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References from Adaptations of the axon initial segment in fast-spiking interneurons of the human neocortex support low action potential thresholds. Local targets link to admitted publications; unresolved targets remain external evidence.
Evolution of cortical neurons supporting human cognition
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A primate-specific short GluN2A-NMDA receptor isoform is expressed in the human brain
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10.1159/000437413 · 2015 · External reference
Human neocortical expansion involves glutamatergic neuron diversification
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Conserved cell types with divergent features in human versus mouse cortex
10.1038/s41586-019-1506-7 · 2019 · External reference
Large-scale cellular-resolution gene profiling in human neocortex reveals species-specific molecular signatures
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Comparative single-cell transcriptomic analysis of primate brains highlights human-specific regulatory evolution
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Evolutionary mechanisms and neural adaptation: selective versus constructive strategies in the development and plasticity of the nervous system.
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Whole-brain comparison of rodent and human brains using spatial transcriptomics
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Transcriptomic and morphophysiological evidence for a specialized human cortical GABAergic cell type
10.1038/s41593-018-0205-2 · 2018 · External reference
Local connectivity and synaptic dynamics in mouse and human neocortex
10.1126/science.abj5861 · 2022 · External reference
Activity-dependent tuning of intrinsic excitability in mouse and human neurogliaform cells
10.7554/elife.57571 · 2020 · External reference
An enhanced role and expanded developmental origins for gamma-aminobutyric acidergic interneurons in the human cerebral cortex
10.1111/joa.12198 · 2015 · External reference
Development and evolution of the primate neocortex from a progenitor cell perspective
10.1242/dev.199797 · 2024 · External reference
Verbal and general IQ associate with supragranular layer thickness and cell properties of the left temporal cortex
10.1093/cercor/bhab330 · 2022 · External reference
Cell type-specific gene expression of alpha 5 subunit-containing gamma-aminobutyric acid subtype a receptors in human and mouse frontal cortex
2019 · External reference
Comparative transcriptomics reveals human-specific cortical features
10.1126/science.ade9516 · 2023 · External reference
h-channels contribute to divergent intrinsic membrane properties of supragranular pyramidal neurons in human versus mouse cerebral cortex
10.1016/j.neuron.2018.10.012 · 2018 · External reference
Neocortical lamination: insights from neuron types and evolutionary precursors
10.3389/fnana.2017.00100 · 2017 · External reference
Development and functional diversification of cortical interneurons
10.1016/j.neuron.2018.10.009 · 2018 · External reference
GABAergic interneurons in the neocortex: from cellular properties to circuits
10.1016/j.neuron.2016.06.033 · 2016 · External reference
Signature morphoelectric properties of diverse GABAergic interneurons in the human neocortex
2023 · External reference
Comparing the electrophysiology and morphology of human and mouse layer 2/3 pyramidal neurons with bayesian networks
10.3389/fninf.2021.580873 · 2021 · External reference
Diversity amongst human cortical pyramidal neurons revealed via their sag currents and frequency preferences
10.1038/s41467-021-22741-9 · 2021 · External reference
Output of neurogliaform cells to various neuron types in the human and rat cerebral cortex
10.3389/neuro.04.004.2007 · 2007 · External reference
Rapid neuromodulation of layer 1 interneurons in human neocortex
10.1016/j.celrep.2018.03.111 · 2018 · External reference
HCN channels at the cell soma ensure the rapid electrical reactivity of fast-spiking interneurons in human neocortex
10.1371/journal.pbio.3002001 · 2023 · External reference
High synaptic threshold for dendritic NMDA spike generation in human layer 2/3 pyramidal neurons
10.1016/j.celrep.2022.111787 · 2022 · External reference
Mechanisms underlying the rules for associative plasticity at adult human neocortical synapses
10.1523/jneurosci.3158-13.2013 · 2013 · External reference
Structural and functional specializations of human fast-spiking neurons support fast cortical signaling
10.1126/sciadv.adf0708 · 2023 · External reference
In search of a unifying theory of complex brain evolution
10.1111/j.1749-6632.2009.04421.x · 2009 · External reference
Modeling reveals human-rodent differences in H-current kinetics influencing resonance in cortical layer 5 neurons
10.1093/cercor/bhaa261 · 2021 · External reference
LRRC37B is a human modifier of voltage-gated sodium channels and axon excitability in cortical neurons
10.1016/j.cell.2023.11.028 · 2023 · External reference
Morpho-electric diversity of human hippocampal CA1 pyramidal neurons
10.1016/j.celrep.2024.114100 · 2024 · External reference
Parvalbumin-positive basket interneurons in monkey and rat prefrontal cortex
10.1152/jn.90396.2008 · 2008 · External reference
Firing frequency maxima of fast-spiking neurons in human, monkey, and mouse neocortex
10.3389/fncel.2016.00239 · 2016 · External reference
High-precision fast-spiking basket cell discharges during complex events in the human neocortex
10.1523/eneuro.0260-17.2017 · 2017 · External reference
Robust perisomatic GABAergic self-innervation inhibits basket cells in the human and mouse supragranular neocortex
10.7554/elife.51691 · 2020 · External reference
Fast-spiking parvalbumin-positive interneurons in brain physiology and Alzheimer’s disease
10.1038/s41380-023-02168-y · 2023 · External reference
Axon initial segments: structure, function, and disease
10.1111/nyas.13718 · 2018 · External reference
The axon initial segment: an updated viewpoint
10.1523/jneurosci.1922-17.2018 · 2018 · External reference
Interneurons. Fast-spiking, parvalbumin⁺ GABAergic interneurons: from cellular design to microcircuit function
10.1126/science.1255263 · 2014 · External reference
Action potential initiation in neocortical inhibitory interneurons
2014 · External reference
Structural and functional plasticity at the axon initial segment
10.3389/fncel.2016.00250 · 2016 · External reference
betaIV spectrin is recruited to axon initial segments and nodes of Ranvier by ankyrinG
10.1083/jcb.200610128 · 2007 · External reference
Axon initial segment cytoskeleton: architecture, development, and role in neuron polarity
10.1155/2016/6808293 · 2016 · External reference
Theoretical relation between axon initial segment geometry and excitability
10.7554/elife.53432 · 2020 · External reference
Signal processing in the axon initial segment
10.1016/j.neuron.2012.01.007 · 2012 · External reference
Roles of axonal sodium channels in precise auditory time coding at nucleus magnocellularis of the chick
10.1113/jphysiol.2008.162651 · 2009 · External reference
Cell-type-dependent molecular composition of the axon initial segment
10.1523/jneurosci.4833-08.2008 · 2008 · External reference
Sodium channel SCN8A (Nav1.6): properties and de novo mutations in epileptic encephalopathy and intellectual disability
2013 · External reference
K+ channels at the axon initial segment dampen near-threshold excitability of neocortical fast-spiking GABAergic interneurons
10.1016/j.neuron.2008.03.003 · 2008 · External reference
Axon initial segment Kv1 channels control axonal action potential waveform and synaptic efficacy
10.1016/j.neuron.2007.07.031 · 2007 · External reference
Function and mechanism of axonal targeting of voltage-sensitive potassium channels
10.1016/j.pneurobio.2011.04.009 · 2011 · External reference
Kv1.1 channelopathies: pathophysiological mechanisms and therapeutic approaches
10.3390/ijms21082935 · 2020 · External reference
Postsynaptic density-93 clusters Kv1 channels at axon initial segments independently of Caspr2
10.1523/jneurosci.4431-07.2008 · 2008 · External reference
Kv1 channels control spike threshold dynamics and spike timing in cortical pyramidal neurones
10.1113/jphysiol.2011.216721 · 2011 · External reference
Patch-seq: advances and biological applications
10.1007/s10571-023-01436-3 · 2023 · External reference
Patch-seq: multimodal profiling of single-cell morphology, electrophysiology, and gene expression
10.1007/978-1-0716-3621-3_15 · 2024 · External reference
K(+) channel expression distinguishes subpopulations of parvalbumin- and somatostatin-containing neocortical interneurons
10.1523/jneurosci.19-21-09332.1999 · 1999 · External reference
Functional and molecular differences between voltage-gated K+ channels of fast-spiking interneurons and pyramidal neurons of rat hippocampus
10.1523/jneurosci.18-20-08111.1998 · 1998 · External reference
Aging-associated weakening of the action potential in fast-spiking interneurons in the human neocortex
10.1016/j.jbiotec.2024.04.020 · 2024 · External reference
The evolution of the neocortex in mammals: how is phenotypic diversity generated?
10.1016/j.conb.2005.07.003 · 2005 · External reference
Gene regulation in primates evolves under tissue-specific selection pressures
10.1371/journal.pgen.1000271 · 2008 · External reference
Genetic basis of human brain evolution
10.1016/j.tins.2008.08.010 · 2008 · External reference
Evolution and genomics of the human brain
2018 · External reference
Molecular features driving cellular complexity of human brain evolution
10.1038/s41586-023-06338-4 · 2023 · External reference
Genetics of human brain development
10.1038/s41576-023-00626-5 · 2024 · External reference
GABAergic cell subtypes and their synaptic connections in rat frontal cortex
10.1093/cercor/7.6.476 · 1997 · External reference
Multiple distinct subtypes of GABAergic neurons in mouse visual cortex identified by triple immunostaining
10.3389/neuro.05.003.2007 · 2008 · External reference
Parvalbumin interneuron vulnerability and brain disorders
10.1038/s41386-020-0778-9 · 2021 · External reference
Cortical parvalbumin interneurons and cognitive dysfunction in schizophrenia
10.1016/j.tins.2011.10.004 · 2012 · External reference
The role of parvalbumin interneurons in neurotransmitter balance and neurological disease
10.3389/fpsyt.2021.679960 · 2021 · External reference
Parvalbumin interneuron deficits in schizophrenia
10.1016/j.euroneuro.2024.02.010 · 2024 · External reference
Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance
10.1038/35051086 · 2001 · External reference
Oxidative phosphorylation, not glycolysis, powers presynaptic and postsynaptic mechanisms underlying brain information processing
10.1523/jneurosci.0026-12.2012 · 2012 · External reference
Updated energy budgets for neural computation in the neocortex and cerebellum
10.1038/jcbfm.2012.35 · 2012 · External reference
GABAergic neurons in barrel cortex show strong, whisker-dependent metabolic activation during normal behavior
10.1523/jneurosci.17-14-05509.1997 · 1997 · External reference
Highly energized inhibitory interneurons are a central element for information processing in cortical networks
10.1038/jcbfm.2014.104 · 2014 · External reference
Cell-specific vulnerability to metabolic failure: the crucial role of parvalbumin expressing neurons in creatine transporter deficiency
10.1186/s40478-023-01533-w · 2023 · External reference
Metabolic constraint imposes tradeoff between body size and number of brain neurons in human evolution
10.1073/pnas.1206390109 · 2012 · External reference
Metabolic acceleration and the evolution of human brain size and life history
10.1038/nature17654 · 2016 · External reference
Heterogeneity of the axon initial segment in interneurons and pyramidal cells of rodent visual cortex
10.3389/fncel.2017.00332 · 2017 · External reference
Covariation of axon initial segment location and dendritic tree normalizes the somatic action potential
10.1073/pnas.1607548113 · 2016 · External reference
TANGO: a generic tool for high-throughput 3D image analysis for studying nuclear organization
10.1093/bioinformatics/btt276 · 2013 · External reference
Full-length RNA-seq from single cells using Smart-seq2
10.1038/nprot.2014.006 · 2014 · External reference
Large-scale low-cost NGS library preparation using a robust tn5 purification and tagmentation protocol
10.1534/g3.117.300257 · 2018 · External reference
STAR: ultrafast universal RNA-seq aligner
10.1093/bioinformatics/bts635 · 2013 · External reference