-022-00465-y · 2022 · External reference
Keratins in health and cancer: more than mere epithelial cell markers
10.1038/onc.2010.456 · 2011 · External reference
An ESRP-regulated splicing programme is abrogated during the epithelial-mesenchymal transition
10.1038/emboj.2010.195 · 2010 · External reference
Infection of a human hepatoma cell line by hepatitis B virus
10.1073/pnas.232137699 · 2002 · External reference
Transdifferentiation of hepatocyte-like cells from the human hepatoma HepaRG cell line through bipotent progenitor
10.1002/hep.21536 · 2007 · External reference
Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation
10.1038/nprot.2016.097 · 2016 · External reference
Aberrant YAP activation in hepatocytes influences myofibroblast activation to induce a specific fibrosis profile in alcohol-related hepatitis
2025 · External reference
Abcb11 deficiency induces cholestasis coupled to impaired β-fatty acid oxidation in mice
10.1074/jbc.m111.329318 · 2012 · External reference
Urinary metabolomics in Fxr-null mice reveals activated adaptive metabolic pathways upon bile acid challenge
10.1194/jlr.m002923 · 2010 · External reference
Epithelial splicing regulatory protein 2-mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis
10.1172/jci132691 · 2020 · External reference
Hepatocyte dedifferentiation profiling in alcohol-related liver disease identifies CXCR4 as a driver of cell reprogramming
10.1016/j.jhep.2023.04.013 · 2023 · External reference
Spatial gene regulatory networks driving cell state transitions during human liver disease
10.1038/s44321-025-00230-6 · 2025 · External reference
Cell identity conversion in liver regeneration after injury
10.1016/j.gde.2022.101921 · 2022 · External reference
From hepatocyte to cholangiocyte: the remarkable potential of transdifferentiation to treat cholestatic diseases
10.1002/hep.30250 · 2019 · External reference
Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis
10.1038/s41467-019-11004-3 · 2019 · External reference
Atypical cholangiocytes derived from hepatocyte-cholangiocyte transdifferentiation mediated by COX-2: a kind of misguided liver regeneration
10.1186/s41232-023-00284-4 · 2023 · External reference
The regulation of the hippo pathway by intercellular junction proteins
2022 · External reference
Role of YAP1 signaling in biliary development, repair, and disease
10.1055/s-0041-1742277 · 2022 · External reference
The role of polarization and early heterogeneities in the mammalian first cell fate decision
10.1016/bs.ctdb.2023.02.006 · 2023 · External reference
Hepatocyte differentiation requires anisotropic expansion of bile canaliculi
10.1242/dev.202777 · 2024 · External reference
EHF is essential for epidermal and colonic epithelial homeostasis, and suppresses Apc-initiated colonic tumorigenesis
10.1242/dev.199542 · 2021 · External reference
The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalian development
10.7554/elife.08954 · 2015 · External reference
Cellular and transcriptional heterogeneity in the intrahepatic biliary epithelium
10.1016/j.gastha.2022.07.015 · 2023 · External reference
Generation of functional ciliated cholangiocytes from human pluripotent stem cells
10.1038/s41467-021-26764-0 · 2021 · External reference
Cellular reprogramming in vivo initiated by SOX4 pioneer factor activity
10.1038/s41467-024-45939-z · 2024 · External reference
MicroRNA 122, regulated by GRLH2, protects livers of mice and patients from ethanol-induced liver disease
10.1053/j.gastro.2017.09.022 · 2018 · External reference
Downregulation of miR122 by grainyhead-like 2 restricts the hepatocytic differentiation potential of adult liver progenitor cells
10.1242/dev.113654 · 2014 · External reference
In vivo CRISPR screening reveals epigenetic regulators of hepatobiliary plasticity
10.1101/gad.352420.124 · 2025 · External reference
The methyltransferases enhancer of zeste homolog (EZH) 1 and EZH2 control hepatocyte homeostasis and regeneration
10.1096/fj.14-261537 · 2015 · External reference
A cis-acting mechanism mediates transcriptional memory at Polycomb target genes in mammals
10.1038/s41588-021-00964-2 · 2021 · External reference
The default and directed pathways of hepatoblast differentiation involve distinct epigenomic mechanisms
10.1016/j.devcel.2023.07.002 · 2023 · External reference
EZH1/2 inhibition augments the anti-tumor effects of sorafenib in hepatocellular carcinoma
10.1038/s41598-021-00889-0 · 2021 · External reference
EZH2: a novel target for cancer treatment
10.1186/s13045-020-00937-8 · 2020 · External reference
Highly efficient gene transfer into hepatocyte-like HepaRG cells: new means for drug metabolism and toxicity studies
10.1002/biot.200900255 · 2010 · External reference
Main drivers of outcome differ between short term and long term in severe alcoholic hepatitis: a prospective study
10.1002/hep.29240 · 2017 · External reference
Combining data from liver disease scoring systems better predicts outcomes of patients with alcoholic hepatitis
10.1053/j.gastro.2015.04.044 · 2015 · External reference
Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
10.1093/nar/30.1.207 · 2002 · External reference
The Encyclopedia of DNA elements (ENCODE): data portal update
10.1093/nar/gkx1081 · 2018 · External reference
Integrative analysis of 111 reference human epigenomes
10.1038/nature14248 · 2015 · External reference
Cistrome Data Browser: integrated search, analysis and visualization of chromatin data
10.1093/nar/gkad1069 · 2024 · External reference
AnimalTFDB 3.0: a comprehensive resource for annotation and prediction of animal transcription factors
2019 · External reference
Nascent RNA sequencing analysis provides insights into enhancer-mediated gene regulation
10.1186/s12864-018-5016-z · 2018 · External reference
The UCSC Genome Browser database: 2019 update
10.1093/nar/gky1095 · 2019 · External reference
The sequence read archive
2011 · External reference
The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2018 update
10.1093/nar/gky379 · 2018 · External reference
HISAT: a fast spliced aligner with low memory requirements
10.1038/nmeth.3317 · 2015 · External reference
HTSeq—a Python framework to work with high-throughput sequencing data
10.1093/bioinformatics/btu638 · 2015 · External reference
Unresolved reference
2023 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
Ensembl 2022
10.1093/nar/gkab1049 · 2022 · External reference
10.1007/978-3-319-24277-4
10.1007/978-3-319-24277-4 · 2016 · External reference
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2022 · External reference
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10.1093/bioinformatics/bts034 · 2012 · External reference
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2008 · External reference
Metascape provides a biologist-oriented resource for the analysis of systems-level datasets
10.1038/s41467-019-09234-6 · 2019 · External reference
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
10.1073/pnas.0506580102 · 2005 · External reference
Integrated analysis of multimodal single-cell data
2021 · External reference
Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression
10.1186/s13059-019-1874-1 · 2019 · External reference
Semi-supervised integration of single-cell transcriptomics data
10.1038/s41467-024-45240-z · 2024 · External reference
ISCEBERG: interactive single cell expression browser for exploration of RNAseq data using graphics (v1.0.1)
2022 · External reference
Alevin efficiently estimates accurate gene abundances from dscRNA-seq data
10.1186/s13059-019-1670-y · 2019 · External reference
Generalizing RNA velocity to transient cell states through dynamical modeling
10.1038/s41587-020-0591-3 · 2020 · External reference
Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics
10.1186/s12864-018-4772-0 · 2018 · External reference
Unresolved reference
External reference
Unresolved reference
2020 · External reference
Fast alignment and preprocessing of chromatin profiles with Chromap
10.1038/s41467-021-26865-w · 2021 · External reference
deepTools2: a next generation web server for deep-sequencing data analysis
10.1093/nar/gkw257 · 2016 · External reference
The ENCODE uniform analysis pipelines
External reference
Integrated genome browser: visual analytics platform for genomics
10.1093/bioinformatics/btw069 · 2016 · External reference
Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration
10.1093/bib/bbs017 · 2013 · External reference
CellRank for directed single-cell fate mapping
10.1038/s41592-021-01346-6 · 2022 · External reference
